Dynamic control of vascular growth and function

About our research

Our research is focused on the formation and maintenance of the blood and lymphatic vascular systems. Vessels form complex branched networks that supply oxygen and nutrients to all body tissues. The signals controlling blood vessel expansion, identity and migration are all downstream of a single, common complex at the cell surface, yet exactly how this diverse range of functions is differentially regulated, depending on the physiological need, remains unknown.

The specific focus of our research is to determine the precise molecular signals that control endothelial cell interactions within the vessel wall and the surrounding environment. If the signals controlling cell adhesion become deregulated, normal vessel growth and function is lost. This contributes to the progression of a wide range of human diseases, including cancer growth and metastasis, diabetic eye disease and stroke. We utilise novel biological models, biochemical assays and imaging techniques to better understand vessel biology, which will enable improved treatment of disease and aid in the development of vascularised, bioengineered organs.

Research areas

  • Blood vessel growth
  • Cell adhesion
  • Cellular dynamics
  • Vascular permeability
  • Cell signalling
  • Pathological eye disease

Publications

The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall. Schimmel, Lilian and Gordon, Emma (2018) The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall. Biochemical Society Transactions46 6: . doi:10.1042/bst20180377

Shear stress and VE-cadherin. Caolo, Vincenza, Peacock, Hanna M., Kasaai, Bahar, Swennen, Geertje, Gordon, Emma, Claesson-Welsh, Lena, Post, Mark J., Verhamme, Peter and Jones, Elizabeth A. V. (2018) Shear stress and VE-cadherin. Arteriosclerosis, Thrombosis, and Vascular Biology38 9: 2174-2183. doi:10.1161/ATVBAHA.118.310823

Mechanisms and regulation of endothelial VEGF receptor signalling. Simons, Michael, Gordon, Emma and Claesson-Welsh, Lena (2016) Mechanisms and regulation of endothelial VEGF receptor signalling. Nature Reviews Molecular Cell Biology17 10: 611-625. doi:10.1038/nrm.2016.87

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Gordon, Emma J., Fukuhara, Daisuke, Westrom, Simone, Padhan, Narendra, Sjostrom, Elisabet O., van Meeteren, Laurens, He, Liqun, Orsenigo, Fabrizio, Dejana, Elisabetta, Bentley, Katie, Spurkland, Anne and Claesson-Welsh, Lena (2016) The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Science Signaling9 437: . doi:10.1126/scisignal.aad9256

Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling. Fleetwood, Filippa, Guler, Rezan, Gordon, Emma, Stahl, Stefan, Claesson-Welsh, Lena and Lofblom, John (2016) Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling. Cellular and Molecular Life Sciences73 8: 1671-1683. doi:10.1007/s00018-015-2088-7

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Li, Xiujuan, Padhan, Narendra, Sjostrom, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sainz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif and Claesson-Welsh, Lena (2016) VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nature Communications7 . doi:10.1038/ncomms11017

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Aspalter, Irene Maria, Gordon, Emma, Dubrac, Alexandre, Ragab, Anan, Narloch, Jarek, Vizan, Pedro, Geudens, Ilse, Collins, Russell Thomas, Franco, Claudio Areias, Abrahams, Cristina Luna, Thurston, Gavin, Fruttiger, Marcus, Rosewell, Ian, Eichmann, Anne and Gerhardt, Holger (2015) Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nature Communications6 1: . doi:10.1038/ncomms8264

Netrin-1 controls sympathetic arterial innervation. Brunet, Isabelle, Gordon, Emma, Han, Jinah, Cristofaro, Brunella, Broqueres-You, Dong, Liu, Chun, Bouvree, Karine, Zhang, Jiasheng, del Toro, Raquel, Mathivet, Thomas, Larrivee, Bruno, Jagu, Julia, Pibouin-Fragner, Laurence, Pardanaud, Luc, Machado, Maria J. C., Kennedy, Timothy E., Zhuang, Zhen, Simons, Michael, Levy, Bernard I., Tessier-Lavigne, Marc, Grenz, Almut, Eltzschig, Holger and Eichmann, Anne (2014) Netrin-1 controls sympathetic arterial innervation. Journal of Clinical Investigation124 7: 3230-3240. doi:10.1172/JCI75181

Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Harvey, Natasha L. and Gordon, Emma J. (2012) Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Vascular Cell4 1: 15. doi:10.1186/2045-824X-4-15

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Bouvree, Karine, Brunet, Isabelle, del Toro, Raquel, Gordon, Emma, Prahst, Claudia, Cristofaro, Brunella, Mathivet, Thomas, Xu, Yunling, Soueid, Jihane, Fortuna, Vitor, Miura, Nayoki, Aigrot, Marie-Stephane, Maden, Charlotte H., Ruhrberg, Christiana, Thomas, Jean Leon and Eichmann, Anne (2012) Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circulation Research111 4: 437-445. doi:10.1161/CIRCRESAHA.112.269316

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Larrivee, Bruno, Prahst, Claudia, Gordon, Emma, del Toro, Raquel, Mathivet, Thomas, Duarte, Antonio, Simons, Michael and Eichmann, Anne (2012) ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.Developmental Cell22 3: 489-500. doi:10.1016/j.devcel.2012.02.005

Erratum: Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation (Development 137, (3899-3910)). Gordon, Emma J., Rao, Sujata, Pollard, Jeffrey W., Nutt, Stephen L., Lang, Richard A. and Harvey, Natasha L. (2011) Erratum: Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation (Development 137, (3899-3910)). Development138 4: 797-797. doi:10.1242/dev.064022

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Gordon, Emma J., Rao, Sujata, Pollard, Jeffrey W., Nutt, Stephen L., Lang, Richard A. and Harvey, Natasha L. (2010) Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development137 22: 3899-3910. doi:10.1242/dev.050021

Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Gordon, Emma J., Gale, Nicholas W. and Harvey, Natasha L. (2008) Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Developmental Dynamics237 7: 1901-1909. doi:10.1002/dvdy.21605

Dr Markus Muttenthaler

Dr Emma Gordon

Group Leader, Vessel Dynamics lab

  +61 7 334 62985  
  e.gordon@imb.uq.edu.au
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Group leader

  • Dr Emma Gordon

    Senior Research Fellow-Group Leader
    Institute for Molecular Bioscience

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