Dr Mathias Francois
Group Leader, Genomics of Development and Disease Division
+61 7 334 62494
Highlights
After finishing his undergraduate degree at the Toulouse III University, Mat Francois undertook a PhD in Paris, studying the role of nuclear receptors in the control of inflammation associated with osteoarthritis, finishing in 2004.
In 2005 he moved to Australia as a postdoctoral scientist in Peter Koopman’s laboratory, and began researching the role of SOX transcription factors in the control of lymphatic vessel development. His research led to the discovery of a molecular switch (SOX18) responsible for triggering the development of the lymphatic vascular system in the embryo. This finding helped him to launch his independent career. He was awarded the ASMR Queensland Premier’s award in 2009 and a UQ Foundation Research Excellence Award in 2011.
Late in 2011 Mat set up his own lab at IMB to focus on the molecular hierarchy that governs endothelial cell differentiation during embryogenesis, and later received a career development award to elucidate the role of SOX protein in the modulation of the lymphatic and blood vascular growth that controls both embryonic development and tumour metastasis.
Mat’s research at IMB is now based on the combination of developmental biology and the use of pathophysiological models (e.g. cancer metastasis and lymphoedema) in combination with a drug discovery pipeline to identify novel therapeutic approaches to block cancer metastasis via the pharmacological manipulation of transcription factor activity.
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Journal Articles
Weng, Mingxi, Hu, Haoqing, Graus, Matthew S., Tan, Daisylyn Senna, Gao, Ya, Ren, Shimiao, Ho, Derek Hoi Hang, Langer, Jakob, Holzner, Markus, Huang, Yuhua, Ling, Guang Sheng, Lai, Cora Sau Wan, Francois, Mathias and Jauch, Ralf (2023). An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming. Science Advances, 9 (34) eadh2501, 1-23. doi: 10.1126/sciadv.adh2501
Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril AB, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann and Francois, Mathias (2023). Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 12 ARTN e90408. doi: 10.7554/elife.90408
Chiang, Ivy K. N., Humphrey, David, Mills, Richard J., Kaltzis, Peter, Pachauri, Shikha, Graus, Matthew, Saha, Diptarka, Wu, Zhijian, Young, Paul, Sim, Choon Boon, Davidson, Tara, Hernandez‐Garcia, Andres, Shaw, Chad A., Renwick, Alexander, Scott, Daryl A., Porrello, Enzo R., Wong, Emily S., Hudson, James E., Red‐Horse, Kristy, del Monte‐Nieto, Gonzalo and Francois, Mathias (2023). Sox7‐positive endothelial progenitors establish coronary arteries and govern ventricular compaction. EMBO reports, 24 (10) e55043, 1-21. doi: 10.15252/embr.202255043
Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K., Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A. ... Hudson, James E. (2023). Vascular cells improve functionality of human cardiac organoids. Cell Reports, 42 (5) 112322, 112322. doi: 10.1016/j.celrep.2023.112322
Chiang, Ivy K. N., Graus, Matthew S., Kirschnick, Nils, Davidson, Tara, Luu, Winnie, Harwood, Richard, Jiang, Keyi, Li, Bitong, Wong, Yew Yan, Moustaqil, Mehdi, Lesieur, Emmanuelle, Skoczylas, Renae, Kouskoff, Valerie, Kazenwadel, Jan, Arriola‐Martinez, Luis, Sierecki, Emma, Gambin, Yann, Alitalo, Kari, Kiefer, Friedmann, Harvey, Natasha L. and Francois, Mathias (2023). The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner. The EMBO Journal, 42 (5) e109032, 1-23. doi: 10.15252/embj.2021109032
Underwood, Adam, Rasicci, Daniel T, Hinds, David, Mitchell, Jackson T, Zieba, Jacob K, Mills, Joshua, Arnold, Nicholas E, Cook, Taylor W, Moustaqil, Mehdi, Gambin, Yann, Sierecki, Emma, Fontaine, Frank, Vanderweele, Sophie, Das, Akansha S, Cvammen, William, Sirpilla, Olivia, Soehnlen, Xavier, Bricker, Kristen, Alokaili, Maram, Green, Morgan, Heeringa, Sadie, Wilstermann, Amy M, Freeland, Thomas M., Qutob, Dinah, Milsted, Amy, Jauch, Ralf, Triche, Timothy J, Krawczyk, Connie M, Bupp, Caleb P ... Prokop, Jeremy W. (2023). Evolutionary landscape of SOX genes to inform genotype-to-phenotype relationships. Genes, 14 (1) 222, 222. doi: 10.3390/genes14010222
Ojala, Päivi M. and Francoís, Mathias (2022). SOX18 Targeting as a Potential, Viable Therapeutic Avenue for Kaposi Sarcoma. JAMA Dermatology, 158 (12), 1458-1459. doi: 10.1001/jamadermatol.2022.4341
Seebauer, Caroline T., Graus, Matthew S., Huang, Lan, McCann, Alex J., Wylie-Sears, Jill, Fontaine, Frank R., Karnezis, Tara, Zurakowski, David, Staffa, Steven J., Meunier, Frédéric A., Mulliken, John B., Bischoff, Joyce and Francois, Mathias (2022). Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. Journal of Clinical Investigation, 132 (3) e151109. doi: 10.1172/jci151109
McCann, Alex J., Lou, Jieqiong, Moustaqil, Mehdi, Graus, Matthew S, Blum, Ailisa, Fontaine, Frank, Liu, Hui, Luu, Winnie, Rudolffi-Soto, Paulina, Koopman, Peter, Sierecki, Emma, Gambin, Yann, Meunier, Frédéric A., Liu, Zhe, Hinde, Elizabeth and Francois, Mathias (2021). A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity. Nucleic Acids Research, 49 (19), 10931-10955. doi: 10.1093/nar/gkab820
Jiang, Keyi, Pichol-Thievend, Cathy, Neufeld, Zoltan and Francois, Mathias (2021). Assessment of heterogeneity in collective endothelial cell behavior with multicolor clonal cell tracking to predict arteriovenous remodeling. Cell Reports, 36 (3) 109395, 109395. doi: 10.1016/j.celrep.2021.109395
Chau, Tevin CY., Baek, Sungmin, Coxam, Baptiste, Skoczylas, Renae, Rondon‐Galeano, Maria, Bower, Neil I., Wainwright, Elanor N., Stacker, Steven A., Cooper, Helen M., Koopman, Peter A., Lagendijk, Anne K., Harvey, Natasha L., François, Mathias and Hogan, Benjamin M. (2021). Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Developmental Dynamics, 251 (2) dvdy.390, 336-349. doi: 10.1002/dvdy.390
Francois, Mathias, Oszmiana, Anna and Harvey, Natasha L. (2021). When form meets function: the cells and signals that shape the lymphatic vasculature during development. Development, 148 (11) 167098, 1-13. doi: 10.1242/dev.167098
Zhao, Jilai, Patel, Jatin, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Styke, Cassandra, Hogan, Isabella, Kahler, Sam, Hamilton, Hamish, Wadlow, Racheal, Dight, James, Hashemi, Ghazaleh, Sormani, Laura, Roy, Edwige, Yoder, Mervin C., Francois, Mathias and Khosrotehrani, Kiarash (2021). Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nature Communications, 12 (1) 2564, 1-17. doi: 10.1038/s41467-021-22717-9
Wong, Emily S., Zheng, Dawei, Tan, Siew Z., Bower, Neil L., Garside, Victoria, Vanwalleghem, Gilles, Gaiti, Federico, Scott, Ethan, Hogan, Benjamin M., Kikuchi, Kazu, McGlinn, Edwina, Francois, Mathias and Degnan, Bernard M. (2020). Deep conservation of the enhancer regulatory code in animals. Science, 370 (6517) 681, 1-9. doi: 10.1126/science.aax8137
Gramolelli, Silvia, Elbasani, Endrit, Tuohinto, Krista, Nurminen, Veijo, Günther, Thomas, Kallinen, Riikka E., Kaijalainen, Seppo P., Diaz, Raquel, Grundhoff, Adam, Haglund, Caj, Ziegelbauer, Joseph M., Pellinen, Teijo, Bower, Mark, Francois, Mathias and Ojala, Päivi M. (2020). Oncogenic herpesvirus engages endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production. Cancer Research, 80 (15), 3116-3129. doi: 10.1158/0008-5472.can-19-3103
Rondon‐Galeano, Maria, Skoczylas, Renae, Bower, Neil I., Simons, Cas, Gordon, Emma, Francois, Mathias, Koltowska, Katarzyna and Hogan, Benjamin M. (2020). MAFB modulates the maturation of lymphatic vascular networks in mice. Developmental Dynamics, 249 (10) dvdy.209, 1201-1216. doi: 10.1002/dvdy.209
Villani, Rehan, Sim, Seen Ling, Roy, Edwige, Wainwright, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98 (3), 179-185. doi: 10.1016/j.jdermsci.2020.04.006
Kinnear, Sophie, Salamonsen, Lois A., Francois, Mathias, Harley, Vincent and Evans, Jemma (2019). Uterine SOX17: a key player in human endometrial receptivity and embryo implantation. Scientific Reports, 9 (1) 15495, 15495. doi: 10.1038/s41598-019-51751-3
Vivien, Celine J., Pichol-Thievend, Cathy, Sim, Choon Boon, Smith, Jacob B., Bower, Neil, Hogan, Benjamin M., Hudson, James E., Francois, Mathias and Porrello, Enzo R. (2019). Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context. Npj Regenerative Medicine, 4 (1) 18, 18. doi: 10.1038/s41536-019-0079-2
Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce and Francois, Mathias (2019). R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8 e43026. doi: 10.7554/elife.43026
Donovan, Prudence, Patel, Jatin, Dight, James, Wong, Ho Yi, Sim, Seen-Ling, Murigneux, Valentine, Francois, Mathias and Khosrotehrani, Kiarash (2019). Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis. Nature Communications, 10 (1) 18, 18. doi: 10.1038/s41467-018-07961-w
Moustaqil, Mehdi, Fontaine, Frank, Overman, Jeroen, McCann, Alex, Bailey, Timothy L., Rudolffi Soto, Paulina, Bhumkar, Akshay, Giles, Nichole, Hunter, Dominic J. B., Gambin, Yann, Francois, Mathias and Sierecki, Emma (2018). Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor. Nucleic Acids Research, 46 (21), 11381-11395. doi: 10.1093/nar/gky897
Francois, Mathias, Donovan, Prue and Fontaine, Frank (2018). Modulating transcription factor activity: interfering with protein-protein interaction networks. Seminars in Cell and Developmental Biology, 99, 12-19. doi: 10.1016/j.semcdb.2018.07.019
Pichol-Thievend, Cathy, Betterman, Kelly L., Liu, Xiaolei, Ma, Wanshu, Skoczylas, Renae, Lesieur, Emmanuelle, Bos, Frank L., Schulte, Dorte, Schulte-Merker, Stefan, Hogan, Benjamin M., Oliver, Guillermo, Harvey, Natasha L. and Francois, Mathias (2018). A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development, 145 (10) dev160184, dev160184. doi: 10.1242/dev.160184
Fontaine, Frank R., Goodall, Stephen, Prokop, Jeremy W., Howard, Christopher B., Moustaqil, Mehdi, Kumble, Sumukh, Rasicci, Daniel T., Osborne, Geoffrey W., Gambin, Yann, Sierecki, Emma, Jones, Martina L., Zuegg, Johannes, Mahler, Stephen and Francois, Mathias (2018). Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. mAbs, 10 (4), 1-11. doi: 10.1080/19420862.2018.1451288
Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Fossat, Nicolas, Radziewic, Tania, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Tam, Patrick P. L., Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin M., Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017). Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (vol 144, pg 2629, 2017). Development, 144 (20), 3847-3848. doi: 10.1242/dev.159715
Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin, Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144 (14), 2629-2639. doi: 10.1242/dev.146241
Villani, Rehan, Hodgson, Samantha, Legrand, Julien, Greaney, Jessica, Wong, Ho Yi, Pichol-Thievend, Cathy, Adolphe, Christelle, Wainwight, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2017). Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development, 144 (10), 1887-1895. doi: 10.1242/dev.143917
Bower, Neil I., Koltowska, Katarzyna, Pichol-Thievend, Cathy, Virshup, Isaac, Paterson, Scott, Lagendijk, Anne K., Wang, Weili, Lindsey, Benjamin W., Bent, Stephen J., Baek, Sungmin, Rondon-Galeano, Maria, Hurley, Daniel G., Mochizuki, Naoki, Simons, Cas, Francois, Mathias, Wells, Christine A., Kaslin, Jan and Hogan, Benjamin M. (2017). Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience, 20 (6), 774-783. doi: 10.1038/nn.4558
Moustaqil, Mehdi Denis, Fontaine, Frank, Overman, Jeroen, Giles, Nichole Denis, Bhumkar, Akshay Denis, O'Caroll, Ailis Denis, Francois, Mathias, Gambin, Yann Denis and Sierecki, Emma Denis (2017). SOX18 transcription factor interactome: Protein‐Protein interaction a new road for anti‐cancer drug discovery. The FASEB Journal, 31 (S1). doi: 10.1096/fasebj.31.1_supplement.908.1
Som, P. M. and Francois, M. (2017). The current concepts of the embryology of the lymphatic system. Neurographics, 7 (2), 129-150. doi: 10.3174/ng.2170198
De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136). Developmental Cell, 40 (4), 421-421. doi: 10.1016/j.devcel.2017.02.005
Patel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Neufeld, Zoltan, Fisk, Nicholas, Francois, Mathias and Khosrotehrani, Kiarash (2017). Functional definition of progenitors versus mature endothelial cells reveals key SoxF-dependent differentiation process. Circulation, 135 (8), 786-805. doi: 10.1161/CIRCULATIONAHA.116.024754
Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003
Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221
De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover. Developmental Cell, 40 (2), 123-136. doi: 10.1016/j.devcel.2016.12.017
Legrand, Julien M. D., Roy, Edwidge, Ellis, Jonathan J., Francois, Mathias, Brooks, Andrew J. and Khosrotehrani, Kiarash (2016). STAT5 activation in the dermal papilla is important for hair follicle growth phase induction. Journal of Investigative Dermatology, 136 (9), 1781-1791. doi: 10.1016/j.jid.2016.04.014
Klaus, Miriam, Prokoph, Nina, Girbig, Mathias, Wang, Xuecong, Huang, Yong-Heng, Srivastava, Yogesh, Hou, Linlin, Narasimhan, Kamesh, Kolatkar, Prasanna R., Francois, Mathias and Jauch, Ralf (2016). Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Nucleic Acids Research, 44 (8), 3922-3935. doi: 10.1093/nar/gkw130
Moustaqil, Mehdi, Overman, Jeroen, Fontaine, Franck, Bailey, Timothey, Francois, Mathias, Gambin, Yann and Sierecki, Emma (2016). Establishing a transcription factors protein network for lymphangiogenesis: identification of binding domains, impact of pathological mutations and perturbations by small molecules. The FASEB Journal, 30 (S1). doi: 10.1096/fasebj.30.1_supplement.600.24
Giles, Nichole, McCann, Alex, Moustaqil, Mehdi, Overman, Jeroen, Fontaine, Franck, Francois, Mathias, Sierecki, Emma and Gambin, Yann (2016). Tracking Dynamics of Vascular Development in Time and Space using Sox18 Dimer split‐Fluorescent Protein Biosensors. The FASEB Journal, 30 (S1). doi: 10.1096/fasebj.30.1_supplement.857.3
Fontaine, Frank, Overman, Jeroen and Francois, Mathias (2015). Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles. Cell Regeneration, 4 (2) 2, 2. doi: 10.1186/s13619-015-0015-x
Zeyad Nassar, Hill, Michelle, Parton, Robert G., Francois, Mathias and Parat, Marie-Odile (2015). Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis. Oncoscience, 2 (7), 635-645. doi: 10.18632/oncoscience.180
Koltowska, Katarzyna, Paterson, Scott, Bower, Neil I., Baillie, Gregory J., Lagendijk, Anne K., Astin, Jonathan W., Chen, Huijun, Francois, Mathias, Crosier, Philip S., Taft, Ryan J., Simons, Cas, Smith, Kelly A. and Hogan, Benjamin M. (2015). mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes and Development, 29 (15), 1618-1630. doi: 10.1101/gad.263210.115
Koltowska, Katarzyna, Lagendijk, Anne K., Pichol-Thievend, Cathy, Fischer, Johanna C., Francois, Mathias, Ober, Elke A., Yap, Alpha S. and Hogan, Benjamin M. (2015). Vegfc regulates bipotential precursor division and prox1 expression to promote lymphatic identity in zebrafish. Cell Reports, 13 (9), 1828-1841. doi: 10.1016/j.celrep.2015.10.055
Moon, Hyeongsun, Ruelcke, Jayde E., Choi, Eunju, Sharpe, Laura J., Nassar, Zeyad D., Bielefeldt-ohmann, Helle, Parat, Marie-Odile, Shah, Anup, Francois, Mathias, Inder, Kerry L., Brown, Andrew J., Russell, Pamela J., Parton, Robert G. and Hill, Michelle M. (2015). Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget, 6 (10), 7438-7453. doi: 10.18632/oncotarget.3476
Pichol-Thievend, Cathy, Hogan, Benjamin M. and Francois, Mathias (2014). Lymphatic vascular specification and its modulation during embryonic development. Microvascular Research, 96, 3-9. doi: 10.1016/j.mvr.2014.07.011
Aspelund, Aleksanteri, Tammela, Tuomas, Antila, Salli, Nurmi, Harri, Leppanen, Veli-Matti, Zarkada, Georgia, Stanczuk, Lukas, Francois, Mathias, Makinen, Taija, Saharinen, Pipsa, Immonen, Ilkka and Alitalo, Kari (2014). The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel. The Journal of Clinical Investigation, 124 (9), 3975-3986. doi: 10.1172/JCI75395
Coxam, Baptiste, Sabine, Amelie, Bower, Neil I., Smith, Kelly A., Pichol-Thievend, Cathy, Skoczylas, Renae, Astin, Jonathan W., Frampton, Emmanuelle, Jaquet, Muriel, Crosier, Philip S., Parton, Robert G., Harvey, Natasha L., Petrova, Tatiana V., Schulte-Merker, Stefan, Francois, Mathias and Hogan, Benjamin M. (2014). Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Reports, 7 (3), 623-633. doi: 10.1016/j.celrep.2014.03.063
Bowles, Josephine, Secker, Genevieve, Nguyen, Christelle, Kazenwadel, Jan, Truong, Vy, Framptom, Emmanuelle, Curtis, Cameron, Skoczylas, Renae, Davidson, Tara-Lynn, Miura, Naoyuki, Hong, Young-Kwon, Koopman, Peter, Harvey, Natasha L. and François, Mathias (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386 (1), 25-33. doi: 10.1016/j.ydbio.2013.12.008
Francois, M., Shayan, R. and Karnezis, T. (2014). Ordered chaos: harnessing developmental pathways in tumor-induced lymphangiogenesis. Journal of Clinical and Cellular Immunology, 05 (05). doi: 10.4172/2155-9899.1000270
Moalem, S., Brouillard, P., Kuypers, D., Legius, E., Harvey, E., Taylor, G., Francois, M., Vikkula, M. and Chitayat, D. (2014). Hypotrichosis-lymphedema-telangiectasia-renal defect associated with a truncating mutation in the SOX18 gene. Clinical Genetics, 87 (4), 378-382. doi: 10.1111/cge.12388
Duong, Tam, Koltowska, Katarzyna, Pichol-Thievend, Cathy, Le Guen, Ludovic, Fontaine, Frank R., Smith, Kelly, Truong, Vy, Skoczylas, Renae, Stacker, Steven A., Achen, Marc G., Koopman, Peter, Hogan, Ben and Francois, Mathias (2013). VEGFD regulates blood vascular development by modulating SOX18 activity. Blood, 123 (7), 1102-1112. doi: 10.1182/blood-2013-04-495432
Kartopawiro, Joëlle, Neil Bower, Neil I., Karnezis, Tara, Kazenwadel, Jan, Betterman, Kelly L., Lesieur, Emmanuelle, Koltowska, Katarzyna, Astin, Jonathan, Crosier, Philip, Vermeren, Sonja, Achen, Marc G., Stacker, Steven A., Smith, Kelly A., Harvey, Natasha L., François, Mathias and Hogan, Benjamin M. (2013). Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, Advance Access (5) ddt518, 1-12. doi: 10.1093/hmg/ddt518
Nassar, Zeyad D., Moon, Hyeongsun, Duong, Tam, Neo, LiQi, Hill, Michelle M., Francois, Mathias, Parton, Robert G. and Parat, Marie-Odile (2013). PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget, 4 (10), 1844-1855. doi: 10.18632/oncotarget.1300
Cermenati, Solei, Moleri, Silvia, Neyt, Christine, Bresciani, Erica, Carra, Silvia, Grassini, Daniela R., Omini, Alice, Goi, Michela, Cotelli, Franco, François, Mathias, Hogan, Benjamin M. and Beltrame, Monica (2013). Sox18 genetically interacts With VegfC to regulate lymphangiogenesis in zebrafish. Arteriosclerosis, Thrombosis and Vascular Biology, 33 (6), 1238-1247. doi: 10.1161/ATVBAHA.112.300254
Svingen, Terje, Francois, Mathias, Wilhelm, Ingrid D. and Koopman, Peter A. (2012). Three-dimensional imaging of Prox1-EGFP transgenic mouse gonads reveals divergent modes of lymphangiogenesis in the testis and ovary. PLoS One, 7 (12) e52620, e52620.1-e52620.11. doi: 10.1371/journal.pone.0052620
Oommen, Shelly, Francois, Mathias, Kawasaki, Maiko, Murrell, Melanie, Kawasaki, Katsushige, Porntaveetus, Thantrira, Ghafoor, Sarah, Young, Neville J., Okamatsu, Yoshimasa, McGrath, John, Koopman, Peter, Sharpe, Paul T. and Ohazama, Atsushi (2012). Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PloS One, 7 (9) e43857, e43857. doi: 10.1371/journal.pone.0043857
Duong, Tam, Proulx, Steven T., Luicani, Paola, Leroux, Jean-Christophe, Detmar, Michael, Koopman, Peter and Francois, Mathias (2012). Genetic ablation of SOX 18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Research, 72 (12), 3105-3114. doi: 10.1158/0008-5472.CAN-11-4026
François, Mathias, Short, Kieran, Secker, Genevieve A., Combes, Alexander, Schwarz, Quenten, Davidson, Tara-Lynn, Smyth, Ian, Hong, Young-Kwon, Harvey, Natasha L. and Koopman, Peter (2012). Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Developmental Biology, 264 (2), 89-98. doi: 10.1016/j.ydbio.2011.12.032
Newman, Beth, Lose, Felicity, Kedda, Mary-Anne, Francois, Mathias, Ferguson, Kaltin, Janda, Monika, Yates, Patsy, Spurdle, Amanda B. and Hayes, Sandra C. (2012). Possible genetic predisposition to lymphedema after breast cancer. Lymphatic Research and Biology, 10 (1), 2-13. doi: 10.1089/lrb.2011.0024
Duong, Tam, Koopman, Peter A. and Francois, Mathias (2012). Tumor lymphangiogenesis as a potential therapeutic target. Journal of Oncology, 2012 204946, 1-23. doi: 10.1155/2012/204946
Francois, Mathias and Ramchandran, Ramani (2012). Studies on Axenfeld-Rieger syndrome patients and mice reveal Foxcl's role in corneal neovascularization. Proceedings of the National Academy of Sciences of the United States of America, 109 (6), 1818-1819. doi: 10.1073/pnas.1119291109
Blanquart, C., François, M., Charrier, C., Bertrand, P. and Gregoire, M. (2011). Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. Current Cancer Drug Targets, 11 (8), 919-928. doi: 10.2174/156800911797264761
Samant, Ganesh V., Schupp, Marcus O., Francois, Mathias, Moleri, Silvia, Kothinti, Rajendra K., Chun, Chang Zoon, Sinha, Indranil, Sellars, Suzanna, Leigh, Noah, Pramanik, Kallal, Horswill, Mark A., Remadevi, Indulehka, Li, Keguo, Wilkinson, George A., Tabatabai, Niloofar, Beltrame, M, Koopman, Peter A. and Ramchandran, Ramani (2011). Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. Journal of Biological Chemistry, 286 (35), 30740-30747. doi: 10.1074/jbc.M111.220665
Francois, Mathias, Harvey, Natasha L. and Hogan, Benjamin M. (2011). The transcriptional control of lymphatic vascular development. Physiology, 26 (3), 146-155. doi: 10.1152/physiol.00053.2010
Francois, M, Koopman, P and Beltrame, M (2009). SoxF genes: Key players in the development of the cardio-vascular system. The International Journal of Biochemistry and Cell Biology, 42 (3), 445-448. doi: 10.1016/j.biocel.2009.08.017
Downes, Meredith, Francois, Mathias, Ferguson, Charles, Parton, Robert G. and Koopman, Peter (2009). Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Human Molecular Genetics, 18 (15), 2839-2850. doi: 10.1093/hmg/ddp219
Hosking, B, Francois, M, Wilhelm, D, Orsenigo, F, Caprini, A, Svingen, T, Tutt, D, Davidson, T, Browne, C, Dejana, E and Koopman, P (2009). Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. DEVELOPMENT, 136 (14), 2385-2391. doi: 10.1242/dev.034827
Francois, Mathias (2009). Sox18 orchestrates the commitment of the lymphatic vessels. M S-Medecine Sciences, 25 (2), 127-129. doi: 10.1051/medsci/2009252127
Francois, Mathias, Caprini, Andrea, Hosking, Brett, Orsenigo, Fabrizio, Wilhelm, Dagmar, Browne, Catherine, Paavonen, Karri, Karnezis, Tara, Shayan, Ramin, Downes, Meredith, Davidson, Tara, Tutt, Desmond, Cheah, Kathryn S. E., Stacker, Steven A., Muscat, George E. O., Achen, Marc G., Dejana, Elisabetta and Koopman, Peter (2008). Sox18 induces development of the lymphatic vasculature in mice. Nature, 456 (7222), 643-647. doi: 10.1038/nature07391
Richette, Pascal, François, Mathias, Vicaut, Eric, Fitting, Catherine, Bardin, Thomas, Corvol, Maїté, Savouret, Jean-François and Rannou, François (2008). A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis. Journal of Rheumatology, 35 (8), 1650-1654.
Bougnères, P., François, M., Pantalone, L., Rodrigue, D., Bouvattier, C., Demesteere, E., Roger, D. and Lahlou, N. (2008). Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone. Journal of Clinical Endocrinology and Metabolism, 93 (6), 2202-2205. doi: 10.1210/jc.2008-0121
Benallaoua, Mourad, Francois, Mathias, Batteux, Frederic, Thelier, Natacha, Shyy, John Y.-J., Fitting, Catherine, Tsagris, Lydia, Boczkowski, Jorge, Savouret, Jean-Francois, Corvol, Marie-Therese, Poiraudeau, Serge and Rannou, Francois (2007). Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice. Arthritis and Rheumatism, 56 (8), 2585-2594. doi: 10.1002/art.22749
Francois, M., Richette, P., Tsagris, L., Fitting, C., Lemay, C., Benallaoua, M., Tahiri, K. and Corvol, M. T. (2006). Activation of the peroxisome proliferator-activated receptor pathway potentiates interleukin-1 receptor antagonist production in cytokine-treated chondrocytes. Arthritis and Rheumatism, 54 (4), 1233-1245. doi: 10.1002/art.21728
Rannou, Francois, Francois, Mathias, Corvol, Marie-Thérèse and Berenbaum, Francis (2006). Cartilage Breakdown in Rheumatoid Arthritis. Joint, Bone, Spine, 73 (1), 29-36. doi: 10.1016/j.jbspin.2004.12.013
Francois, M., Richette, P. and Corvol, M. T. (2005). Peroxisome proliferator-activated receptor gamma and its ligands in controlling interleukin-1 beta target gene expression: A confusing story. Drug News and Perspectives, 18 (4), 257-261. doi: 10.1358/dnp.2005.18.4.908660
Rannou, François, François, Mathias, Corvol, Marie Thérèse and Berenbaum, Francis (2005). Cartilage deterioration and rheumatoid arthritis Dégradation du cartilage et polyarthrite rhumatoïde. Revue du Rhumatisme (Edition Francaise), 72 (4), 322-330. doi: 10.1016/j.rhum.2004.12.021
Moulin, M. F., Bianchi, D., Boyault, A., Morin, S., Koufany, S., Francois, M., Netter, P., Jouzeau, J. Y. and Terlain, B. (2005). Rosiglitazone Induces Interleukin-1 Receptor Antagonist in Interleukin-1-beta-stimulated Rat Synovial Fibroblasts via a Peroxisome Proliferator-activated Receptor Beta/Delta-dependent Mechanism. Arthritis and Rheumatism, 52 (3), 759-769. doi: 10.1002/art.20868
Boyault, Sandrine, Bianchi, Arnaud, Moulin, David, Morin, Sylvie, Francois, Mathias, Netter, Patrick, Terlain, Bernard and Bordji, Karim (2004). 15-Deoxy-Δ12,14-prostaglandin J2 inhibits IL-1β-induced IKK enzymatic activity and IκBα degradation in rat chondrocytes through a PPARγ-independent pathway. FEBS Letters, 572 (1-3), 33-40. doi: 10.1016/j.febslet.2004.06.090
Francois, Mathias, Richette, Pascal, Tsagris, Lydia, Raymondjean, Michel, Fulchignoni-Lataud, Marie-Claude, Forest, Claude, Savouret, Jean-Francois and Corvol, Marie-Therese (2004). Peroxisome Proliferator-activated Receptor-{gamma} Down-regulates Chondrocyte Matrix Metalloproteinase-1 via a Novel Composite Element. Journal of Biological Chemistry, 279 (27), 28411-28418. doi: 10.1074/jbc.M312708200
Richette, P., Dumontier, M. F., Francois, M., Tsagris, L ., Korwin-Zmijowska, C., Rannou, F and Corvol, M. T. (2004). Dual Effects of 17ß-oestradiol on Interleukin 1ß-induced Proteoglycan Degradation in Chondrocytes. Annals of the Rheumatic Diseases, 63 (2), 191-199. doi: 10.1136/ard.2003.006510
Rannou, F., Richette, P., Benallaoua, M., Francois, M., Genries, V., Korwin-Zmijowska, C., Revel, M., Corvol, M. and Poiraudeau, S. J. (2003). Cyclic Tensile Stretch Modulates Proteoglycan Production by Intervertebral Disc Annulus Fibrosus Cells through Production of Nitrite Oxide. Journal of Cellular Biochemistry. Supplement, 90 (1), 148-157. doi: 10.1002/jcb.10608
Francois, Mathias, Le Cabec, Véronique, Dupont, Marie-Ange, Sansonetti, Philippe J. and Maridonneau-Parini, Isabelle (2000). Induction of necrosis in human neutrophils by Shigella flexneri requires type III secretion, IpaB and IpaC invasins, and actin polymerization. Infection and Immunity, 68 (3), 1289-1296. doi: 10.1128/IAI.68.3.1289-1296.2000
Conference Papers
Patel, Jatin, Seppanen, Elke J., Rodero, Mathieu, Wong, Ho Yi, Donovan, Prudence, Fisk, Nicholas M., Francois, Mathias and Khosrotehrani, Kiarash (2017). A novel in vivo endothelial hierarchy from progenitor to mature endothelial cells reveals key SoxF-dependent differentiation process. American-Heart-Association's Arteriosclerosis, Thrombosis and Vascular Biology/Peripheral Vascular Disease Scientific Sessions, Minneapolis MN, United States, 4-6 May 2017. Philadelphia, PA United States: Lippincott Williams & Wilkins.
Donovan, P., Patel, J., Francois, M. and Khosrotehrani, K. (2016). Origin of vascular progenitors driving melanoma angiogenesis in vivo. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
Patel, J., Francois, M. and Khosrotehrani, K. (2016). Resident progenitors of endothelial origin contribute to neo-vessel formation through the expression of Sox18 during skin wound healing. Annual Meeting of the European Society for Dermatological Research (ESDR), Munich, Germany, 7-10 September 2016. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2016.06.596
Villani, R. M., Hodgson, S., Legrand, J., Greaney, J., Wong, H., Pichol-Thievend, C., Adolphe, C., Wainwright, B., Francois, M. and Khosrotehrani, K. (2015). Dominant negative mutation of Sox18 inhibits normal dermal papilla development during embryogenesis and regeneration. 45th Annual Meeting of the European Society for Dermatological Research, Rotterdam, Netherlands, 9-12 September 2015. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2015.272
Aspelund, Aleksanteri, Tammela, Tuomas, Antila, Salli, Nurmi, Harri, Leppanen, Veli-Matti, Zarkada, Georgia, Stanczuk, Lukas, Francois, Mathias, Makinen, Taija, Saharinen, Pipsa, Immonen, Ilkka and Alitalo, Kari (2015). Therapeutic Insights to Lymphangiogenic Growth Factors. Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO), Pisa, Italy, 03-06 June 2015. Basel, Switzerland: S. Karger AG. doi: 10.1159/000433498
Nguyen, C., Skoczylas, R., Pichol-Thievend, C., Frampton, E., Rannou, F. and Francois, M. (2014). Forelimb Development in the Mouse: An Original Model of Organo-Dependent Lymphangiogenesis. 15th Annual European Congress of Rheumatology (EULAR), Paris, France, 11-14 June 2014. London, United Kingdom: B M J Group. doi: 10.1136/annrheumdis-2014-eular.3954
Moon, Hyeongsun, Sharpe, Laura, Choi, Eunju, Bielefeldt-Ohmann, Helle, Nassar, Zeyad, Parat, Marie-Odile, Francois, Mathias, Lee, C. Soon, Brown, Andrew, Russell, Pamela, Inder, Kerry and Hill, Michelle (2014). Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-4950
Cermenati, Solei, Moleri, Silvia, Neyt, Christine, Bresciani, Erica, Carra, Silvia, Grassini, Daniela R., Omini, Alice, Cotelli, Franco, Francois, Mathias, Hogan, Benjamin M. and Beltrame, Monica (2013). Sox18 and VegfC genetically interact in the early phases of lymphatic development in zebrafish. NAVBO Workshops in Vascular Biology, Pacific Grove, CA, United States, 14-18 October 2012. Dordrecht, Netherlands: Springer. doi: 10.1007/s10456-012-9326-5
Hodgson, S. S., Francois, M. and Khosrotehrani, K. (2012). A mouse model for in vivo quantitative monitoring of Wnt/b-catenin signaling in skin reveals hair cycle dynamics in sox18 mutant mice. 22nd Annual Meeting of the European Tissue Repair Society, Athens, Greece, October 4–5 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1524-475X.2012.00835.x
Francois, Mathias, Hosking, Brett and Koopman, Peter (2009). Molecular and Cellular Events Regulating the Early Development of the Lymphatic Vasculature in Mice. 14th Meeting of the Australian-and-New-Zealand-Microcirculation-Society, Queenstown New Zealand, Aug 25-27, 2009. BASEL: KARGER.
Richette, Pascal, Francois, Mathias, Vicaut, Eric, Bardin, Thomas, Fitting, Catherine, Cavaillon, Jean-Marc, Savouret, Jean-Francois and Rannou, Francois (2006). Assessment of the synovial fluid interleukin-1 receptor antagonist (IL-1Ra)/interleukin-1 beta (IL-1beta) ratio in patients with osteoarthritis and rheumatoid arthritis.. 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Washington Dc, Nov 10-15, 2006. HOBOKEN: WILEY-LISS.
Benallaoua, Mourad, Francois, Mathias, Batteux, Frederic, Shyy John, Y. -J., Fitting, Catherine, Tsagris, Lydia, Boczkowski, Jorge, Savouret, Jean-Francois, Corvol, Marie-Therese, Poiraudeau, Serge and Rannou, Francois P. (2006). Pharmacological induction of heme oxygenase-1 decreases the acute phase of inflammatory arthritis in a mouse model of polyarthritis.. 70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Washington Dc, Nov 10-15, 2006. HOBOKEN: WILEY-LISS.
Richette, P., Francois, M., Bardin, T., Bazille, C., Fitting, C., Cavaillon, J., Corvol, M. and Rannou, F. (2006). High synovial fluid interleukin-1 receptor antagonist (IL-1 RA)/interleukin-1 beta (IL-1beta) ratio naturally occurs in human knee osteoarthritis. Annual European Congress of Rheumatology (EULAR 2006), Amsterdam Netherlands, Jun 21-24, 2006. LONDON: B M J PUBLISHING GROUP.
Benallaoua, Mourad, Richette, Pascal, Francois, Mathias, Tsagris, Lydia, Revel, Michel, Corvol, Maité, Poiraudeau, Serge, Savouret, Jean-François and Rannou, François (2006). Modulation of proteoglycan production by cyclic tensile stretch in intervertebral disc cells through a post-translational mechanism. 4th International Symposium on Mechanobiology of Cartilage and Chondrocyte, Budapest, Hungary, 20–22 May 2006. United Kingdom: IOS Press.
Richette, P, Francois, M, Fitting, C, Rannou, F, Tsagris, L and Corvol, MT (2004). A PPARalpha-dependent pathway increases IL-1ra production and protects from IL-1beta detrimental effects in articular chondrocytes. 68th Annual Scientific Meeting of the American-College-of-Rheumatology/39th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, San Antonio Tx, Oct 16-21, 2004. HOBOKEN: WILEY-LISS.
Moulin, D, Bianchi, A, Boyaul, SD, Morin, S, Koufany, M, Francois, M, Netter, P, Terlain, B and Jouzeau, JY (2004). Modulation of interleukin-1 receptor antagonist by peroxisome proliferator-activated receptor gamma agonists in rat synoviocytes is PPARgamma-independent. 68th Annual Scientific Meeting of the American-College-of-Rheumatology/39th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, San Antonio Tx, Oct 16-21, 2004. HOBOKEN: WILEY-LISS.
Rannou, FP, Liu, Y, Francois, M, Benallaoua, M, Richette, P, Poiraudeau, S, Shyy, JY and Lee, TSY (2004). Induction of heme oxygenase-1 inhibits interleukin-1 beta-dependant nitrite oxide production in articular chondrocytes. 68th Annual Scientific Meeting of the American-College-of-Rheumatology/39th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, San Antonio Tx, Oct 16-21, 2004. HOBOKEN: WILEY-LISS.
Rannou, FP, Liu, Y, Benallaoua, M, Francois, M, Richette, P, Poiraudeau, S, Shyy, JY and Lee, TS (2004). Induction of heme oxygenase-1 inhibits interleukin-1 beta-dependant nitrite oxide production in articular chondrocytes. 9th World Congress of the Osteoarthritis-Research-Society-International, Chicago Il, Dec 02-05, 2004. HOBOKEN: W B SAUNDERS CO LTD.
Richette, P, Dumontier, MF, Francois, M, Tsagris, L, Korwin-Zmijowska, C, Rannou, F and Corvoi, MT (2003). Dual effects of 17 beta-estradiol on IL-1 beta-induced proteoglycan degradation in chondrocytes. Annual European Congress of Rheumatology, Lisbon Portugal, Jun 18, 2003. LONDON: B M J PUBLISHING GROUP.
Francois, M, Tsagris, L, Forest, C, Richette, P, Raymondjean, M and Corvol, MT (2003). Evidence that rosiglitazone acts as an antidegradative agent on cartilage cells in vitro. 3rd World Congress of the Global-Arthritis-Research-Network (GARN), Miyakazi Japan, Sep 14-17, 2003. LONDON: BIOMED CENTRAL LTD. doi: 10.1186/ar856
Richette, P, Tsagris, L, Korwin-Zmijowska, C, Francois, M, Dumontier, MF, Laborde, K and Corvol, MT (2000). Dose-responsive effects of estrogens on interleukin-1 beta induced metalloprotease gene expression and no production by articular chondrocytes.. Annual European Congress of Rheumatology, Lisbon Portugal, Jun 18, 2003. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.