Dr Zyta M. Ziora
Senior Research Officer
Institute for Molecular Bioscience
+61 7 334 62156
Book Chapters
Hamada, Yoshio and Ziora, Zyta M. (2020). Peptidomimetic synthesis: drug discovery for Alzheimer's disease. Peptide synthesis: methods and protocols . (pp. 215-223) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0227-0_14
Hansford, Karl A., Ziora, Zyta M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Solid-phase synthesis of octapeptin lipopeptides. Peptide synthesis: methods and protocols. (pp. 199-213) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0227-0_13
Mital, Mariusz, Sęk, Jakub P. and Ziora, Zyta M. (2020). Metal-peptide complexes to study neurodegenerative diseases. Peptide synthesis. (pp. 323-336) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0227-0_22
Ziora, Zyta, Skwarczynski, Mariusz and Kiso, Yoshiaki (2011). Medicinal chemistry of a-hydroxy-b-amino acids. Amino Acids, Peptides and Proteins in Organic Chemistry: Volume 4 - Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. (pp. 189-234) edited by Andrew B. Hughes. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527631827.ch6
Journal Articles
Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2020). Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 30 (1) 126722, 1-5. doi: 10.1016/j.bmcl.2019.126722
Cao, Yuxue, Naseri, Mahdi, He, Yan, Xu, Chun, Walsh, Laurence J. and Ziora, Zyta M. (2019). Non-antibiotic antimicrobial agents to combat biofilm-forming bacteria. Journal of Global Antimicrobial Resistance, 21, 445-451. doi: 10.1016/j.jgar.2019.11.012
Yuan, Ye, Jin, Wanli, Nazir, Yasir, Fercher, Christian, Thomas Blaskovich, Mark A., Cooper, Matthew A., Barnard, Ross T. and Ziora, Zyta M. (2019). Tyrosinase inhibitors as potential antibacterial agents. European Journal of Medicinal Chemistry, 187 111892, 111892. doi: 10.1016/j.ejmech.2019.111892
Pham, Thu D. M., Ziora, Zyta M. and Blaskovich, Mark A. T. (2019). Quinolone antibiotics. MedChemComm, 10 (10) 1719-1739. doi:10.1039/c9md00120d
Sim, Wilson, Barnard, Ross, Blaskovich, M.A.T. and Ziora, Zyta (2018). Antimicrobial silver in medicinal and consumer applications: a patent review of the past decade (2007–2017). Antibiotics, 7 (4) 93, 93. doi: 10.3390/antibiotics7040093
Möhler, Jasper S., Sim, Wilson, Blaskovich, Mark A. T., Cooper, Matthew A. and Ziora, Zyta M. (2018). Silver bullets: a new lustre on an old antimicrobial agent. Biotechnology Advances, 36 (5) 1391-1411. doi:10.1016/j.biotechadv.2018.05.004
Naseri-Nosar, Mahdi and Ziora, Zyta Maria (2018). Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites. Carbohydrate Polymers, 189, 379-398. doi: 10.1016/j.carbpol.2018.02.003
Mital, Mariusz and Ziora, Zyta (2018). Biological applications of Ru(II) polypyridyl complexes. Coordination Chemistry Reviews, 375434-458. doi:10.1016/j.ccr.2018.02.013
Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G, Roberts, Jason A and Paterson, David L. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w
Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028
Azmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10) 2235-2241. doi:10.1016/j.bmc.2016.03.053
Hang, Zhou, Cooper, Matthew A. and Ziora, Zyta M. (2016). Platinum-based anticancer drugs encapsulated liposome and polymeric micelle formulation in clinical trials. Biochemical Compounds, 4 doi: 10.7243/2052-9341-4-2
McRae, Jacqui M., Ziora, Zyta M., Kassara, Stella, Cooper, Matthew A. and Smith, Paul A. (2015). Ethanol concentration influences the mechanisms of wine tannin interactions with poly(l -proline) in model wine. Journal of Agricultural and Food Chemistry, 63 (17) 4345-4352. doi:10.1021/acs.jafc.5b00758
Cheng, Mu, Ziora, Zyta M., Hansford, Karl A., Blaskovich, Mark A., Butler, Mark S. and Cooper, Matthew A. (2014). Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin. Organic and Biomolecular Chemistry, 12 (16), 2568-2575. doi: 10.1039/c3ob42428f
Simerska, Pavla, Suksamran, Tittaya, Ziora, Zyta Maria, Rivera, Fabian de Labastida, Engwerda, Christian and Toth, Istvan (2014). Ovalbumin lipid core peptide vaccines and their CD4+ and CD8+ T cell responses. Vaccine, 32 (37) 4743-4750. doi:10.1016/j.vaccine.2014.06.049
Ahmad Fuaad, Abdullah A. H., Jia, Zhongfan, Hartas, Jon, Ziora, Zyta M., Lin, I-Chun, Moyle, Peter M., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2014). Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine. Nanomedicine, 9 (1), 35-43. doi: 10.2217/NNM.13.7
Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2013). ChemInform abstract: lipoamino acids as major components of absorption promoters in drug delivery. ChemInform, 44 (43), no-no. doi: 10.1002/chin.201343267
Simerska, Pavla, Ziora, Zyta Maria, Fagan, Vincent, Goodwin, Daryn, Edrous, Farrah and Toth, Istvan (2013). Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system. Drug Delivery and Translational Research, Online First (3), 1-10. doi: 10.1007/s13346-013-0173-8
Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2013). Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules, 14 (8), 2798-2806. doi: 10.1021/bm400626w
Skwarczynski, Mariusz, Kowapradit, Jariya, Ziora, Zyta Maria and Toth, Istvan (2013). pH-Triggered peptide self-assembly into fibrils: a potential peptide-based subunit vaccine delivery platform. Biochemical Compounds, 1 doi:10.7243/2052-9341-1-2
Zaman, Mehfuz, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Ziora, Zyta M., Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2012). Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes. Journal of Medicinal Chemistry, 55 (19) 8515-8523. doi:10.1021/jm301074n
Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2012). Lipoamino acids as major components of absorption promoters in drug delivery. Current Topics in Medicinal Chemistry, 12 (14), 1562-1580. doi: 10.2174/156802612802652448
Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2012). Lipopeptides for the fragment-based pharmaceutics design. International Journal of Organic Chemistry, 2, 75-81. doi: 10.4236/ijoc.2012.21013
Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2011). Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydrate Research, 346 (12) 1439-1444. doi:10.1016/j.carres.2011.03.019
Lin, I-Chun, Liang, Mingtao, Liu, Tzu-Yu, Ziora, Zyta M., Monteiro, Michael J. and Toth, Istvan (2011). Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers. Biomacromolecules, 12 (4), 1339-1348. doi: 10.1021/bm200116z
Skwarczynski, Mariusz, Ahmad Fuaad, Abdullah A. H., Rustanti, Lina, Ziora, Zyta M., Aqil, Mohammed, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2011). Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein. Drug Delivery Letters, 1 (1) 2-8. doi:10.2174/2210304X11101010002
Kakizawa, Taeko, Hidaka, Koushi, Hamada, Daisuke, Yamaguchi, Ryoji, Uemura, Tsuyoshi, Kitamura, Hitomi, Tagad, Harichandra D., Hamada, Takashi, Ziora, Zyta, Hamada, Yoshio, Kimura, Tooru and Kiso, Yoshiaki (2010). Tetrapeptides, as small-sized peptidic inhibitors; Synthesis and their inhibitory activity against BACE1. Journal of Peptide Science, 16 (6), 257-262. doi: 10.1002/psc.1238
Bergeon, Julie A., Ziora, Zyta M., Abdelrahim, Adel S., Pernevi, Niklas, Moss, Anne R. and Toth, Istvan (2010). In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs. Journal of Pharmaceutical Sciences, 99 (5) 2333-2342. doi:10.1002/jps.21999
Skwarczynski, Mariusz, Ziora, Zyta M., Coles, Daniel J., Lin, I-Chun and Toth, Istvan (2010). Thymine, adenine and lipoamino acid based gene delivery systems. Chemical Communications, 46 (18) 3140-3142. doi:10.1039/b924371b
Abdelrahim, Adel. S., Ziora, Zyta M., Bergeon, Julie A., Moss, Anne R. and Toth, Istvan (2009). Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery. Tetrahedron, 65 (45), 9436-9442. doi: 10.1016/j.tet.2009.08.072
Ziora, Zyta and Kafarski, Pawel (2009). Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates. Phosphorus, Sulfur, and Silicon and the Related Elements, 184 (4), 1047-1053. doi: 10.1080/10426500902737356
Calas, Michele, Outtara, Mahama, Piquet, Giles, Ziora, Zyta, Bordat, Y., Ancelin, Marie L., Escale, Roger and Vial, Henri (2007). Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines. Journal of Medicinal Chemistry, 50 (25) 6307-6315. doi:10.1021/jm0704752
Nagahama, Masahiro, Otsuka, Akiko, Oda, Masataka, Singh, Rajesh K., Ziora, Zyta M., Imagawa, Hiroshi, Nishizawa, Mugio and Sakurai, Jun (2007). Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1768 (11) 2940-2945. doi:10.1016/j.bbamem.2007.08.016
Ziora, Zyta, Kasai, Soko, Hidaka, Koushi, Nagamine, Ayaka, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2007). Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4(phenylthio)butyric acid. Bioorganic and Medicinal Chemistry Letters, 17 (6) 1629-1633. doi:10.1016/j.bmcl.2006.12.097
Hamada, Yoshio, Igawa, Naoto, Ikari, Hayato, Ziora, Zyta, Nguyen, Jeffrey-Tri, Yamani, Abdellah, Hidaka, Koushi, Kimura, Tooru, Saito, Kazuki, Hayashi, Yoshio, Ebina, Maiko, Ishiura, Shoichi and Kiso, Yoshiaki (2006). beta-Secretase inhibitors: Modification at the P-4 position and improvement of inhibitory activity in cultured cells. Bioorganic and Medicinal Chemistry Letters, 16 (16) 4354-4359. doi:10.1016/j.bmcl.2006.05.046
Ziora Zyta, Kasai Soko, Hidaka Koushi, Nagamine Ayaka, Kimura Tooru, Saito K., Hayashi Yoshio and Kiso Yoshiaki (2006). Phenylthionorstatine as a transition-state mimic in BACE1 inhibitors. Peptide Science, 2006237-238.
Zyta, Ziora, Tooru, KImura and Yoshiaki, Kiso (2006). Small-sized BACE1 inhibitors. Drugs of the Future, 31 (1) 53-63. doi:10.1358/dof.2006.031.01.957326
Holband, J, Wojcik, G, Ziora, Z and Kafarski, P (2001). Conformational polymorphism of diethyl 1-(phthalylglycyloxy)-2-phthalylaminoethenephosphonate. Journal of Molecular Structure, 595 (1-3), 167-174. doi: 10.1016/S0022-2860(01)00521-X
Ziora, Zyta, Kafarski, Pawel, Holband, Jolanta and Wojcik, Grazyna (2001). Synthesis and spectroscopic characterization of protected N-phosphonomethylglycine dipeptides. Journal of Peptide Science, 7 (9), 466-473. doi: 10.1002/psc.340
Jedrzejczyk, D, Ziora, Z and Kafarski, P (2000). H-1 NMR studies of rotational isomerism in phosphonic analogues of aspartic acid. Magnetic Resonance in Chemistry, 38 (5) 370-374. doi:10.1002/1097-458x(200005)38:5<370::aid-mrc651>3.0.co;2-m
Ziora, Zyta, Maly, Alina, Lejczak, Barbara, Kafarski, Pawel, Holband, Jolanta and W�jcik, Gra?yna (2000). Reactions of N-phthalylamino acid chlorides with trialkyl phosphites. Heteroatom Chemistry, 11 (3), 232-239. doi: 10.1002/(sici)1098-1071(2000)11:3<232::aid-hc12>3.0.co;2-u
Ziora, Z, Cierpicki, T, Grembecka, J and Kafarski, P (1999). Synthesis of triethyl N-formyl-N-phosphonomethylglycinate and diethyl N-formyl-N- phosphonomethylglycine and studies of their rotational conformers by dynamic NMR. Journal of Chemical Research (2), 68-69A. doi: 10.1039/a806474a
Conference Papers
Skwarczynski, Mariusz, Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J. and Toth, Istvan (2014). Synthesis of therapeutic vaccine against cervical cancer. 4th Asia-Pacific International Peptide Symposium in conjunction with 50th Japanese Peptide Symposium, Osaka, Japan, 6-8 November 2013. Osaka, Japan: Japanese Peptide Society.
Skwarczynski, M., Fuaad, A. A. H. A., Zaman, M., Jia, Z., Kowapradit, J., Rustanti, L., Ziora, Z. M., Monteiro, M. L. J., Batzloff, M. R., Goodc, M. F. and Toth, I. (2012). Nanoparticles-based peptide subunit vaccines against group A Streptococcus. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2448
Gong, Y., Muldoon, C. A., Premraj, R., Ziora, Z. M., Bradford, T. A., Cheng, M., Ramu, S., Huang, J. X., Kavanagh, A., Pelingon, R., Lee, J. C., Wong, K., Butler, M. S., Blaskovich, M. A. and Cooper, M. A. (2012). New glycopeptidic antibiotics to combat multidrug resistant pathogens. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2449
Ziora, Zyta, Shuto, Daisuke, Kasai, Soko, Liu, Ping, Hidaka, Koushi, Igawa, Nagai, Nagamine, Ayaka, Stochaj, Monika, Hamada, Takashi, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2006). Modification of P4 position in beta-Secretase (BACE1) inhibitors containing phenylnorstatine. 42nd Japanese Peptide Symposium, Osaka, Japan, 27-29 October 2005. Osaka, Japan: Japanese Peptide Society.
Sohma, Youhei, Sasaki, Masato, Ziora, Zyta, Takahashi, N., Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2004). A novel approach for the hydrophobic peptides synthesis and purification through O-N intramolecular acyl migration reaction. 18th American Peptide Symposium, Boston, MA, U.S.A., 19-23 July 2003. San Diego, CA, U.S.A.: American Peptide Society.