Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Wu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J.Developmental Cell, 2024; doi: 10.1016/j.devcel.2024.01.019
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. Meredith A Redd, Yusuke Yoshikawa, Nemat Khan, Maleeha Waqar, Natalie J Saez, Jennifer E Outhwaite, Jake S Russell, Amy D Hanna, Han S Chiu, Sing Yan Er, Neville J Butcher, Karine Mardon, John F Fraser, Mark L Smythe, Lachlan D Rash, Walter G Thomas, Glenn F King, Melissa E Reichelt, Nathan J Palpant. European Heart Journal, 2023; ehad793
HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Friedman, Clayton E., Cheetham, Seth W., Negi, Sumedha, Mills, Richard J., Ogawa, Masahito, Redd, Meredith A., Chiu, Han Sheng, Shen, Sophie, Sun, Yuliangzi, Mizikovsky, Dalia, Bouveret, Romaric, Chen, Xiaoli, Voges, Holly K., Paterson, Scott, De Angelis, Jessica E., Andersen, Stacey B., Cao, Yuanzhao, Wu, Yang, Jafrani, Yohaann M.A., Yoon, Sohye, Faulkner, Geoffrey J., Smith, Kelly A., Porrello, Enzo, Harvey, Richard P., Hogan, Benjamin M., Nguyen, Quan, Zeng, Jian, Kikuchi, Kazu, Hudson, James E. and Palpant, Nathan J.Developmental Cell, 59 (1), 91-107.e1. 2023; doi: 10.1016/j.devcel.2023.11.012
Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations. Mizikovsky D, Sanchez MN, Nefzger CM, Cuellar Partida G*, Palpant NJ*. Nucleic Acids Research, 2022; gkac413
Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Redd MA, Scheuer SE, Saez NJ, Yoshikawa Y, Chiu HS, Gao L, Hicks M, Villanueva JE, Joshi Y, Chow CY, Cuellar-Partida G, Peart JN, See Hoe LE, Chen X, Sun Y, Suen JY, Hatch RJ, Rollo B, Alzubaidi MAH, Maljevic S, Quaife-Ryan GA, Hudson JE, Porrello ER, White MY, Cordwell SJ, Fraser JF, Petrou S, Reichelt ME, Thomas WG, King GF*, Macdonald PS*, Palpant NJ*. Circulation. 2021;144:947–960
Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation. Sophie Shen S, Sun Y, Matsumoto M, Sinniah E, Wilson SB, Little MH, Powell JE, Nguyen Q, Palpant NJ. Trends in Molecular Medicine. 2021, 27, 1135-1158.
Conserved epigenetic regulatory logic infers genes governing cell identity. Shim WJ, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, Shen S, Sun Y, Balderson B, Boix C, Peng G, Jing N, Wang Y, Kellis M, Tam P, Smith A, Piper M, Christiaen L, Nguyen Q, Boden M**, Palpant NJ**. Cell Systems. 11, 625-639 e613 (2020).
Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. Friedman CE, Nguyen Q, Lukowski SW, Chiu HS, Helfer A, Miklas J, Suo SS, Han JDJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE**, and Palpant NJ**. Cell Stem Cell. 2018 Oct 4;23(4):586-598.e8.
