Developing toolkits to link structural and cellular biology

Recent advances in instrumentation and workflows in the field of cryo-electron microscopy (cryo-EM) have enabled significant improvements in in situ cellular structural biology. However, unambiguous targeting of cellular structures in the heterogeneous, dense, and compacted environment of the cellular cytoplasm remains challenging by cryo-EM. My lab overcomes these challenges by combining the atomic resolution imaging capabilities of cryo-EM with targeting power of super-resolution fluorescence microscopy. We aim to develop novel systems to facilitate improved correlative cryo-light and electron microscopy on mechanically tuneable substrata.