Dynamic control of vascular growth and function

About our research

Our research is focused on the formation and maintenance of the blood and lymphatic vascular systems. Vessels form complex branched networks that supply oxygen and nutrients to all body tissues. The signals controlling blood vessel expansion, identity and migration are all downstream of a single, common complex at the cell surface, yet exactly how this diverse range of functions is differentially regulated, depending on the physiological need, remains unknown.

The specific focus of our research is to determine the precise molecular signals that control endothelial cell interactions within the vessel wall and the surrounding environment. If the signals controlling cell adhesion become deregulated, normal vessel growth and function is lost. This contributes to the progression of a wide range of human diseases, including cancer growth and metastasis, diabetic eye disease and stroke. We utilise novel biological models, biochemical assays and imaging techniques to better understand vessel biology, which will enable improved treatment of disease and aid in the development of vascularised, bioengineered organs.

Research areas

  • Blood vessel growth
  • Cell adhesion
  • Cellular dynamics
  • Vascular permeability
  • Cell signalling
  • Pathological eye disease

Dr Markus Muttenthaler

Dr Emma Gordon

Group Leader, Vessel Dynamics lab

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Group leader

  • Dr Emma Gordon

    IMB Fellow
    Senior Research Fellow-Group Leader
    Institute for Molecular Bioscience

Research members