Dr Gene Hopping
Senior Research Fellow
Institute for Molecular Bioscience
Publications
Journal Articles
Crook, Zachary R., Girard, Emily, Sevilla, Gregory P., Merrill, Morgan, Friend, Della, Rupert, Peter B., Pakiam, Fiona, Nguyen, Elizabeth, Yin, Chunfeng, Ruff, Raymond O., Hopping, Gene, Strand, Andrew D., Finton, Kathryn A. K., Coxon, Margo, Mhyre, Andrew J., Strong, Roland K. and Olson, James M. (2020). A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules. Journal of Molecular Biology, 432 (14), 3989-4009. doi: 10.1016/j.jmb.2020.04.002
Sangar, Michelle L. Cook, Girard, Emily J., Hopping, Gene, Yin, Chunfeng, Pakiam, Fiona, Brusniak, Mi-Youn, Nguyen, Elizabeth, Ruff, Raymond, Gewe, Mesfin M., Byrnes-Blake, Kelly, Nairn, Natalie W., Miller, Dennis M., Mehlin, Christopher, Strand, Andrew D., Mhyre, Andrew J., Correnti, Colin E., Strong, Roland K., Simon, Julian A. and Olson, James M. (2020). A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure. Science Translational Medicine, 12 (533). doi: 10.1126/scitranslmed.aay1041
Sottero, Theo L., Girard, Emily J., Myers, Carrie, Hopping, Gene, Mhyre, Andrew J. and Olson, James M. (2018). Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging. Anticancer Research, 38 (1), 51-60. doi: 10.21873/anticanres.12191
Kellock, Jackson, Hopping, Gene, Caughey, Byron and Daggett, Valerie (2016). Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence. Journal of Molecular Biology, 428 (11), 2317-2328. doi: 10.1016/j.jmb.2016.03.013
Towse, Clare-Louise, Hopping, Gene, Vulovic, Ivan and Daggett, Valerie (2014). Nature versus design: the conformational propensities of d-amino acids and the importance of side chain chirality. Protein Engineering Design and Selection, 27 (11), 447-455. doi: 10.1093/protein/gzu037
Hopping, Gene, Kellock, Jackson, Barnwal, Ravi Pratap, Law, Peter, Bryers, James, Varani, Gabriele, Caughey, Byron and Daggett, Valerie (2014). Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers. eLife, 2014 (3) e01681. doi: 10.7554/elife.01681
Hopping, Gene, Wang, C-I Anderson, Hogg, Ron C., Nevin, Simon T., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2014). Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology, 91 (4), 534-542. doi: 10.1016/j.bcp.2014.07.025
Hopping, Gene, Kellock, Jackson, Caughey, Byron and Daggett, Valerie (2013). Designed Trpzip-3 beta-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems. Acs Medicinal Chemistry Letters, 4 (9), 824-828. doi: 10.1021/ml300478w
Dantas de Araujo, Aline, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J. and Alewood, Paul F. (2011). Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Edition), 50 (29), 6527-6529. doi: 10.1002/anie.201101642
Alewood, Dianne, Hopping, Gene, Brust, Andreas, Reid, Robert C. and Alewood, Paul F. (2010). Benzhydrylamine linker grafting: A strategy for the improved synthesis of C-terminal peptide amides. Journal of Peptide Science, 16 (10), 551-557. doi: 10.1002/psc.1248
Hopping , Gene, Lewis, Richard J. and Alewood, Paul F. (2009). Rapid access to omega conotoxin chimeras using native chemical ligation. Austalian Journal of Chemistry, 62 (10), 1333-1338. doi: 10.1071/CH09216
Dutertre, S., Ulens, C, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G., Alewood, P. F., Schroeder, C., Nicke, A, Smit, AB, Sixma, TK and Lewis, R. J. (2007). AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. Embo Journal, 26 (16), 3858-3867. doi: 10.1038/sj.emboj.7601785
Hogg, R. C., Hopping, G., Alewood, P. F., Adams, D. J. and Bertrand, D. (2003). alpha-conotoxins PnIA and [A10L] PnIA stabilize different states of the alpha 7-L247T nicotinic acetylcholine receptor. Journal of Biological Chemistry, 278 (29), 26908-26914. doi: 10.1074/jbc.M212628200
Alewood, P., Hopping, G. and Armishaw, C. (2003). Marine toxins as sources of drug leads. Australian Journal of Chemistry, 56 (8), 769-774. doi: 10.1071/CH03043