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  • Montgomery Group

      Group Leader

    Professor Grant Montgomery

    Director, UQ Genome Innovation Hub
    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    Professor Grant Montgomery FAHMS FSRB Hon FRSNZ

    Professor Montgomery was born in New Zealand, completed PhD studies in Animal Science at Massey University and post-doctoral research in France. In 1987, he co-founded the New Zealand Sheep Genomics Program in the Biochemistry Department at the University of Otago and pioneered the introduction of genome mapping methods in farm animals. He moved to Australia in 1999 and joined the Queensland Institute of Medical Research where he ran a successful genome mapping program for human complex disease. In 2016, he moved to the University of Queensland and holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI). He is a National Health and Medical Research Council Leadership Fellow and Director of the UQ Genome Innovation Hub. He was elected a Fellow the Society for Reproductive Biology in 2012, Fellow of the Australian Academy of Health and Medical Sciences in 2015, and Honorary Fellow of the Royal Society of New Zealand in 2016. His research focusses on discovery of critical genes and pathways increasing risk for common diseases especially reproductive diseases including endometriosis.

    Body: 

    Highlights

    Professor Grant Montgomery uses genetic approaches to discover critical genes and pathways increasing risk for reproductive disorders. He applies state of the art genomic techniques to identify risk factors and understand how these genetic differences regulate gene expression and epigenetics to alter disease risk. The goal is to understand disease biology and help develop better methods for diagnosis and treatment.

    A major focus is women’s health and the pathogenesis of endometriosis. Together with colleagues in Brisbane, he led a recent large international study on genetic risk factors for endometriosis which confirmed 14 regions of the genome are associated with the disease, including 5 novel regions. His research is now moving to functional studies to identify the target genes in each region and determine how changes in the regulation of these genes contribute to disease. Professor Montgomery has published the first examples of likely target genes for two regions.

    He is also using genomic approaches to help understand environmental risk factors for this disease. Environmental risk factors may leave epigenetic signals on DNA that are associated with disease and he is part of an international study on global methylation analysis in endometriosis.

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    ResearcherID Scopus Orcid

     

      Researchers

    Dr Sugarniya Subramaniam

    Research Assistant
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Dr Brett McKinnon

    Senior Research Fellow
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    I am a basic science researcher with training in cell biology, genetics and research translation. My research investigates the female reproductive system by focusing on the contribution of individual cells. I aim to understand the influence of genetic architecture, differentiation and maturation on these individual cells and how this contributes to changes in the microenvironment that can contribute to disease initiation and progression.

    After the completion of my PhD in 2008 at the University of Queensland, I undertook post-doctoral studies at the University of Bern, Department of Biomedical Research (DBMR), focusing on endometriosis, ovarian and endometrial cancer. I curated patient samples from clinical research trials to investigate inflammatory and metabolic components of reproductive tissue and disease and began developing patient-derived models of the endometrium. I established a relationship between endometriosis lesions, nerves and pain and how this interaction was mediated by inflammation. I further developed patient-derived in vitro models to understand the interaction between inflammation and hormonal response of endometriotic lesions and how this could be utilized to target current and novel treatments. On returning to Australia in 2016 I joined the Genomics of Reproductive Disorders laboratory to integrate genetic background into patient-derived in vitro models. I established the Endometriosis Research Queensland Study (ERQS) in collaboration with the Royal Brisbane and Women's Hospital (RBWH) and extended in vitro models into complex multi-cellular assembloids (combinations of organoids and surrounding stromal cells).

    Dr Sally Mortlock

    Research Fellow/Senior Research officer
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 

    Mr Sharat Atluri

    Researcher profile is public: 
    0
    Supervisor: 

    Dr Lindsay Fowles

    Adjunct Research Fellow
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Dr Sam Lukowski

    Honorary Research Fellow
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Dr Sushma Marla

    Casual Research Assistant
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Students

    Mr Isaac Kyei Barffour

    Researcher profile is public: 
    0
    Supervisor: 

    Miss Isabelle McGrath

    PhD student
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Miss Li Ying Thong

    PhD student
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Mr Kei Tanaka

    PhD student
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
  • Masters Student
    Institute for Molecular Bioscience
  • Postdoctoral Research Fellow
    Institute for Molecular Bioscience

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