Dr Roos van Schuijlenburg
Research Officer
Institute for Molecular Bioscience
Researcher biography
I completed my PhD in the Netherlands, where I focused on host–pathogen interactions between the malaria sporozoite and human immune cells. I also used mouse models to investigate which organs and organ-specific immune cells are involved during the early stages of malaria infection after sporozoite entry into the body. In addition, I contributed to human clinical trials evaluating newly designed genetically attenuated malaria parasites as vaccine candidates.
My main expertise lies in human co-culture systems and malaria infection models, with a strong focus on malaria vaccine research.
At UQ, I began my postdoctoral fellowship at IMB, where I investigate malaria-specific vaccine targets, focusing on human cellular immune responses.
Publications
Journal Articles
van Pul, Lisa, Rosendahl Huber, Sietske Karla, Jacobi, Ronald, Hendriks, Marion, van Schuijlenburg, Roos, van Sleen, Yannick, Bijvank, Elske, de Wit, Jelle and van Beek, Josine (2026). Cross-reactive antibody and T-cell responses after influenza virus infection in community-dwelling older adults. Journal of Virology e00407-26. doi: 10.1128/jvi.00407-26
van Schuijlenburg, Roos, Naar, Chanel M., de Bes-Roeleveld, Helena M., Chevalley-Maurel, Séverine, Zigó, Lili A., Houlder, Emma L., Lambooij, Joost M., Baalbergen, Els, Roestenberg, Meta and Franke-Fayard, Blandine (2025). Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells. Scientific Reports, 15 (1) 43673, 1-15. doi: 10.1038/s41598-025-27588-4
Naar, Chanel Milène, van Schuijlenburg, Roos, van Meerbeek, Maarten, Almeida, Luís, van Leeuwen, Fijs W.B. and Roestenberg, Meta (2025). A Trojan horse: Chemical boosting of Plasmodium falciparum whole sporozoite vaccine immunogenicity. Biomedicine and Pharmacotherapy, 192 118666, 1-11. doi: 10.1016/j.biopha.2025.118666
Van Schuijlenburg, Roos, Naar, Chanel, Van der Wees, Stefanie, Chevalley-Maurel, Severine, Duszenko, Nikolas, De Bes-Roeleveld, Laura, Iliopoulou, Eva, Houlder, Emma, Geurten, Fiona, Baalbergen, Els, Roestenberg, Meta and Franke-Fayard, Blandine (2025). Early activation of lung CD8+ T cells after immunization with live plasmodium berghei malaria sporozoites. Pathogens and Immunity, 10 (2), 46-68. doi: 10.20411/pai.v10i2.794
Roozen, Geert V. T., van Schuijlenburg, Roos, Hensen, Annefleur D. O., Koopman, Jan Pieter R., Lamers, Olivia A. C., Geurten, Fiona J. A., Sijtsma, Jeroen C., Baalbergen, Els, Janse, Jacqueline J., Chevalley-Maurel, Séverine, Naar, Chanel M., Bezemer, Sascha, Kroeze, Hans, van de Stadt, Huybert J. F., de Visser, Bram, Meij, Pauline, Tihaya, Mara S., Colstrup, Emil, Iliopoulou, Eva, de Bes-Roeleveld, Helena M., Wessels, Els, van der Stoep, M. Y. Eileen C., Janse, Chris J., Murugan, Rajagopal, Franke-Fayard, Blandine M. D. and Roestenberg, Meta (2025). Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial. Nature Medicine, 31 (1), 218-222. doi: 10.1038/s41591-024-03347-2
van Schuijlenburg, Roos, Azargoshasb, Samaneh, de Korne, Clarize M, Sijtsma, Jeroen C, Bezemer, Sascha, van der Ham, Alwin J, Baalbergen, Els, Geurten, Fiona, de Bes-Roeleveld, Laura M, Chevalley-Maurel, Severine C, van Oosterom, Matthias N, van Leeuwen, Fijs W B, Franke-Fayard, Blandine and Roestenberg, Meta (2024). Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro. Malaria Journal, 23 (1) 111, 1-14. doi: 10.1186/s12936-024-04946-7
Hoogerwerf, Marie-Astrid, Janse, Jacqueline J., Kuiper, Vincent P., van Schuijlenburg, Roos, Kruize, Yvonne C. M., Sijtsma, Jeroen C., Nosoh, Beckley A., Koopman, Jan-Pieter R, Verbeek-Menken, Petra H, Westra, Inge M, Meij, Pauline, Brienen, Eric A. T., Visser, Leo G., van Lieshout, Lisette, Jochems, Simon P., Yazdanbakhsh, Maria and Roestenberg, Meta (2023). Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial. The Lancet: Microbe, 4 (12), e1024-e1034. doi: 10.1016/S2666-5247(23)00218-5
van der Plas, Johan L., Kuiper, Vincent P., Bagchus, Wilhelmina M., Bödding, Matthias, Yalkinoglu, Özkan, Tappert, Aliona, Seitzinger, Andrea, Spangenberg, Thomas, Bezuidenhout, Deon, Wilkins, Justin, Oeuvray, Claude, Dhingra, Satish K., Thathy, Vandana, Fidock, David A., Smidt, Lisanne C. A., Roozen, Geert V. T., Koopman, Jan Pieter R., Lamers, Olivia A. C., Sijtsma, Jeroen, van Schuijlenburg, Roos, Wessels, Els, Meij, Pauline, Kamerling, Ingrid M. C., Roestenberg, Meta and Khandelwal, Akash (2023). Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands. The Lancet. Infectious diseases, 23 (10), 1164-1174. doi: 10.1016/S1473-3099(23)00212-8
Duszenko, Nikolas, van Schuijlenburg, Roos, Chevalley-Maurel, Severine, van Willigen, Danny M., de Bes-Roeleveld, Laura, van der Wees, Stefanie, Naar, Chanel, Baalbergen, Els, Heieis, Graham, Bunschoten, Anton, Velders, Aldrik H., Franke-Fayard, Blandine, van Leeuwen, Fijs W. B. and Roestenberg, Meta (2023). Chemically augmented malaria sporozoites display an altered immunogenic profile. Frontiers in Immunology, 14 1204606, 1-14. doi: 10.3389/fimmu.2023.1204606
de Korne, C M, van Schuijlenburg, R, Sijtsma, J C, de Bes, H M, Baalbergen, E, Azargoshasb, S, van Oosterom, M N, McCall, M B B, van Leeuwen, F W B and Roestenberg, M (2022). Sporozoite motility as a quantitative readout for anti-CSP antibody inhibition. Scientific Reports, 12 (1) 17194, 1-11. doi: 10.1038/s41598-022-22154-8
van den Berg, Sara P H, Lanfermeijer, Josien, Jacobi, Ronald H J, Hendriks, Marion, Vos, Martijn, van Schuijlenburg, Roos, Nanlohy, Nening M, Borghans, José A M, van Beek, Josine, van Baarle, Debbie and de Wit, Jelle (2021). Latent CMV infection is associated with lower influenza virus-specific memory t-cell frequencies, but not with an impaired t-cell response to acute influenza virus infection. Frontiers in Immunology, 12 663664, 1-15. doi: 10.3389/fimmu.2021.663664
Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Langenberg, Marijke C. C., van Schuijlenburg, Roos, Kruize, Yvonne C. M., Brienen, Eric A. T., Manurung, Mikhael D., Verbeek-Menken, Petra, van der Beek, Martha T., Westra, Inge M., Meij, Pauline, Visser, Leo G., van Lieshout, Lisette, de Vlas, Sake J., Yazdanbakhsh, Maria, Coffeng, Luc E. and Roestenberg, Meta (2021). A randomized controlled trial to investigate safety and variability of egg excretion after repeated controlled human hookworm infection. The Journal of Infectious Diseases, 223 (5), 905-913. doi: 10.1093/infdis/jiaa414
Miyazaki, Yukiko, Marin-Mogollon, Catherin, Imai, Takashi, Mendes, António M, van der Laak, Rianne, Sturm, Angelika, Geurten, Fiona J A, Miyazaki, Shinya, Chevalley-Maurel, Severine, Ramesar, Jai, Kolli, Surendra K, Kroeze, Hans, van Schuijlenburg, Roos, Salman, Ahmed M, Wilder, Brandon K, Reyes-Sandoval, Arturo, Dechering, Koen J, Prudêncio, Miguel, Janse, Chris J, Khan, Shahid M and Franke-Fayard, Blandine (2020). Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing Plasmodium vivax circumsporozoite protein for malaria vaccine Development. Frontiers in Cellular and Infection Microbiology, 10 591046, 1-14. doi: 10.3389/fcimb.2020.591046
Winkel, Béatrice M F, Pelgrom, Leonard R, van Schuijlenburg, Roos, Baalbergen, Els, Ganesh, Munisha S, Gerritsma, Heleen, de Korne, Clarize M, Duszenko, Nikolas, Langenberg, Marijke C C, Chevalley-Maurel, Séverine C, Smits, Hermelijn H, de Jong, Esther C, Everts, Bart, Franke-Fayard, Blandine and Roestenberg, Meta (2020). Plasmodium sporozoites induce regulatory macrophages. PLoS Pathogens, 16 (9) e1008799, 1-24. doi: 10.1371/journal.ppat.1008799
Duszenko, Nikolas, van Willigen, Danny M., Welling, Mick M, de Korne, Clarize M., van Schuijlenburg, Roos, Winkel, Beatrice M. F., van Leeuwen, Fijs W. B. and Roestenberg, Meta (2020). A supramolecular platform technology for bacterial cell surface modification. ACS Infectious Diseases, 6 (7), 1734-1744. doi: 10.1021/acsinfecdis.9b00523
Casacuberta-Partal, Miriam, Janse, Jacqueline J, van Schuijlenburg, Roos, de Vries, Jutte J C, Erkens, Marianne A A, Suijk, Kitty, van Aalst, Mariëlle, Maas, Jaap J, Grobusch, Martin P, van Genderen, Perry J J, de Dood, Claudia, Corstjens, Paul L A M, van Dam, Govert J, van Lieshout, Lisette and Roestenberg, Meta (2020). Antigen-based diagnosis of Schistosoma infection in travellers: a prospective study. Journal of Travel Medicine, 27 (4) taaa055, 1-9. doi: 10.1093/jtm/taaa055
Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Kos-van Oosterhoud, Janneke, Feijt, Carola, Jochems, Simon P., de Dood, Claudia J., van Schuijlenburg, Roos, Ozir-Fazalalikhan, Arifa, Manurung, Mikhael D., Sartono, Erliyani, van der Beek, Martha T., Winkel, Béatrice M. F., Verbeek-Menken, Petra H., Stam, Koen A., van Leeuwen, Fijs W. B., Meij, Pauline, van Diepen, Angela, van Lieshout, Lisette, van Dam, Govert J., Corstjens, Paul L. A. M., Hokke, Cornelis H., Yazdanbakhsh, Maria, Visser, Leo G. and Roestenberg, Meta (2020). A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics. Nature Medicine, 26 (3), 326-332. doi: 10.1038/s41591-020-0759-x
Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Janse, Jacqueline J., van Lieshout, Lisette, Corstjens, Paul L. A. M., Roestenberg, Meta, CoHSI clinical trial team and van Schuijlenburg, Roos (2019). Katayama syndrome without Schistosoma mansoni eggs. Annals of Internal Medicine, 170 (10), 732-733. doi: 10.7326/L18-0438