We hypothesize that flattening of caveolae helps cells cope with changes in membrane tension caused, for example during excessive muscle activity. During this process, caveolae are stretched, causing cavins to be released into the cell and allowing them to interact with cellular components. We are investigating the cellular network of cavin interacting proteins using proteomic-based approaches combined with cellular assays.

Project members

Key contact

Professor Robert Parton

Group Leader, Centre for Cell Biology of Chronic Disease
ARC Laureate Fellow - Group Leader
Institute for Molecular Bioscience