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- Senior Laboratory TechnicianInstitute for Molecular Bioscience
- PhD StudentInstitute for Molecular Bioscience
Cater Lab Team
Group Leader
Dr Rosemary Cater
Senior Research Fellow & Group LeaderInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Dr. Rosemary Cater is a Senior Research Fellow and Group Leader at the University of Queensland’s Institute for Molecular Bioscience in Australia. She fulfilled her Ph.D. under the supervision of Prof. Renae Ryan at the University of Sydney, where she used electrophysiology and x-ray protein crystallography to understand how glutamate transporters serve a secondary function as chloride channels. She then went on to complete her post-doctoral training in the lab of Prof. Filippo Mancia at Columbia University, where she used single-particle cryo-electron microscopy and antigen-binding technology to determine structures of small membrane proteins. The overarching goal of the Cater Lab is to understand the molecular mechanisms of nutrient transport at the blood-brain barrier, and how variations to this are implicated in different diseases states.
Dr Cater is a current ARC DECRA Fellow, and has received several prestigious awards and fellowships, for her research including the New York Academy of Sciences Blavatnik Regional Award (2022) and the Eppendorf & Science Journal Award for Neurobiology (2024).
Researchers
Dr Farrah Blades
Postdoctoral Research FellowInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:My research interests are in cell structure, intra-cellular pathways and in protein structure. During my honors I characterised two mouse models of Multiple Sclerosis, looking at T-cell permeability through the blood-brain barrier and the CXCR4/ CXCL12 chemokine axis. During my PhD I found critical roles for the tyrosine kinase receptor, Tyro3, in myelination and retinal ganglion cell function while assessing the neuronal functional outcomes of Tyro3 driven myelin structural deficits. Following my PhD, I moved to the university of Queensland to begin a post doctoral research fellowship under the supervision of Prof. Ben Hankamer, where I focussed on cryogenic electron microscopy and single particle analysis of the photosystem II supercomplex. During this time I also helped establish a virtual desktop which runs from the Bunya supercomputer, making research software accessible and easier to use across UQ.
As of 2024 I have begun as a post doctoral research fellow under the supervision of Dr. Rosemary Cater, I will be assessing the structure and function of membrane transporter proteins such as FLVCR2 and MFSD2A in the context of the blood-brain and blood-retinal barrier. Our goal is twofold: first, to comprehend the fundamental biology of these transporters; second, to discover a mechanism that enables drug access across the blood-brain and blood-retinal barriers. This advancement will facilitate therapeutic treatments for an array of central nervous system diseases.
Body:Dr Farrah Blade's research interests are in cell structure, intra-cellular pathways and in protein structure. During her honours she characterised two mouse models of Multiple Sclerosis, looking at T-cell permeability through the blood-brain barrier and the CXCR4/ CXCL12 chemokine axis.
During her PhD, Farrah found critical roles for the tyrosine kinase receptor, Tyro3, in myelination and retinal ganglion cell function while assessing the neuronal functional outcomes of Tyro3 driven myelin structural deficits.
Following her PhD, Farrah moved to The University of Queensland (UQ) to begin a Post Doctoral Research Fellowship under the supervision of Professor Ben Hankamer, where she focused on cryogenic electron microscopy and single particle analysis of the photosystem II supercomplex. During this time she also helped establish a virtual desktop which runs from the Bunya supercomputer, making research software accessible and easier to use across UQ.As of 2024, Farrah has begun a post doctoral research position under the supervision of Dr Rosemary Cater, assessing the structure and function of membrane transporter proteins such as FLVCR2 and MFSD2A in the context of the blood-brain and blood-retinal barrier. The goal is twofold: first, to comprehend the fundamental biology of these transporters; second, to discover a mechanism that enables drug access across the blood-brain and blood-retinal barriers. This advancement will facilitate therapeutic treatments for an array of central nervous system diseases.
Students
Mr Matthew van der Burg
PhD StudentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Ms Ariana Ivanic
PhD StudentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Miss Ruohua Gao
PhD StudentInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Mr Parteek Mandhan
StudentInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:- PhD student & Research OfficerInstitute for Molecular Bioscience
- Research StaffInstitute for Molecular Bioscience
- PhD studentInstitute for Molecular Bioscience
- StudentInstitute for Molecular Bioscience
Senior Leadership Team
Professor Ian Henderson
Institute DirectorInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Body:Professor Ian Henderson is the Executive Director of the Institute for Molecular Bioscience at The University of Queensland. In this role, he is responsible for developing the research strategy of an established, world-leading research institute with over 500 staff and students, fostering collaboration and raising the profile of the Institute and University internationally.
Prior to becoming Executive Director, he was Deputy Director (Research) at IMB. Professor Henderson was previously the Director of the Institute of Microbiology and Infection at University of Birmingham from 2015-2018.
He is a Professor of Microbial Biology who completed his Bachelor of Science (Hons) at University College Dublin and his PhD at Trinity College Dublin. He also holds a Postgraduate Certificate in Teaching and Learning in Higher Education from The University of Birmingham. Professor Henderson is a Fellow of the Royal Society of Biology.
Professor Henderson's research interests focus on the cell surface of bacteria. This focus is based on the philosophy that the bacterial cell surface offers a rich source of molecules, which can be utilised and adapted to diagnose, prevent or treat infections that can lead to life-threatening disease in humans and animals.
His research group has three major themes exploiting a range of experimental techniques to address fundamental questions in the biology of host-pathogen interactions:
(1) Using biochemical and biophysical methodologies to study protein secretion in Gram negative bacteria
(2) using molecular biology, cellular biology and immunological methodologies to study the roles outer membrane proteins play in the interaction of pathogens with their hosts
(3) using genetic, structural, biochemical and biophysical techniques to understand the molecular basis for the integrity of the Gram-negative outer membrane.Professor Henderson has published over 150 research papers, reviews and book chapters. He has an H-index of 62, and his publications have been cited over 15,000 times, with an average of 100 citations per paper.
Mrs Lisa Cornish
Director, Institute OperationsInstitute for Molecular BioscienceResearcher profile is public:0Supervisor:Professor Mark Blaskovich
Director of Translation & Professorial Research Fellow & Group LeaderInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:Professor Mark Blaskovich is an antibiotic hunter and Director of Translation at the Institute for Molecular Bioscience at The University of Queensland. He is co-founder and former Director of the Centre for Superbug Solutions at IMB.
A medicinal chemist with 15 years of industrial drug development experience prior to his academic career, Mark has been developing new antibiotics to treat drug resistant pathogens and using modified antibiotics to detect bacterial infections. He is a co-founder of the Community for Open Antimicrobial Drug Discovery, a global antibiotic discovery initiative, and has led a number of UQ-industry collaborations focused on antibiotic development. An inventor on eleven patent families, Mark has developed drugs in clinical trials, published more than eighty research articles, and received over $10m in grant funding.
Professor Irina Vetter
NHMRC Leadership Fellow - Group Leader & Director for Higher Degree ResearchInstitute for Molecular BioscienceResearcher profile is public:1Supervisor:Researcher biography:I am an NHMRC Leadership Fellow with joint apointments at the Institute for Molecular Bioscience (IMB) and School of Pharmacy, UQ. My research interests lie in the fields of peripheral pain mechanisms, target identification and analgesic drug discovery. I investigate the contribution of ion channels to sensory neuronal physiology using highly subtype-selective toxins isolated from venomous animals with the aim to develop novel analgesics with improved efficacy and tolerability.
Body:Highlights
Associate Professor Irina Vetter has a strong background in neuropharmacology, pain models, toxinology and high-throughput screening. Currently her primary research interests lie in the fields of peripheral pain mechanisms, target identification, biodiscovery of venom peptide ion channel modulators and analgesic drug discovery.
Associate Professor Vetter has always been fascinated by how we perceive the world around us, in particular, the role of sensory neurons in the body. Sensory neurons are an intricate network of nerve cells that convert external stimuli from the environment into messages within the body, like pain. Her research is demystifying the different pathways that contribute to pain in various disease states. She is using biomedical research and pharmacology to develop pain treatments from venoms and toxins.
Associate Professor Vetter is an ARC Future Fellow and Deputy Director of the Centre for Pain Research at The University of Queensland. She is a registered pharmacist and has worked in hospital as well as community pharmacy. She obtained her PhD in 2007 from the School of Pharmacy, and conducted postdoctoral studies as an NHMRC postdoctoral fellow under Prof Geoffrey Goodhill at the Queensland Brain Institute and under Prof Richard J Lewis at the Institute for Molecular Bioscience in the areas of axon guidance and venom peptide pharmacology
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