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Montgomery Group
Group Leader
Professor Grant Montgomery
Director, UQ Genome Innovation HubEmeritus Professor & Centre Director of Institute for Molecular BioscienceInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Body:Highlights
Professor Grant Montgomery uses genetic approaches to discover critical genes and pathways increasing risk for reproductive disorders. He applies state of the art genomic techniques to identify risk factors and understand how these genetic differences regulate gene expression and epigenetics to alter disease risk. The goal is to understand disease biology and help develop better methods for diagnosis and treatment.
A major focus is women’s health and the pathogenesis of endometriosis. Together with colleagues in Brisbane, he led a recent large international study on genetic risk factors for endometriosis which confirmed 14 regions of the genome are associated with the disease, including 5 novel regions. His research is now moving to functional studies to identify the target genes in each region and determine how changes in the regulation of these genes contribute to disease. Professor Montgomery has published the first examples of likely target genes for two regions.
He is also using genomic approaches to help understand environmental risk factors for this disease. Environmental risk factors may leave epigenetic signals on DNA that are associated with disease and he is part of an international study on global methylation analysis in endometriosis.
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Researchers
Dr Sugarniya Subramaniam
Research AssistantInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Dr Brett McKinnon
Senior Research FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:I am a basic science researcher with training in cell biology, genetics and research translation. My research investigates the female reproductive system by focusing on the contribution of individual cells. I aim to understand the influence of genetic architecture, differentiation and maturation on these individual cells and how this contributes to changes in the microenvironment that can contribute to disease initiation and progression.
After the completion of my PhD in 2008 at the University of Queensland, I undertook post-doctoral studies at the University of Bern, Department of Biomedical Research (DBMR), focusing on endometriosis, ovarian and endometrial cancer. I curated patient samples from clinical research trials to investigate inflammatory and metabolic components of reproductive tissue and disease and began developing patient-derived models of the endometrium. I established a relationship between endometriosis lesions, nerves and pain and how this interaction was mediated by inflammation. I further developed patient-derived in vitro models to understand the interaction between inflammation and hormonal response of endometriotic lesions and how this could be utilized to target current and novel treatments. On returning to Australia in 2016 I joined the Genomics of Reproductive Disorders laboratory to integrate genetic background into patient-derived in vitro models. I established the Endometriosis Research Queensland Study (ERQS) in collaboration with the Royal Brisbane and Women's Hospital (RBWH) and extended in vitro models into complex multi-cellular assembloids (combinations of organoids and surrounding stromal cells).
Mr Sharat Atluri
Researcher profile is public:0Supervisor:Dr Sam Lukowski
Honorary Senior FellowInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Students
Mr Isaac Kyei Barffour
Researcher profile is public:0Supervisor:Miss Isabelle McGrath
PhD studentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Miss Li Ying Thong
PhD studentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Mr Kei Tanaka
PhD studentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:- PhD studentInstitute for Molecular Bioscience
- PhD studentInstitute for Molecular Bioscience
- Probes are hining a light on how an individual bacterium develops resistance
- ProfessorBiozentrum, University of Basel (Switzerland)
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The Edge: Genetics
People have known for thousands of years that parents pass traits to their children, but it is only relatively recently that our technology has caught up to our curiosity, enabling us to delve into the mystery of how this inheritance occurs, and the implications for predicting, preventing and treating disease.
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