Dr Waleed Hussein
Research Fellow/Senior Research officer
Institute for Molecular Bioscience
+61 7 344 36285
Book Chapters
Hussein, Waleed H., Stephenson, Rachel J. and Toth, Istvan (2021). Preface. Peptide conjugation: methods and protocols. (pp. v-v) New York, NY USA: Humana Press.
Hussein, Waleed M. and Toth, Istvan (2021). Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition. Peptide conjugation: methods and protocols. (pp. 57-64) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_6
Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates. Peptide conjugation: methods and protocols. (pp. 141-150) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_13
Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition. Methods in Molecular Biology. (pp. 1-7) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_1
Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). An isodipeptide building block for microwave-assisted solid-phase synthesis of difficult sequence-containing peptides. Peptide synthesis: methods and protocols. (pp. 139-150) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer. doi: 10.1007/978-1-0716-0227-0_9
Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Preface. Peptide synthesis: methods and protocols. (pp. v-v) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer.
Journal Articles
Hussein, Waleed M., Zhu, Yuxuan, Salim, Angela A. and Capon, Robert J. (2024). Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism. Marine Drugs, 22 (10) 454, 454. doi: 10.3390/md22100454
Wu, Taizong, Hussein, Waleed M., Samarasekera, Kaumadi, Zhu, Yuxuan, Khalil, Zeinab G., Jin, Shengbin, Bruhn, David F., Moreno, Yovany, Salim, Angela A. and Capon, Robert J. (2024). Australian Marine and Terrestrial Streptomyces-Derived Surugamides, and Synthetic Analogs, and Their Ability to Inhibit Dirofilaria immitis (Heartworm) Motility. Marine Drugs, 22 (7) 312, 312. doi: 10.3390/md22070312
Alharbi, Nedaa, Shalash, Ahmed O., Koirala, Prashamsa, Boer, Jennifer C., Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2024). Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection. Journal of Colloid and Interface Science, 663, 43-52. doi: 10.1016/j.jcis.2024.02.134
Nahar, Ummey J., Wang, Jingwen, Shalash, Ahmed O., Lu, Lantian, Islam, Md. T., Alharbi, Nedaa, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2024). Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant. Vaccine, 42 (23) 126060, 126060. doi: 10.1016/j.vaccine.2024.06.027
Dewa, Amila Agampodi, Khalil, Zeinab G., Hussein, Waleed M., Jin, Shengbin, Wang, Yanan, Cruz-Morales, Pablo and Capon, Robert J. (2024). Pullenvalenes A–D: Nitric oxide-mediated transcriptional activation (NOMETA) enables discovery of triterpene aminoglycosides from Australian Termite nest-derived fungi. Journal of Natural Products, 87 (4), 935-947. doi: 10.1021/acs.jnatprod.3c01233
Koirala, Prashamsa, Shalash, Ahmed O., Chen, Sung-Po R., Faruck, Mohammad O., Wang, Jingwen, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2024). Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation. Vaccines, 12 (2) 198, 1-14. doi: 10.3390/vaccines12020198
Salim, Angela A., Hussein, Waleed M., Dewapriya, Pradeep, Hoang, Huy N., Zhou, Yahao, Samarasekera, Kaumadi, Khalil, Zeinab G., Fairlie, David P. and Capon, Robert J. (2023). Talarolides Revisited: Cyclic Heptapeptides from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. CMB-TU011. Marine Drugs, 21 (9) 487, 1-17. doi: 10.3390/md21090487
Paul, Marina, Barreda, Anna Paredes, Gregson, Amy, Kahl, Richard, King, Madeline, Hussein, Waleed M., Walker, Frederick R., Smith, Roger, Zakar, Tamas and Paul, Jonathan W. (2023). Regulation of 20α-hydroxysteroid dehydrogenase expression in term pregnant human myometrium ex vivo. Reproductive Sciences, 31 (1), 1-12. doi: 10.1007/s43032-023-01333-6
Jin, Shengbin, Zhang, Jiahui, Nahar, Ummey J., Huang, Wenbin, Alharbi, Nedaa A., Shalash, Ahmed O., Koirala, Prashamsa, Yang, Jieru, Kiong, Jolynn J. E., Khalil, Zeinab G., Capon, Robert J., Stephenson, Rachel J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2023). Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems. ACS Infectious Diseases, 9 (8), 1570-1581. doi: 10.1021/acsinfecdis.3c00159
Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383
Samarasekera, Kaumadi, Hussein, Waleed M., Wu, Taizong, Salim, Angela A. and Capon, Robert J. (2023). Glyclauxins A–E: dimeric oxaphenalenone aminoglycosides from an Australian wasp nest-derived fungus Talaromyces sp. CMB-MW102. Journal of Natural Products, 86 (3), 517-525. doi: 10.1021/acs.jnatprod.2c01069
Firdaus, Farrhana Z., Bartlett, Stacey, Hussein, Waleed M., Lu, Lantian, Wright, Quentin, Huang, Wenbin, Nahar, Ummey J., Yang, Jieru, Khongkow, Mattaka, Veitch, Margaret, Koirala, Prashamsa, Ruktanonchai, Uracha R., Monteiro, Michael J., Gonzalez Cruz, Jazmina L., Stephenson, Rachel J., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2023). Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer. Pharmaceutics, 15 (2) 602, 1-15. doi: 10.3390/pharmaceutics15020602
Yang, Jieru, Boer, Jennifer C., Khongkow, Mattaka, Phunpee, Sarunya, Khalil, Zeinab G., Bashiri, Sahra, Deceneux, Cyril, Goodchild, Georgia, Hussein, Waleed M., Capon, Robert J., Ruktanonchai, Uracha, Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines. Vaccines, 11 (2) 305. doi: 10.3390/vaccines11020305
Koirala, Prashamsa, Chen, Sung‐Po R., Boer, Jennifer C., Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Lu, Lantian, Faruck, Mohammad Omer, Shalash, Ahmed O., Bashiri, Sahra, Capon, Robert J., Hussein, Waleed M., Monteiro, Michael J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). Polymeric nanoparticles as a self‐adjuvanting peptide vaccine delivery system: the role of shape. Advanced Functional Materials, 33 (12) 2209304, 2209304. doi: 10.1002/adfm.202209304
Skwarczynski, Mariusz, Zhao, Guangzu, Ozberk, Victoria, Giddam, Ashwini Kumar, Khalil, Zeinab G., Pandey, Manisha, Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Capon, Robert J., Good, Michael F. and Toth, Istvan (2023). Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation. Australian Journal of Chemistry, 76 (8), 429-436. doi: 10.1071/ch22167
Kiong, Jolynn, Nahar, Ummey Jannatun, Jin, Shengbin, Shalash, Ahmed O., Zhang, Jiahui, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2022). Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus. Pharmaceutics, 14 (10) 2151, 1-12. doi: 10.3390/pharmaceutics14102151
Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212
Fan, Jingyi, Jin, Shengbin, Gilmartin, Lachlan, Toth, Istvan, Hussein, Waleed M. and Stephenson, Rachel J. (2022). Advances in infectious disease vaccine adjuvants. Vaccines, 10 (7) 1120, 1-62. doi: 10.3390/vaccines10071120
Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Toth, Istvan and Skwarczynski, Mariusz (2022). Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection. Journal of Allergy and Clinical Immunology, 150 (1), 157-169.e10. doi: 10.1016/j.jaci.2022.02.020
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856
Huang, Wenbin, Madge, Harrison Y. R., Zhang, Jiahui, Gilmartin, Lachlan, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines. International Journal of Pharmaceutics, 617 121614, 1-12. doi: 10.1016/j.ijpharm.2022.121614
Islam, Md. Tanjir, Ho, Mei-Fong, Nahar, Ummey J., Shalash, Ahmed O., Koirala, Prashamsa, Hussein, Waleed M., Stanisic, Danielle I., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2022). Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens. PLoS One, 17 (3) e0264961, e0264961. doi: 10.1371/journal.pone.0264961
Zhang, Jiahui, Fan, Jingyi, Skwarczynski, Mariusz, Stephenson, Rachel J, Toth, Istvan and Hussein, Waleed M (2022). Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances. International Journal of Nanomedicine, 17, 869-900. doi: 10.2147/ijn.s269986
Madge, Harrison Y. R., Huang, Wenbin, Gilmartin, Lachlan, Rigau-Planella, Berta, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Santiago, Viviene S., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus. Biomaterials Science, 10 (1), 281-293. doi: 10.1039/d1bm01333e
Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Hookworm infection: toward development of safe and effective peptide vaccines. Journal of Allergy and Clinical Immunology, 148 (6), 1394-1419.e6. doi: 10.1016/j.jaci.2021.10.013
Ilicic, Marina, Zakar, Tamas, Gregson, Amy, Hussein, Waleed M., Smith, Roger and Paul, Jonathan W. (2021). Histone deacetylase inhibitors: providing new insights and therapeutic avenues for unlocking human birth. Reproductive Sciences, 29 (11), 1-13. doi: 10.1007/s43032-021-00778-x
Stanisic, Danielle I., Ho, Mei-Fong, Nevagi, Reshma, Cooper, Emily, Walton, Maddison, Islam, Md Tanjir, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan and Good, Michael F. (2021). Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria. mBio, 12 (5) e02657-21, e0265721. doi: 10.1128/mBio.02657-21
Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Skwarczynski, Mariusz and Toth, Istvan (2021). Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy. Vaccines, 9 (9) 1034, 1034. doi: 10.3390/vaccines9091034
Azuar, Armira, Shibu, Mohini A., Adilbish, Nomin, Marasini, Nirmal, Hung, Hong, Yang, Jieru, Luo, Yacheng, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00333, 2307-2317. doi: 10.1021/acs.bioconjchem.1c00333
Feder, Daniel, Mohd-Pahmi, Siti H., Hussein, Waleed M., Guddat, Luke W., McGeary, Ross P. and Schenk, Gerhard (2021). Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach. ChemMedChem, 16 (21) cmdc.202100486, 3342-3359. doi: 10.1002/cmdc.202100486
Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative. Advanced Science, 8 (16) 2100985, 1-35. doi: 10.1002/advs.202100985
Al-Nazal, Hanan A., Cooper, Emily, Ho, Mei Fong, Eskandari, Sharareh, Majam, Victoria, Giddam, Ashwini Kumar, Hussein, Waleed M., Islam, Md Tanjir, Skwarczynski, Mariusz, Toth, Istvan, Kumar, Sanjai, Zaid, Ali, Batzloff, Michael, Stanisic, Danielle I. and Good, Michael F. (2021). Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis. Cell Host and Microbe, 29 (6), 894-903. doi: 10.1016/j.chom.2021.04.008
Dai, Charles C., Huang, Wenbin, Yang, Jieru, Hussein, Waleed M., Wang, Jingwen, Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2021). Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines. Bioorganic and Medicinal Chemistry Letters, 40 127920, 1-7. doi: 10.1016/j.bmcl.2021.127920
Yang, Jieru, Firdaus, Farrhana, Azuar, Armira, Khalil, Zeinab G., Marasini, Nirmal, Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus. Vaccines, 9 (5) 499, 499. doi: 10.3390/vaccines9050499
Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665
Khatun, Farjana, Dai, Charles C., Rivera-Hernandez, Tania, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2021). Immunogenicity assessment of cell wall carbohydrates of Group A Streptococcus via self-adjuvanted glyco-lipopeptides. ACS Infectious Diseases, 7 (2) acsinfecdis.0c00722, 390-405. doi: 10.1021/acsinfecdis.0c00722
Azuar, Armira, Li, Zhuoqing, Shibu, Mohini A., Zhao, Lili, Luo, Yacheng, Shalash, Ahmed O., Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid)-based self-adjuvanting nanoparticles for Group A Streptococcus vaccine delivery. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01660, 2648-2658. doi: 10.1021/acs.jmedchem.0c01660
Kandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919
Zhao, Lili, Yang, Jieru, Nahar, Ummey Jannatun, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: lipidation and polyelectrolyte complexes. Bioorganic and Medicinal Chemistry, 28 (24) 115823, 115823. doi: 10.1016/j.bmc.2020.115823
Shaaban, Marwa M., Ragab, Hanan M., Akaji, Kenichi, McGeary, Ross P., Bekhit, Alaa-Eldin A., Hussein, Waleed M., Kurz, Julia L., Elwakil, Bassma H., Bekhit, Salma A., Ibrahim, Tamer M., Mahran, Mona A. and Bekhit, Adnan A. (2020). Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors. Bioorganic Chemistry, 105 104386, 104386. doi: 10.1016/j.bioorg.2020.104386
Dai, Charles C., Yang, Jieru, Hussein, Waleed M., Zhao, Lili, Wang, Xiumin, Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2020). Polyethylenimine: an intranasal adjuvant for liposomal peptide-based subunit vaccine against Group A Streptococcus. ACS Infectious Diseases, 6 (9) acsinfecdis.0c00452, 2502-2512. doi: 10.1021/acsinfecdis.0c00452
Skwarczynski, Mariusz, Chandrudu, Saranya, Rigau-Planella, Berta, Islam, Md. Tanjir, Cheong, Yee S., Liu, Genan, Wang, Xiumin, Toth, Istvan and Hussein, Waleed M. (2020). Progress in the development of subunit vaccines against malaria. Vaccines, 8 (3) 373, 1-19. doi: 10.3390/vaccines8030373
Dai, Chuankai, Khalil, Zeinab G., Hussein, Waleed M., Yang, Jieru, Wang, Xiumin, Zhao, Lili, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2020). Opsonic activity of conservative versus variable regions of the Group A Streptococcus M protein. Vaccines, 8 (2) 210, 210. doi: 10.3390/vaccines8020210
Madge, Harrison Y. R., Sharma, Hansa, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert John, Toth, Istvan and Stephenson, Rachel (2020). Structure–activity analysis of cyclic multicomponent lipopeptide self-adjuvanting vaccine candidates presenting Group A Streptococcus antigens. Journal of Medicinal Chemistry, 63 (10) acs.jmedchem.0c00203, 5387-5397. doi: 10.1021/acs.jmedchem.0c00203
Zhao, Lili, Jin, Wanli, Cruz, Jazmina Gonzalez, Marasini, Nirmal, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Development of polyelectrolyte complexes for the delivery of peptide-based subunit vaccines against group A streptococcus. Nanomaterials, 10 (5) 823, 823. doi: 10.3390/nano10050823
Bayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899
Skwarczynski, Mariusz, Zhao, Guangzu, Boer, Jennifer C., Ozberk, Victoria, Azuar, Armira, Gonzalez Cruz, Jazmina, Kumar Giddam, Ashwini, Khalil, Zeinab G., Pandey, Manisha, Shibu, Mohini A., Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Wells, James W., Capon, Robert J., Plebanski, Magdalena, Good, Michael F. and Toth, Istvan (2020). Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines. Science Advances, 6 (5) eaax2285, eaax2285. doi: 10.1126/sciadv.aax2285
Faruck, Mohammad Omer, Zhao, Lili, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2020). Polyacrylate–peptide antigen conjugate as a single-dose oral vaccine against Group A Streptococcus. Vaccines, 8 (1) 23, 1-10. doi: 10.3390/vaccines8010023
Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2020). Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 30 (1) 126722, 1-5. doi: 10.1016/j.bmcl.2019.126722
Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Low, Leanne M., Liu, Xue Q., Ho, Mei-Fong, Zaman, Mehfuz, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I. and Good, Michael F. (2019). Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice. Vaccine, 38 (6), 1494-1504. doi: 10.1016/j.vaccine.2019.11.063
Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611
Azuar, Armira, Zhao, Lili, Hei, Tsui Ting, Nevagi, Reshma J., Bartlett, Stacey, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Skwarczynski, Mariusz (2019). Cholic acid-based delivery system for vaccine candidates against Group A Streptococcus. ACS Medicinal Chemistry Letters, 10 (9) acsmedchemlett.9b00239, 1253-1259. doi: 10.1021/acsmedchemlett.9b00239
Hussein, Waleed M., Cheong, Yee S., Liu, Chang, Liu, Genan, Begum, Anjuman Ara, Attallah, Maria Adly, Moyle, Peter Michael, Torchilin, Vladimir, Smith, Roger and Toth, Istvan (2019). Peptide-based targeted polymeric nanoparticles for siRNA delivery. Nanotechnology, 30 (41) 415604, 415604. doi: 10.1088/1361-6528/ab313d
Nevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system. Bioorganic and Medicinal Chemistry, 27 (14), 3082-3088. doi: 10.1016/j.bmc.2019.05.033
Azuar, Armira, Jin, Wanli , Mukaida, Saori, Hussein, Waleed , Toth, Istvan and Skwarczynski, Mariusz (2019). Recent advances in the development of peptide vaccines and their delivery systems against Group A Streptococcus. Vaccines, 7 (3) 58, 58. doi: 10.3390/vaccines7030058
Nevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system. European Journal of Medicinal Chemistry, 179, 100-108. doi: 10.1016/j.ejmech.2019.06.047
Begum, Anjuman A., Toth, Istvan, Hussein, Waleed M. and Moyle, Peter Michael (2019). Advances in targeted gene delivery. Current Drug Delivery, 16 (7), 588-608. doi: 10.2174/1567201816666190529072914
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019). Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 (1), 61-71. doi: 10.1039/c8md00491a
Khongkow, Mattaka, Liu, Tzu-yu, Bartlett, Stacey, Hussein, Waleed M., Nevagi, Reshma, Jia, Zhongfan, Monteiro, Michael J., Wells, James, Ruktanonchai, Uracha Rungsardthong, Skwarczynski, Mariusz and Toth, Istvan (2018). Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer. Precision Nanomedicine, 1 (3), 183-193. doi: 10.33218/prnano1(3).181003.1
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018). Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157, 462-479. doi: 10.1016/j.ejmech.2018.08.004
Hussein, Waleed M., Choi, Phil M., Zhang, Cheng, Sierecki, Emma, Johnston, Wayne, Jia, Zhongfan, Monteiro, Michael J., Skwarczynski, Mariusz, Gambin, Yann and Toth, Istvan (2018). Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2. AIMS Allergy and Immunology, 2 (3), 141-147. doi: 10.3934/allergy.2018.3.141
Nevagi, Reshma J., Khalil, Zeinab G., Hussein, Waleed M., Powell, Jessica, Batzloff, Michael R., Capon, Robert J., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2018). Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus. Acta Biomaterialia, 80, 278-287. doi: 10.1016/j.actbio.2018.09.037
Hussein, Waleed M., Mukaida, Saori, Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2017). Fluorinated lipids conjugated to peptide antigens do not induce immune responses against cervical cancer. Vaccination Research Open Journal, 1 (1), 39-44. doi: 10.17140/VROJ-1-107
Fagan, Vincent, Hussein, Waleed M., Su, Mei, Gidda, Ashwini K., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Simerska, Pavla (2017). Synthesis, characterization and immunological evaluation of self-adjuvanting group a streptococcal vaccine candidates bearing various lipidic adjuvanting moieties. ChemBioChem, 18 (6), 545-553. doi: 10.1002/cbic.201600639
Hussein, Waleed M., Mukaida, Saori, Azmi, Fazren, Bartlett, Stacey, Olivier, Celine, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2017). Comparison of fluorinated and nonfluorinated lipids in self-adjuvanting delivery systems for peptide-based vaccines. ACS Medicinal Chemistry Letters, 8 (2), 227-232. doi: 10.1021/acsmedchemlett.6b00453
Hussein, Waleed M., Xu, Jiaxin, Simerska, Pavla and Toth, Istvan (2017). Synthesis of multicomponent peptide-based vaccine candidates against group A streptococcus. Australian Journal of Chemistry, 70 (2), 184-190. doi: 10.1071/CH16501
Hussein, Waleed, Choi, Phil, Zhang, Cheng, Su, Mei, Sierecki, Emma, Johnston, Wayne, Fagan, Vincent, Alexandrov, Kirill, Skwarczynski, Mariusz, Gambin, Yann, Toth, Istvan and Simerska, P. (2017). Evaluation of lipopeptides as toll-like receptor 2 ligands. Current Drug Delivery, 14 (7), 935-943. doi: 10.2174/1567201813666160804114107
Marasini, Nirmal, Giddam, Ashwini K., Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Skwarczynski, Mariusz (2016). Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery. Nanomedicine, 11 (24), 3223-3235. doi: 10.2217/nnm-2016-0291
Marasini, Nirmal, Khalil, Zeinab G., Giddam, Ashwini K., Abdul Ghaffar, Khairunnisa, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. International Journal of Pharmaceutics, 513 (1-2), 410-420. doi: 10.1016/j.ijpharm.2016.09.057
Hussein, Waleed M., Liu, Tzu-Yu, Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2016). Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer. Bioorganic and Medicinal Chemistry, 24 (18), 4372-4380. doi: 10.1016/j.bmc.2016.07.036
Chandrudu, Saranya, Bartlett, Stacey, Khalil, Zeinab G., Jia, Zhongfan, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2016). Linear and branched polyacrylates as a delivery platform for peptide-based vaccines. Therapeutic Delivery, 7 (9), 601-609. doi: 10.4155/tde-2016-0037
Arjomandi, Omid Khalili, Hussein, Waleed M., Vella, Peter, Yusof, Yusralina, Sidjabat, Hanna E., Schenk, Gerhard and McGeary, Ross P. (2016). Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1. European Journal of Medicinal Chemistry, 114, 318-327. doi: 10.1016/j.ejmech.2016.03.017
Moradi, Shayli Varasteh, Hussein, Waleed M., Varamini, Pegah, Simerska, Pavla and Toth, Istvan (2016). Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides. Chemical Science, 7 (4), 2492-2500. doi: 10.1039/C5SC04392A
Hussein, Waleed M., Liu, Tzu-Yu, Maruthayanar, Pirashanthini, Mukaida, Saori, Moyle, Peter M., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2016). Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines. Chemical Science, 7 (3), 2308-2321. doi: 10.1039/C5SC03859F
Chan, Amy, Hussein, Waleed M., Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Mostafa, Ahmed, Eskandari, Sharareh, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorganic and Medicinal Chemistry, 24 (14), 3095-3101. doi: 10.1016/j.bmc.2016.03.063
Moyle, Peter M., Dai, Wei, Liu, Tzu-Yu, Hussein, Waleed M., Maruthayanar, Pirashanthini, Wells, James W., McMillan, Nigel A. J., Skwarczynski, Mariusz and Toth, Istvan (2015). Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5570-5575. doi: 10.1016/j.bmcl.2015.10.049
Ghaffar, Khairunnisa Abdul, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2015). Levofloxacin and indolicidin for combination antimicrobial therapy. Current Drug Delivery, 12 (1), 108-114. doi: 10.2174/1567201811666140910094050
Liu, Tzu-Yu, Hussein, Waleed M., Giddam, Ashwini Kumar, Jia, Zhongfan, Reiman, Jennifer M., Zaman, Mehfuz, McMillan, Nigel A. J., Good, Michael F., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2015). Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine. Journal of Medicinal Chemistry, 58 (2), 888-896. doi: 10.1021/jm501514h
Liu, Tzu-Yu, Giddam, Ashwini Kumar, Hussein, Waleed M., Jia, Zhongfan, McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2015). Self-adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model. Current Drug Delivery, 12 (1), 3-8. doi: 10.2174/1567201811666141001155729
Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 (22), 3359-3371. doi: 10.2217/nnm.15.137
Hussein, Waleed M. and McGeary, Ross P. (2014). Use of ethyl (benzothiazol-2-ylsulfonyl)acetate for malonic ester-type syntheses of carboxylic acids and esters. Australian Journal of Chemistry, 67 (8-9), 1222-1227. doi: 10.1071/CH14085
Christie, Michelle P., Simerská, Pavla, Jen, Freda E.-C., Hussein, Waleed M., Rawi, Mohamad F. M., Hartley-Tassell, Lauren E., Day, Christopher J., Jennings, Michael P. and Toth, Istvan (2014). A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. PLoS One, 9 (4) e95024, e95024.1-e95024.10. doi: 10.1371/journal.pone.0095024
Hussein, Waleed M., Liu, Tzu-Yu, Skwarczynski, Mariusz and Toth, Istvan (2014). Toll-like receptor agonists: a patent review (2011 - 2013). Expert Opinion on Therapeutic Patents, 24 (4), 453-470. doi: 10.1517/13543776.2014.880691
Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2013). Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules, 14 (8), 2798-2806. doi: 10.1021/bm400626w
Hussein, Waleed M., Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2013). Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method. Organic and Biomolecular Chemistry, 11 (14), 2370-2376. doi: 10.1039/c3ob00030c
Varamini, Pegah, Hussein, Waleed M., Mansfeld, Friederike M. and Toth, Istvan (2012). Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives. Bioorganic & Medicinal Chemistry, 20 (21), 6335-6343. doi: 10.1016/j.bmc.2012.09.003
Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001
Hussein, Waleed M., Fatahala, Samar S., Mohamed, Zainab M., McGeary, Ross P., Schenk, Gerhard, Ollis, David L. and Mohamed, Mosaad S. (2012). Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology and Drug Design, 80 (4), 500-515. doi: 10.1111/j.1747-0285.2012.01440.x
Liu, Tzu-Yu, Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2012). Advances in peptide-based Human papillomavirus therapeutic vaccines. Current Topics in Medicinal Chemistry, 12 (14), 1581-1592. doi: 10.2174/156802612802652402
Wu, Feng-Ling, Hussein, Waleed M., Ross, Benjamin P. and McGeary, Ross P. (2012). 2-Mercaptobenzothiazole and its derivatives: Syntheses, reactions and applications. Current Organic Chemistry, 16 (13), 1555-1580. doi: 10.2174/138527212800840964
Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123
Faridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012). 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 (1), 380-386. doi: 10.1016/j.bmcl.2011.10.116
Mohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011). Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 (12), 6075-6082. doi: 10.1016/j.ejmech.2011.10.030
Vella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027
Mohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024
Landsberg, MJ, Ruggles, JL, Hussein, WM, McGeary, RP, Gentle, IR and Hankamer, B (2010). Molecular packing of functionalized fluorinated lipids in langmuir mono layers. Langmuir, 26 (24), 18868-18873. doi: 10.1021/la103743e
Hussein, Waleed M., Ross, Benjamin P., Landsberg, Michael J., Levy, Daniel, Hankamer, Ben and McGeary, Ross P. (2009). Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations. Journal of Organic Chemistry, 74 (4), 1473-1479. doi: 10.1021/jo802651p
Hussein. Waleed M., Ross, Benjamin P., Landsberg, M. J., Hankamer, B and McGeary, Ross P. (2009). Synthetic approaches to functionalized lipids for protein monolayer crystallizations. Current Organic Chemistry, 13 (14), 1378-1405. doi: 10.2174/138527209789055081
Conference Papers
Aljohani, Salwa, Hussein, Waleed M., Toth, Istvan and Simerska, Pavla (2019). Carbohydrates in vaccine development. Controlled Release Asia Meeting, Singapore, 24-25 September, 2018. Sharjah, United Arab Emirates: Bentham Science Publishers. doi: 10.2174/1567201816666190702153612
Nevagi, Reshma Jayprakash, Dai, Wei, Khalil, Zeinab, Hussein, Waleed, Capon, Robert, Skwarczynski, Mariusz and Toth, Istvan (2019). Development of polymer-based nanoparticulate intranasal lipopeptide vaccine constructs against group A streptococcus. National Meeting of the American Chemical Society (ACS), Orlando, FL, United States, 31 March - 4 April, 2019. Washington, DC, United States: American Chemical Society.
Skwarczynski, Mariusz, Liu, Tzu-Yu, Hussein, Waleed M., Jia, Zhongfan, Ziora, Zyta M., McMillan, Nigel A. J., Monteiro, Michael J. and Toth, Istvan (2014). Synthesis of therapeutic vaccine against cervical cancer. 4th Asia-Pacific International Peptide Symposium in conjunction with 50th Japanese Peptide Symposium, Osaka, Japan, 6-8 November 2013. Osaka, Japan: Japanese Peptide Society.
Thesis
Waleed Hussein (2009). Synthesis of Nickel-Chelating Fluorinated Lipids for Membrane Protein Monolayer Crystallisations. PhD Thesis, School of Chemistry and Molecular Bioscience, The University of Queensland.