Dr Simon de Veer
Research Fellow
Institute for Molecular Bioscience
+61 7 334 62021
Book Chapters
de Veer, Simon J. and Craik, David J. (2017). Naturally occurring disulfide-rich cyclic peptides from plants and animals: Synthesis and biosynthesis. Chemical biology of natural products. (pp. 491-529) edited by David J. Newman, Gordon M. Cragg and Paul Grothaus. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781315117089-14
Swedberg, Joakim E., de Veer, Simon J. and Harris, Jonathan M. (2012). Natural, engineered and synthetic inhibitors of kallikrein-related peptidases. Kallikrein-related peptidases: characterization, regulation, and interactions within the protease web. (pp. 141-160) edited by Viktor Magdolen. Berlin, Germany: De Gruyter.
Journal Articles
Tian, Sixin, Durek, Thomas, Wang, Conan K., Zdenek, Christina N., Fry, Bryan G., Craik, David J. and de Veer, Simon J. (2022). Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa. Journal of Medicinal Chemistry, 65 (23), 15698-15709. doi: 10.1021/acs.jmedchem.2c01080
Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951
Rehm, Fabian B. H., Tyler, Tristan J., Veer, Simon J., Craik, David J. and Durek, Thomas (2022). Enzymatic C‐to‐C Protein Ligation. Angewandte Chemie International Edition, 134 (11) e202116672, e202116672. doi: 10.1002/anie.202116672
Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9
Rehm, Fabian B. H., Tyler, Tristan J., Yap, Kuok, de Veer, Simon J., Craik, David J. and Durek, Thomas (2021). Enzymatic C-terminal protein engineering with amines. Journal of the American Chemical Society, 143 (46) jacs.1c08976, 19498-19504. doi: 10.1021/jacs.1c08976
Liu, Wenyu, de Veer, Simon J., Huang, Yen-Hua, Sengoku, Toru, Okada, Chikako, Ogata, Kazuhiro, Zdenek, Christina N., Fry, Bryan G., Swedberg, Joakim E., Passioura, Toby, Craik, David J. and Suga, Hiroaki (2021). An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold. Journal of the American Chemical Society, 143 (44) jacs.1c07574, 18481-18489. doi: 10.1021/jacs.1c07574
Durek, Thomas, Kaas, Quentin, White, Andrew M., Weidmann, Joachim, Fuaad, Abdullah Ahmad, Cheneval, Olivier, Schroeder, Christina I., de Veer, Simon J., Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Plowright, Alleyn T. and Craik, David J. (2021). Melanocortin 1 receptor agonists based on a bivalent, bicyclic peptide framework. Journal of Medicinal Chemistry, 64 (14) acs.jmedchem.1c00095, 9906-9915. doi: 10.1021/acs.jmedchem.1c00095
Yap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0
de Veer, Simon J., White, Andrew M. and Craik, David (2020). Sunflower trypsin inhibitor-1 (SFTI-1): sowing seeds in the fields of chemistry and biology. Angewandte Chemie (International Edition), 59 (15), 2-24. doi: 10.1002/anie.202006919
Yap, Kuok, Du, Junqiao, Looi, Fong Yang, Tang, Shyn Ric, de Veer, Simon J., Bony, Anuja R., Rehm, Fabian B. H., Xie, Jing, Chan, Lai Yue, Wang, Conan K., Adams, David J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2020). An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides. Green Chemistry, 22 (15), 5002-5016. doi: 10.1039/d0gc01366h
White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020). Angewandte Chemie, 132 (28), 11258-11258. doi: 10.1002/ange.202006713
White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020). Angewandte Chemie International Edition, 59 (28), 11162-11162. doi: 10.1002/anie.202006713
White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides. Angewandte Chemie International Edition, 132 (28) anie.202003435, 11369-11373. doi: 10.1002/anie.202003435
Li, Choi Yi, Yap, Kuok, Swedberg, Joakim E., Craik, David J. and de Veer, Simon J. (2020). Binding loop substitutions in the cyclic peptide SFTI-1 generate potent and selective chymase inhibitors. Journal of Medicinal Chemistry, 63 (2) acs.jmedchem.9b01811, 816-826. doi: 10.1021/acs.jmedchem.9b01811
de Veer, Simon J., Kan, Meng-Wei and Craik, David J. (2019). Cyclotides: from structure to function. Chemical Reviews, 119 (24) acs.chemrev.9b00402, 12375-12421. doi: 10.1021/acs.chemrev.9b00402
Tian, Sixin, Swedberg, Joakim E., Li, Choi Yi, Craik, David J. and de Veer, Simon J. (2019). Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3. ACS Medicinal Chemistry Letters, 10 (8) acsmedchemlett.9b00253, 1234-1239. doi: 10.1021/acsmedchemlett.9b00253
Riley, Blake T., Ilyichova, Olga, de Veer, Simon J., Swedberg, Joakim E., Wilson, Emily, Hoke, David E., Harris, Jonathan M. and Buckle, Ashley M. (2019). KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors. Biochemistry, 58 (21), 2524-2533. doi: 10.1021/acs.biochem.9b00191
Li, Choi Yi, de Veer, Simon J., White, Andrew M., Chen, Xingchen, Harris, Jonathan M., Swedberg, Joakim E. and Craik, David J. (2019). Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases. Journal of Medicinal Chemistry, 62 (7), 3696-3706. doi: 10.1021/acs.jmedchem.9b00211
Chen, Xingchen, Riley, Blake T., De Veer, Simon J., Hoke, David E., Van Haeften, Jessica, Leahy, Darren, Swedberg, Joakim E., Brattsand, Maria, Hartfield, Perry J., Buckle, Ashley M. and Harris, Jonathan M. (2019). Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif. PLoS ONE, 14 (1) e0210842, e0210842. doi: 10.1371/journal.pone.0210842
Li, Choi Yi, de Veer, Simon J., Law, Ruby H. P., Whisstock, James C., Craik, David J. and Swedberg, Joakim E. (2019). Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. ChemBioChem, 19 (1), 46-50. doi: 10.1002/cbic.201800395
Swedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J. and Craik, David J. (2018). Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II. ACS Medicinal Chemistry Letters, 9 (12) acsmedchemlett.8b00422, 1258-1262. doi: 10.1021/acsmedchemlett.8b00422
de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018). Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155, 695-704. doi: 10.1016/j.ejmech.2018.06.029
Magnen, Melia, Gueugnon, Fabien, Guillon, Antoine, Baranek, Thomas, Thibault, Virginie C., Petit-Courty, Agnes, de Veer, Simon J., Harris, Jonathan, Humbles, Alison A., Si-Tahar, Mustapha and Courty, Yves (2017). Kallikrein-related peptidase 5 contributes to H3N2 influenza virus infection in human lungs. Journal of Virology, 91 (16) e00421-17. doi: 10.1128/JVI.00421-17
de Veer, Simon J., Weidmann, Joachim and Craik, David J. (2017). Cyclotides as tools in chemical biology. Accounts of Chemical Research, 50 (7), 1557-1565. doi: 10.1021/acs.accounts.7b00157
de Veer, Simon J., Furio, Laetitia, Swedberg, Joakim E., Munro, Christopher A., Brattsand, Maria, Clements, Judith A., Hovnanian, Alain and Harris, Jonathan M. (2017). Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum. The Journal of Investigative Dermatology, 137 (2), 430-439. doi: 10.1016/j.jid.2016.09.017
Swedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017). Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 (2), 658-667. doi: 10.1021/acs.jmedchem.6b01509
McGovern, J. A., Meinert, C., de Veer, S. J., Hollier, B. G., Parker, T. J. and Upton, Z. (2017). Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. British Journal of Dermatology, 176 (1), 145-158. doi: 10.1111/bjd.14879
De Veer, Simon J., Swedberg, Joakim E., Brattsand, Maria, Clements, Judith A. and Harris, Jonathan M. (2016). Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors. Biological Chemistry, 397 (12), 1237-1249. doi: 10.1515/hsz-2016-0112
Riley, Blake T., Ilyichova, Olga, Costa, Mauricio G. S., Porebski, Benjamin T., De Veer, Simon J., Swedberg, Joakim E., Kass, Itamar, Harris, Jonathan M., Hoke, David E. and Buckle, Ashley M. (2016). Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics. Scientific Reports, 6 (1) 35385, 35385. doi: 10.1038/srep35385
Swedberg, Joakim E., Mahatmanto, Tunjung, Ghani, Hafiza Abdul, de Veer, Simon J., Schroeder, Christina I., Harris, Jonathan M. and Craik, David J. (2016). Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. Journal of Medicinal Chemistry, 59 (15), 7287-7292. doi: 10.1021/acs.jmedchem.6b00557
de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148
de Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2), 243-253. doi: 10.1042/BJ20150412
Duchatelet, S., Guibbal, L., de Veer, S., Fraitag, S., Nitschké, P., Zarhrate, M., Bodemer, C. and Hovnanian, A. (2014). Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutations. British Journal of Dermatology, 171 (3), 675-678. doi: 10.1111/bjd.12951
de Veer, Simon J., Furio, Laetitia, Harris, Jonathan M. and Hovnanian, Alain (2014). Proteases and proteomics: cutting to the core of human skin pathologies. Proteomics - Clinical Applications, 8 (5-6), 389-402. doi: 10.1002/prca.201300081
Duchatelet, Sabine, Pruvost, Solenn, de Veer, Simon, Fraitag, Sylvie, Nitschké, Patrick, Bole-Feysot, Christine, Bodemer, Christine and Hovnanian, Alain (2014). A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia. JAMA Dermatology, 150 (3), 303-306. doi: 10.1001/jamadermatol.2013.8709
de Veer, Simon J., Furio, Laetitia, Harris, Jonathan M. and Hovnanian, Alain (2014). Proteases: common culprits in human skin disorders. Trends in Molecular Medicine, 20 (3), 166-178. doi: 10.1016/j.molmed.2013.11.005
Furio, Laetitia, de Veer, Simon, Jaillet, Madeleine, Briot, Anais, Robin, Aurelie, Deraison, Celine and Hovnanian, Alain (2014). Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome. The Journal of Experimental Medicine, 211 (3), 499-513. doi: 10.1084/jem.20131797
de Veer, Simon J., Ukolova, Svetlana S., Munro, Christopher A., Swedberg, Joakim E., Buckle, Ashley M. and Harris, Jonathan M. (2013). Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1. Biopolymers, 100 (5), 510-518. doi: 10.1002/bip.22231
Sanchez, Washington Y., de Veer, Simon J., Swedberg, Joakim E., Hong, Eui-Ju, Reid, Janet C., Walsh, Terry P., Hooper, John D., Hammond, Geoffrey L., Clements, Judith A. and Harris, Jonathan M. (2012). Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells. Endocrinology, 153 (7), 3179-3189. doi: 10.1210/en.2012-1011
Swedberg, Joakim, de Veer, Simon J., Sit, Kei C., Reboul, Cyril F., Buckle, Ashley M. and Harris, Jonathan M. (2011). Mastering the canonical loop of serine protease inhibitors: Enhancing potency by optimising the internal hydrogen bond network. PLoS One, 6 (4) e19302, e19302.1-e19302.11. doi: 10.1371/journal.pone.0019302
Swedberg, Joakim E., Nigon, Laura V., Reid, Janet C., de Veer, Simon J., Walpole, Carina M., Stephens, Carson R., Walsh, Terry P., Takayama, Thomas K., Hooper, John D., Clements, Judith A., Buckle, Ashley M. and Harris, Jonathan M. (2009). Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chemistry and Biology, 16 (6), 633-643. doi: 10.1016/j.chembiol.2009.05.008
Conference Papers
Duchatelet, S., de Veer, S., Guibbal, L., Freitag, S., Nitschke, P., Bole-Feysot, C., Bodemers, C. and Hovnanian, A. (2014). Dominant and recessive Olmsted syndrome with erythromelalgia due to TRPV3 mutations. 44th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Copenhagen Denmark, Sep 10-13, 2014. NEW YORK: NATURE PUBLISHING GROUP.
de Veer, Simon J., Swedberg, Joakim E., Parker, Edward A. and Harris, Jonathan M. (2012). Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14. *, *, *. Berlin, Germany: Walter de Gruyter. doi: 10.1515/BC-2011-250
Swedberg, Joakim E., de Veer, Simon J. and Harris, Jonathan M. (2010). Natural and engineered kallikrein inhibitors: An emerging pharmacopeia. IKS 2009: 3rd International Symposium on Kallikreins and Kallikrein-Related Peptidases, Munich, Germany, 30 August-2 September 2009. Berlin, Germany: Walter de Gruyter. doi: 10.1515/BC.2010.037