In recent years, bioengineering and biotechnology approaches have emerged for studying complex developmental processes with high resolution and precision. Understanding how cell fate choices are controlled during development will help us delve into the basis of congenital and acquired cardiovascular diseases and enable us to make high purity cell types from stem cells that can be used for therapeutic applications.

Our team aims to understand how cell fate choices are made during the early stages of cardiovascular development. We use human pluripotent stem cells, coupled with advanced techniques in bioengineering, genome engineering and deep sequencing to dissect the molecular basis of lineage choices.

Traineeships, honours and PhD projects include

  • Use gene editing of stem cells to study the genetic basis of cardiovascular lineage choice
  • Use computational approaches to study single cell sequencing data to dissect gene networks underlying derivation of cell subpopulations during differentiation
  • Determine the genetic and epigenetic mechanisms controlling cardiovascular development
  • Identify and study novel small molecules that control lineage choices during differentiation from pluripotency

Project members

Group Leader

Dr Nathan Palpant

Group Leader, Genomics of Development and Disease Division
Senior Research Fellow
Institute for Molecular Bioscience