IMB's latest news, explainers and more

 


Risk of depression and heart disease linked in women

Read more

Get the latest research to your inbox

Subscribe
 

  • Montgomery Group

      Group Leader

    Professor Grant Montgomery

    Director, UQ Genome Innovation Hub
    Emeritus Professor & Centre Director of Institute for Molecular Bioscience
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 
    Body: 

    Highlights

    Professor Grant Montgomery uses genetic approaches to discover critical genes and pathways increasing risk for reproductive disorders. He applies state of the art genomic techniques to identify risk factors and understand how these genetic differences regulate gene expression and epigenetics to alter disease risk. The goal is to understand disease biology and help develop better methods for diagnosis and treatment.

    A major focus is women’s health and the pathogenesis of endometriosis. Together with colleagues in Brisbane, he led a recent large international study on genetic risk factors for endometriosis which confirmed 14 regions of the genome are associated with the disease, including 5 novel regions. His research is now moving to functional studies to identify the target genes in each region and determine how changes in the regulation of these genes contribute to disease. Professor Montgomery has published the first examples of likely target genes for two regions.

    He is also using genomic approaches to help understand environmental risk factors for this disease. Environmental risk factors may leave epigenetic signals on DNA that are associated with disease and he is part of an international study on global methylation analysis in endometriosis.

    Video

    Connect

    ResearcherID Scopus Orcid

     

      Researchers

    Dr Sugarniya Subramaniam

    Research Assistant
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Dr Brett McKinnon

    Senior Research Fellow
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    I am a basic science researcher with training in cell biology, genetics and research translation. My research investigates the female reproductive system by focusing on the contribution of individual cells. I aim to understand the influence of genetic architecture, differentiation and maturation on these individual cells and how this contributes to changes in the microenvironment that can contribute to disease initiation and progression.

    After the completion of my PhD in 2008 at the University of Queensland, I undertook post-doctoral studies at the University of Bern, Department of Biomedical Research (DBMR), focusing on endometriosis, ovarian and endometrial cancer. I curated patient samples from clinical research trials to investigate inflammatory and metabolic components of reproductive tissue and disease and began developing patient-derived models of the endometrium. I established a relationship between endometriosis lesions, nerves and pain and how this interaction was mediated by inflammation. I further developed patient-derived in vitro models to understand the interaction between inflammation and hormonal response of endometriotic lesions and how this could be utilized to target current and novel treatments. On returning to Australia in 2016 I joined the Genomics of Reproductive Disorders laboratory to integrate genetic background into patient-derived in vitro models. I established the Endometriosis Research Queensland Study (ERQS) in collaboration with the Royal Brisbane and Women's Hospital (RBWH) and extended in vitro models into complex multi-cellular assembloids (combinations of organoids and surrounding stromal cells).

    Mr Sharat Atluri

    Researcher profile is public: 
    0
    Supervisor: 

    Dr Sam Lukowski

    Honorary Senior Fellow
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Students

    Mr Isaac Kyei Barffour

    Researcher profile is public: 
    0
    Supervisor: 

    Miss Isabelle McGrath

    PhD student
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Miss Li Ying Thong

    PhD student
    Institute for Molecular Bioscience
    Researcher profile is public: 
    0
    Supervisor: 

    Mr Kei Tanaka

    PhD student
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
  • PhD student
    Institute for Molecular Bioscience
  • PhD student
    Institute for Molecular Bioscience
  • Probes are hining a light on how an individual bacterium develops resistance
  • Professor
    Biozentrum, University of Basel (Switzerland)

Pages

Strawberry DNA extraction activity

Extract and view DNA from a strawberry using common household ingredients.

Get started

 

 

 

The Edge: Genetics

People have known for thousands of years that parents pass traits to their children, but it is only relatively recently that our technology has caught up to our curiosity, enabling us to delve into the mystery of how this inheritance occurs, and the implications for predicting, preventing and treating disease.

 View online
 Download magazine

Subscribe to our newsletter

Get the latest research straight to your inbox. 
Stay up-to-date as we answer questions about hot topics, and share the latest news at IMB, Australia’s #1 research institute.

Subscribe

General enquiries

  +61 7 3346 2222
  imb@imb.uq.edu.au

Media enquiries

IMB fully supports UQ's Reconciliation Action Plan and is implementing actions within our institute.

Support us

Donate to research
100% of donations go to the cause