Dr Jennifer Deuis

Vetter, Irina, Carter, David, Bassett, John, Deuis, Jennifer R., Tay, Bryan, Jami, Sina and Robinson, Samuel D. (2020). High-throughput fluorescence assays for ion channels and GPCRs. Calcium Signaling. (pp. 27-72) edited by Md. Shahidul Islam. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-12457-1_3

Deuis, Jennifer, Vetter, Irina and Zimmermann, Katharina (2013). Characterizing response properties of cutaneous nociceptors using in vitro skin-nerve preparations. Pain models: translational relevance and applications. (pp. 33-46) edited by Hermann Handwerker and Lars Arendt-nielsen. Washington, United States: IASP Press.

Dashevsky, Daniel, Deuis, Jennifer R., Vetter, Irina, Huynh, Tam, Hodgson, Wayne C., Tan, Choo Hock, Nouwens, Amanda and Fry, Bryan G. (2021). Novel neurotoxic activity in Calliophis intestinalis venom. Neurotoxicity Research, 40 (1), 173-178. doi: 10.1007/s12640-021-00413-2

Tran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452

Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457

Jensen, Timo, Walker, Andrew A., Nguyen, Son H., Jin, Ai-Hua, Deuis, Jennifer R., Vetter, Irina, King, Glenn F., Schmidt, Justin O. and Robinson, Samuel D. (2021). Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae). Cellular and Molecular Life Sciences, 78 (12), 5163-5177. doi: 10.1007/s00018-021-03847-1

Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452

McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391

Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828

Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148

Israel, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina and Durek, Thomas (2020). Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe. Biomedicines, 8 (6) 155, 155. doi: 10.3390/biomedicines8060155

McMahon, Kirsten L., Tay, Bryan, Deuis, Jennifer R., Tanaka, Brian S., Peigneur, Steve, Jin, Ai-Hua, Tytgat, Jan, Waxman, Stephen G., Dib-Hajj, Sulayman D., Vetter, Irina and Schroeder, Christina I. (2020). Pharmacological activity and NMR solution structure of the leech peptide HSTX-I. Biochemical Pharmacology, 181 114082, 114082. doi: 10.1016/j.bcp.2020.114082

Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020). Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 (15), 5067-5080. doi: 10.1074/jbc.ra119.012281

Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037

Mueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002

Tran, Hue, Tran, Poanna, Deuis, Jennifer R., Agwa, Akello Joanna, Zhang, Alan H., Vetter, Irina and Schroeder, Christina I (2019). Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition. Bioconjugate Chemistry, 31 (1) acs.bioconjchem.9b00744, 64-73. doi: 10.1021/acs.bioconjchem.9b00744

Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019). Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, 160 (8), 1766-1780. doi: 10.1097/j.pain.0000000000001567

Starobova, Hana, Mueller, Alexander, Deuis, Jennifer R., Carter, David A. and Vetter, Irina (2019). Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin in C57BL/6J mice. The Journal of Pain, 21 (1-2), 182-194. doi: 10.1016/j.jpain.2019.06.008

Israel, Mathilde R., Tanaka, Brian S., Castro, Joel, Thongyoo, Panumart, Robinson, Samuel D., Zhao, Peng, Deuis, Jennifer R., Craik, David J., Durek, Thomas, Brierley, Stuart M., Waxman, Stephen G, Dib-Hajj, Sulayman D. and Vetter, Irina (2019). NaV1.6 regulates excitability of mechanosensitive sensory neurons. Journal of Physiology, 597 (14), 3751-3768. doi: 10.1113/JP278148

Tay, Bryan, Stewart, Teneale A., Davis, Felicity M., Deuis, Jennifer R. and Vetter, Irina (2019). Development of a high-throughput fluorescent no-wash sodium influx assay. PLOS One, 14 (3) e0213751, e0213751. doi: 10.1371/journal.pone.0213751

Dash, Thomas S., Shafee, Thomas, Harvey, Peta J., Zhang, Chuchu, Peigneur, Steve, Deuis, Jennifer R., Vetter, Irina, Tytgat, Jan, Anderson, Marilyn A., Craik, David J., Durek, Thomas and Undheim, Eivind A. B. (2019). A centipede toxin family defines an ancient class of CSαβ defensins. Structure, 27 (2), 315-326. doi: 10.1016/j.str.2018.10.022

Yapa, Kunsala T. D. S., Deuis, Jennifer, Peters, Amelia A., Kenny, Paraic A., Roberts-Thomson, Sarah J., Vetter, Irina and Monteith, Gregory R. (2018). Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sciences, 198, 128-135. doi: 10.1016/j.lfs.2018.02.030

Israel, Mathilde R., Morgan, Michael, Tay, Bryan and Deuis, Jennifer R. (2018). Toxins as tools: fingerprinting neuronal pharmacology. Neuroscience Letters, 679, 4-14. doi: 10.1016/j.neulet.2018.02.001

Morgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016

Israel, Mathilde R., Thongyoo, Panumart, Deuis, Jennifer R., Craik, David J., Vetter, Irina and Durek, Thomas (2018). The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6. Journal of Medicinal Chemistry, 61 (4), 1730-1736. doi: 10.1021/acs.jmedchem.7b01609

Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398

Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017). Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 (4), 708-734. doi: 10.1093/pm/pnx228

Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848

Deuis, Jennifer R., Dvorakova, Lucie S. and Vetter, Irina (2017). Methods used to evaluate pain behaviors in rodents. Frontiers in Molecular Neuroscience, 10 284, 284. doi: 10.3389/fnmol.2017.00284

Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017). Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 (29), 8495-8499. doi: 10.1002/anie.201703360

Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865

Deuis, Jennifer R., Mueller, Alexander, Israel, Mathilde R. and Vetter, Irina (2017). The pharmacology of voltage-gated sodium channel activators. Neuropharmacology, 127, 87-108. doi: 10.1016/j.neuropharm.2017.04.014

Israel, Mathilde R., Tay, Bryan, Deuis, Jennifer R. and Vetter, Irina (2017). Sodium Channels and Venom Peptide Pharmacology. Advances in Pharmacology, 79, 67-116. doi: 10.1016/bs.apha.2017.01.004

Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551

Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883

Deuis, Jennifer R., Yin, Kathleen, Cooper, Matthew A., Schroder, Kate and Vetter, Irina (2016). Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns, 43 (2), 304-309. doi: 10.1016/j.burns.2016.09.001

Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015

Yin, Kathleen, Deuis, Jennifer R., Lewis, Richard J. and Vetter, Irina (2016). Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain, 12, 1-13. doi: 10.1177/1744806916665366

Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662

Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078

Deuis, Jennifer R. and Vetter, Irina (2016). The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice. Temperature, 3 (2), 199-207. doi: 10.1080/23328940.2016.1157668

Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113

Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178

Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011

Deuis, Jennifer R., Lim, Yu Ling, Rodrigues de Sousa, Silmara, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2014). Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology, 16 (10), 1324-1332. doi: 10.1093/neuonc/nou048

Zimmermann, Katharina, Deuis, Jennifer R., Inserra, Marco C., Collins, Lindon S., Namer, Barbara, Cabot, Peter J., Reeh, Peter W., Lewis, Richard J. and Vetter, Irina (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. Pain, 154 (10), 1999-2006. doi: 10.1016/j.pain.2013.06.015

Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J. and Vetter, Irina (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways. Pain, 154 (9), 1749-1757. doi: 10.1016/j.pain.2013.05.032

Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, 27 Feb - 2 Mar 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.247

Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.

Deuis, Jennifer (2016). Using toxins to elucidate the role of voltage-gated sodium channels in pain. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/uql.2016.53

Dr Jennifer Deuis

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