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Stow Group
Group Leader
Professor Jennifer Stow
Professorial Research FellowNHMRC Leadership FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Professor Jennifer Stow is a molecular cell biologist, an NHMRC Leadership Fellow and head of the Protein Trafficking and Inflammation research laboratory in The University of Queensland's Institute of Molecular Bioscience (IMB). Her previous leadership appointments include as Division Head and Deputy Director (Research) at IMB (12 years) and she currently serves on national and international advisory boards, editorial boards and steering committees, and as an elected Associate Member of the European Molecular Biology Organisation (EMBO).
Jenny Stow received her undergraduate and PhD qualifications at Melbourne's Monash University before undertaking postdoctoral training in the Department of Cell Biology at Yale University School of Medicine, USA. With training as a microscopist in kidney research, she gained further experience at Yale as a postdoc in the lab of eminent cell biologist and microscopist, Dr Marilyn Farquhar, where protein trafficking was both a theme and a passion. Jenny then took up her first faculty appointment as an Assistant Professor in the Renal Unit at Massachusetts General Hospital (MGH) and Harvard Medical School in Boston USA, where her research uncovered new roles for a class of enzymes, GTPases, in regulating trafficking within cells. At MGH her research also formed part of a highly successful NIH Renal Cell Biology Program. In late 1994, Jenny moved her research lab back to Australia, to The University of Queensland, in late 1994 as a Wellcome Trust International Medical Research Fellow. As part of IMB since, the Stow lab has continued a focus on protein trafficking, including pioneering live-cell imaging, to spearhead their work on trafficking in inflammation, cancer and chronic disease. Major discoveries include identifying new proteins and pathways for recycling adhesion proteins in epithelial cells, inflammatory cytokine secretion in macrophages and immune signalling through Toll-like receptors in inflammation and infection. Small GTPases of the Rab family, signalling adaptors and kinases feature among the molecules studied in the Stow lab for their functional roles and their potential as drug targets in inflammation and cancer. A keen focus is to understand the role of the fluid uptake pathway, macropinocytosis, in controlling inflammation, cancer and mucosal absorption.
Professor Stow has been awarded multiple career fellowships including from American Heart Association, Wellcome Trust and NHMRC. She has published >200 papers, cited over 15,500 times and she is the recipient of awards and honours, most recently including the 2019 President's Medal from the Australia and New Zealand Society for Cell and Developmental Biology. She is also academic head of IMB Microscopy, a world-class fluorescence microscopy and image analysis facility. Her research is funded by a variety of agencies and industry partnerships, in addition to NHMRC and ARC, including through the ARC Centre of Excellence in Quantum Biotechnology, QUBIC. The Stow lab work with national and international collaborators and welcome students and postdoctoral trainees to participate in their research. We value having a diverse, inclusive and supportive culture for research and celebrate the many diverse and wonderful successes of Stow lab alumni.
Body:Highlights
Professor Jennifer Stow is a molecular cell biologist. She has had a lifelong fascination with cells, the ‘ultimate factories’, and how they work. After being awarded a PhD from Monash University, and training at Yale University School of Medicine, her first faculty appointment was at Massachusetts General Hospital/Harvard Medical School.
Professor Stow is renowned for her research on protein trafficking which has revealed how proteins critical for inflammation and cancer are moved around inside cells or transported out of cells. The cell signalling pathways that regulate these processes are also investigated in her search for ways to combat disease. Advanced imaging of molecules in living cells provides Professor Stow’s group with a remarkable window into the sub cellular universe and a way to observe cell behaviour.
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Researchers
Mr Darren Brown
Senior Research AssistantInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Mrs Tatiana Khromykh
NHMRC Research AssistantInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Dr Xichun Li
Postdoctoral Research FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Dr Alina Vitak
Senior Research Assistant/Technician/Coordinator (Supervisor)Institute for Molecular BioscienceResearcher profile is public:0Supervisor:Body:Alina completed her Bachelors and Masters degrees in Kyiv, Ukraine, specialising in biochemistry and molecular biology.
Her interest in cell signalling brought her to Professor Svetlana Sidorenko’s lab where her BSc research project focused on CD150-mediated signalling in B cells. Her MSc research involved characterising a new receptor, FcR-like 6, found on the surface of T cells. After her MSc studies, Alina applied her understanding of the adaptive immune responses by working in the R&D group of a biotech start-up company, developing ELISA-based diagnostic kits for human infectious diseases.
In 2012, Alina commenced her PhD in the Inflammasome Lab, switching to innate immunity and inflammation research. She is currently writing her thesis that focuses on the molecular and functional characterisation of NLRP12.
Students
Mr Hongyu Shen
Global Challenges ScholarInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Miss Sylvia Tan
PhD studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Miss Vrushali Maste
PhD studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Miss Wanyi Wang
Researcher profile is public:0Supervisor:- One of the barriers to stemming the rise of resistance to antibiotics is their overuse, and often this is because bacterial and viral infections have very similar symptoms.
- PhD studentInstitute for Molecular Bioscience
- Director Food Systems ProgramGlobal Change Institute
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The Edge: Genetics
People have known for thousands of years that parents pass traits to their children, but it is only relatively recently that our technology has caught up to our curiosity, enabling us to delve into the mystery of how this inheritance occurs, and the implications for predicting, preventing and treating disease.
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