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Risk of depression and heart disease linked in women
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- Dr Christina Schroeder discusses using venoms to develop medicines, and why encouraging women into science is not a women's issue.
Nefzger group
Group Leader
Dr Christian Nefzger
Senior Research Fellow - GLInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Kindly visit my laboratory's webpage for more information
Research Members
Dr Xiaoli Chen
Supervisor, Laboratory/ies & Research AssistantInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Dr Marina Naval Sanchez
NHMRC Emerging Leadership FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Dr. Marina Naval-Sanchez is a NHMRC Research Fellow at the Institute for Molecular Bioscience at The University of Queensland (Australia). She pursued postdoctoral studies in 2019-2024 in the Institute for Molecular Bioscience, The University of Queensland (Australia) and as an Office Chief Executive (OCE) Fellow in 2015-2019 at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) (Australia). She received her PhD in Molecular Biosciences in 2014 from KULeuven (Belgium). She received her MSc in Applied Bioinformatics in 2009 from Cranfield University (UK) and MSc in Agriculture Engineering in 2008 from the Universitat de Lleida (Spain).
Marina's research program applies state-of-the-art bioinformatic, machine learning, and genetic and genomic tools to unearth the master regulators and enhancer grammar governing development and ageing across species (mouse and human) and to decipher the genomic (regulatory) impact of evolution, domestication and human selection in farm species (sheep, cattle, salmon). Her research outcomes have been published in high-impact journals such as Cell Metabolism, Nature Communications, Genome Biology, Nucleic Acids Research, Genome Research and Molecular Biology and Evolution.
Her research efforts have been supported by domestic and international fellowships and grants, including the Australian National Health and Medical Research Council (NHMRC, EL1 2024 Recipient), Advance Queensland, UQ Innovation Connections, CSIRO Scientific Investment Projects, CSIRO OCE Fellowships, and Flanders Wetesnchappelijk Onderzoek (FWO) PhD Fellowship.
Ying Yang
PhD StudentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Jingyu Zhang
Masters StudentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Monisha Ganesan
Masters StudentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Sharda Kolekar
Research AssistantInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Yifei Huang
Masters StudentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Dr Ralph Patrick
Postdoctoral Research FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Ralph Patrick is a researcher focussed on understanding the molecular drivers of ageing and age-associated diseases and developing new therapeutic approaches to help alleviate diseases of ageing. He is trained as a computational biologist, with a BSc (Hons) and PhD from the University of Queensland (UQ). After completion of his PhD in 2016, he worked as a postdoctoral scientist at the Victor Chang Cardiac Research Institute (VCCRI) in Sydney for nearly six years. At the VCCRI, a major focus of his research was mapping out how the individual cells of the heart respond to a heart attack at the gene expression level and how these compare to other forms of chronic heart disease. Following the VCCRI, he joined the Ageing and Cellular Reprogramming lab at the IMB in 2022 as a postdoctoral fellow. His work at the IMB focusses on understanding the epigenetic and transcription factor drivers of the ageing process and leveraging this knowledge to develop new strategies for restoring youthful cell states. Any potential collaborators or students interested in this research area are welcome to contact him.
Mr Mohammadhosein Esmaeili
Researcher profile is public:0Supervisor:- PhD StudentInstitute for Molecular Bioscience
Coin Group
Group Leader
Dr Lachlan Coin
Honorary Associate ProfessorInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Body:Highlights
Professor Lachlan Coin is a mathematician with a research focus on developing genomics and bioinformatics tools in infectious disease and cancer. He was originally drawn by the rigour and intellectual challenge of pure mathematics but now uses his maths background as a toolkit for solving complex problems in analysing high throughput biological data.
Professor Coin is best known for using approaches borrowed from machine learning, statistics and probability theory to interrogate genomic data.
In particular, Professor Coin has focussed on using these approaches to uncover genomic deletions and amplifications and has identified changes that are associated with increased risk of obesity and diabetes.
He has also developed approaches for finding minimal biomarker signatures associated with disease, and has applied these approaches to find biomarkers that distinguish bacterial from viral infection, and for the presence of active tuberculosis infection. He is also applying his methodology to develop a diagnostic tool for cancer from cell free DNA
Ultimately, Professor Coin is motivated by making discoveries that are routinely used in clinical practice and to inform public policy to improve health outcomes.
Professor Coin holds an Honorary Professor appointment with UQ, and is a Professor at the Doherty Institute at the University of Melbourne.
Connect
Researchers
Dr Quan Nguyen
Senior Research FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Dr Quan Nguyen is a Group Leader at the Institute for Molecular Bioscience (IMB), The University of Queensland. He is leading the Genomics and Machine Learning (GML) lab to study neuroinflammation and cancer-immune cells at single-cell resolution and within spatial morphological tissue context. His research interest is about revealing gene and cell regulators that determine the states of the complex cancer and neuronal ecosystems. Particularly, he is interested in quantifying cellular diversity and the dynamics of cell-cell interactions within the tissues to find ways to improve cancer diagnosis or cell-type specific treatments or the immunoinflammation responses that cause neuronal disease.
Using machine learning and genomic approaches, his group are integrating single-cell spatiotemporal sequencing data with tissue imaging data to find causal links between cellular genotypes, tissue microenvironment, and disease phenotypes. GML lab is also developing experimental technologies that enable large-scale profiling of spatial gene and protein expression (spatial omics) in a range of cancer tissues (focusing on brain and skin cancer) and in mouse brain and spinal cord.
Dr Quan Nguyen completed a PhD in Bioengineering at the University of Queensland in 2013, postdoctoral training in Bioinformatics at RIKEN institute in Japan in 2015, a CSIRO Office of Chief Executive (OCE) Research Fellowship in 2016, an IMB Fellow in 2018, an Australian Research Council DECRA fellowship (2019-2021), and is currently a National Health and Medical Research Council leadership fellow (EL2). He has published in top-tier journals, including Cell, Cell Stem Cell, Nature Methods, Nature Protocols, Nature Communications, Genome Research, Genome Biology and a prize-winning paper in GigaScience. In the past three years, he has contributed to the development of x8 open-source software, x2 web applications, and x4 databases for analysis of single-cell data and spatial transcriptomics. He is looking for enthusiastic research students and research staff to join his group.
Students
Dr Son Nguyen
Higher degree by research (PhD) studentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Ms Miranda Pitt
Higher degree by research (PhD) studentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Mr Haojing Shao
Higher degree by research (PhD) studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Mr Chenxi Zhou
Higher degree by research (PhD) studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Mr Hyun Jae Lee
Higher degree by research (PhD) studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Ms Janice Reid
Honours studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Ms Dilys Li
Honours studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Support staff
- Honorary Associate ProfessorInstitute for Molecular Bioscience
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Strawberry DNA extraction activity
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The Edge: Genetics
People have known for thousands of years that parents pass traits to their children, but it is only relatively recently that our technology has caught up to our curiosity, enabling us to delve into the mystery of how this inheritance occurs, and the implications for predicting, preventing and treating disease.
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