Stem cells and cardiovascular development
Cultural statement
The Palpant lab is comprised of members with a range of career development from honours and PhD students to research assistants and postdocs that enable training at all levels. The lab has diverse areas of expertise including wet lab work on stem cell biology and animal models to dry lab work with expertise analysing large scale genomic data. This diversity provides an ideal environment for interdisciplinary collaborations across the lab that result in high impact papers delivered by members at all levels of training. I am engaged with project design and analysis across the lab and aim to mentor groups to work together on projects to facilitate team involvement while ensuring each member has a clear and distinct project to work on.
Publications
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Conserved epigenetic regulatory logic infers genes governing cell identity
Woo Jun Shim, Enakshi Sinniah, Jun Xu, Burcu Vitrinel, Michael Alexanian, GaiaAndreoletti, Sophie Shen, Yuliangzi Sun, Brad Balderson, Carles Boix, GuangdunPeng, Naihe Jing, Yuliang Wang, Manolis Kellis, Patrick P L Tam, Aaron Smith, Michael Piper, Lionel Christiaen, Quan Nguyen, Mikael Bodén, Nathan J. Palpant
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Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury
Meredith A. Redd, Sarah E. Scheuer, Natalie J. Saez, Ling Gao, Mark Hicks, Jeanette E. Villanueva, Melissa E. Reichelt, Jason N. Peart, Louise E. See Hoe, Han S. Chiu, Xiaoli Chen, Yuliangzi Sun, Jacky Y. Suen, Robert J Hatch, Ben Rollo, Mubarak A.H.Alzubaidi, Snezana Maljevic, Greg A. Quaife-Ryan, Walter G. Thomas, James E.Hudson, Enzo R. Porrello, Gabriel Cuellar-Partida, John F. Fraser, Steven Petrou, Glenn F. King, Peter S. Macdonald, Nathan J. Palpant
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Drew Neavin, Quan Nguyen, Maciej S. Daniszewski, Helena H. Liang, Han ShengChiu, Anne Senabouth, Samuel W Lukowski, Duncan E. Crombie, Grace E.Lidgerwood, Damián Hernández, James C. Vickers, Anthony L. Cook, Nathan J.Palpant, Alice Pébay, Alex W. Hewitt, Joseph E. Powell
Partnerships and collaborations
We are working with collaborators around the world to make an impact on human health using the most current technologies in computational genomics, genome editing, stem cell differentiation, animal modelling, and drug discovery.
Dr Palpant collaborates widely both in Australia and internationally.
Australian collaborators include:
- Mat Francois, Ben Hogan and Kelly Smith from IMB's Genomics of Development and Disease Division in cardiovascular development.
- James Hudson (UQ, SBMS) with cardiac bioengineering expertise, Mikael Boden (UQ, SCMB) with expertise in epigenetics, and Joseph Powell (IMB) with computational genomics and single cell expertise.
- Dr John Fraser (The Prince Charles Hospital, Brisbane) is a key clinical collaborator for the lab’s translational research.
- Collaborators across the network of Australian stem cell scientists, Stem Cells Australia, including Richard Harvey and Cath Suter (VCCRI) and Patrick Tam (CMRI).
International collaborations include:
- Yuliang Wang from the Computational Biology Program at the Department of Biomedical Engineering, Oregon Health Sciences University, USA in Analysis of chromatin dynamics and gene expression in mesoderm progenitor populations.
- Jonathan Epstein, Cell and Developmental Biology, University of Pennsylvania, USA in Analysis of HOPX in developmental hematopoiesis.
- Irwin Bernstein, of the Fred Hutchinson Cancer Research Center, USA, in Analysis of hematopoietic potential from hESC-derived endothelial populations.
- Hannele Ruohola Baker, Institute for Stem Cell and Regenerative Medicine, University of Washington, analysis of genetic regulators of cardiovascular development.