Dr Dominic Hunter
Senior Research Assistant
Institute for Molecular Bioscience
+61 7 334 62337
Book Chapter
Gillam, E. M. J. and Hunter, D. J. B. (2007). Chemical Defence and Exploitation: Biotransformation of Xenobiotics by Cytochrome P450 Enzymes. Metal Ions in Life Sciences. (pp. 477-560) edited by Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. West Sussex: John Wiley and sons. doi: 10.1002/9780470028155.ch15
Journal Articles
Leitão, André D. G., Rudolffi-Soto, Paulina, Chappard, Alexandre, Bhumkar, Akshay, Lau, Derrick, Hunter, Dominic J. B., Gambin, Yann and Sierecki, Emma (2021). Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein. Communications Biology, 4 (1) 1124, 1124. doi: 10.1038/s42003-021-02624-x
Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6
Rae, James, Ferguson, Charles, Ariotti, Nicholas, Webb, Richard I., Cheng, Han-Hao, Mead, James L., Riches, James D., Hunter, Dominic J.B., Martel, Nick, Baltos, Joanne, Christopoulos, Arthur, Bryce, Nicole S., Cagigas, Maria Lastra, Fonseka, Sachini, Sayre, Marcel E., Hardeman, Edna C., Gunning, Peter W., Gambin, Yann, Hall, Thomas E. and Parton, Robert G. (2021). A robust method for particulate detection of a genetic tag for 3D electron microscopy. eLife, 10 e64630, 1-17. doi: 10.7554/eLife.64630
Böcking, Till, Jacques, David A., Lau, Derrick, Walsh, James C., Dickson, Claire F., Tuckwell, Andrew, Stear, Jeffrey H., Hunter, Dominic J.B., Bhumkar, Akshay, Shah, Vaibhav, Turville, Stuart G., Sierecki, Emma and Gambin, Yann (2021). Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy. Analytical Chemistry, 93 (8), 3786-3793. doi: 10.1021/acs.analchem.0c04250
Moustaqil, Mehdi, Ollivier, Emma, Chiu, Hsin-Ping, Van Tol, Sarah, Rudolffi-Soto, Paulina, Stevens, Christian, Bhumkar, Akshay, Hunter, Dominic J. B., Freiberg, Alexander N., Jacques, David, Lee, Benhur, Sierecki, Emma and Gambin, Yann (2021). SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species. Emerging Microbes and Infections, 10 (1), 178-195. doi: 10.1080/22221751.2020.1870414
Brown, James W. P., Bauer, Arnaud, Polinkovsky, Mark E, Bhumkar, Akshay, Hunter, Dominic J. B., Gaus, Katharina, Sierecki, Emma and Gambin, Yann (2019). Single-molecule detection on a portable 3D-printed microscope. Nature Communications, 10 (1) 5662, 5662. doi: 10.1038/s41467-019-13617-0
Strohmaier, Silja J., Huang, Weiliang, Baek, Jong-Min, Hunter, Dominic J. B. and Gillam, Elizabeth M. J. (2019). Rational evolution of the cofactor-binding site of cytochrome P450 reductase yields variants with increased activity towards specific cytochrome P450 enzymes. FEBS Journal, 286 (22) febs.14982, 4473-4493. doi: 10.1111/febs.14982
Gumulya, Yosephine, Huang, Weiliang, D'Cunha, Stephlina A., Richards, Katelyn E., Thomson, Raine E.S., Hunter, Dominic J.B., Baek, Jong-Min, Harris, Kurt L., Boden, Mikael, De Voss, James J., Hayes, Martin A., Isin, Emre M., Andersson, Shalini, Jurva, Ulrik and Gillam, Elizabeth (2019). Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE). ChemCatChem, 11 (2) cctc.201801644, 841-850. doi: 10.1002/cctc.201801644
O'Carroll, Ailís, Chauvin, Brieuc, Brown, James W.P., Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J.B., Ve, Thomas, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2018). Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88. BMC Biology, 16 (149) 149, 149. doi: 10.1186/s12915-018-0611-7
Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5
Moustaqil, Mehdi, Fontaine, Frank, Overman, Jeroen, McCann, Alex, Bailey, Timothy L., Rudolffi Soto, Paulina, Bhumkar, Akshay, Giles, Nichole, Hunter, Dominic J. B., Gambin, Yann, Francois, Mathias and Sierecki, Emma (2018). Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor. Nucleic Acids Research, 46 (21), 11381-11395. doi: 10.1093/nar/gky897
Jung, WooRam, Sierecki, Emma, Bastiani, Michele, O'Carroll, Ailis, Alexandrov, Kirill, Rae, James, Johnston, Wayne, Hunter, Dominic J. B., Ferguson, Charles, Gambin, Yann, Ariotti, Nicholas and Parton, Robert G. (2018). Cell-free formation and interactome analysis of caveolae. The Journal of Cell Biology, 217 (6), 2141-2165. doi: 10.1083/jcb.201707004
Hunter, Dominic J. B., Bhumkar, Akshay, Giles, Nichole, Sierecki, Emma and Gambin, Yann (2018). Unexpected instabilities explain batch-to-batch variability in cell-free protein expression systems. Biotechnology and Bioengineering, 115 (8), 1904-1914. doi: 10.1002/bit.26604
Gambin, Yann, Giles, Nichole, O'Carroll, Allis, Polinkovsky, Mark E., Hunter, Dominic J. B. and Sierecki, Emma (2018). Corrigendum to Single-molecule fluorescence reveals the oligomerisation and folding steps driving the prion-like behaviour of ASC [J. Mol. Biol. 430 (4) (February 16, 2018) 491–508]. Journal of Molecular Biology, 430 (8), 1263-1263. doi: 10.1016/j.jmb.2018.02.011
Leitao, Andre, Bhumkar, Akshay, Hunter, Dominic J. B., Gambin, Yann and Sierecki, Emma (2018). Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein. International Journal of Molecular Sciences, 19 (2) 334, 1-17. doi: 10.3390/ijms19020334
Gambin, Yann, Giles, Nichole, O'Carroll, Ailís, Polinkovsky, Mark, Hunter, Dominic and Sierecki, Emma (2017). Single-molecule fluorescence reveals the oligomerisation and folding steps driving the prion-like behaviour of ASC. Journal of Molecular Biology, 430 (4), 491-508. doi: 10.1016/j.jmb.2017.12.013
Moustaqil, Mehdi, Bhumkar, Akshay, Gonzalez, Laura, Raoul, Lisa, Hunter, Dominic J. B., Carrive, Pascal, Sierecki, Emma and Gambin, Yann (2017). A split-luciferase reporter recognizing GFP and mCherry tags to facilitate studies of protein–protein interactions. International Journal of Molecular Sciences, 18 (12) 2681, 2681. doi: 10.3390/ijms18122681
Johnston, Wayne A., Hunter, Dominic J. B., Noble, Christopher J., Hanson, Graeme R., Stok, Jeanette E., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2011). Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. Journal of Biological Chemistry, 286 (47), 40750-40759. doi: 10.1074/jbc.M111.300871
Hunter, D.J.B., Behrendorff, J.B.Y.H., Johnston, W.A., Hayes, P.Y., Huang, W., Bonn, B., Hayes, M.A., De Voss, J.J. and Gillam, E.M.J (2011). Facile production of minor metabolites for drug development using a CYP3A shuffled library. Metabolic Engineering, 13 (6), 682-693. doi: 10.1016/j.ymben.2011.09.001
Gillam, Elizabeth M. J. and Hunter, Dominic J. B. (2007). Chemical defense and exploitation, biotransformation of xenobiotics by cytochrome P450 enzymes. Metal Ions in Life Sciences, 3, 477-560.
Hunter, DJB, Roberts, GA, Ost, TWB, White, JH, Muller, S, Turner, NJ, Flitsch, SL and Chapman, SK (2005). Analysis of the domain properties of the novel cytochrome P450 RhF. FEBS Letters, 579 (10), 2215-2220. doi: 10.1016/j.febslet.2005.03.016
Hunter, DJB, Macmaster, R, Roszak, AW, Riboldi-Tunnicliffe, A, Griffiths, IR and Freer, AA (2005). Structure of myelin P2 protein from equine spinal cord. Acta Crystallographica Section D: Biological Crystallography, 61 (8), 1067-1071. doi: 10.1107/S0907444905014162
Zhong, WQ, Alexeev, D, Harvey, I, Guo, ML, Hunter, DJB, Zhu, HZ, Campopiano, DJ and Sadler, PJ (2004). Assembly of an oxo-zirconium(IV) cluster in a protein cleft. Angewandte Chemie - International Edition, 43 (44), 5914-5918. doi: 10.1002/anie.200460806
Roberts, Gareth A., Celik, Ayhan, Hunter, Dominic J. B., Ost, Tobias W. B., White, John H., Chapman, Stephen K., Turner, Nicholas J. and Flitsch, Sabine L. (2003). A self-sufficient cytochrome P450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center. Journal of Biological Chemistry, 278 (49), 48914-48920. doi: 10.1074/jbc.M309630200
Zhu, HZ, Alexeev, D, Hunter, DJB, Campopiano, DJ and Sadler, PJ (2003). Oxo-iron clusters in a bacterial iron-trafficking protein: New roles for a conserved motif. Biochemical Journal, 376 (1), 35-41. doi: 10.1042/BJ20031283
Alexeev, D, Zhu, HZ, Guo, ML, Zhong, WQ, Hunter, DJB, Yang, WP, Campopiano, DJ and Sadler, PJ (2003). A novel protein-mineral interface. Nature Structural Biology, 10 (4), 297-302. doi: 10.1038/nsb903
Ramsay, Rona R. and Hunter, Dominic J. B. (2003). Interactions of D-amphetamine with the active site of monoamine oxidase-A. Inflammopharmacology, 11 (2), 127-133. doi: 10.1163/156856003765764290
Ramsay, RR and Hunter, DJB (2002). Inhibitors alter the spectrum and redox properties of monoamine oxidase A. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1601 (2), 178-184. doi: 10.1016/S1570-9639(02)00466-1
Ramsay, Rona R. and Hunter, Dominic J. B. (2002). Inhibitors alter the spectrum and redox properties of monoamine oxidase A. Biochimica et biophysica acta, 1601 (2), 178-184.
Mclaughlin, M, Hunter, DJB, Thomson, CE, Yool, D, Kirkham, D, Freer, AA and Griffiths, IR (2002). Evidence for possible interactions between PLP and DM20 within the myelin sheath. GLIA, 39 (1), 31-36. doi: 10.1002/glia.10091
Hunter, DJB, Oganesyan, VS, Salerno, JC, Butler, CS, Ingledew, WJ and Thomson, AJ (2000). Angular dependences of perpendicular and parallel mode electron paramagnetic resonance of oxidized beef heart cytochrome c oxidase. Biophysical Journal, 78 (1), 439-450. doi: 10.1016/S0006-3495(00)76606-9
Pettigrew, GW, Gilmour, R, Goodhew, CF, Hunter, DJB, Devreese, B, Van Beeumen, J, Costa, C, Prazeres, S, Krippahl, L, Palma, PN, Moura, and Moura, JJG (1998). The surface-charge asymmetry and dimerisation of cytochrome c550 from Paracoccus denitrificans - implications for the interaction with cytochrome c peroxidase. European Journal of Biochemistry, 258 (2), 559-566. doi: 10.1046/j.1432-1327.1998.2580559.x
Hunter, DJB, Salerno, JC and Ingledew, WJ (1998). Angular dependence of electron paramagnetic resonances of an azide-NO complex of cytochrome c oxidase: Orientation of the haem-copper axis in cytochrome aa3 from ox heart. Biochimica et Biophysica Acta - Bioenergetics, 1364 (1), 55-62. doi: 10.1016/S0005-2728(98)00006-1
Hunter, DJB, Moody, AJ, Rich, PR and Ingledew, WJ (1997). EPR spectroscopy of Escherichia coli cytochrome bo which lacks Cu(B). FEBS Letters, 412 (1), 43-47. doi: 10.1016/S0014-5793(97)00735-7
GOODHEW, CF, WILSON, IBH, HUNTER, DJB and PETTIGREW, GW (1990). THE CELLULAR LOCATION AND SPECIFICITY OF BACTERIAL CYTOCHROME-C PEROXIDASES. Biochemical Journal, 271 (3), 707-712. doi: 10.1042/bj2710707
HUNTER, DJB, BROWN, KR and PETTIGREW, GW (1989). THE ROLE OF CYTOCHROME-C4 IN BACTERIAL RESPIRATION - CELLULAR LOCATION AND SELECTIVE REMOVAL FROM MEMBRANES. Biochemical Journal, 262 (1), 233-240. doi: 10.1042/bj2620233
Augusteyn R.C. and Augusteyn R.C. (1973). Primary structure of cytochrome c from the Emu, Dromaeus novaehollandiae. BBA - Protein Structure, 303 (1), 1-7. doi: 10.1016/0005-2795(73)90141-4
Conference Papers
O'Carroll, Allis, Ve, Thomas, Moustaqil, Mehdi, Giles, Nichole, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2017). Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL USA, Apr 22-26, 2017. Bethesda, MD, USA: Federation of American Societies for Experimental Biology.
Singh, Arti, Cryle, M., Hunter, D,, Stok, J. and De Voss, J. (2009). Cytochrome P450-mediated fatty acid oxidation: Mechanistic investigations. ICCC2009: 16th International Conference on Cytochrome P450. Biochemistry, Biophysics, Biotechnology, Nago, Okinawa, Japan, 21-25 June 2009. Bologna, Italy: Medimond S.r.l..
Gillam, Elizabeth M. J., Johnston, W. A., DeVoss, J. J., Soucek, Pavel and Hunter, D. J. B. (2006). Dna family shuffling of mammalian P450s from CYP2A and CYP3A subfamilies. 14th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics, Rio Grande, Puerto Rico, 22-26 October 2006. Philadelphia, PA USA: Taylor & Francis.