Institute for Molecular Bioscience

Dr Alina Vitak

Senior Research Assistant/Technician/Coordinator (Supervisor)
Institute for Molecular Bioscience

Alina completed her Bachelors and Masters degrees in Kyiv, Ukraine, specialising in biochemistry and molecular biology.

Her interest in cell signalling brought her to Professor Svetlana Sidorenko’s lab where her BSc research project focused on CD150-mediated signalling in B cells. Her MSc research involved characterising a new receptor, FcR-like 6, found on the surface of T cells. After her MSc studies, Alina applied her understanding of the adaptive immune responses by working in the R&D group of a biotech start-up company, developing ELISA-based diagnostic kits for human infectious diseases.

In 2012, Alina commenced her PhD in the Inflammasome Lab, switching to innate immunity and inflammation research. She is currently writing her thesis that focuses on the molecular and functional characterisation of NLRP12.

Publications

Book Chapters (2)
Journal Articles (5)
Conference Paper (1)

Book Chapters

Sester, David P., Zamoshnikova, Alina, Thygesen, Sara J., Vajjhala, Parimala R., Cridland, Simon O., Schroder, Kate and Stacey, Katryn J. (2016). Assessment of inflammasome formation by flow cytometry. Current protocols in immunology. (pp. 14.40.1-14.40.29) edited by Coligan, John E., Bierer, Barbara, Margulies, David H., Shevach, Ethan M. and Strober, Warren. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/cpim.13
Chen, Kaiwen W., Richards, Ayanthi A., Zamoshnikova, Alina and Schroder, Kate (2014). Inflammasomes and inflammation. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects. (pp. 103-117) edited by Yusuke Hiraku, Shosuke Kawanishi and Hiroshi Ohshima. Hoboken, NJ, USA: John Wiley & Sons. doi: 10.1002/9781118826621.ch8

Journal Articles

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
Domínguez Cadena, Leslie C., Schultz, Thomas E., Zamoshnikova, Alina, Donovan, Meg L., Mathmann, Carmen D., Yu, Chien-Hsiung, Mori, Giorgia, Stow, Jennifer L and Blumenthal, Antje (2021). Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection. Immunology and Cell Biology, 99 (10), 1067-1076. doi: 10.1111/imcb.12503
Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7
Zamoshnikova, Alina, Grob, Christina J., Schuster, Steffen, Chen, Kaiwen W., Wilson, Anne, Tacchini-Cottier, Fabienne and Schroder, Kate (2016). NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology, 221 (2), 341-346. doi: 10.1016/j.imbio.2015.10.001
Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020

Conference Paper

Zamoshnikova, Alina, Gross, Christina J., Vasquez, Flor, Schuster, Steffen, Tacchini-Cottier, Fabienne, Richards, Ayanthi and Schroder, Kate (2014). Exploring NLRP12-An emerging member of NOD-like receptor family. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, 26-29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.217