Dr Alesha Hatton
Postdoctoral Research Fellow
Institute for Molecular Bioscience
Researcher biography
Alesha Hatton is a postdoctoral research fellow specializing in statistical genetics and genetic epidemiology at the Institute for Molecular Bioscience, University of Queensland. Currently, her research focuses on understanding the genetic and environmental aetiology underlying complex traits through use of Mendelian randomization and statistical genetics methodologies. Her PhD was in systems genomics, applying quantitative genetics methods to investigate the role of DNA methylation in complex trait variation. Alesha has a bachelor's degree in medical mathematics from the University of Wollongong (2016) and previously was employed as a statistician at the South Australian health and Medical Research Institute.
Journal Articles
Hatton, Alesha A., Cheng, Fei-Fei, Lin, Tian, Shen, Ren-Juan, Chen, Jie, Zheng, Zhili, Qu, Jia, Lyu, Fan, Harris, Sarah E., Cox, Simon R., Jin, Zi-Bing, Martin, Nicholas G., Fan, Dongsheng, Montgomery, Grant W., Yang, Jian, Wray, Naomi R., Marioni, Riccardo E., Visscher, Peter M. and McRae, Allan F. (2024). Genetic control of DNA methylation is largely shared across European and East Asian populations. Nature Communications, 15 (1) 2713, 1-12. doi: 10.1038/s41467-024-47005-0
Vaotuua, D., O’Connor, P., Belford, M., Lewis, P., Hatton, A., Holder, C. and McAuliffe, M. (2023). The effect of surgeon volume on revision for periprosthetic joint infection: an analysis of 602,919 primary total knee arthroplasties. Journal of Bone and Joint Surgery, 105 (21), 1663-1675. doi: 10.2106/jbjs.22.01351
Hatton, Alesha A., Hillary, Robert F., Bernabeu, Elena, McCartney, Daniel L., Marioni, Riccardo E. and McRae, Allan F. (2023). Blood-based genome-wide DNA methylation correlations across body-fat- and adiposity-related biochemical traits. The American Journal of Human Genetics, 110 (9), 1564-1573. doi: 10.1016/j.ajhg.2023.08.004
Sandow, Michael, Page, Richard, Hatton, Alesha and Peng, Yi (2022). Total shoulder replacement stems in osteoarthritis – short, long or reverse? An analysis of the impact of cross-linked polyethylene. Journal of Shoulder and Elbow Surgery, 31 (11), 2249-2255. doi: 10.1016/j.jse.2022.04.015
Agarwal, Sujit, Eckhard, Lukas, Walter, William L., Peng, Andrea, Hatton, Alesha, Donnelly, Bill and de Steiger, Richard (2021). The use of computer navigation in total hip arthroplasty is associated with a reduced rate of revision for dislocation: a study of 6,912 navigated THA procedures from the Australian Orthopaedic Association National Joint Replacement Registry. Journal of Bone and Joint Surgery: American Volume, 103 (20), 1900-1905. doi: 10.2106/JBJS.20.00950
Stoney, James, Graves, Stephen E., de Steiger, Richard N., Rainbird, Sophia, Kelly BMath, Thu-Lan and Hatton, Alesha (2021). Reply to the letter to the editor: is the survivorship of Birmingham hip resurfacing better than selected conventional hip arthroplasties in men younger than 65 years of age? A study from the Australian Orthopaedic Association National Joint Replacement Registry. Clinical Orthopaedics and Related Research, 479 (9), 2108-2109. doi: 10.1097/CORR.0000000000001902
Gill, David R J, Page, Richard S, Graves, Stephen E, Rainbird, Sophia and Hatton, Alesha (2021). The rate of 2nd revision for shoulder arthroplasty as analyzed by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). Acta Orthopaedica, 92 (3), 1-6. doi: 10.1080/17453674.2020.1871559
Hoskins, Wayne, Griffin, Xavier, Hatton, Alesha, de Steiger, Richard N and Bingham, Roger (2021). THA for a fractured femoral neck: comparing the revision and dislocation rates of standard-head, large-head, dual-mobility, and constrained liners. Clinical Orthopaedics and Related Research, 479 (1), 72-81. doi: 10.1097/CORR.0000000000001447
Hoskins, Wayne, Bingham, Roger, Hatton, Alesha and de Steiger, Richard N. (2020). Standard, large-head, dual-mobility, or constrained-liner revision total hip arthroplasty for a diagnosis of dislocation: an analysis of 1,275 revision total hip replacements. Journal of Bone and Joint Surgery: American Volume, 102 (23), 2060-2067. doi: 10.2106/JBJS.20.00479
Hoskins, Wayne, Bingham, Roger, Lorimer, Michelle, Hatton, Alesha and de Steiger, Richard N. (2020). Early rate of revision of total hip arthroplasty related to surgical approach: an analysis of 122,345 primary total hip arthroplasties. Journal of Bone and Joint Surgery: American Volume, 102 (21), 1874-1882. doi: 10.2106/JBJS.19.01289
Stoney, James, Graves, Stephen E., de Steiger, Richard N., Rainbird, Sophia, Kelly, Thu-Lan and Hatton, Alesha (2020). Is the survivorship of Birmingham hip resurfacing better than selected conventional hip arthroplasties in men younger than 65 years of age? A study from the Australian Orthopaedic Association National Joint Replacement Registry. Clinical Orthopaedics and Related Research, 478 (11), 2625-2636. doi: 10.1097/CORR.0000000000001453
Calabro, Lorenzo, Yong, Mostyn, Whitehouse, Sarah L., Hatton, Alesha, de Steiger, Richard and Crawford, Ross W. (2020). Mortality and implant survival with simultaneous and staged bilateral total hip arthroplasty: experience from the Australian Orthopaedic Association National Joint Replacement Registry. Journal of Arthroplasty, 35 (9), 2518-2524. doi: 10.1016/j.arth.2020.04.027
Knight, Matthew, Lewis, Peter, Peng, Yi, Hatton, Alesha B. and Parkinson, Ben (2020). Survivorship of highly constrained prostheses in primary and revision total knee arthroplasty: analysis of 6070 cases. ANZ Journal of Surgery, 90 (10) ans.16182, 2061-2067. doi: 10.1111/ans.16182
Klasan, Antonio, de Steiger, Richard, Holland, Sherina, Hatton, Alesha, Vertullo, Christopher J. and Young, Simon W. (2020). Similar risk of revision after kinematically aligned, patient-specific instrumented total knee arthroplasty, and all other total knee arthroplasty: combined results from the Australian and New Zealand joint replacement registries. Journal of Arthroplasty, 35 (10), 2872-2877. doi: 10.1016/j.arth.2020.05.065
Lewis, Peter L., Graves, Stephen E., de Steiger, Richard N., Campbell, David G., Peng, Yi, Hatton, Alesha and Lorimer, Michelle (2020). Does knee prosthesis survivorship improve when implant designs change? Findings from the Australian Orthopaedic Association National Joint Replacement Registry. Clinical Orthopaedics and Related Research, 478 (6), 1156-1172. doi: 10.1097/corr.0000000000001229
de Steiger, R N., Hatton, Alesha, Peng, Yi and Graves, Stephen (2020). What is the risk of THA revision for ARMD in patients with non-metal-on-metal bearings? A study from the Australian National Joint Replacement Registry. Clinical Orthopaedics and Related Research, 478 (6), 1244-1253. doi: 10.1097/corr.0000000000001277
Blythe, Robin, O'Gorman, Patricia M., Crawford, Ross W., Feenan, Rachel, Hatton, Alesha, Whitehouse, Sarah L. and Graves, Nicholas (2020). Fixation method for hip arthroplasty stem following hip fracture: a population-level cost-effectiveness analysis. Journal of Arthroplasty, 35 (6), 1614-1621. doi: 10.1016/j.arth.2020.02.001
Brown, Jamie S., Gordon, Robert J., Peng, Yi, Hatton, Alesha, Page, Richard S. and Macgroarty, Kelly A. (2020). Lower operating volume in shoulder arthroplasty is associated with increased revision rates in the early postoperative period: long-term analysis from the Australian Orthopaedic Association National Joint Replacement Registry. Journal of Shoulder and Elbow Surgery, 29 (6), 1104-1114. doi: 10.1016/j.jse.2019.10.026
Harris, Ian A., Hatton, Alesha, de Steiger, Richard, Lewis, Peter and Graves, Stephen (2020). Declining early mortality after hip and knee arthroplasty. ANZ Journal of Surgery, 90 (1-2), 119-122. doi: 10.1111/ans.15529
Coory, Joseph A., Tan, Kelvin G., Whitehouse, Sarah L., Hatton, Alesha, Graves, Stephen E. and Crawford, Ross W. (2020). The outcome of total knee arthroplasty with and without patellar resurfacing up to 17 years: a report from the Australian Orthopaedic Association National Joint Replacement Registry. Journal of Arthroplasty, 35 (1), 132-138. doi: 10.1016/j.arth.2019.08.007
Gill, Stephen D., Hatton, Alesha, de Steiger, Richard N. and Page, Richard S. (2020). One-surgeon vs two-surgeon single-anesthetic bilateral total knee arthroplasty: revision and mortality rates from the Australian Orthopedic Association National Joint Replacement Registry. Journal of Arthroplasty, 35 (7), 1852-1856. doi: 10.1016/j.arth.2020.02.066
Critchley, Owain, McLean, Andrew, Page, Richard, Taylor, Fraser, Graves, Stephen, Lorimer, Michelle, Peng, Yi, Hatton, Alesha and Bain, Gregory (2020). Reverse total shoulder arthroplasty compared to stemmed hemiarthroplasty for proximal humeral fractures: a registry analysis of 5946 patients. Journal of Shoulder and Elbow Surgery, 29 (12), 2538-2547. doi: 10.1016/j.jse.2020.04.005
Viveen, Jetske, van den Bekerom, Michel P. J., Doornberg, Job N., Hatton, Alesha, Page, Richard, Koenraadt, Koen L. M., Wilson, Christopher, Bain, Gregory I., Jaarsma, Ruurd L. and Eygendaal, Denise (2019). Use and outcome of 1,220 primary total elbow arthroplasties from the Australian Orthopaedic Association National Joint Arthroplasty Replacement Registry 2008–2018. Acta Orthopaedica, 90 (6), 511-516. doi: 10.1080/17453674.2019.1657342
McLean, Andrew S., Price, Nathan, Graves, Stephen, Hatton, Alesha and Taylor, Fraser J. (2019). Nationwide trends in management of proximal humeral fractures: an analysis of 77,966 cases from 2008 to 2017. Journal of Shoulder and Elbow Surgery, 28 (11), 2072-2078. doi: 10.1016/j.jse.2019.03.034
Mooney, Luke, Lewis, Peter L., Campbell, David G., Peng, Yi and Hatton, Alesha (2019). Rates and outcomes of total knee replacement for rheumatoid arthritis compared to osteoarthritis. ANZ Journal of Surgery, 89 (3), 184-190. doi: 10.1111/ans.15035
Conference Papers
Vaotuua, D., O'Connor, P., Belford, M., Lewis, P., Hatton, A. and McAuliffe, M. (2023). The Effect Of Surgeon Volume On Revision For Deep Periprosthetic Joint Infection: An Analysis Of 602,919 Primary Total Knee Arthroplasties. New Zealand Orthopaedic Association and the Australian Orthopaedic Association (NZOA AOA) Combined Annual Scientific Meeting, Christchurch, New Zealand, 31 October – 3 November 2022. London, United Kingdom: British Editorial Society of Bone & Joint Surgery. doi: 10.1302/1358-992x.2023.2.056
Gill, David R J, Page BMedSci, Richard S., Graves, Stephen E., Rainbird, Sophia and Hatton, Alesha (2021). A comparison of revision rates for osteoarthritis of primary reverse total shoulder arthroplasty to primary anatomic shoulder arthroplasty with a cemented all-polyethylene glenoid: analysis from the Australian Orthopaedic Association National Joint Replacement Registry. Philadelphia, PA, United States: Lippincott Williams and Wilkins. doi: 10.1097/CORR.0000000000001869
Harris, Ian A., Hatton, Alesha, Pratt, Nicole, Lorimer, Michelle, Naylor, Justine M., De Steiger, Richard, Lewis, Peter and Graves, Stephen E. (2019). How does mortality risk change over time after hip and knee arthroplasty?. 7th International Congress of Arthroplasty Registries, Reykjavik, Iceland, 9-11 June 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/CORR.0000000000000673
Thesis
Hatton, Alesha (2024). Quantitative genetics approaches to elucidate the role of DNA methylation in complex trait variation. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/6e8bd7f