Mr Justin Mitchell
Higher degree by research (PhD) student
Institute for Molecular Bioscience
+61 7 334 62386
Journal Articles
Plisson, Fabien, Hill, Timothy A., Mitchell, Justin M., Hoang, Huy N., de Araujo, Aline D., Xu, Weijun, Cotterell, Adam, Edmonds, David J., Stanton, Robert V., Derksen, David R., Loria, Paula M., Griffith, David A., Price, David A., Liras, Spiros and Fairlie, David P. (2017) Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. European Journal of Medicinal Chemistry, 127 703-714. doi:10.1016/j.ejmech.2016.10.044
Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros and Craik, David J. (2016) Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro. Journal of Biological Chemistry, 291 30: 15778-15787. doi:10.1074/jbc.M116.724542
Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015) Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103 175-184. doi:10.1016/j.ejmech.2015.08.046
Hoang, Huy N., Song, Kun, Hill, Timothy A., Derksen, David R., Edmonds, David J., Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M., Mascitti, Vincent, Mathiowetz, Alan M., Mitchell, Justin M., Piotrowski, David W., Price, David A., Stanton, Robert V., Suen, Jacky Y., Withka, Jane M., Griffith, David A. and Fairlie, David P. (2015) Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Journal of Medicinal Chemistry, 58 9: 4080-4085. doi:10.1021/acs.jmedchem.5b00166
Low, Jiun T., Zavortink, Michael, Mitchell, Justin M., Gan, Wan J., Do, Oanh Hoang, Schwiening, Christof J., Gaisano, Herbert Y. and Thorn, Peter (2014) Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature. Diabetologia, 57 8: 1655-1663. doi:10.1007/s00125-014-3252-6
Low, Jiun T., Mitchell, Justin M., Do, Oanh H., Bax, Jacinda, Rawlings, Alicia, Zavortink, Michael, Garry Morgan, Parton, Robert G., Gaisano, Herbert Y. and Thorn, Peter (2013) Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia, 56 12: 2629-2637. doi:10.1007/s00125-013-3019-5
Jang, Yujin, Soekmadji, Carolina, Mitchell, Justin M., Thomas, Walter G. and Thorn, Peter (2012) Real-time measurement of F-Actin remodelling during exocytosis using Lifeact-EGFP transgenic animals. Plos One, 7 7: e39815.1-e39815.7. doi:10.1371/journal.pone.0039815
Thesis
Mitchell, Justin (2017). Towards ligand directed control of GLP-1R signalling PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi:10.14264/uql.2017.1069