Dr Fernanda Cardoso
Senior Research Fellow
Institute for Molecular Bioscience
+61 7 344 33402
Researcher biography
Dr Fernanda Cardoso is a Brazil-born Australian researcher interested in venom peptide-based biodiscovery and therapeutics development. Cardoso was awarded an MSc in Molecular Pharmacology and a PhD with an emphasis in Biochemistry and Immunology and is part of the Institute for Molecular Bioscience, where she develops novel therapies for complex neurological diseases. Cardoso has interdisciplinary training in the fields of neuropharmacology, medicinal chemistry and chemical biology and a strong background in drug discovery, which provides the skills to identify naturally occurring or synthetic bioactive molecules and to study their effects in human physiology with applications in neurologic disorders such as chronic pain, irritable bowel syndrome (IBS), and motor neuron disease (MND). Please see Dr Cardoso's Grants and Publications list for more details.
Before joining the University of Queensland, Dr Cardoso was part of the Queensland Institute for Medical Research, holding a prestigious CAPES Postdoctoral Fellowship. During this period, Cardoso developed unique high-throughput screen platforms for discovering protein and peptide targets of novel therapies to combat infectious diseases and novel helminth-derived bioactives with anti-inflammatory properties. Please see Dr Cardoso's Publications list for more details.
Dr Cardoso is currently part of the Centre for Drug Discovery and manages several industry and academic projects studying ion channel modulators derived from natural repertoires, particularly venoms, and developing novel, effective drugs to treat neurological disorders.
Publications
Book Chapters
Muller, Jessica A.I., Kotapati, Charan, Bourke, Lachlan, Tran, Le Thuy Van and Cardoso, Fernanda C. (2024). Amphibian and Reptile Neurotoxins. Reference Module in Neuroscience and Biobehavioral Psychology. (pp. 1-1) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-323-95702-1.00238-4
Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297
Journal Articles
Muller, Jessica A.I. and Cardoso, Fernanda C. (2024). Voltage-gated sodium channel 1.6 as a novel target for amyotrophic lateral sclerosis treatment. Toxicon, 248 107968, 29-29. doi: 10.1016/j.toxicon.2024.107968
Zdenek, Christina N., Cardoso, Fernanda C., Robinson, Samuel D., Mercedes, Raine S., Raidjõe, Enriko R., Hernandez-Vargas, María José, Jin, Jiayi, Corzo, Gerardo, Vetter, Irina, King, Glenn F., Fry, Bryan G. and Walker, Andrew A. (2024). Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs. iScience, 27 (9) 110723, 110723. doi: 10.1016/j.isci.2024.110723
Goudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Mitchell, Michela L., Cook, Lyn G., King, Glenn F. and Walker, Andrew A. (2024). Phylogeny, envenomation syndrome, and membrane permeabilising venom produced by Australia’s electric caterpillar Comana monomorpha. Scientific Reports, 14 (1) 14172, 14172. doi: 10.1038/s41598-024-65078-1
Bittenbinder, Mátyás A., van Thiel, Jory, Cardoso, Fernanda C., Casewell, Nicholas R., Gutiérrez, José-María, Kool, Jeroen and Vonk, Freek J. (2024). Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies. Communications Biology, 7 (1) 358. doi: 10.1038/s42003-024-06019-6
Kramer, Simon, Kotapati, Charan, Cao, Yuanzhao, Fry, Bryan G., Palpant, Nathan J., King, Glenn F. and Cardoso, Fernanda C. (2024). High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms. Toxicon: X, 21 100184, 100184. doi: 10.1016/j.toxcx.2024.100184
Bispat, Anjie, Cardoso, Fernanda, Hasan, Md. Mahadhi, Dongol, Yashad, Wilcox, Ricki, Lewis, Richard, Duggan, Peter James and Tuck, Kellie (2024). Inhibition of N-Type Calcium Channels by Phenoxyaniline and Sulfonamide Analogues. RSC Medicinal Chemistry, 15 (3), 916-936. doi: 10.1039/d3md00714f
Schmit, Matthieu, Hasan, Md. Mahadhi, Dongol, Yashad, Cardoso, Fernanda C., Kuiper, Michael J., Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2024). N-Sulfonylphenoxazines as neuronal calcium ion channel blockers. RSC Medicinal Chemistry, 15 (7), 2400-2412. doi: 10.1039/d4md00336e
Dongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2023). Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes. Frontiers in Pharmacology, 14 1277143, 1-13. doi: 10.3389/fphar.2023.1277143
Ahmadi, Shirin, Benard-Valle, Melisa, Boddum, Kim, Cardoso, Fernanda C., King, Glenn F., Laustsen, Andreas Hougaard and Ljungars, Anne (2023). From squid giant axon to automated patch-clamp: electrophysiology in venom and antivenom research. Frontiers in Pharmacology, 14 1249336, 1-10. doi: 10.3389/fphar.2023.1249336
Walker, Andrew A., Robinson, Samuel D., Merritt, David J., Cardoso, Fernanda C., Goudarzi, Mohaddeseh Hedayati, Mercedes, Raine S., Eagles, David A., Cooper, Paul, Zdenek, Christina N., Fry, Bryan G., Hall, Donald W., Vetter, Irina and King, Glenn F. (2023). Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae). Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120. doi: 10.1073/pnas.2305871120
Grundy, Luke, Tay, Cindy, Christie, Stewart, Harrington, Andrea M., Castro, Joel, Cardoso, Fernanda C., Lewis, Richard J., Zagorodnyuk, Vladimir and Brierley, Stuart M. (2023). The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164 (5), 1012-1026. doi: 10.1097/j.pain.0000000000002795
Servent, Denis, Cardoso, Fernanda C. and De Lima, Maria Elena (2023). Editorial: venom peptides: a rich combinatorial library for drug development, volume II. Frontiers in Molecular Biosciences, 10 1186828, 1-2. doi: 10.3389/fmolb.2023.1186828
Cardoso, F. C., Walker, A. A., King, G. F. and Gomez, M. V. (2023). Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics. Frontiers in Molecular Biosciences, 10 1069764, 1069764. doi: 10.3389/fmolb.2023.1069764
Cardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077
Cardoso, Fernanda C., Servent, Denis and de Lima, Maria Elena (2022). Venom peptides: a rich combinatorial library for drug development. Frontiers in Molecular Biosciences, 9 924023, 924023. doi: 10.3389/fmolb.2022.924023
Cardoso, Fernanda C., Schmit, Matthieu, Kuiper, Michael J., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2022). Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain. RSC Medicinal Chemistry, 13 (2), 183-195. doi: 10.1039/d1md00331c
Dongol, Yashad, Choi, Phil M., Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid. Frontiers in Pharmacology, 12 795455, 795455. doi: 10.3389/fphar.2021.795455
Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457
Jiang, Yan, Castro, Joel, Blomster, Linda V., Agwa, Akello J., Maddern, Jessica, Schober, Gudrun, Herzig, Volker, Chow, Chun Yuen, Cardoso, Fernanda C., Demétrio De Souza França, Paula, Gonzales, Junior, Schroeder, Christina I., Esche, Steffen, Reiner, Thomas, Brierley, Stuart M. and King, Glenn F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology & Translational Science, 4 (4) acsptsci.1c00072, 1362-1378. doi: 10.1021/acsptsci.1c00072
Hasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645
Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041
Peschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107
Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655
Wang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343
Cardoso, Fernanda C (2020). Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology, 181 114107, 114107. doi: 10.1016/j.bcp.2020.114107
Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways. Toxins, 11 (11) 10.3390/toxins11110626, 626. doi: 10.3390/toxins11110626
Estrada-Gomez, Sebastian, Cardoso,Fernanda Caldas, Vargas-Muñoz, Leidy Johana, Quintana-Castillo, Juan Carlos, Gómez, Claudia Marcela Arenas, Pineda, Sandy Steffany and Saldarriaga-Cordoba, Monica Maria (2019). Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channels. Toxins, 11 (9) 496, 496. doi: 10.3390/toxins11090496
Ferraz, Camila R., Arrahman, Arif, Xie, Chunfang, Casewell, Nicholas R., Lewis, Richard J., Kool, Jeroen and Cardoso, Fernanda C. (2019). Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis. Frontiers in Ecology and Evolution, 7 (JUN) 218. doi: 10.3389/fevo.2019.00218
Cardoso, Fernanda C. and Lewis, Richard J. (2019). Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels. Frontiers in Pharmacology, 10 (APR) 366, 366. doi: 10.3389/fphar.2019.00366
Ziegman, Rebekah , Brust, Andreas , Jha, Prerna , Cardoso, Fernanda C. , Lewis, Richard J. and Alewood, Paul F. (2019). ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs, 17 (3) 165, 165. doi: 10.3390/md17030165
Slagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R. and Kool, Jeroen (2018). Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon, 148, 213-222. doi: 10.1016/j.toxicon.2018.04.022
Sairaman, Anjali, Cardoso, Fernanda Caldas, Bispat, Anjie, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2018). Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic and Medicinal Chemistry, 26 (11), 3046-3059. doi: 10.1016/j.bmc.2018.03.031
Stefanucci, Azzurra, Novelino, Ettore, Macedonio, Giorgia, Dimmito, Marilia Pia, Mirzaie, Sako, Cardoso, Fernanda Caldas , Lewis, Richard, Zador, Ferenc, Erdei, Anna I., Dvoracsko, Szabolcs, Tomboly, Csaba, Benych, Sandor, Pieretti, Stefano, Minosi, Paola and Mollica, Adriano (2018). Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry, 42 (8), 5656-5659. doi: 10.1039/c7nj04969b
Cardoso, Fernanda C., Hasan, Mahadhi, Zhao, Tianjiao and Lewis, Richard J. (2018). Toxins in pain. Current Opinion in Supportive and Palliative Care, 12 (2), 1-10. doi: 10.1097/SPC.0000000000000335
Cardoso, Fernanda Caldas and Lewis, Richard J. (2017). Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology, 175 (12), 2138-2157. doi: 10.1111/bph.13962
Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865
Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551
Touchard, Axel, Brust, Andreas, Cardoso, Fernanda C., Chin, K.-Y., Herzig, Volker, Jin, Ai-Hua, Dejean, Alain, Alewood, Paul F., King, Glenn F., Orivel, Jérôme and Escoubas, Pierre (2016). Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus. Biochimica et Biophysica Acta, 1860 (11 Part A), 2553-2562. doi: 10.1016/j.bbagen.2016.07.027
Prashanth, J. R., Dutertre, S., Jin, A. H., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2015). The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology, 25 (2), 598-615. doi: 10.1111/mec.13504
Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178
Driguez, Patrick, McWilliam, Hamish E. G., Gaze, Soraya, Piedrafita, David, Pearson, Mark S., Nakajima, Rie, Duke, Mary, Trieu, Angela, Doolan, Denise L., Cardoso, Fernanda C., Jasinskas, Algis, Gobert, Geoffrey N., Felgner, Philip L., Loukas, Alex, Meeusen, Els and McManus, Donald P. (2015). Specific humoral response of hosts with variable schistosomiasis susceptibility. Immunology and Cell Biology, 94 (1), 52-65. doi: 10.1038/icb.2015.61
Driguez, Patrick, Li, Yuesheng, Gaze, Soraya, Pearson, Mark S., Nakajima, Rie, Trieu, Angela, Doolan, Denise L., Felgner, Philip L., Hou, Xunya, Cardoso, Fernanda C., Jasinskas, Algis, Gobert, Geoffrey, Loukas, Alexander C. and McManus, Donald P. (2015). Antibody signatures reflect different disease pathologies in schistosomiasis japonica. Journal of Infectious Diseases, 213 (1), 122-130. doi: 10.1093/infdis/jiv356
Pinheiro, Carina S., Ribeiro, Ana Paula Dias, Cardoso, Fernanda C., Martins, Vicente P., Figueiredo, Barbara C. P., Assis, Natan R. G., Morais, Suellen B., Caliari, Marcelo V., Loukas, Alex and Oliveira, Sergio C. (2014). A multivalent chimeric vaccine composed of Schistosoma mansoni SmTSP-2 and Sm29 was able to induce protection against infection in mice. Parasite Immunology, Accepted Article (7), 1-23. doi: 10.1111/pim.12118
Gaze, Soraya, Driguez, Patrick, Pearson, Mark S., Mendes, Tiago, Doolan, Denise L., Trieu, Angela, McManus, Donald P., Gobert, Geoffrey N., Periago, Maria Victoria, Correa Oliveira, Rodrigo, Cardoso, Fernanda C., Oliveira, Guilherme, Nakajima, Rie, Jasinskas, Al, Hung, Chris, Liang, Li, Pablo, Jozelyn, Bethony, Jeffrey M., Felgner, Philip L. and Loukas, Alex (2014). An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas. PLoS Pathogens, 10 (3) e1004033, e1004033.1-e1004033.16. doi: 10.1371/journal.ppat.1004033
Cardoso, Fernanda C., Roddick, Joanne S., Groves, Penny and Doolan, Denise L. (2011). Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale. Plos One, 6 (11) e27666, e27666.1-e27666.14. doi: 10.1371/journal.pone.0027666
Rodrigues, Thiago de Souza, Cardoso, Fernanda Caldas, Ribeiro Teixeira, Santuza Maria, Oliveira, Sergio Costa and Braga, Antonio Padua (2011). Protein classification with extended-sequence coding by sliding window. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 8 (6) 5765931, 1721-1726. doi: 10.1109/TCBB.2011.78
Pinho, J. M. R., Cardoso, F. C., Lopes, D. O., Pinheiro, C. S., Caliari, M. V., Oliveira, F. M. S., Leite, L. C. and Oliveira, S. C. (2010). Immunization with SmIg, a novel tegument protein from Schistosoma mansoni, fails to induce protection in mice but reduces liver pathology. Parasitology, 137 (07), 1079-1088. doi: 10.1017/S0031182009991387
Cardoso, L. S., Oliveira, S. C., Góes, A. M., Oliveira, R. R., Pacífico, L. G., Marinho, F. V., Fonseca, C. T., Cardoso, F. C., Carvalho, E. M. and Araujo, M. I. (2010). Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation. Clinical and Experimental Immunology, 160 (2), 266-274. doi: 10.1111/j.1365-2249.2009.04084.x
Nogueira, Lucas, Cardoso, Fernanda C., Mattos, Ana M., Bordignon, Juliano, Figueiredo, Cláudia P., Dahlstrom, Pedro, Frota, Cristiane C., Duarte dos Santos, Cláudia N., Chalhoub, Marcelo, Cavada, Benildo S., Teixeira, Henrique C., Oliveira, Sérgio C., Barral-Netto, Manoel and Báfica, André (2010). Mycobacterium tuberculosis Rv1419 encodes a secreted 13 kDa lectin with immunological reactivity during human tuberculosis. European Journal of Immunology, 40 (3), 744-753. doi: 10.1002/eji.200939747
Farias, Leonardo P., Cardoso, Fernanda C., Miyasato, Patricia A., Montoya, Bogar O., Tararam, Cibele A., Roffato, Henrique K., Kawano, Toshie, Gazzinelli, Andrea, Correa-Oliveira, Rodrigo, Coulson, Patricia S., Wilson, R. Alan, Oliveira, Sérgio C. and Leite, Luciana C. C. (2010). Schistosoma mansoni Stomatin like protein-2 is located in the tegument and induces partial protection against challenge infection. PLoS Neglected Tropical Diseases, 4 (2) e597, e597-1-e597-13. doi: 10.1371/journal.pntd.0000597
Drummond, Marcela G., Calzavara-Silva, Carlos E., D'Astolfo, Diego S., Cardoso, Fernanda C., Rajao, Matheus A., Mourão, Marina M., Gava, Elisandra, Oliveira, Sérgio C., Macedo, Andréa M., Machado, Carlos R., Pena, Sérgio D. J., Kitten, Gregory T. and Franco, Glória R. (2009). Molecular characterization of the Schistosoma mansoni zinc finger protein SmZF1 as a transcription factor. PLoS Neglected Tropical Diseases, 3 (11) e547, e547.1-e547.10. doi: 10.1371/journal.pntd.0000547
Lopes, Debora O., Paiva, Leonardo F., Martins, Mauricio A., Cardoso, Fernanda C., Rajao, Matheus A., Pinho, Jean M., Caliari, Marcelo V., Correa-Oliveira, Rodrigo, Mello, Samantha M., Leite, Luciana. C. C. and Oliveira, Sergio C. (2009). Sm21.6 a novel EF-hand family protein member located on the surface of Schistosoma mansoni adult worm that failed to induce protection against challenge infection but reduced liver pathology. Vaccine, 27 (31), 4127-4135. doi: 10.1016/j.vaccine.2009.04.068
Pihno, Jean Marcel Rodrigues, Dorella, Fernanda Alves, Coelho, Keila da Silva, Fonseca, Cristina Toscano, Cardoso, Fernanda Caldas, Meyer, Roberto, Portela, Ricardo Wagner Dias, Oliveira, Sergio Costa, Miyoshi, Anderson and Azevedo, Vasco (2009). Immunization with recombinant Corynebacterium pseudotuberculosis heat-shock protein (Hsp)-60 is able to induce an immune response in mice, but fails to confer protection against infection. The Open Veterinary Science Journal, 3, 22-27. doi: 10.2174/1874318809003010022
Oliveira, Sergio C., Fonseca, Cristina T., Cardoso, Fernanda C., Farias, Leonardo P. and Leite, Luciana C. C. (2008). Recent advances in vaccine research against schistosomiasis in Brazil. Acta Tropica, 108 (2-3), 256-262. doi: 10.1016/j.actatropica.2008.05.023
Cardoso, Fernanda C., Macedo, Gilson C., Gava, Elisandra, Kitten, Gregory T., Mati, Vitor L., de Melo, Alan L., Caliari, Marcelo V., Almeida, Giulliana T., Venancio, Thiago M., Verjovski-Almeida, Sergio and Oliveira, Sergio C. (2008). Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection. PLoS Neglected Tropical Diseases, 2 (10) e308, e308.1-e308.10. doi: 10.1371/journal.pntd.0000308
Miyoshi, Anderson, Rosinha, Gracia M.S., Camargo, Ilana L.B.C., Trant, Cyntia M.C., Cardoso, Fernanda C., Azevedo, Vasco and Oliveira, Sergio C. (2007). The role of the vacB gene in the pathogenesis of Brucella abortus. Microbes and Infection, 9 (3), 375-391. doi: 10.1016/j.micinf.2006.12.004
Cardoso, F. C., Pinho, J. M. R., Azevedo, V. and Oliveira, S. C. (2006). Identification of a new Schistosoma mansoni membrane-bound protein through bioinformatic analysis. Genetics and Molecular Research, 5 (4), 609-618.
Cardoso, F. C., Pacífico, R. N. A., Mortara, R. A. and Oliveira, S. C. (2006). Human antibody responses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies. Clinical and Experimental Immunology, 144 (3), 382-391. doi: 10.1111/j.1365-2249.2006.03081.x
Cardoso, F. C., Pacífico, L. G., Carvalho, D. C., Victoria, J. M. N., Neves, A. L. G., Chavez-Olortegui, C., Gomez, M. V. and Kalapothakis, E. (2003). Molecular cloning and characterization of Phoneutria nigriventer toxins active on calcium channels. Toxicon, 41 (7), 755-763. doi: 10.1016/S0041-0101(03)00011-4
Conference Papers
Kotapati, Charan and Cardoso, Fernanda C. (2024). Modulation of the complex NaV1.2β4 as a therapeutic strategy to cease motor neuron hyperexcitability prior to the onset of Amyotrophic Lateral Sclerosis. Cellular and Molecular Advances in Neurodegeneration, Brisbane, QLD, Australia, 3 - 4 December 2024.
Muller, Jessica A.I. and Cardoso, Fernanda C. (2024). Voltage-gated sodium channel 1.6 as a novel target for amyotrophic lateral sclerosis treatment. Cellular and Molecular Advances in Neurodegeneration, Brisbane, QLD, Australia, 3 - 4 December 2024.
Cardoso, Fernanda C. (2024). Venom peptides unlock dysfunctional ion channels in motor neurodegeneration and shed light onto pathophysiology and key drug targets. IST World Congress 2024, Singapore, 20 - 25 May 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2024.107904
Cardoso, Fernanda C. (2024). Probing ion channels on motor neuron pathways to elucidate pathophysiological mechanisms and unravel novel drug targets in motor neurodegeneration. Ion Channel Modulation Symposium, Cambridge, United Kingdom, 18-20 July 2024.
Pinter, Michael, Wirth, Hayden, Goudarzi, Mohaddeseh, Muller, Jessica A. I., Nixon, Samantha, Walker, Andrew A., King, Glenn F. and Cardoso, Fernanda C. (2024). Characterisation of novel venom peptides from the underexplored Australian Wishbone Spider. East Coast Protein Meeting by the Australian Society for Biochemistry and Molecular Biology (ASBMB), Coffs Coast, NSW, Australia, 17-19 July 2024.
Kotapati, Charan and Cardoso, Fernanda C. (2024). Modulation of the complex NaV1.2β4 as a therapeutic strategy to cease motor neuron hyperexcitability prior to the onset of Amyotrophic Lateral Sclerosis. Institute for Molecular Bioscience Student Symposium, Brisbane, QLD, Australia, 12 July.
Pinter, Michael, Wirth, Hayden, Goudarzi, Mohaddeseh, Muller, Jessica A.I., Nixon, Samantha, Walker, Andrew A., King, Glenn F. and Cardoso, Fernanda C. (2024). Characterisation of novel venom peptides from the underexplored Australian Wishbone Spider. Institute for Molecular Bioscience Student Symposium, Brisbane, QLD, Australia, 12 July 2024.
Cardoso, Fernanda C. (2024). Probing ion channels on motor neuron pathways to elucidate pathophysiological mechanisms and unravel novel drug targets in motor neurodegeneration. Venom Week IX, Durham, USA, 5-8 June 2024.
Cardoso, Fernanda C. (2024). Probing ion channels on motor neuron pathways to elucidate pathophysiological mechanisms and unravel novel drug targets in motor neurodenegeration. 22nd World Congress of the International Society on Toxinology, Singapore, 20 - 25 May 2024.
Muller, Jessica A.I. and Cardoso, Fernanda C. (2024). Voltage-gated sodium channel 1.6 as a novel target for amyotrophic lateral sclerosis treatment. 22nd World Congress of the International Society on Toxinology, Singapore, 20 - 25 May 2024.
Muller, Jessica A.I. and Cardoso, Fernanda C. (2024). Voltage-gated sodium channel 1.6 as a novel target for amyotrophic lateral sclerosis treatment. XIII World Congress of the International Society on Toxinology, Singapore, Singapore, 20 - 25 May 2024.
Cardoso, Fernanda C. (2023). Novel neuroprotective drugs inspired by venom-peptide inhibitors of ion channels to treat Amyotrophic Lateral Sclerosis. XVII Congress of the Brazilian Society of Toxinology/XIII Congress of the Pan American Section of the International Society on Toxinology, Brasilia, Brazil, 9-13 November 2023.
Kotapati, Charan and Cardoso, Fernanda C. (2023). Peptide-based medicine: designing novel voltage-gated sodium channel inhibitors to treat motor neuron disease. Centre for Chemistry and Drug Development Symposium, Brisbane, QLD, Australia, 2 November 2023.
Cardoso, Fernanda C. (2023). Venom peptide inhibitors of sodium channels are a new drug class to treat neurodegenerative diseases. V2D 2023: 8th Venom to Drugs Conference, Moreton Island, QLD, Australia, 9 - 14 October 2023.
Goudarzi, Mohaddeseh H., Robinson, Samuel, Cardoso, Fernanda C., Lawrence, Nicole, Eagles, David, Chin, Y., King, Glenn F. and Walker, Andrew A. (2023). Structure, function, and evolution of nettle caterpillar venom toxins. V2D 2023: 8th Venoms to Drugs Conference, Moreton Island, QLD, Australia, 9-13 October 2023.
Bourke, Lachlan A., Fry, Bryan, G. and Cardoso, Fernanda C. (2023). Using a novel high throughput multiplex assay to evaluate cytotoxicity and calcium modulation of Bothrops venoms. Institute for Molecular Bioscience Student Symposium, Brisbane, QLD, Australia, 7 July 2023.
Cardoso, Fernanda C. (2023). Novel inhibitors of sodium channels in the fight against motor neuron disease. Gordon Research Conference in Motor Neuron Disease, Les Diableretes, Switzerland, 2 - 7 July 2023.
Cardoso, Fernanda C. (2022). Modulation of neuronal hyperexcitability by the spider peptide ProTx-III prevents loss of motor function in motor neuron disease. 21st World Congress of the International Society on Toxinology, Adu Dhabi, United Arab Emirates, 16-21 October 2022.
Cardoso, Fernanda C. (2022). From venoms to bedside table: lessons from venoms targeting ion channels in disease. II Simpósio Internacional de Pesquisa e Extensão Acadêmica, Belo Horizonte, Brazil, 15 September 2022.
Cardoso, Fernanda C. (2022). High-throughput bioassays applied to phylogenetic and envenomation studies of spider and snake venoms. Venom Week VIII, Scottsdale, AZ, United States, 18-21 July 2022.
Wirth, Hayden and Cardoso, Fernanda C. (2022). The unexplored pharmacopeia of Australian spider venoms: learning from the experts. Pathogens and Natural Toxins e-Conference section Venomous Animals, Brisbane, Australia, 1 July - 31 August 2022.
Kotapati, Charan , Bellingham, Mark C. and Cardoso, Fernanda C. (2022). Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease. Pathogens and Natural Toxins e-Conference section Diagnostics and Therapeutics From Natural Toxins, Brisbane, Australia, 1 July - 31 August 2022.
Cardoso, Fernanda C. (2021). Rapid optimization of spider peptides using conserved structure-function traits. Venom to Drugs Conference, Daydream Island, QLD Australia, 15-19 March 2021.
Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.
Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7. Venom to Drugs, Daydream Island, QLD, Australia, 15-19 March 2021.
Zhao, Tianjiao, Rosengren, Johan K., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Structure-function of the spider peptide ProTx-III. Venom to Drugs, Daydream Island, QLD Australia, 15-19 March 2021.
Dongol, Y., Choi, P., Wilson, D., Cardoso, F. C. and Lewis, R. J. (2020). Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency
and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy. SBMS Postgraduate Symposium in Biomedical Sciences, Brisbane, QLD Australia, 24 November 2020.
Cardoso, Fernanda (2020). Harnessing multifunctional spider-venom peptides to modulate pain pathways. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier . doi: 10.1016/j.toxicon.2019.10.082
Cardoso, Fernanda C., King, Glenn F. and Lewis, R. J. (2019). Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017. Oxford, United Kingdom: Elsevier.
Cardoso, Fernanda C. (2019). Harnessing multifunctional spider peptides to modulate pain pathways. International Society for Toxinology World Conference 2019, Buenos Aires, Argentina, 8-13 September 2019. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD.
Cardoso, Fernadna C. (2019). Structure-function relationships of spider venom neurotoxins: what are we learning from it?. Pain Retreat 2019, Stradbroke Island, QLD, Australia, 27-29 May 2019.
Dongol, Yashad, Choi, Phil, Wilson, David, Cardoso, Fernanda C. and Lewis, Richards J. (2019). Rational design of spider knottin Phlo3a to strategically modulate multiple noxious NaV channels. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD, Australia, 29 November 2019.
Mawlawi, Saja E., Zhao, Thianjiao, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Cooperative interactions of loops 1, 4 and C-terminal of the ICK spider peptide Tap1a engender NaV inhibitory properties. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.
Hu, Huyiu, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Molecular interactions between spider toxins and the sodium channel Nav1.1. Pain Retreat 2019, Stradbroke Island, QLD Australia, 27-29 May 2019.
Zhao, Tianjiao, Rosengren, K. Johan, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.
Wang, Dan, Himaya, S. W. A., Giacomotto, Jean, Hasan, Mahadhi, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Characterization of δ-conotoxin Tx-VIA as selective T-type modulator. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD, Australia, 29 November 2019.
Hasan, Mahadhi, Mueller, Alexander, Starobova, Hana, Vetter, Irina, Cardoso, Fernanda C. and Lewis, Richard J. (2019). New insights in ω-conotoxin analgesic efficacy in postsurgical pain and oxaliplatin/cisplatin induced peripheral neuropathy. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.
Dongol, Y., Cardoso, F. C. and Lewis, R. J. (2018). Can Phlo3a – a newly discovered spider knottin – meets the challenges to strategically modulate noxious Nav-channels?. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.
Hasan, M.D., Cardoso, F.C. and Lewis, R.J. (2018). Comparative analysis of transfection methods to establish high-throughput automated electrophysiology assays for key ion channels involved in pain. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.
Cardoso, F. C., Herzig, V., King, G. F. and Lewis, R. J. (2018). Counter screen of spider venoms reveals novel sodium and calcium channel inhibitors of chronic pain targets.. Gordon Research Conference on Venom Evolution, Function and Biomedical Applications 2018, Mount Snow, VT, United States, 5-10 August 2018.
Ferraz, C. R., Cardos, F. C., Clissa, P. B., Vetter, I., Verri Jr, W. A. and Lewis, R. J. (2018). Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.
Zhao, T., Cardoso, F.C. and Lewis, R.J. (2018). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.
Cardoso, Fernanda C., King, Glenn F. and Lewis, Richard J. (2017). Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain.. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017.
Cardoso, Fernanda C., Bellingham, Mark C., King, Glenn F. and Lewis, Richard J. (2017). Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.
Wang, D., Herzig, V., Dekan, Z., Ragnarsson, Lotten K. N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). High-throughput cell-based assays for screening Cav3.2 modulators from venoms. Venom to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017.
Hassan, Mahadhi, Abraham, Nikita, Ragnarsson, Lotten K.N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.
Sairaman, Anjali, Cardoso, Fernanda Caldas , Lewis, Richard J., Kaliappana, Krishna P., Tuck, Kellie L. and Duggan, Peter J. (2016). The inhibition of neuronal calcium channels with aminobenzothiazole derivatives. RACI Medicinal Chemistry and Chemical Biology Conference 2016, Coogee Beach, NSW, Australia, 7-9 November 2016.
Cardoso, Fernanda Caldas , Herzig, Volker , King, Glenn F. and Lewis, Richard J. (2015). Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays. 18th World Congress of the International Society on Toxinology, Oxford UK, 25-30 September 2015.
Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.
Prashanth, J. R., Dutertre, S., Jean, A., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2014). Unique evolution of D-conotoxins for defence. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 August 2014.
Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.
Erickson, A., Cardoso, F. C., Lewis, R. J. and King, G. F. (2014). Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.
Prashanth, J. R., Dutertre, S., Lavergne, V., Hamilton, B., Cardoso, F. C., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2013). The injected venom of vermivorous cone snails. 10th Australian Peptides Conference, Penang, Malaysia, 8-13 September 2013.
Cardoso, F. C., Herzig, V., Hauke, T., King, G. F. and Lewis, R. J. (2013). Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain. CASB Division Symposium 2013, Brisbane Australia, 7 November, 2013.
Cardoso, F. C., Herzig, V., Hauke, T., Lewis, R. J. and King, G. F. (2013). Discovery of novel spider peptides blocking hNav1.7. 3rd Annual Conference of the Toxinological Society of India and 1st International Conference on “Biology of Natural Toxins”, Goa, India, 19-21 December, 2013.
Cardoso, F. C., Groves, P., Roddick, J. and Doolan, D. L. (2010). Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses. XII International Conference for Parasitology, Melbourme, Australia, 15-20 August 2010.
Cardoso, F. C., Trieu, A., Groves, P. and Doolan, D. L. (2010). Proteome-wide screening of antigens targeted by cell mediated immune responses. 14th International Congress of Immunology, Kobe, Japan, 22-27 August 2010.
Cardoso, F. C., Pearson, M., Giacomoantonio, P., Tribolet, L., Pickering, D., Shoemaker, C., Oliveira, S. C. and Loukas, A. (2008). Vaccines against Schistosomiasis: production of single and chimeric tegument antigens for pre-clinical and clinical studies. 11th Symposium of Schistosomiasis, Salvador, BA, Brazil, 20-22 August 2008.
Cardoso, F. C., Gava, E., Macedo, G. C., Kitten, G. T., Mello, A. L., Caliari, M. V. and Oliveira, S. C. (2007). Vaccine against schistosomiasis: The role of a new tegument protein Sm29 on human and murine protective immune responses. 13th International Congress of Immunology, Rio de Janeiro, Brazil, 21-25 August 2007.
Cardoso, F. C., Pacifico, R. N. A. and Oliveira, S. C. (2005). Human IgG3 recognition of Schistosoma mansoni 29 kDa membrane bound protien identified by a bioinformatic approach. XLI Congress of Brazilian Society of Tropical Medicine, Florianopolis, Brazil, 6-10 March 2005.
Preprint
Seminar Papers
Cardoso, Fernanda C. (2024). Probing ion channels to unlock effective therapies for Motor Neuron Disease. MND@UQ Collective Meeting, The University of Queensland, Brisbane.
Cardoso, Fernanda C. (2023). Venom peptides targeting ion channels: discovery and translation into novel therapeutics. Centre of Excellence in New Target Discovery, Butantan Institute.
Cardoso, Fernanda C. (2023). Next generation of neurological drugs inspired by venom-peptide inhibitors of voltage-gated ion channels. International Society for Toxinology Asia-Pacific section Webinar series, International Society for Toxinology Asia-Pacific section.
Cardoso, Fernanda C. (2023). Venom-based drug discovery focused on ion channels modulation. Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland.
Cardoso, Fernanda C. (2023). Novel peptide inhibitors of sodium channels in the fight against motor neuron disease. UQ Centre for Clinical Research, The University of Queensland.
Cardoso, Fernanda C. (2022). Spider-venom peptides: discovery, structure-function properties, and translation into novel therapeutics. Faculdade Santa Casa, Faculdade Santa Casa, Belo Horizonte, Brazil.
Cardoso, Fernanda C. (2022). Bioassays applied to venomics: from phylogenetics to therapeutic leads unravelled via high-throughput screening bioassays. Chemistry and Structural Biology Division, The University of Queensland.
Patents
Cardoso, F. C. and Oliveira, S. C. (2007). Membrane protein Sm29 of S. mansoni and uses thereof as vaccine and for diagnosing of schistosomiasis. WO 2007118292 A2.