Dr Lotten Ragnarsson

Ragnarsson, Lotten, Dodd, Peter R. and Latif, Matthew R. (2023). Role of Ionotropic Glutamate receptors in neurodegenerative and other disorders. Handbook of neurotoxicity. (pp. 1969-1997) edited by Richard M. Kostrzewa. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-031-15080-7_144

Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.

Ragnarsson, Lotten, Dodd, Peter R. and Hynd, Matthew R. (2014). Role of ionotropic glutamate receptors in neurodegenerative and other disorders. Handbook of neurotoxicity. (pp. 1039-1070) New York, NY, United States: Springer Science+Business Media. doi: 10.1007/978-1-4614-5836-4_144

Wang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain. International Journal of Molecular Sciences, 25 (9) 4745. doi: 10.3390/ijms25094745

Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152

Ragnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776

Tran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664

Tran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert and Lewis, Richard (2022). Diindolylmethane derivatives: new selective blockers for T-type calcium channels. Membranes, 12 (8) 749, 1-13. doi: 10.3390/membranes12080749

Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013

Deuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker and Vetter, Irina (2022). The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation. Frontiers in Pharmacology, 12 789570, 789570. doi: 10.3389/fphar.2021.789570

Hasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645

Wang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343

Mohan, Madhan Kumar, Abraham, Nikita, Rajesh, R. P., Jayaseelan, Benjamin Franklin, Ragnarsson, Lotten, Lewis, Richard J. and Sarma, Siddhartha P. (2020). Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 295 (20), 7096-7112. doi: 10.1074/jbc.RA119.012098

Giribaldi, Julien, Ragnarsson, Lotten, Pujante, Tom, Enjalbal, Christine, Wilson, David, Daly, Norelle L., Lewis, Richard J. and Dutertre, Sebastien (2020). Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris. Marine Drugs, 18 (3) md18030150, 150. doi: 10.3390/md18030150

Jha, Prerna, Ragnarsson, Lotten and Lewis, Richard J. (2020). Structure-function of the high affinity substrate binding site (S1) of human norepinephrine transporter. Frontiers in Pharmacology, 11 217, 217. doi: 10.3389/fphar.2020.00217

Scheib, Holger, Nekaris, K. Anne-Isola, Rode-Margono, Johanna, Ragnarsson, Lotten, Baumann, Kate, Dobson, James S., Wirdateti, Wirdateti, Nouwens, Amanda, Nijman, Vincent, Martelli, Paolo, Ma, Rui, Lewis, Richard J., Kwok, Hang Fai and Fry, Bryan Grieg (2020). The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein. Toxins, 12 (2) toxins12020086, 86. doi: 10.3390/toxins12020086

Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Åsa, Brust, Andreas, Dekan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2019). The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports, 9 (1) 17841, 17841. doi: 10.1038/s41598-019-54186-y

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2019). Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors. Science Signaling, 12 (572) eaas9485, eaas9485. doi: 10.1126/scisignal.aas9485

Wang, Dan, Ragnarsson, Lotten and Lewis, Richard J. (2019). Insight into T-type calcium channel structure, function and modulation. Current medicinal chemistry, 27 (19), 3098-3122. doi: 10.2174/0929867325666181001112821

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert J. and Lewis, Richard J. (2018). Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Marine Drugs, 16 (12) 475, 475. doi: 10.3390/md16120475

Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4

Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398

Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848

Abraham, Nikita, Healy, Michael, Ragnarsson, Lotten, Brust, Andreas, Alewood, Paul F. and Lewis, Richard J. (2017). Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports, 7 (1) 45466, 45466. doi: 10.1038/srep45466

Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407

Abraham, Nikita, Paul, Blessy, Ragnarsson, Lotten and Lewis, Richard J. (2016). Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs). PLoS One, 11 (6) e0157363, e0157363. doi: 10.1371/journal.pone.0157363

Brust, Andreas, Croker, Daniel, Colless, Barbara, Ragnarsson, Lotten K. N., Andersson, Asa, Jain, Kapil, Garcia-Caraballo, Sonia, Castro, Joel, Brierley, Stuart M., Alewood, Paul F. and Lewis, Richard J. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59 (6), 2381-2395. doi: 10.1021/acs.jmedchem.5b00911

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2015). Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functions. Molecular Pharmacology, 87 (1), 121-129. doi: 10.1124/mol.114.094557

Sousa, Silmara R., Vetter, Irina, Ragnarsson, Lotten and Lewis, Richard J. (2013). Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cells. PloS One, 8 (3) e59293, e59293. doi: 10.1371/journal.pone.0059293

Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Asa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2013). Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor. Journal of Biological Chemistry, 288 (3), 1814-1827. doi: 10.1074/jbc.M112.430785

Schenning, Mitja, Proctor, Dustin T., Ragnarsson, Lotten, Barbier, Julien, Lavidis, Nickolas A., Molgo, Jordi J., Zamponi, Gerald W., Schiavo, Giampietro and Meunier, Frederic A. (2006). Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons. Journal of Neurochemistry, 98 (3), 894-904. doi: 10.1111/j.1471-4159.2006.03938.x

Ragnarsson, L., Yasuda, T., Lewis, R. J., Dodd, P. R. and Adams, D. J. (2006). NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G. Journal of Neurochemistry, 96 (1), 283-291. doi: 10.1111/j.1471-4159.2005.03574.x

Ragnarsson, L, Stromberg, T, Wijdenes, J, Totterman, TH and Weigelt, C (2001). Multiple myeloma cells are killed by syndecan-1-directed superantigen-activated T cells. Cancer Immunology Immunotherapy, 50 (7), 382-390. doi: 10.1007/s002620100211

Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.

Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Asa, Brust, Andreas, Deakan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2020). Re-evaluating the nirvana cabal deployed by piscivorous cone snails. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.044

Fernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014

Hassan, Mahadhi, Abraham, Nikita, Ragnarsson, Lotten K.N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

Wang, D., Herzig, V., Dekan, Z., Ragnarsson, Lotten K. N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). High-throughput cell-based assays for screening Cav3.2 modulators from venoms. Venom to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017.

Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley.

Sousa, Silmara R., Ragnarsson, Lotten, Vetter, Irina, Herzig, Volker, King, Glenn F. and Lewis, Richard J. (2012). Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.033

Ragnarsson, Lotten, Wang, Ching-I. Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2012). The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.137

Meunier, FA, Ragnarsson, L, Proctor, D, Feng, ZP, Molgo, J, Zamponi, GW and Schiavo, G (2005). Glycerotoxin and the regulation of neurotransmitter release. 20th Biennial Meeting of the International-Society-for-Neurochemistry/European-Society-for-Neurochemistry, Innsbruck Austria, Aug 21-26, 2005. OXFORD: BLACKWELL PUBLISHING.

Ragnarsson, L, Yasuda, T, Adams, DJ, Lewis, RJ and Dodd, PR (2004). NMDA receptor variant responses to conantokins. 6th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry, Hong Kong Peoples R China, Feb 04-07, 2004.

Ragnarsson, L. K., Yasuda, T., Adams, D. J., Lewis, R. J. and Dodd, P. R. (2004). NMDA receptor variant responses to conantokins. 6th Biennial Meeting of Asian-Pacific Society for Neurochemistry, Hong Kong, 4th - 7th February, 2004. Oxford, UK: Blackwell. doi: 10.1046/j.1474-1644.2003.2314p26_01.x

Ragnarsson, L, Dodd, P and Lewis, R (2002). Regional variation in the, pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins. NEW YORK: ELSEVIER SCIENCE INC.

Ragnarsson, L., Eckert, A. L., Dodd, P. R. and Lewis, R. J. (1999). Spermine modulation of the glutamate NMDA site is differentially responsive to conantokins in normal and ALzheimer disease human cerebral cortex. 19th Annual Meeting of the Australian Neuroscience Society, Hobart Convention Centre, Hobart, 31st January - 3rd February, 1999. Melbourne: Australian Neuroscience Society.

Dodd, P. R., Ragnarsson, L., Eckert, A. L., Alewood, P. F. and Lewis, R. (1999). Effect of conantokins on the spermine modulation of glutamate-NMDA sites in normal and Alzheimer disease human cerebral cortex. Joint meeting of the International Society for Neurochemistry (ISN) and the European Society for Chemistry (ESN), Berlin, Germany, 8 - 14 August, 1999. Hagerstown: Lipponcott-Raven.

Totterman, TH, Gidlof, C, Ragnarsson, L, Hogbom, E, Lindeberg, M, von der Lehr, N, Einarsson, A, Soegaard, M, Kristensson, K, Kalland, T and Dohlsten, M (1998). Targeted superantigens for immunotherapy of haematopoietic tumours. 25th Congress of the International-Society-of-Blood-Transfusion, Oslo Norway, Jun 27-Jul 02, 1998. BASEL: KARGER.

Dr Lotten Ragnarsson

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