Nuclear Magnetic Resonance (NMR) Spectroscopy Facility

Nuclear magnetic resonance spectroscopy is a key technology for determining the structures of molecules and visualising the anatomy of living tissue. NMR is one of only two techniques available for complete determination of the structure of proteins, providing the fundamental molecular information used in drug design programs.

NMR targets magnetic nuclei by aligning them with an applied constant magnetic field and perturbing this alignment using an alternating magnetic field. The intramolecular magnetic field around an atom in a molecule changes the resonance frequency, thus giving access to details of the electronic structure of the molecule and its individual functioning groups.

Our instruments are used for applications such as:

  • determination of high-resolution structures of biological macromolecules such as proteins
  • characterisation of protein/ligand interactions
  • determination of molecular size and oligomerisation state
  • metabonomic studies of various biofluids.

Using our NMR facilities, researchers have successfully characterised a number of novel peptides and venoms, including an oxytocic plant peptide that modulates the human oxytocin/vasopressin receptor, and venoms from cone snails, snakes and scorpions.

IMB is part of the Queensland NMR Network (QNN), which supports a developing biotechnology industry in this state by enabling access to world-class facilities and industry-leading software.

The facility also holds collaborations with researchers from other Australian universities as well as several international collaborators, most recently with scientists from Europe, China, and the US.

Equipment 

External users

Contacts