Microbial Genomics and Bioinformatics

We envision a future where genomic data-driven approaches revolutionise our ability to control and mitigate the impact of infectious diseases worldwide

Our research focuses on microbial genomics and Bioinformatics, with key areas including patho-genomics, antimicrobial resistance (AMR), genomic epidemiology, genomic surveillance of Infectious Diseases and translating genomic research into clinical practice.

Our work delves into understanding the evolution of antimicrobial resistance (AMR), a critical global health concern, specifically focusing on mobile genetic elements and their roles in carriage and dissemination of AMR genes and driving the evolution of new resistant genotypes.

A primary focus of our clinical research is the application of computational methods for high-throughput analysis of priority pathogens, to facilitate rapid identification and characterisation of these pathogens, which is crucial for timely intervention and treatment. Specifically, we employ genomic epidemiology as a tool for elucidating the transmission dynamics of infectious diseases, aiding in the development of targeted interventions and infection prevention and control strategies. A key facet of our work in this area is to bridge the gap between genomics and routine clinical practice by developing pipelines for seamless integration of genomics into everyday healthcare. This has the potential to revolutionise healthcare delivery and improve patient outcomes.

We are commitment to translating genomic research into tangible clinical applications. Our research into transmission in healthcare facilities, along with genomic analysis workflows and visualization tools, underpin a NATA-accredited genomics surveillance program deployed with Queensland Health. This program has empowered Queensland healthcare facilities to offer microbial genomics as a clinical service, ultimately benefiting patient care.