Professor Henderson's research group studies bacteria and their interaction with humans and animals. Their research is focused on the discovery of genes that are important for building the cell membrane of bacteria. Using genetic, biochemical and structural techniques they study the activity, regulation and function of these genes and their products. Using mice as a model they assess if the products of these genes are important for infectious disease. The group's purpose is to apply this understanding to the diagnosis, prevention and treatment of infections that can lead to life-threatening disease in humans and animals. Professor Henderson seeks targets for developing new antibiotics, vaccines and novel therapies.