Endothelial Nitric Oxide Synthase (eNOS) in Cardiovascular Disease

eNOS is critical for regulating vascular tone and its dysregulation is causal in the development of cardiovascular diseases like atherosclerosis and hypertension. The modulation of eNOS activation has received significant attention as a potential mechanism to prevent cardiovascular disease progression. eNOS function is linked with cell surface structures called caveolae. My laboratory investigates these links and the role of endocytic processes in redistributing eNOS and aims to characterise novel mechanisms that modulate eNOS signalling.