We use human pluripotent stem cells coupled with genomics approaches including single cell sequencing, analysis of transcription factor binding, and chromatin dynamics, to study how cells navigate fate choices during cardiac and vascular differentiation. We couple these approaches with genome edited cell lines to study how loss of individual genes or perturbation of gene networks impact cell states to understand mechanisms governing cell differentiation.

Project members

Key contacts

Dr Nathan Palpant

Group Leader, Genomics of Development and Disease Division
Senior Research Fellow - GL
Institute for Molecular Bioscience