Dr Greg Bourne
Senior Research Officer
Institute for Molecular Bioscience
+61 7 334 62976
Book Chapter
Bourne, Gregory T., Nielson, Jonathon L., Coughlan, Justin F., Darwen, Paul, Campitelli, Marc R., Horton, Douglas A., Rhumann, Andreas, Love, Stephen G., Tran, Tran T. and Smythe, Mark L. (2005). A convenient method for the synthesis of cyclic peptide libraries. Peptide synthesis and applications. (pp. 151-166) edited by John Howl. Clifton, NJ, USA: Humana Press.
Journal Articles
Ranganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G., Liu, Guang, Tran, Tran T., Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E., Graul, Chris, Griffin, Aliesha, Schairer, Wayne C., Higgins, Carolyn, Reza, Tammi L., Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim ... Carlson, Kenneth E. (2015). Discovery and characterization of a potent interleukin-6 binding peptide with neutralizing activity in vivo. PLoS One, 10 (11) e0141330, 1-19. doi: 10.1371/journal.pone.0141330
Pettit, George R., Tang, Yuping, Zhang, Qingwen, Bourne, Gregory T., Arm, Christoph A., Leet, John E., Knight, John C., Pettit, Robin K., Chapuis, Jean-Charles, Doubek, Dennis L., Ward, Franklin J., Weber, Christine and Hooper, John N. A. (2013). Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1). Journal of Natural Products, 76 (3), 420-424. doi: 10.1021/np300828y
Christ, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a
Bourne, Gregory T., Kuster, Daniel J. and Marshall, Garland R. (2010). Synthesis of the phenylpyridal scaffold as a helical peptide mimetic. Chemistry: A European Journal, 16 (28), 8439-8445. doi: 10.1002/chem.201000315
Severinsen, Rune, Bourne, Gregory T., Tran, Tran T., Ankersen, Michael, Begtrup, Mikael and Smythe, Mark L. (2008). Library of biphenyl privileged substructures using a safety-catch linker approach. Journal of Combinatorial Chemistry, 10 (4), 557-566. doi: 10.1021/cc800006g
Horton, D. A., Bourne, G. T., Coughlan, J., Kaiser, S. M., Jacobs, C. M., Jones, A., Ruhmann, A., Turner, J. Y. and Smythe, M. L. (2008). Cyclic tetrapeptides via the ring contraction strategy: Chemical techniques useful for their identification. Organic & Biomolecular Chemistry, 6 (8), 1386-1395. doi: 10.1039/b800464a
Schweitzer-Stenner, Reinhard, Gonzales, Widalys, Bourne, Gregory T., Feng, Jianwen A. and Marshall, Garland R. (2007). Conformational manifold of α-aminoisobutyric acid (Aib) containing alanine-Based tripeptides in aqueous solution explored by vibrational spectroscopy, electronic circular dichroism spectroscopy, and molecular dynamics simulations. Journal of the American Chemical Society, 129 (43), 13095-13109. doi: 10.1021/ja0738430
Darwen, PJ, Tran, TT, Bourne, GT, Nielson, JL and Smythe, ML (2006). A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide libraries. Combinatorial Chemistry & High Throughput Screening, 9 (7), 559-563. doi: 10.2174/138620706777935333
Bourne, Gregory T, Nielson, Jonathon L, Coughlan, Justin F, Darwen, Paul, Campitelli, Marc R, Horton, Douglas A, Rhümann, Andreas, Love, Stephen G, Tran, Tran T and Smythe, Mark L (2005). A convenient method for synthesis of cyclic peptide libraries. Methods in molecular biology (Clifton, N.J.), 298, 151-165. doi: 10.1385/1-59259-877-3:151
Ravn, J, Bourne, GT and Smythe, ML (2005). A safety catch linker for Fmoc-based assembly of constrained cyclic peptides. Journal of Peptide Science, 11 (9), 572-578. doi: 10.1002/psc.651
Horton, Douglas A., Severinsen, Rune, Kofod-Hansen, Mikael, Bourne, Gregorty T. and Smythe, Mark L. (2005). A versatile synthetic approach to peptidyl privileged structures using a "safety-catch" linker. Journal of Combinatorial Chemistry, 7 (3), 421-435. doi: 10.1021/cc049829q
Tran, TT, McKie, J, Meutermans, WDF, Bourne, GT, Andrews, PR and Smythe, ML (2005). Topological side-chain classification of beta-turns: Ideal motifs for peptidomimetic development. Journal of Computer-aided Molecular Design, 19 (8), 551-566. doi: 10.1007/s10822-005-9006-2
Meutermans, W., Bourne, G. T., Golding, S., Horton, D., Campitelli, M. R., Craik, D. J., Scanlon, M. J. and Smythe, M. L. (2003). Difficult macrocyclizations: New strategies for synthesizing highly strained cyclic tetrapeptides. Organic Letters, 5 (15), 2711-2714. doi: 10.1021/ol034907o
Horton, DA, Bourne, GT and Smythe, ML (2003). The combinatorial synthesis of bicyclic privileged structures or privileged substructures. Chemical Reviews, 103 (3), 893-930. doi: 10.1021/cr020033s
Horton, D. A., Bourne, G. T. and Smythe, M. L. (2002). Exploring privileged structures: the combinatorial synthesis of cyclic peptides. Journal of Computer-aided Molecular Design, 16 (5-6), 415-431. doi: 10.1023/A:1020863921840
Bourne, G.T., Golding, S., Meutermans, W. and Smythe, M.L. (2001). Synthesis of a cyclic peptide library based on the somatostatin sequence using the backbone amide linker approach. Letters in Peptide Science, 7 (6), 311-316. doi: 10.1023/A:1013057832044
Bourne, Gregory T., Golding, Simon W., McGeary, Ross P., Meutermans, Wim D. F., Jones, Alun, Marshall, Garland R., Alewood, Paul F. and Smythe, Mark L. (2001). The development and application of a novel safety-catch linker for BOC-based assembly of libraries of cyclic peptides. Journal of Organic Chemistry, 66 (23), 7706-7713. doi: 10.1021/jo010580y
Horton, DA, Bourne, GT and Smythe, ML (2000). Exploring privileged structures: The combinatorial synthesis of cyclic peptides. Molecular Diversity, 5 (4), 289-304. doi: 10.1023/A:1021365402751
Meutermans, Wdf, Golding, SW, Bourne, GT, Miranda, LP, Dooley, MJ and Alewood, PF (1999). Synthesis of Difficult Cyclic Peptides by Inclusion of a Novel Photolabile Auxiliary in a Ring Contraction Strategy. Journal of American Chemical Society, 121 (42), 9790-9796. doi: 10.1021/ja992173y
Bourne, GT, Meutermans, WDF, Alewood, PF, McGeary, RP, Watson, AA and Smythe, ML (1999). A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1. Journal of Organic Chemistry, 64 (9), 3095-3101. doi: 10.1021/jo9818780
Bourne, G. T., Meutermans, W. D. F. and Smythe, M. L. (1999). The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides. Tetrahedron Letters, 40 (40), 7271-7274. doi: 10.1016/S0040-4039(99)01473-2
Meutermans, WDF, Alewood, PF, Bourne, GT, Hawkins, B and Smythe, ML (1997). Synthesis of alpha-aspartyl-containing cyclic peptides. Letters In Peptide Science, 4 (2), 79-84. doi: 10.1023/A:1008878017315
Meutermans W.D.F., Alewood P.F., Bourne G.T., Hawkins B. and Smythe M.L. (1997). Synthesis of α-aspartyl-containing cyclic peptides. Letters in Peptide Science, 4 (2), 79-84. doi: 10.1007/BF02443518
Musgrave, R. P., Jacobsen, N. W., Bourne, G., Kennard, C. H. L., Smith, G. and Mak, T. C. W. (1995). Cycloaddition Reactions of 3-Dimethylamino-1-methyl-1,2,4-triazinium-5-olates With Dimethyl Acetylenedicarboxylate. Australian Journal of Chemistry, 48 (6), 1175-1181. doi: 10.1071/CH9951175
BOURNE, GT, HORWELL, DC and PRITCHARD, MC (1993). THE RATIONAL DESIGN AND SYNTHESIS OF NONPEPTIDE RHEGNYLOGUES OF CCK-26-33 - A NOVEL SERIES OF CCK-A SELECTIVE LIGANDS. Bioorganic & Medicinal Chemistry Letters, 3 (5), 889-894. doi: 10.1016/S0960-894X(00)80687-3
BOURNE, GT, CRICH, D, DAVIES, JW and HORWELL, DC (1991). ENANTIOSPECIFIC SYNTHESIS WITH AMINO-ACIDS .1. TRYPTOPHAN AS A CHIRON FOR THE SYNTHESIS OF ALPHA-SUBSTITUTED TRYPTOPHAN DERIVATIVES. Journal of the Chemical Society-Perkin Transactions 1 (7), 1693-1699. doi: 10.1039/p19910001693
BOURNE, GT, HORWELL, DC and PRITCHARD, MC (1991). SYNTHESIS OF AN ALPHA-CH2CO2H FUNCTIONALIZED TRYPTOPHAN AND ITS INCORPORATION INTO AN ANALOG OF CHOLECYSTOKININ. Tetrahedron, 47 (26), 4763-4774. doi: 10.1016/S0040-4020(01)86480-2
Conference Papers
Bourne, Gregory, Zhao, Li, Bhandari, Ashok, Frederick, Brian, McMahon, Jaimee, Tran, Vinh, Zhang, Jenny, Stephenson, Adam, Tovera, James, Bai, Lu, Annamalai, Thamil, Patel, Dinesh, Smythe, Mark and Liu, David (2017). Hepcidin Mimetic Ptg-300 for Treatment of Ineffective Erythropoiesis and Iron Overload. Seventh Congress of the International BioIron Society (IBIS)Biennial World Meeting (BioIron 2017), Los Angeles, CA, United States, 7 - 11 May 2017. Hoboken, NJ United States: Wiley.
Kulis, C., Bourne, G., Kellie, S. and Smythe, M. (2010). Design, synthesis and evaluation of inhibitors targeting the SHP-1 catalytic domain. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.1303
Schroeder, CI, Nielsen, KJ, Adams, DA, Loughnan, M, Thomas, L, Bourne, GT, Smythe, ML, Alewood, PF, Craik, DJ and Lewis, RJ (2004). From Omega-Conotoxins to Macrocycle Mimetics. CHICHESTER: JOHN WILEY & SONS LTD.
Golding, S.W., Bourne, G.T., Meutermans, W.D.F., Jones, A. and Smythe, M.L. (2001). The use of a novel safety catch linker for BOC-based assembly of cyclic peptide libraries. 17th Australian Peptide Conference, San Diego, Calafornia, 9-14 June, 2001. USA: American Peptide Society.
Bourne, G. T., Cassidy, P.J., Meutermans, W., Campitelli, M.R. and Smythe, M.L. (2001). Incorporation of a cis-amide bond isostere in the synthesis of cyclic tetrapeptides. Peptides: The wave of the future, San Diego, 9-14/6/01. USA: American Peptide Society.
Meutermans, W., Golding, S., Campitelli, M.R., Horton, D., Bourne, G. T. and Smythe, M. L. (2001). Privilege structures: New strategies for the synthesis of cyclic tetrapepties. 17th AFS, San Diego, 9-15th June, 2001. USA: American Peptide Society.