Mr Darren Brown
Senior Research Assistant
Institute for Molecular Bioscience
+61 7 334 62365
Journal Articles
Watson, Mark L., Brown, Darren L., Stilgoe, Alexander B., Stow, Jennifer L. and Rubinsztein-Dunlop, Halina (2022). Rotational optical tweezers for active microrheometry within living cells. Optica, 9 (9), 1066-1072. doi: 10.1364/optica.468713
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
Koh, Yvette W. H., Hung, Yu, Tuladhar, Neeraj, Xiao, Zhijian, Brown, Darren L., Condon, Nicholas D. and Stow, Jennifer L. (2021). Live fluorescence, inverse imaging of cell ruffling, and macropinocytosis. Journal of Visualized Experiments (174) ARTN e62870. doi: 10.3791/62870
Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828
Guo, Dajiang, Lui, Goldie Y. L., Lai, Siew Li, Wilmott, James S., Tikoo, Shweta, Jackett, Louise A., Quek, Camelia, Brown, Darren L., Sharp, Danae M., Kwan, Rain Y. Q., Chacon, Diego, Wong, Jason H., Beck, Dominik, van Geldermalsen, Michelle, Holst, Jeff, Thompson, John F., Mann, Graham J., Scolyer, Richard A., Stow, Jennifer L., Weninger, Wolfgang, Haass, Nikolas K. and Beaumont, Kimberley A. (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. International Journal of Cancer, 144 (12), 3070-3085. doi: 10.1002/ijc.32064
Kojic, Marija, Gaik, Monika, Kiska, Bence, Salerno-Kochan, Anna, Hunt, Sarah, Tedoldi, Angelo, Mureev, Sergey, Jones, Alun, Whittle, Belinda, Genovesi, Laura A., Adolphe, Christelle, Brown, Darren L., Stow, Jennifer L., Alexandrov, Kirill, Sah, Pankaj, Glatt, Sebastian and Wainwright, Brandon J. (2018). Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Nature Communications, 9 (1) 3195, 3195. doi: 10.1038/s41467-018-05765-6
Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027
Vajjhala, Parimala R., Lu, Alvin, Brown, Darren L., Pang, Siew Wai, Sagulenko, Vitaliya, Sester, David P., Cridland, Simon O., Hill, Justine M., Schroder, Kate, Stow, Jennifer L., Wu, Hao and Stacey, Katryn J. (2015). The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. Journal of Biological Chemistry, 290 (49), 29217-29230. doi: 10.1074/jbc.M115.687731
Cristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W. and Rash, Lachlan D. (2015). Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports, 5 (1) 14763, 14763.1-14763.12. doi: 10.1038/srep14763
King, Nathan P., Newton, Patrice, Schuelein, Ralf, Brown, Darren L., Petru, Marketa, Zarsky, Vojtech, Dolezal, Pavel, Luo, Lin, Bugarcic, Andrea, Stanley, Amanda C., Murray, Rachael Z., Collins, Brett M., Teasdale, Rohan D., Hartland, Elizabeth L. and Stow, Jennifer L. (2015). Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector. Cellular Microbiology, 17 (6), 767-784. doi: 10.1111/cmi.12405
Jagirdar, Kasturee, Smit, Darren J., Ainger, Stephen A., Lee, Katie J., Brown, Darren L., Chapman, Brett, Zhao, Zhen Zhen, Montgomery, Grant W., Martin, Nicholas G., Stow, Jennifer L., Duffy, David L. and Sturm, Richard A. (2014). Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits. Pigment Cell and Melanoma Research, 27 (4), 552-564. doi: 10.1111/pcmr.12253
Wykes, Michelle N., Kay, Jason G., Manderson, Anthony, Liu, Xue Q., Brown, Darren L., Richard, Derek J., Wipasa, Jiraprapa, Jiang, Suhua H., Jones, Malcolm K., Janse, Chris J., Waters, Andrew P., Pierce, Susan K., Miller, Louis H., Stow, Jennifer L. and Good, Michael F. (2011). Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proceedings of the National Academy of Sciences of the United States of America, 108 (27), 11205-11210. doi: 10.1073/pnas.1108579108
Beaumont, Kimberley A., Hamilton, Nicholas A., Moores, Matthew T., Brown, Darren L., Ohbayashi, Norihiko, Cairncross, Oliver, Cook, Anthony L., Smith, Aaron G., Misaki, Ryo, Fukuda, Mitsunori, Taguchi, Tomohiko, Sturm, Richard A. and Stow, Jennifer L. (2011). The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic, 12 (5), 627-643. doi: 10.1111/j.1600-0854.2011.01172.x
Reefman, E, Kay, JG, Wood, SM, Offenhauser, C, Brown, DL, Roy, S, Stanley, AC, Low, PC, Manderson, AP and Stow, JL (2010). Cytokine secretion is distinct from secretion of cytotoxic granules in NK cells. Journal of immunology, 184 (9), 4852-4862. doi: 10.4049/jimmunol.0803954
Kerr, Markus C., Wang, Jack T. H., Castro, Natalie A., Hamilton, Nicholas A., Town, Liam, Brown, Darren L., Meunier, Frederic A., Brown, Nat F., Stow, Jennifer L. and Teasdale, Rohan D. (2010). Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. EMBO Journal, 29 (8), 1331-1347. doi: 10.1038/emboj.2010.28
Cook, Anthony L., Chen, Wei, Thurber, Amy E., Smit, Darren J., Smith, Aaron G., Bladen, Timothy G., Brown, Darren L., Duffy, David L., Pastorino, Lorenza, Bianchi-Scarra, Giovanna, Leonard, J. Helen, Stow, Jennifer L. and Sturm, Richard A. (2009). Analysis of Cultured Human Melanocytes Based on Polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P Loci. Journal of Investigative Dermatology, 129 (2), 392-405. doi: 10.1038/jid.2008.211
Greenwood, K. P., Daly, N. L., Brown, D. L., Stow, J. L. and Craik, D. J. (2007). The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. International Journal of Biochemistry & Cell Biology, 39 (12), 2252-2264. doi: 10.1016/j.biocel.2007.06.016
Derby, Merran C., Lieu, Zi Zhao, Brown, Darren, Stow, Jennifer L., Goud, Bruno and Gleeson, Paul A. (2007). The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic, 8 (6), 758-773. doi: 10.1111/j.1600-0854.2007.00563.x
Manderson, A, P., Kay, J. G., Hammond, L. A., Brown, D. L. and Stow, J. L. (2007). Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα. Journal of Cell Biology, 178 (1), 57-69. doi: 10.1083/jcb.200612131
Percival, J. M., Hughes, J. A. I., Brown, D. L., Schevzov, G., Heimann, K., Vrhovski, B., Bryce, N., Stow, J. L. and Gunning, P. W. (2004). Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex. Molecular Biology of The Cell, 15 (1), 268-280. doi: 10.1091/mbc.E03-03-0176
Derby, M. C., van Vilet, C., Brown, D., Luke, M. R., Lei, L., Hong, W. J., Stow, J. L. and Gleeson, P. A. (2004). Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. Journal of Cell Science, 117 (24), 5865-5874. doi: 10.1242/jcs.01497
Shearwin-Whyatt, L. M., Brown, D. L., Wylie, F. G., Stow, J. L. and Kumar, S. (2004). N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. Journal of Cell Science, 117 (16), 3679-3689. doi: 10.1242/jcs.01212
Leonard, J. Helen, Marks, Lisa H., Chen, Wei, Cook, Anthony L., Boyle, Glen M., Smit, Darren J., Brown, Darren L., Stow, Jennifer L., Parsons, Peter G. and Sturm, Richard A. (2003). Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: Pigmentation marker, ultrastructural and UV-survival studies. Pigment Cell Research, 16 (3), 198-207. doi: 10.1034/j.1600-0749.2003.00033.x
Sturm, R. A., Duffy, D. L., Box, N. F., Chen, W., Smit, D. J., Brown, D. L., Stow, J. L., Leonard, J. H. and Martin, N. G. (2003). The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. Pigment Cell Research, 16 (3), 266-272. doi: 10.1034/j.1600-0749.2003.00041.x
Luke, M. R., Kjer-Nielsen, L., Brown, D. L., Stow, J. L. and Gleeson, P. A. (2003). GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. Journal of Biological Chemistry, 278 (6), 4216-4226. doi: 10.1074/jbc.M210387200
Wylie, F. G., Lock, J. G., Jamriska, L., Khromykh, T., Brown, D. L. and Stow, J. L. (2003). GAIP participates in budding of membrane carriers at the trans-Golgi network. Traffic, 4 (3), 175-189. doi: 10.1034/j.1600-0854.2003.00106.x
Little, Melissa H., Wilkinson, Lorine, Brown, Darren L., Piper, Michael, Yamada, Toshiya and Stow, Jennifer L. (2001). Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein. American Journal of Physiology-cell Physiology, 281 (2), C486-C495. doi: 10.1152/ajpcell.2001.281.2.c486
Brown, D. L., Heimann, K., Lock, J., Kjer-Nielsen, L., van Vliet, C., Stow, J. L. and Gleeson, P. A. (2001). The GRIP domain is a specific targeting sequence for a population of trans-Golgi network derived tubulo-vesicular carriers. Traffic, 2 (5), 336-344. doi: 10.1034/j.1600-0854.2001.002005336.x
Shurety, W., Merino-Trigo, A., Brown, D. L., Hume, D. A. and Stow, J. L. (2000). Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.. Journal of Interferon and Cytokine Research, 20 (4), 427-438. doi: 10.1089/107999000312379
Wylie, Fiona, Heimann, Kirsten R., Luan Le, Tam, Brown, Darren, Rabnott, Glenn C. and Stow, Jennifer (1999). GAIP, a Galpha(i-3)-binding protein, is associated with Golgi-derived vesicles and protein trafficking. American Journal of Physiology, 276 (2), C497-C506. doi: 10.1152/ajpcell.1999.276.2.c497
Conference Papers
Guo, D., Lui, G. Y., Wilmott, J. S., Tikoo, S., Brown, D. L., Mann, G. J., Scolyer, R. A., Stow, J. L., Weninger, W., Beaumont, K. A. and Haass, N. (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. 46th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Munich, GERMANY, MAR 13-16, 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Vajjhala, P., Lu, A., Brown, D., Sagulenko, V, Schroder, K., Stow, J., Wu, H. and Stacey, K. (2016). Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Greenwood, K. P., Daly, N. L., Brown, D. L., Stow, J. L. and Craik, D. J. (2007). The cyclic cystine knot miniprotein MCoTI-II crosses the plasma membrane by macropinocytosis. 20th American Peptide Society Symposium, Montreal, Canada, 26-30 June 2007 . Hoboken, NJ, United States: John Wiley & Sons.
Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology In..