Dr Maria Ikonomopoulou
Honorary Associate Professor
Institute for Molecular Bioscience
Book Chapters
Marcos-Pasero, Helena, Aguilar-Aguilar, Elena, Ikonomopoulou, Maria P. and Loria-Kohen, Viviana (2021). BDNF gene as a precision skill of obesity management. Recent advances in NGF and related molecules: the continuum of the NGF “saga”. (pp. 233-248) edited by Laura Calzà, Luigi Aloe and Luciana Giardino. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-74046-7_15
Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. (pp. 221-244) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry.. doi: 10.1039/9781849737876-00221
Journal Articles
Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF
V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923
von Reumont, Bjoern M., Anderluh, Gregor, Antunes, Agostinho, Ayvazyan, Naira, Beis, Dimitris, Caliskan, Figen, Crnković, Ana, Damm, Maik, Dutertre, Sebastien, Ellgaard, Lars, Gajski, Goran, German, Hannah, Halassy, Beata, Hempel, Benjamin-Florian, Hucho, Tim, Igci, Nasit, Ikonomopoulou, Maria P., Karbat, Izhar, Klapa, Maria I., Koludarov, Ivan, Kool, Jeroen, Lüddecke, Tim, Ben Mansour, Riadh, Vittoria Modica, Maria, Moran, Yehu, Nalbantsoy, Ayse, Ibáñez, María Eugenia Pachón, Panagiotopoulos, Alexios, Reuveny, Eitan ... Zancolli, Giulia (2022). Modern venomics-Current insights, novel methods, and future perspectives in biological and applied animal venom research. GigaScience, 11 giac048, 1-27. doi: 10.1093/gigascience/giac048
op den Brouw, Bianca, Ghezellou, Parviz, Casewell, Nicholas R., Ali, Syed Abid, Fathinia, Behzad, Fry, Bryan G., Bos, Mettine H.A. and Ikonomopoulou, Maria P. (2021). Pharmacological characterisation of Pseudocerastes and Eristicophis viper venoms reveal anticancer (melanoma) properties and a potentially novel mode of fibrinogenolysis. International Journal of Molecular Sciences, 22 (13) 6896, 1-17. doi: 10.3390/ijms22136896
Ryan, Rachael Y. M., Seymour, Jamie, Loukas, Alex, Lopez, J. Alejandro, Ikonomopoulou, Maria P. and Miles, John J. (2021). Immunological Responses to Envenomation. Frontiers in Immunology, 12 661082, 1-20. doi: 10.3389/fimmu.2021.661082
Ikonomopoulou, Maria P., Lopez-Mancheño, Yaiza, Novelle, Marta G., Martinez-Uña, Maite, Gangoda, Lahiru, Pal, Martin, Costa-Machado, Luis Filipe, Fernandez-Marcos, Pablo Jose, Ramm, Grant A. and Fernandez-Rojo, Manuel Alejandro (2021). LXR stimulates a metabolic switch and reveals cholesterol homeostasis as a statin target in Tasmanian devil facial tumor disease. Cell Reports, 34 (11) 108851. doi: 10.1016/j.celrep.2021.108851
Moral-Sanz, Javier, Fernandez-Rojo, Manuel A., Potriquet, Jeremy, Mukhopadhyay, Pamela, Brust, Andreas, Wilhelm, Patrick, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., Alewood, Paul F., Waddell, Nicola, Miles, John J., Mulvenna, Jason P. and Ikonomopoulou, Maria P. (2021). ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations. Toxins, 13 (2) 146, 1-19. doi: 10.3390/toxins13020146
op den Brouw, Bianca, Coimbra, Francisco C. P., Bourke, Lachlan A., Huynh, Tam Minh, Vlecken, Danielle H. W., Ghezellou, Parviz, Visser, Jeroen C., Dobson, James S., Fernandez-Rojo, Manuel A., Ikonomopoulou, Maria P., Casewell, Nicholas R., Ali, Syed A., Fathinia, Behzad, Hodgson, Wayne C. and Fry, Bryan G. (2021). Extensive variation in the activities of Pseudocerastes and Eristicophis viper venoms suggests divergent envenoming strategies are used for prey capture. Toxins, 13 (2) 112, 1-21. doi: 10.3390/toxins13020112
Aguilar-Aguilar, Elena, Marcos-Pasero, Helena, Ikonomopoulou, Maria P. and Loria-Kohen, Viviana (2020). Food implications in central sensitization syndromes. Journal of Clinical Medicine, 9 (12) 4106, 1-18. doi: 10.3390/jcm9124106
Ikonomopoulou, Maria P. and Fernandez-Rojo, Manuel A. (2018). The antiproliferative and apoptotic profile of gomesin against DFTD. Cell Death & Disease, 9 (8) 833, 833. doi: 10.1038/s41419-018-0885-2
Ikonomopoulou, Maria P., Fernandez-Rojo, Manuel A., Pineda, Sandy S., Cabezas-Sainz, Pablo, Winnen, Brit, Morales, Rodrigo A. V., Brust, Andreas, Sanchez, Laura, Alewood, Paul F., Ramm, Grant A., Miles, John J. and King, Glenn F. (2018). Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation. Scientific Reports, 8 (1) 11519, 11519. doi: 10.1038/s41598-018-29826-4
Fernandez-Rojo, Manuel A., Deplazes, Evelyne, Pineda, Sandy S., Brust, Andreas, Marth, Tano, Wilhelm, Patrick, Martel, Nick, Ramm, Grant A., Mancera, Ricardo L., Alewood, Paul F., Woods, Gregory M., Belov, Katherine, Miles, John J., King, Glenn F. and Ikonomopoulou, Maria P. (2018). Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells. Cell Death Discovery, 4 (1) 19, 19. doi: 10.1038/s41420-018-0030-0
Goldenberg, Jonathan, Cipriani, Vittoria, Jackson, Timothy N. W., Arbuckle, Kevin, Debono, Jordan, Dashevsky, Daniel, Panagides, Nadya, Ikonomopoulou, Maria P., Koludarov, Ivan, Li, Bin, Santana, Renan Castro, Nouwens, Amanda, Jones, Alun, Hay, Chris, Dunstan, Nathan, Allen, Luke, Bush, Brian, Miles, John J, Ge, Lilin, Kwok, Hang Fai and Fry, Bryan G (2018). Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 205, 53-61. doi: 10.1016/j.cbpc.2018.01.001
Jimenez, Rocio, Ikonomopoulou, Maria P., Lopez, J Alejandro and Miles, John J. (2017). Immune drug discovery from venoms. Toxicon : Official Journal of the International Society on Toxinology, 141, 18-24. doi: 10.1016/j.toxicon.2017.11.006
Smith, Jennifer J., Herzig, Volker, Ikonomopoulou, Maria P., Dziemborowicz, Slawomir, Bosmans, Frank, Nicholson, Graham M. and King, Glenn F. (2017). Insect-active toxins with promiscuous pharmacology from the African theraphosid spider Monocentropus balfouri. Toxins, 9 (5) 155, 155. doi: 10.3390/toxins9050155
Panagides, Nadya, Jackson, Timothy N.W., Ikonomopoulou, Maria P., Arbuckle, Kevin, Pretzler, Rudolf, Yang, Daryl C., Ali, Syed A., Koludarov, Ivan, Dobson, James, Sanker, Brittany, Asselin, Angelique, Santana, Renan C., Hendrikx, Iwan, van der Ploeg, Harold, Tai-A-Pin, Jeremie, van den Bergh, Romilly, Kerkkamp, Harald M.I., Vonk, Freek J., Naude, Arno, Strydom, Morné A., Jacobsz, Louis, Dunstan, Nathan, Jaeger, Marc, Hodgson, Wayne C., Miles, John and Fry, Bryan G. (2017). How the cobra got its flesh-eating venom: Cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting. Toxins, 9 (103) 103, 103. doi: 10.3390/toxins9030103
Ikonomopoulou, Maria P., Smith, Jennifer J., Herzig, Volker, Pineda, Sandy S., Dziemborowicz, Sławomir, Er, Sing-Yan, Durek, Thomas, Gilchrist, John, Alewood, Paul F., Nicholson, Graham M., Bosmans, Frank and King, Glenn F. (2016). Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix. Toxicon, 123, 62-70. doi: 10.1016/j.toxicon.2016.10.013
Herzig, Volker, Ikonomopoulou, Maria, Smith, Jennifer J., Dziemborowicz, Slawomir, Gilchrist, John, Kuhn-Nentwig, Lucia, Rezende, Fernanda Oliveira, Moreira, Luciano Andrade, Nicholson, Graham M., Bosmans, Frank and King, Glenn F. (2016). Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami. Scientific Reports, 6 (1) 29538, 29538. doi: 10.1038/srep29538
Ikonomopoulou, Maria P., Bradley, Adrian J., Ibrahim, Kammarudin, Limpus, Colin J., Fernandez-Rojo, Manuel A., Vagenas, Dimitrios and Whittier, Joan M. (2014). Hormone and metabolite profiles in nesting green and flatback turtles: Turtle species with different life histories. Advances in Zoology, 2014 (Article ID 503209), 1-9. doi: 10.1155/2014/503209
Pineda, Sandy S., Undheim, Eivind A. B., Rupasinghe, Darshani B., Ikonomopoulou, Maria P. and King, Glenn F. (2014). Spider venomics: implications for drug discovery. Future Medicinal Chemistry, 6 (15), 1699-1714. doi: 10.4155/FMC.14.103
Fernández Rojo, Manuel, Gongora, Milena, Fitzsimmons, Rebecca L., Martel, Nick, Martin, Sheree D., Nixon, Susan, Brooks, Andrew J., Ikonomopoulou, Maria P., Martin, Sally, Lo, Harriet P., Myers, Stephen A., Restall, Christina, Ferguson, Charles, Pilch, Paul F., McGee, Sean L., Anderson, Robin L., Waters, Michael J., Hancock, John F., Grimmond, Sean M., Muscat, George E. and Parton, Robert G. (2013). Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Reports, 4 (2), 238-247. doi: 10.1016/j.celrep.2013.06.017
Ikonomopoulou, Maria P., Olszowy, Henry, Francis, Rod, Ibrahim, Kamarruddin and Whittier, Joan (2013). Accumulation of trace metals in the embryos and hatchlings of Chelonia mydas from Peninsular Malaysia incubated at different temperatures. Science of the Total Environment, 450, 301-306. doi: 10.1016/j.scitotenv.2013.02.031
Ikonomopoulou, Maria and King, Glenn (2013). Natural born insect killers: Spider-venom peptides and their potential for managing arthropod pests. Outlooks on Pest Management, 24 (1), 16-19. doi: 10.1564/v24_feb_05
Ikonomopoulou, Maria P., Hodge, Mary and Whittier, Joan M. (2012). An investigation of organochlorine and polychlorobiphenyl concentrations in the blood and eggs of the carnivorous flatback turtle, Natator depressus, from Queensland, Australia. Chelonian Conservation and Biology, 11 (2), 255-259. doi: 10.2744/CCB-0981.1
Ikonomopoulou, Maria P., Aland, Rachel C., Ibrahim, Kamarrudin, Gosden, Edward and Whittier, Joan M. (2012). Quantitative sex identification of hatchling green sea turtles (Chelonia mydas). Journal of Herpetology, 46 (3), 331-337. doi: 10.1670/10-333
Ikonomopoulou, Maria P., Olszowy, H, Limpus, C, Francis, R and Whittier, Joan (2011). Trace element concentrations in nesting flatback turtles (Natator depressus) from Curtis Island, Queensland, Australia. Marine Environmental Research, 71 (1), 10-16. doi: 10.1016/j.marenvres.2010.09.003
Ikonomopoulou, M. P., Olszowy, H., Hodge, M. and Bradley, A. J. (2009). The effect of organochlorines and heavy metals on sex steroid-binding proteins in vitro in the plasma of nesting green turtles, Chelonia mydas. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, 179 (5), 653-662. doi: 10.1007/s00360-009-0347-3
Ikonomopoulou, M. P., Ibrahim, K. and Bradley, A. J. (2008). Sex steroid binding proteins in the plasma of hatchling Chelonia mydas. Journal of comparative physiology B, 178 (7), 837-843. doi: 10.1007/s00360-008-0271-y
Ikonomopoulou, MP, Bradley, AJ, Whittier, JM and Ibrahim, K (2006). Identification and properties of steroid-binding proteins in nesting Chelonia mydas plasma. Journal of Comparative Physiology B, 176 (8), 775-782. doi: 10.1007/s00360-006-0099-2
Ikonomopoulou, Maria P. and Rose, Randy W. (2006). The development of endothermy during pouch life in the eastern barred bandicoot (Perameles gunnii), a marsupial. Physiological and Biochemical Zoology, 79 (3), 468-473. doi: 10.1086/502819
Ikonomopoulou, M. P., Smolenski, A. P. and Rose R. W. (2005). Changes in milk composition during lactation in the eastern barred bandicoot (Perameles gunnii) (Marsupialia: Peramelidae). Australian Journal of Zoology, 53 (1), 59-65. doi: 10.1071/ZO04044
Rose, Randy W. and Ikonomopoulou, Maria P. (2005). Shivering and non-shivering thermogenesis in a marsupial, the eastern barred bandicoot (Perameles gunnii). Journal of Thermal Biology, 30 (2), 85-92. doi: 10.1016/j.jtherbio.2004.07.006
Ikonomopoulou, M. P. and Rose, R. W. (2003). The metabolic rate and thermal conductance of the eastern barred bandicoot (Perameles gunnii) at different ambient temperatures. Australian Journal of Zoology, 51 (6), 603-610. doi: 10.1071/ZO03064
Conference Papers
Ryan, R., Ikonomopoulou, M., Haigh, O., Lutzky, V, Martinez, Jimenez R., Ratnatunga, C., Wong, Y., Rojas, Leal, I, Lopez, A., Fry, B., Herzig, V, King, G. and Miles, J. (2016). Exploring the immunosuppressive potential of venom-derived molecules. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Jimenez-Martinez, R., Ikonomopoulou, M., Haigh, O., Lutzky, V, Leal-Rojas, I, Ryan, R., Ratnatunga, C., Wong, Y., Lopez, A., Fry, B., Herzig, V, King, G. and Miles, J. J. (2016). Investigating venom-derived molecules that augment human immune function. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Ikonomopoulou, M. P., Whittier, J. M., Ibrahim, K. and Bradley, A. J. (2007). Sex steroid binding proteins in the plasma of hatchling Chelonia mydas. 45th Annual Meeting of the Australian Marine Sciences Association: AMSA2007, Melbourne, Australia, 9-13 July 2007. Melbourne, Australia: Australian Marine Sciences Association.
Ikonomopoulou, M. P., Bradley, A. J., Whittier J. M. and Ibrahim, K. (2005). Identification and properties of sex steroid binding proteins in nesting Chelonia mydas plasma. ANZSCPB 2005: 22nd Annual Meeting of the Australian and New Zealand Society for Comparative Physiology and Biochemistry, Dunedin, Otago, N.Z., 9-11 December 2005. Dunedin, NZ: Australian & New Zealand Society for Comparative Physiology & Biochemistry.