Institute for Molecular Bioscience

Dr Stefan Emming

ARC DECRA Fellow
Institute for Molecular Bioscience
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Researcher biography

Stefan has a long-standing interest in trying to understand cellular processes at a detailed molecular level. He did his Master in Biochemistry in a Structural Biology lab, investigating the structure and function of the intracellular innate immune sensors AIM2 and STING. Following a short period at the Biozentrum in Basel (Switzerland), Stefan joined the Molecular Immunology lab of S. Monticelli at the Institute for Research in Biomedicine (Bellinzona, Switzerland) to conduct a PhD. After a deep dive into transcriptional and post-transcriptional regulation of gene expression in T cells during his PhD, Stefan joined the Inflammasome Lab in 2019 as a Postdoctoral Research Officer and was awarded an ARC DECRA fellowship starting in 2022. His research is focused on the multi-step mechanism of inflammasome activation and its regulation on a molecular level

Publications

Book Chapter (1)
Journal Articles (13)

Book Chapter

Emming, Stefan, Monteleone, Mercedes M., Kambara, Hiroto, Starchenko, Alina, Alley, Jennifer, Nolan, Michael A., Li, Wei, Kilty, Iain and Schroder, Kate (2023). Quantifying Cell Death Induced by the NLRC4 Inflammasome. NLR Proteins: Methods and Protocols. (pp. 199-210) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-3350-2_13

Journal Articles

Coombs, Jared R., Zamoshnikova, Alina, Holley, Caroline L., Maddugoda, Madhavi P., Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M., Mellacheruvu, Manasa, Coll, Rebecca C., Heinz, Leonhard X., Burgener, Sabrina S., Emming, Stefan, Chamaillard, Mathias, Boucher, Dave and Schroder, Kate (2024). NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling, 17 (820) abg8145, eabg8145. doi: 10.1126/scisignal.abg8145
Yap, Jeremy KY, Emming, Stefan and Schroder, Kate (2023). Oxidized thioredoxin 1 places a leash on NLRP1 inflammasome activity. Immunology & Cell Biology, 102 (1), 5-7. doi: 10.1111/imcb.12710
Mellacheruvu, Manasa, Lawrence, Grace M. E. P., Emming, Stefan and Schroder, Kate (2023). Reversing the mitochondrial hex that bewitches NLRP3. Science Immunology, 8 (84) eadh2967, 1-4. doi: 10.1126/sciimmunol.adh2967
Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366
De Simone, Marco, Chirichella, Michele, Emming, Stefan, Mazzara, Saveria, Ranzani, Valeria, Gruarin, Paola, Moschetti, Giorgia, Pulvirenti, Nadia, Maglie, Stefano, Vasco, Chiara, Crosti, Maria Cristina, Rossetti, Grazisa, Pagani, Massimiliano, Abrignani, Sergio, Monticelli, Silvia and Geginat, Jens (2021). Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R. European Journal of Immunology, 51 (12), 3243-3246. doi: 10.1002/eji.202149315
Bianchi, Niccolò, Emming, Stefan, Zecca, Chiara and Monticelli, Silvia (2020). Vitamin D and IFN-β modulate the inflammatory gene expression program of primary human T lymphocytes. Frontiers in Immunology, 11 566781. doi: 10.3389/fimmu.2020.566781
Emming, Stefan, Bianchi, Niccolò, Polletti, Sara, Balestrieri, Chiara, Leoni, Cristina, Montagner, Sara, Chirichella, Michele, Delaleu, Nicolas, Natoli, Gioacchino and Monticelli, Silvia (2020). A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes. Nature Immunology, 21 (4), 388-399. doi: 10.1038/s41590-020-0622-8
Sacco, Rosaria, Emming, Stefan, Gobbi, Claudio, Zecca, Chiara and Monticelli, Silvia (2020). Rebound of disease activity after fingolimod withdrawal: immunological and gene expression profiling. Multiple Sclerosis and Related Disorders, 40 101927, 101927. doi: 10.1016/j.msard.2020.101927
Emming, Stefan and Schroder, Kate (2019). Tiered DNA sensors for escalating responses. Science, 365 (6460), 1375-1376. doi: 10.1126/science.aay2701
Emming, Stefan, Chirichella, Michele and Monticelli, Silvia (2018). MicroRNAs as modulators of T cell functions in cancer. Cancer Letters, 430, 172-178. doi: 10.1016/j.canlet.2018.05.019
Montagner, Sara, Leoni, Cristina, Emming, Stefan, Della Chiara, Giulia, Balestrieri, Chiara, Barozzi, Iros, Piccolo, Viviana, Togher, Susan, Ko, Myunggon, Rao, Anjana, Natoli, Gioacchino and Monticelli, Silvia (2017). Erratum: TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities (Cell Reports (2016) 15 (7)(1566#x2013;1579) (S2211124716304715) (10.1016/j.celrep.2016.04.044)). Cell Reports, 20 (7). doi: 10.1016/j.celrep.2017.08.011
Montagner, Sara, Leoni, Cristina, Emming, Stefan, Della Chiara, Giulia, Balestrieri, Chiara, Barozzi, Iros, Piccolo, Viviana, Togher, Susan, Ko, Myunggon, Rao, Anjana, Natoli, Gioacchino and Monticelli, Silvia (2016). TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Reports, 15 (7), 1566-1579. doi: 10.1016/j.celrep.2016.04.044
Leoni, Cristina, Vincenzetti, Lucia, Emming, Stefan and Monticelli, Silvia (2015). Epigenetics of T lymphocytes in health and disease. Swiss Medical Weekly, 145 w14191. doi: 10.4414/smw.2015.14191