IMB's latest news, explainers and more

 


'Just add water' - the magic of tardigrades

Read more

Get the latest research to your inbox

Subscribe
 

  • Visiting Academic
    Institute for Molecular Bioscience
  • Senior Research Fellow
    Institute for Molecular Bioscience
  • Higher degree by research (PhD) student
    Institute for Molecular Bioscience
  • Higher degree by research (PhD) student
    Institute for Molecular Bioscience
  • Centre Directors

    Professor Brett Collins

    Director, Centre for Cell Biology of Chronic Disease
    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    Brett Collins is an NHMRC Career Development Fellow and head of the Molecular Trafficking Lab at UQ's Institute for Molecular Bioscience. He was a lead investigator in the seminal structural studies of AP2, the protein adaptor molecule central to clathrin-mediated endocytosis, and has since defined the molecular basis for the function of critical proteins regulating membrane trafficking and signalling at the endosome organelle. His team is now focused on understanding how discrete molecular interactions between proteins and lipids control these processes in human cells.

    Associate Professor Collins was awarded his PhD in 2001 and has published over 75 papers including in Cell, Nature, Nature Structural and Molecular Biology, Developmental Cell, and The Proceedings of the National Academy of Sciences USA, altogether cited more than 3100 times. He is the recipient of 3 prestigious fellowships, including a previous Career Development Award from the National Health and Medical Research Council and a Future Fellowship from the Australian Research Council, and was awarded the University of Queensland Research Excellence Award in 2008. In 2015 he was awarded the Emerging Leader Award of the ANZSCDB and in 2016 the Merck Research Medal from the ASBMB. He is currently the President of the Queensland Protein Group.

    Body: 

    Highlights

    Seeing the structure of a protein at the atomic level as an undergrad set off a career in structural biology for Brett Collins. His interest in how cells work, and the techniques used to visualise the complex interaction mechanisms of the structures within, earned him his PhD in 2001. Postdoctorate work at Cambridge University steered him towards ‘membrane trafficking’, the term used to describe how proteins are moved from one part of a cell to another, or indeed between cells, via a complex system of membranes.

    Now, as head of IMB’s Membrane Trafficking Group, he’s using techniques such as X-ray crystallography and cryo-electron microscopy to visualise protein structure at the atomic level to investigate why things sometimes go wrong with our cells’ protein transport system. Faulty proteins are known to cause the development of neurodegenerative conditions such as Parkinson’s and Alzheimer’s disease, and muscular dystrophy.

    Connect

     

    Professor David Fairlie

    Director, Centre for Drug Discovery
    NHMRC Leadership Fellow and Group Leader
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    Professor Fairlie is an NHMRC Research Investigator Fellow (Level 3) (2022-present), a Node Leader of the ARC Centre of Excellence for Innovations in Peptide Protein Science, one of four Centre Directors and former Head of the Division of Chemistry of Structural Biology at the Institute for Molecular Bioscience (since 2009), and an Affiliate Professor of the School of Chemistry and Molecular Biosciences. He was previously an NHMRC Senior Principal Research Fellow (2012-2021), a Node Leader at the ARC Centre of Excellence in Advanced Molecular Imaging (2014-2021), an ARC Federation Fellow (2006-2011), an ARC Professorial Fellow (2002-2006), and Scientific Director and Chief Scientific Officer of a startup company. He undertook postdoctoral studies at Stanford University and University of Toronto, postgraduate studies at Australian National University and University of New South Wales, and undergraduate studies at University of Adelaide.

    His research group works across the disciplines of chemistry (synthesis, structure, reaction mechanisms), biochemistry (enzyme inhibitors, protein-protein interactions, GPCRs, transcription factors), immunology (innate immune cells in health and disease, mucosal T cells), and pharmacology (molecular pharmacology and human cell signalling, experimental pharmacology in rodent models of human diseases). He has published over 450 scientific journal articles in high impact chemistry journals (e.g. Chem Rev, J Am Chem Soc, Angew Chem Int Edit, Chem Sci, J Med Chem, Org Lett, J Org Chem) and biology journals (e.g. Nature, Science, Nature Immunology, Immunity, Science Immunology, Nature Communications, J Exp Med, J Clin Invest, Proc Natl Acad Sci, Diabetes, Cancer Res, Br J Pharmacol). He has been a Highly Cited Researcher (Clarivate Analytics), with over 37,000 citations and 104 publications with over 100 citations (Google Scholar), and has collaborated with many of the world's largest pharmaceutical and biotechnology companies.

    Body: 

    Highlights

    Professor David Fairlie is internationally known for his research contributions in the fields of medicinal chemistry, organic chemistry, biological chemistry and in several disciplines in biology (pharmacology, virology, immunology, neurobiology, biochemistry). He has had strong research programs in chemistry, biochemistry and pharmacology continuously funded by the Australian Research Council (ARC) since 1991 and the National Health and Medical Research Council (NHMRC) since 1995. He was awarded prestigious fellowships from the ARC, in the form of an Australian Professorial Fellowship (2002-2006) and an Australian Federation Fellowship (2006-2011), and from the NHMRC, in the form of a Senior Principal Research Fellowship (2012-2016 and 2017-2021). He has held numerous research grants in chemistry, biochemistry, pharmacology, virology, immunology, parasitology, neurobiology and oncology; including 15 multimillion dollar grants from industry and governments. He has served on academic and industry advisory panels, company boards, and research grant panels both in Australia and overseas. He collaborates with some of the world's largest pharmaceutical companies.

    Professor Fairlie has >300 publications (h index >60; >14,000 citations; >35 cites per article; >30 articles >100 citations) and presents 5-10 invited plenary and keynote lectures around the world each year. He is also well known in the international pharmaceutical arena, having consulted to multiple big pharma on protease inhibitors, GPCR modulators, protein and peptide mimics, drug design and discovery, and pharmacology. He has been involved in four startup companies in Australia and the USA.

    Connect

    ResearcherIDScopusOrcid

     

    Professor Grant Montgomery

    Director, UQ Genome Innovation Hub
    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    Professor Grant Montgomery FAHMS FSRB Hon FRSNZ

    Professor Montgomery was born in New Zealand, completed PhD studies in Animal Science at Massey University and post-doctoral research in France. In 1987, he co-founded the New Zealand Sheep Genomics Program in the Biochemistry Department at the University of Otago and pioneered the introduction of genome mapping methods in farm animals. He moved to Australia in 1999 and joined the Queensland Institute of Medical Research where he ran a successful genome mapping program for human complex disease. In 2016, he moved to the University of Queensland and holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI). He is a National Health and Medical Research Council Leadership Fellow and Director of the UQ Genome Innovation Hub. He was elected a Fellow the Society for Reproductive Biology in 2012, Fellow of the Australian Academy of Health and Medical Sciences in 2015, and Honorary Fellow of the Royal Society of New Zealand in 2016. His research focusses on discovery of critical genes and pathways increasing risk for common diseases especially reproductive diseases including endometriosis.

    Body: 

    Highlights

    Professor Grant Montgomery uses genetic approaches to discover critical genes and pathways increasing risk for reproductive disorders. He applies state of the art genomic techniques to identify risk factors and understand how these genetic differences regulate gene expression and epigenetics to alter disease risk. The goal is to understand disease biology and help develop better methods for diagnosis and treatment.

    A major focus is women’s health and the pathogenesis of endometriosis. Together with colleagues in Brisbane, he led a recent large international study on genetic risk factors for endometriosis which confirmed 14 regions of the genome are associated with the disease, including 5 novel regions. His research is now moving to functional studies to identify the target genes in each region and determine how changes in the regulation of these genes contribute to disease. Professor Montgomery has published the first examples of likely target genes for two regions.

    He is also using genomic approaches to help understand environmental risk factors for this disease. Environmental risk factors may leave epigenetic signals on DNA that are associated with disease and he is part of an international study on global methylation analysis in endometriosis.

    Video

    Connect

    ResearcherID Scopus Orcid

     

    Professor Mark Schembri

    Professorial Research Fellow & Group Leader
    Institute for Molecular Bioscience
    Researcher profile is public: 
    1
    Supervisor: 
    Researcher biography: 

    Professor Mark Schembri is a prominent microbiologist with experience in combating the global health crisis presented by multi-drug resistant pathogens. Professor Schembri's expertise on the virulence of bacterial pathogens and his innovative analysis of biofilm formation aims to improve the outcomes of the >150 million individuals that suffer from urinary tract infections each year across the globe.

    Through the application of genetic, genomic and functional studies on uropathogenic E. coli, Professor Schembri has identified targets to reduce the virulence of this pathogen, and will pursue the development of life-saving therapeutic and preventative advances with the assistance of an NHMRC Senior Research Fellowship. Professor Schembri has tracked the rapid emergence and global spread of a virulent, drug-resistant E. coli clone and used genome sequencing to understand its evolution and virulence.

    Links: Professor Schembri collaborates with national and international research leaders, including in Denmark, where he was a lecturer. Professor Schembri has strong links with other international experts in his field, including at the Pasteur Institute and the Wellcome Trust Sanger Institute in Cambridge. His research collaborations also span lead groups at UQ and other top Australian institutes, including Griffith and La Trobe Universities.

    Membership, Funding and patents: Since 2014, Professor Schembri has been awarded over $8 million in funding from competitive national research funding councils. He holds provisional patents for the development of novel therapeutic agents and vaccine antigens. He is a Fellow of the American Academy of Microbiology, and is regularly invited to speak at international conferences in his field.

    Awards and Communication: Professor Schembri was the recipient of the Frank Fenner Award (2010) and the ASM BacPath Oration Award (2019) for his outstanding original research contribution to the study of Infectious Disease. He was an Australian Research Council Future Fellow (2011-2015) and currently holds a National Health and Medical Research Council Senior Research Fellowship. Professor Schembri is the author of >200 peer-reviewed research manuscripts.

  • Director, Centre for Population and Disease Genomics
    Joint Appointment
    Queensland Brain Institute
    Professorial Research Fellow
    Institute for Molecular Bioscience

Pages

Strawberry DNA extraction activity

Extract and view DNA from a strawberry using common household ingredients.

Get started

 

The Edge: Infection

The latest research and discovery

We are tackling the problem of drug-resistant bacteria through developing new diagnostics and treatments, and by empowering the community with knowledge on how to fight back against the threat of superbugs.

 View the latest issue
 Download magazine

Subscribe to our newsletter

Get the latest research straight to your inbox. 
Stay up-to-date as we answer questions about hot topics, and share the latest news at IMB, Australia’s #1 research institute.

Subscribe

General enquiries

  +61 7 3346 2222
  imb@imb.uq.edu.au

Media enquiries

IMB fully supports UQ's Reconciliation Action Plan and is implementing actions within our institute.

Support us

Donate to research
100% of donations go to the cause