Mr James Hill
Higher degree by research (PhD) student
Institute for Molecular Bioscience
+61 7 334 62204
Publications
Journal Articles
Hill, James R., Shao, Xia, Massey, Nicholas L., Stauff, Jenelle, Sherman, Phillip S., Robertson, Avril A. B. and J. H. Scott, Peter (2020). Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals. Bioorganic and Medicinal Chemistry Letters, 30 (12) 127186, doi:10.1016/j.bmcl.2020.127186
Hill, James R., Coll, Rebecca C., Schroder, Kate and Robertson, Avril A.B. (2020). Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters, 61 (19) 151849, doi:10.1016/j.tetlet.2020.151849
Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7
Hill, James R. and Robertson, Avril A. B. (2018). Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis. Journal of Medicinal Chemistry, 61 (16) acs.jmedchem.7b01561, 6945-6963. doi:10.1021/acs.jmedchem.7b01561
Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17) 1449-1457. doi:10.1002/cmdc.201700270
Tucey, Timothy M., Verma-Guar, Jiyoti, Nguyen, Julie, Hewitt, Victoria L., Lo, Tricia L., Shingu-Vazquez, Miguel, Robertson, Avril A. B., Hill, James R., Pettolino, Filomena A., Beddoe, Travis, Cooper, Matthew A., Naderer, Thomas and Traven, Ana (2016). The endoplasmic reticulum-mitochondrion tether ERMES orchestrates fungal immune evasion, illuminating inflammasome responses to hyphal signals. mSphere, 1 (3) e00074-16, 1-18. doi:10.1128/mSphere.00074-16