Dr Jian Zeng
NHMRC Emerging Leader Fellow
Institute for Molecular Bioscience
+61 7 334 62276
Journal Articles
Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2019) Improved polygenic prediction by Bayesian multiple regression on summary statistics. Nature Communications, 10 1: 5086. doi:10.1038/s41467-019-12653-0
Wang, Huanwei, Zhang, Futao, Zeng, Jian, Wu, Yang, Kemper, Kathryn E., Xue, Angli, Zhang, Min, Powell, Joseph E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2019) Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. Science Advances, 5 8: . doi:10.1126/sciadv.aaw3538
Sidorenko, Julia, Kassam, Irfahan, Kemper, Kathryn E., Zeng, Jian, Lloyd-Jones, Luke R., Montgomery, Grant W., Gibson, Greg, Metspalu, Andres, Esko, Tonu, Yang, Jian, McRae, Allan F. and Visscher, Peter M. (2019) The effect of X-linked dosage compensation on complex trait variation. Nature Communications, 10 1: 3009. doi:10.1038/s41467-019-10598-y
Xue, Angli, Wu, Yang, Zhu, Zhihong, Zhang, Futao, Kemper, Kathryn E., Zheng, Zhili, Yengo, Loic, Lloyd-Jones, Luke R., Sidorenko, Julia, Wu, Yeda, eQTLGen Consortium, McRae, Allan F., Visscher, Peter M., Zeng, Jian and Yang, Jian (2018) Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications, 9 1: 2941. doi:10.1038/s41467-018-04951-w
Qi, Ting, Wu, Yang, Zeng, Jian, Zhang, Futao, Xue, Angli, Jiang, Longda, Zhu, Zhihong, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, eQTLGen Consortium, Marioni, Riccardo E., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018) Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications, 9 1: 2282. doi:10.1038/s41467-018-04558-1
Guo, Jing, Wu, Yang, Zhu, Zhihong, Zheng, Zhili, Trzaskowski, Maciej, Zeng, Jian, Robinson, Matthew R., Visscher, Peter M. and Yang, Jian (2018) Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications, 9 1: 1865. doi:10.1038/s41467-018-04191-y
Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018) Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 5: 746-753. doi:10.1038/s41588-018-0101-4
Zeng, Jian, Garrick, Dorian, Dekkers, Jack and Fernando, Rohan (2018) A nested mixture model for genomic prediction using whole-genome SNP genotypes. PloS one, 13 3: e0194683. doi:10.1371/journal.pone.0194683
Cheng, Hao, Kizilkaya, Kadir, Zeng, Jian, Garrick, Dorian and Fernando, Rohan (2018) Genomic prediction from multiple-trait bayesian regression methods using mixture priors. Genetics, 209 1: 89-103. doi:10.1534/genetics.118.300650
Wu, Yang, Zeng, Jian, Zhang, Futao, Zhu, Zhihong, Qi, Ting, Zheng, Zhili, Lloyd-Jones, Luke R., Marioni, Riccardo E., Martin, Nicholas G., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018) Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nature Communications, 9 918: . doi:10.1038/s41467-018-03371-0
Yang, Jian, Zeng, Jian, Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2017) Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49 9: 1304-1310. doi:10.1038/ng.3941
Lloyd-Jones, Luke R., Robinson, Matthew R., Moser, Gerhard, Zeng, Jian, Beleza, Sandra, Barsh, Gregory S., Tang, Hua and Visscher, Peter M. (2017) Inference on the genetic basis of eye and skin color in an admixed population via Bayesian linear mixed models. Genetics, 206 2: 1113-1126. doi:10.1534/genetics.116.193383
Heidaritabar, M., Wolc, A., Arango, J., Zeng, J., Settar, P., Fulton, J. E., O'Sullivan, N. P., Bastiaansen, J. W. M., Fernando, R. L., Garrick, D. J. and Dekkers, J. C. M. (2016) Impact of fitting dominance and additive effects on accuracy of genomic prediction of breeding values in layers. Journal of Animal Breeding and Genetics, 133 5: 334-346. doi:10.1111/jbg.12225
Zhao, Yusheng, Gowda, Manje, Wuerschum, Tobias, Longin, C. Friedrich H., Korzun, Viktor, Kollers, Sonja, Schachschneider, Ralf, Zeng, Jian, Fernando, Rohan, Dubcovsky, Jorge and Reif, Jochen C. (2013) Dissecting the genetic architecture of frost tolerance in Central European winter wheat. Journal of Experimental Botany, 64 14: 4453-4460. doi:10.1093/jxb/ert259
Zeng, Jian, Toosi, Ali, Fernando, Rohan L., Dekkers, Jack C. M. and Garrick, Dorian J. (2013) Genomic selection of purebred animals for crossbred performance in the presence of dominant gene action. Genetics Selection Evolution, 45 1: . doi:10.1186/1297-9686-45-11
Zhao, Yusheng, Zeng, Jian, Fernando, Rohan and Reif, Jochen C. (2013) Genomic prediction of hybrid wheat performance. Crop Science, 53 3: 802-810. doi:10.2135/cropsci2012.08.0463
Zeng, Jian, Pszczola, Marcin, Wolc, Anna, Strabel, Tomasz, Fernando, Rohan L., Garrick, Dorian J. and Dekkers, Jack C. M. (2012) Genomic breeding value prediction and QTL mapping of QTLMAS2011 data using Bayesian and GBLUP methods. BMC Proceedings, 6 S2: . doi:10.1186/1753-6561-6-S2-S7
Conference Paper
Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. In: 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, (525-525). 20-23 June 2018.
Research Reports
Zeng, Jian, Garrick, Dorian J., Dekkers, Jack C. and Fernando, Rohan L (2016) A nested mixture model for genomic prediction using whole-genome SNP genotypes Ames: Iowa State University, Digital Repository
Zeng, Jian, Toosi, Ali, Fernando, Rohan L., Dekkers, Jack C. M. and Garrick, Dorian J. (2013) Genomic selection of purebred animals for crossbred performance in the presence of dominant gene action Ames: Iowa State University, Digital Repository
Deng, Xuemei, Arango, Jesus, Kizilkaya, Kadir, Zeng, Jian, Cai, Weiguo, Fulton, Janet, O'Sullivan, Neil and Dekkers, Jack C.M. (2011) Whole genome association analysis of idiopathic eosinophilic enteritis in brown egg layers Ames, United States: Iowa State University