Professor Matt Sweet uses techniques in immunology, cell biology and biochemistry to understand how the innate immune system functions in health and disease. His current research focuses on characterizing genes and pathways in macrophages that either drive inflammation or are involved in the clearance of bacterial pathogens. The ultimate aim of this research is to learn how to manipulate the innate immune system to either limit pathological inflammation or unleash its power against infection.

During his career, he has elucidated mechanisms by which bacterial CpG DNA activates macrophages, identified ST2 as a regulator of macrophage activation, characterized mechanisms by which histone deacetylase enzymes regulate inflammation and host defence pathways, defined CSF-1 as a key regulator of macrophage inflammatory responses, and characterized mechanisms by which the bacterial pathogens Salmonella and UPEC subvert innate immunity.

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Innate immunity, infection and inflammation