Professor Luke O'Neill
Honorary Research Fellow
Institute for Molecular Bioscience
Publications
Journal Articles
Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017) Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 10: 1-11. doi:10.1038/s41564-017-0015-4
Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017) Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 32: E6480-E6489. doi:10.1073/pnas.1701868114
Kim, Richard Y., Pinkerton, James W., Essilfie, Ama T., Robertson, Avril A. B., Baines, Katherine J., Brown, Alexandra C., Mayall, Jemma R., Ali, M. Khadem, Starkey, Malcolm R., Hansbro, Nicole G., Hirota, Jeremy A., Wood, Lisa G. , Simpson, Jodie L., Knight, Darryl A., Wark, Peter A., Gibson, Peter G., O'Neill, Luke A. J., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2017) Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. American Journal of Respiratory and Critical Care Medicine, 196 3: 283-297. doi:10.1164/rccm.201609-1830OC
Domingo-Fernandez, Raquel, Coll, Rebecca C., Kearney, Jay, Breit, Samuel and O'Neill, Luke A. J. (2017) The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome. Journal of Biological Chemistry, 292 29: 12077-12087. doi:10.1074/jbc.M117.797126
Pinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C. and Hansbro, Philip M. (2017) Inflammasomes in the lung. Molecular Immunology, 86 44-55. doi:10.1016/j.molimm.2017.01.014
Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016) The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 25: 2960-2975. doi:10.1182/blood-2016-07-730556
Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J. and Lynch, M. A. (2016) Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, Behavior, and Immunity, 61 306-316. doi:10.1016/j.bbi.2016.12.014
Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016) T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 6292: 1424+-U95. doi:10.1126/science.aad1210
Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 3: 248-257. doi:10.1038/nm.3806
Greenhill, Claire J., Jones, Gareth W., Nowell, Mari A., Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul N., Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela, Taylor, Philip R., O'Neill, Luke A., Humphreys, Ian R., Williams, Anwen S. and Jones, Simon A. (2014) Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy, 16 4: . doi:10.1186/s13075-014-0419-y
Haneklaus, Moritz, O'Neill, Luke A. J. and Coll, Rebecca C. (2013) Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: Recent developments. Current Opinion in Immunology, 25 1: 40-45. doi:10.1016/j.coi.2012.12.004
Ryan, Anthony, Lynch, Mark, Smith, Sinead M., Amu, Sylvie, Nel, Hendrik J., McCoy, Claire E., Dowling, Jennifer K., Draper, Eve, O'Reilly, Vincent, McCarthy, Ciara, O'Brien, Julie, Eidhin, Deirdre Ni, O'Connell, Mary J., Keogh, Brian, Morton, Charles O., Rogers, Thomas R., Fallon, Padraic G., O'Neill, Luke A., Kelleher, Dermot and Loscher, Christine E. (2011) A role for TLR4 in clostridium difficile infection and the recognition of surface layer proteins. PloS Pathogens, 7 6: . doi:10.1371/journal.ppat.1002076
Masters, Seth L., Dunne, Aisling, Subramanian, Shoba L., Hull, Rebecca L., Tannahill, Gillian M., Sharp, Fiona A., Becker, Christine, Franchi, Luigi, Yoshihara, Eiji, Chen, Zhe, Mullooly, Niamh, Mielke, Lisa A., Harris, James, Coll, Rebecca C., Mills, Kingston H. G., Mok, K. Hun, Newsholme, Philip, Nunez, Gabriel, Yodoi, Junji, Kahn, Steven E., Lavelle, Ed C. and O'Neill, Luke A. J. (2010) Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes. Nature Immunology, 11 10: 897-904. doi:10.1038/ni.1935