Dr Annie Kan
Manager, Business Administration
Institute for Molecular Bioscience
+61 7 334 62049
Book Chapters
Craik, David J., Zhang, Yuhui, Zhou, Yan, Kaas, Quentin and Kan, Meng-Wei (2022). Cyclotides—cyclic and disulfide-knotted polypeptides. Topological polymer chemistry: concepts and practices. (pp. 135-147) Singapore, Singapore: Springer Singapore. doi: 10.1007/978-981-16-6807-4_9
Huang, Yen-Hua, Kan, Meng-Wei and Craik, David J. (2021). Protocols for measuring the stability and cytotoxicity of cyclotides. Antimicrobial peptides. (pp. 19-40) edited by Leslie M. Hicks. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.mie.2021.09.007
Kan, Meng-Wei and Craik, David J. (2018). Trends in cyclotide research. Cyclic peptides: from bioorganic synthesis to applications. (pp. 302-339) edited by Jesko Koehnke, James Naismith and Wilfred A. van der Donk. Cambridge: Royal Society of Chemistry. doi: 10.1039/9781788010153-00302
Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2017). Cyclotides: plant defense toxins. Plant toxins. (pp. 221-242) edited by P. Gopalakrishnakone, Célia Regina Carlini and Rodrigo Ligabue-Braun. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-6464-4_7
Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2017). Cyclotides: plant defense toxins. Plant toxins. (pp. 221-243) edited by P Gopalakrishnakone, Célia R Carlini and Rodrigo Ligabue-Braun. Dordrecht, The Netherlands: Springer, Dordrecht. doi: 10.1007/978-94-007-6464-4
Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2015). Natural functions and structure-activity relationships of cyclotides. Advances in Botanical Research. (pp. 187-226) edited by Craik, DJ. Maryland Heights, United States: Academic Press. doi: 10.1016/bs.abr.2015.10.001
Journal Articles
Troeira Henriques, Sónia, Lawrence, Nicole, Kan, Meng-Wei, Malins, Lara R. and Craik, David J. (2025). Cell-penetrating cyclic and disulfide-rich peptides are privileged molecular scaffolds for intracellular targeting. Biochemistry, 64 (7), 1437-1449. doi: 10.1021/acs.biochem.4c00845
Xie, Jing, Kan, Meng‐Wei, de Veer, Simon J., Wang, Conan and Craik, David J. (2024). Display technologies for expanding the pharmaceutical applications of cyclotides. Israel Journal of Chemistry, 64 (8-9) e202400010. doi: 10.1002/ijch.202400010
Frøsig-Jørgensen, Majbrit, Ji, Jing, Gorman, Declan M., Kan, Meng-Wei and Craik, David J. (2023). Discovery and optimisation of conotoxin Vc1.1 and analogues with analgesic properties. Australian Journal of Chemistry, 76 (10), 1-16. doi: 10.1071/ch23155
Craik, David J. and Kan, Meng-Wei (2021). How can we improve peptide drug discovery? Learning from the past. Expert Opinion on Drug Discovery, 16 (12), 1-4. doi: 10.1080/17460441.2021.1961740
Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087
Kan, Meng-Wei and Craik, David J. (2020). Discovery of cyclotides from Australasian plants. Australian Journal of Chemistry, 73 (4), 287-299. doi: 10.1071/ch19658
de Veer, Simon J., Kan, Meng-Wei and Craik, David J. (2019). Cyclotides: from structure to function. Chemical Reviews, 119 (24) acs.chemrev.9b00402, 12375-12421. doi: 10.1021/acs.chemrev.9b00402
Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611
Poth, Aaron G., Huang, Yen-Hua, Le, Thao T., Kan, Meng-Wei and Craik, David J. (2019). Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. International Journal of Pharmaceutics, 565, 437-446. doi: 10.1016/j.ijpharm.2019.05.001
Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014). Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 (2), 248-257. doi: 10.1016/j.ejmech.2014.03.011
Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001
Thesis
Meng-Wei (Annie) Kan (2011). The Development of New Purple Acid Phosphatase Inhibitors: A Light into Anti-osteoporotic Drugs. PhD Thesis, School of Chemistry & Molecular Biosciences, The University of Queensland.