Transcriptional regulation of blood and lymphatic vessels

Transcription factor control of vascular development

Associate Professor Francois has a dual research interest in the vertebrate vascular tree.

The first one is in exploring the genetic program responsible for building and regenerating blood and lymphatic vessel networks.

The second is in the pharmacological manipulation of key proteins that act as molecular switches for vessel development in the hope of developing novel drugs for use in the treatment of vascular disorders.

“There are a range of diseases where aberrant formation of lymphatic vessels are at play, including rheumatoid arthritis, lymphoedema and cardiovascular malformation,” said Associate Professor Francois.

“Faulty vasculature also plays a central role in solid tumour metastasis. In each of these conditions, vascular development becomes dysregulated.

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A/Prof Mat Francois

Associate Professor Mat Francois

Group Leader, Genomics of Development and Disease Division
Investigator, Centre for Rare Diseases Research

  +61 7 3346 2494  
  m.francois@imb.uq.edu.au
  IMB Researcher Profile
  Centre for Cardiac and Vascular Biology


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  • Miss Keyi Jiang

    Higher degree by research (PhD) student
    Institute for Molecular Bioscience
  • Miss Alex Mccann

    Higher degree by research (PhD) student
    Institute for Molecular Bioscience
  • Ms Siew Zhuan Tan

    Higher degree by research (PhD) student
    Institute for Molecular Bioscience