Rebecca completed her PhD research under Prof. Luke O’Neill in Trinity College Dublin at one of the leading laboratories in the innate immunity field.
For her work on the regulation of TLR signalling she received the International Endotoxin and Innate Immunity Society Young Investigator Award in 2012. However, her main research focus has been inflammasomes and their therapeutic targeting by small molecule drugs. Her recent first author publication on MCC950 in Nature Medicine has been widely acclaimed (the subject of seven commentaries in leading journals and attention from 24 international news outlets) and is already a highly cited paper.
She joined the Schroder group in May 2014 with the goal of defining the molecular target of MCC950 as part of a broader collaboration between the Schroder, Cooper and O’Neill labs.
Book Chapter
Bezbradica, Jelena S., Coll, Rebecca C. and Boucher, Dave (2022). Activation of the Non-canonical Inflammasome in Mouse and Human Cells. Methods in Molecular Biology. (pp. 51-63) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-2144-8_5
Journal Articles
Hartman, George, Humphries, Paul, Hughes, Robert, Ho, Andrew, Montgomery, Rusty, Deshpande, Aditi, Mahanta, Maitriyee, Tronnes, Sarah, Cowdin, Samantha, He, Xu, Liu, Fangchao, Zhang, Lifang, Liu, Chuan, Dou, Dengfeng, Li, Jin, Spasic, Aleksander, Coll, Rebecca, Marleaux, Michael, Hochheiser, Inga V., Geyer, Matthias, Rubin, Paul, Fortney, Kristen and Wilhelmsen, Kevin (2024). The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening. Bioorganic & Medicinal Chemistry Letters, 102 129675, 129675. doi: 10.1016/j.bmcl.2024.129675
Coombs, Jared R., Zamoshnikova, Alina, Holley, Caroline L., Maddugoda, Madhavi P., Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M., Mellacheruvu, Manasa, Coll, Rebecca C., Heinz, Leonhard X., Burgener, Sabrina S., Emming, Stefan, Chamaillard, Mathias, Boucher, Dave and Schroder, Kate (2024). NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling, 17 (820) abg8145, eabg8145. doi: 10.1126/scisignal.abg8145
Mehta, Puja, Samanta, Romit J, Wick, Katherine, Coll, Rebecca C, Mawhinney, Thea, McAleavey, Patrick G, Boyle, Andrew J, Conlon, John, Shankar-Hari, Manu, Rogers, Angela, Calfee, Carolyn S, Matthay, Michael A, Summers, Charlotte, Chambers, Rachel Clare, McAuley, Daniel Francis and O'Kane, Cecilia M (2023). Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS). Thorax, 79 (3), thorax-2023. doi: 10.1136/thorax-2023-220292
Turton, Keren, Parks, Hannah J., Zarodkiewicz, Paulina, Hamad, Mohamad A., Dwane, Rachel, Parau, Georgiana, Ingram, Rebecca J., Coll, Rebecca C., Bryant, Clare E. and Valvano, Miguel A. (2023). The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes. Cell reports, 42 (8) 113012, 1-22. doi: 10.1016/j.celrep.2023.113012
Coll, Rebecca C., Schroder, Kate and Pelegrín, Pablo (2022). NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends in Pharmacological Sciences, 43 (8), 653-668. doi: 10.1016/j.tips.2022.04.003
Schroder, Kate and Coll, Rebecca C. (2021). Caging NLRP3 tames inflammasome activity. Cell, 184 (26), 6224-6226. doi: 10.1016/j.cell.2021.11.035
McKee, Chloe M., Fischer, Fabian A., Bezbradica, Jelena S. and Coll, Rebecca C. (2021). PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling. Biochemical Society Transactions, 49 (6), 2495-2507. doi: 10.1042/bst20200987
McKee, Chloe M. and Coll, Rebecca C. (2020). NLRP3 inflammasome priming: a riddle wrapped in a mystery inside an enigma. Journal of Leukocyte Biology, 108 (3) JLB.3MR0720-513R, 937-952. doi: 10.1002/jlb.3mr0720-513r
Hill, James R., Coll, Rebecca C., Schroder, Kate and Robertson, Avril A.B. (2020). Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters, 61 (19) 151849, 151849. doi: 10.1016/j.tetlet.2020.151849
Coll, Rebecca C. (2019). Role reversal: adaptive immunity instructs inflammasome activation for anti‐viral defence. The EMBO Journal, 38 (21) e103533, e103533. doi: 10.15252/embj.2019103533
Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7
Holley, Caroline L., Coll, Rebecca C. and Schroder, Kate (2018). NLRC3 restrains responses to a T. Immunity, 49 (6), 989-991. doi: 10.1016/j.immuni.2018.12.003
Coll, Rebecca C., Holley, Caroline L. and Schroder, Kate (2018). Correction: Mitochondrial DNA synthesis fuels NLRP3 inflammasome. Cell Research, 28 (12), 1202-1202. doi: 10.1038/s41422-018-0112-9
Coll, Rebecca C., Holley, Caroline L. and Schroder, Kate (2018). Mitochondrial DNA synthesis fuels NLRP3 inflammasome. Cell Research, 28 (11), 1046-1047. doi: 10.1038/s41422-018-0093-8
Kammoun, H. L., Allen, T. L., Henstridge, D. C., Barre, S., Coll, R. C., Lancaster, G. I., Cron, L., Reibe, S., Chan, J. Y., Bensellam, M., Laybutt, D. R., Butler, M. S., Robertson, A. A. B., O'Neill, L. A., Cooper, M. A. and Febbraio, M. A. (2018). Evidence against a role for NLRP3-driven islet inflammation in db/db mice. Molecular Metabolism, 10, 66-73. doi: 10.1016/j.molmet.2018.02.001
Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222
Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114
Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270
Domingo-Fernandez, Raquel, Coll, Rebecca C., Kearney, Jay, Breit, Samuel and O'Neill, Luke A. J. (2017). The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome. Journal of Biological Chemistry, 292 (29), 12077-12087. doi: 10.1074/jbc.M117.797126
Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016). The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 (25), 2960-2975. doi: 10.1182/blood-2016-07-730556
Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210
West, Erin E, Arbore, Giuseppina, Robertson, Avril A.B., Klos, Andreas, Woodruff, Trent M, O’Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J, Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cells. The Journal of Immunology, 196 (1_Supplement), 58.6-58.6. doi: 10.4049/jimmunol.196.supp.58.6
Coll, R. C., O'Neill, L. A. J. and Schroder, K. (2016). Questions and Controversies in innate immune research: What is the physiological role of NLRP3?. Cell Death Discovery, 2 (Art No.: 16019) 16019, 16019. doi: 10.1038/cddiscovery.2016.19
Bezbradica, Jelena S., Coll, Rebecca C. and Schroder, Kate (2016). Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular and Molecular Immunology, 1-9. doi: 10.1038/cmi.2016.11
Finucane, Orla M., Lyons, Claire L., Murphy, Aoife M., Reynolds, Clare M., Klinger, Rut, Healy, Niamh P., Cooke, Aoife A., Coll, Rebecca C., McAllan, Liam, Nilaweera, Kanishka N., O'Reilly, Marcella E., Tierney, Audrey C., Morine, Melissa J., Alcala-Diaz, Juan F., Lopez-Miranda, Jose, O'Connor, Darran P., O'Neill, Luke A., McGillicuddy, Fiona C. and Roche, Helen M. (2015). Monounsaturated fatty acid enriched high fat-diets impede adipose NLRP3 inflammasome mediated IL-1β secretion and insulin resistance despite obesity. Diabetes, 64 (6), 2116-2128. doi: 10.2337/db14-1098
Menon, Deepthi, Coll, Rebecca, O'Neill, Luke A. J and Board, Philip G (2015). GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway. Journal of Cell Science, 128 (10), 1982-1990. doi: 10.1242/jcs.167858
Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806
Greenhill, Claire J., Jones, Gareth W., Nowell, Mari A., Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul N., Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela, Taylor, Philip R., O'Neill, Luke A., Humphreys, Ian R., Williams, Anwen S. and Jones, Simon A. (2014). Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy, 16 (4) 419. doi: 10.1186/s13075-014-0419-y
Menon, Deepthi, Coll, Rebecca, O'Neill, Luke A. J. and Board, Philip G. (2014). Glutathione transferase Omega 1 is required for the lipopolysaccharide- stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages. Free Radical Biology and Medicine, 73, 318-327. doi: 10.1016/j.freeradbiomed.2014.05.020
Coll, R. C., Robertson, A. A.B., Butler, M., Cooper, M. and O'Neill, L. A.J. (2013). Erratum: The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE, 8 (7) e29539. doi: 10.1371/annotation/78d328b9-2c8c-4978-84b1-7e6a0b12ada1
Coll, Rebecca C. and O'Neill, Luke A. J. (2013). Correction: The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes (PLoS ONE). PLoS ONE, 8 (2). doi: 10.1371/annotation/9f221489-155d-4978-a36d-30c51853e438
Haneklaus, Moritz, O'Neill, Luke A. J. and Coll, Rebecca C. (2013). Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: Recent developments. Current Opinion in Immunology, 25 (1), 40-45. doi: 10.1016/j.coi.2012.12.004
Coll, Rebecca C., Robertson, Avril, Butler, Mark, Cooper, Matthew and O'Neill, Luke A. J. (2011). The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE, 6 (12) e29539, e29539. doi: 10.1371/journal.pone.0029539
Masters, Seth L., Dunne, Aisling, Subramanian, Shoba L., Hull, Rebecca L., Tannahill, Gillian M., Sharp, Fiona A., Becker, Christine, Franchi, Luigi, Yoshihara, Eiji, Chen, Zhe, Mullooly, Niamh, Mielke, Lisa A., Harris, James, Coll, Rebecca C., Mills, Kingston H. G., Mok, K. Hun, Newsholme, Philip, Nunez, Gabriel, Yodoi, Junji, Kahn, Steven E., Lavelle, Ed C. and O'Neill, Luke A. J. (2010). Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes. Nature Immunology, 11 (10), 897-904. doi: 10.1038/ni.1935
Coll, Rebecca C. and O'Neill, Luke A. J. (2010). New insights into the regulation of signalling by toll-like receptors and nod-like receptors. Journal of Innate Immunity, 2 (5), 406-421. doi: 10.1159/000315469
Conference Papers
McKelvey, Michael C., Mckee, Chloe M., Mawhinney, Thea, Coll, Rebecca C., O'Kane, Cecilia M., Mcauley, Daniel F., Weldon, Sinead and Taggart, Clifford C. (2023). Understanding the extracellular immunoproteasome in ARDS. Annual congress of the European-Respiratory-Society (ERS), Milan Ia, Sep 09-13, 2023. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2023.PA2335
Schroder, Kate, Boucher, Dave and Coll, Rebecca (2019). New insights into inflammasome signalling and function during inflammation. 48th Annual Scientific Meeting International Society for Experimental Hematology, Brisbane, QLD Australia, 22-25 August 2019. Philadelphia, PA United States: Elsevier . doi: 10.1016/j.exphem.2019.06.258
West, Erin E., Arbore, Giuseppina, Robertson, Avril A. B., Klos, Andreas, Woodruff, Trent M., O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Joerg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cells. Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, United States, 13-17 May 2016. Bethesda, MD, United States: American Association of Immunologists.
Kammoun, H. L., Allen, T. L., Henstridge, D. C., Barre, S., Coll, R. C., Butler, M. S., Roberston, A. A. B., O'Neill, L. A., Murphy, A. J., Cooper, M. A. and Febbraio, M. A. (2016). Evidence against a role for NLRP3-driven inflammation in the db/db mouse model of type 2 diabetes. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200
McGarry, T., Coll, R.C., Robertson, A.A.B., Cooper, M.A., O’Neill, L.A., Veale, D.J. and Fearon, U. (2015). Novel compound cytokine release inhibitory drug 3 (CRID3) inhibits the NLRP3 inflammasome in rheumatoid arthritis. 35th European Workshop for Rheumatology Research, Budapest, Hungary, 5-7 March 2015. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2015-207259.144
Basiorka, A., Mcgraw, K., Eksioglu, E., Chen, X., Johnson, J., Padron, E., Komrokji, R., Sokol, L., Coll, R., O'Neill, L., Cooper, M., Robertson, A., Wei, S. and List, A. (2015). Activation of Redox-Sensitive Inflammasomes Underlies the Biological Phenotype of Myelodysplastic Syndromes. 13th International Symposium on Myelodysplastic Syndromes (MDS), Washington DC, United States, Apr 29-May 02, 2015. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/S0145-2126(15)30033-3
McGarry, T., Robertson, A. A., Orr, C., Coll, R. C., Cooper, M. A., O'Neill, L. A., Veale, D. J. and Fearon, U. (2015). The effect of novel compound MCC950 On the NLRP3 inflammasome in the RA joint. Annual European Congress of Rheumatology, Rome, Italy, 10-13 July 2015. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2015-eular.3985
Arbore, Giuseppina, Fara, Antonella F., Coll, Rebecca, Robertson, Avril, Cooper, Matthew, O'Neill, Luke A. J., Lavender, Paul, Cope, Andrew, Lachmann, Helen J. and Kemper, Claudia (2014). Control of the human Th1 response via autocrine complement-regulated NLRP3 inflammasome activation within CD4(+) T cells. 25th International Complement Workshop, Rio de Janeiro, Brazil, 14-18 September 2014. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2014.07.010
McGarry, Trudy, Connolly, Mary, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., O'Neill, Luke A., Veale, Douglas J. and Fearon, Ursula (2014). Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis. 78th Annual Meeting of the American College of Rheumatology/49th Annual Meeting of the Association of Rheumatology Health Professionals, Boston, MA United States, 14-19 November 2014. Hoboken, NJ United States: John Wiley and Sons.
Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Dungan, Lara S., Munoz-Planillo, Raul, Monks, Brian G., Croker, Daniel E., Sutton, Caroline E., Stutz, Andrea, Nunez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matt A. and O'Neill, Luke A. J. (2014). MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, Oct 26-29, 2014. London United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.037
Dempsey, Colin, Coll, Rebecca, Robertson, Avril, Cooper, Matthew, O'Neill, Luke and Lynch, Marina (2014). Cytokine release inhibitor drug, CRID3, inhibits the NLRP3 inflammasome in glia. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/j.jneuroim.2014.08.393
Greenhill, C. J., Jones, G. W., Nowell, M. A., Harvey, A. K., Moideen, A. N., Collins, F. L., Bloom, A. C., Coll, R., Rosas, M., Taylor, P. R., O'Neill, L. A., Humphreys, I. R., Williams, A. S. and Jones, S. A. (2013). Interleukin 10 control of the inflammasome restricts arthritic bone erosion. Annual Joint Conference of the International-Cytokine-Society and the International-Society-for-Interferon-and-Cytokine-Research, San Francisco Ca, Sep 29-Oct 03, 2013. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2013.06.105
Patents
O'Neill, Luke , Coll, Rebecca , Cooper, Matt , Robertson, Avril , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Sulfonylureas and related compounds and use of the same. WO2017140778.
O'Neill, L. A., Coll, R. C., Cooper, M. A., Robertson, A. A. B., Schroder, K., MacLeod, A. M. and Miller, D. J. (2017). Novel compounds and uses. PCT/IB2017/053059.
O'Neill, Luke, Coll, Rebecca, Cooper, Matt, Robertson, Avril and Schroder, Kate (2016). Sulfonylureas and related compounds and use of the same. WO2016131098.