Cargo specificity in intracellular trafficking

In mammalian cells, there is a multitude of cargoes each with a unique fingerprint for delivery to a specific place at a specific time. But how the cell orchestrates this control and the molecular players involved in these processes remain poorly characterised. My lab is interested in understanding, and directly imaging, cargo specificity to discover the links between dynein and dynactin activating adaptors, endosomes, and the cytoskeleton. This project is a collaboration with the Ananthanarayanan Group (EMBL Australia, UNSW Sydney).