Dr Rhia Stone
Higher degree by research (PhD) student & Postdoctoral Research Fellow/Research Officer
Institute for Molecular Bioscience
+61 7 334 62375
+61 7 344 38271
Researcher biography
Dr M. Rhia L. Stone is an emerging leader in probe design and orthogonal modification of biologically relevant molecules. She obtained her PhD in 2020 from The University of Queensland (UQ), working on synthesis of fluorescent and radiolabelled antibiotics. This was followed by postdoctoral positions at Rutgers, the State University of New Jersey (USA), the ARC Training Centre for Innovation in Biomedical Imaging Technology at UQ and is now based at the Centre for Superbug Solutions at the University of Queensland. Rhia has extensive experience with small molecule, peptide, and protein scaffolds, including rational design, synthesis, and characterisation of novel molecules. In their current position, Rhia utilises synthesis, microbiology and animal imaging, working with a range of interdisciplinary collaborators.
Book Chapter
Zhang, Bing, Stone, M. Rhia L., Kc, Sanjaya, Łapińska, Urszula, Pagliara, Stefano and Blaskovich, Mark A.T. (2022). Application of antibiotic-derived fluorescent probes to bacterial studies. Methods in enzymology. (pp. 1-28) edited by Erin E. Carlson. San Diego, CA United States: Academic Press. doi: 10.1016/bs.mie.2021.11.010
Journal Articles
Gutierrez, Bryan, Aggarwal, Tushar, Erguven, Huseyin, Stone, M. Rhia L., Guo, Changjiang, Bellomo, Alyssa, Abramova, Elena, Stevenson, Emily R., Laskin, Debra L., Gow, Andrew J. and Izgu, Enver Cagri (2023). Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite. iScience, 26 (12) 108567, 1-23. doi: 10.1016/j.isci.2023.108567
Zhang, Bing, Phetsang, Wanida, Stone, M. Rhia L., Kc, Sanjaya, Butler, Mark S., Cooper, Matthew A., Elliott, Alysha G., Łapińska, Urszula, Voliotis, Margaritis, Tsaneva-Atanasova, Krasimira, Pagliara, Stefano and Blaskovich, Mark A. T. (2023). Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage. Communications Biology, 6 (1) 409, 1-16. doi: 10.1038/s42003-023-04745-x
Hast, Kern, Stone, M. Rhia L., Jia, Zhaojun, Baci, Melih, Aggarwal, Tushar and Izgu, Enver Cagri (2023). Bioorthogonal functionalization of material surfaces with bioactive molecules. ACS Applied Materials and Interfaces, 15 (4), 4996-5009. doi: 10.1021/acsami.2c20942
Łapińska, Urszula, Voliotis, Margaritis, Lee, Ka Kiu, Campey, Adrian, Stone, Rhia M. L., Tuck, Brandon, Phetsang, Wanida, Zhang, Bing, Tsaneva-Atanasova, Krasimira, Blaskovich, Mark A. T. and Pagliara, Stefano (2022). Fast bacterial growth reduces antibiotic accumulation and efficacy. eLife, 11 e74062, 1-33. doi: 10.7554/ELIFE.74062
Conners, Rebecca, McLaren, Mathew, Łapińska, Urszula, Sanders, Kelly, Stone, M. Rhia L., Blaskovich, Mark A. T., Pagliara, Stefano, Daum, Bertram, Rakonjac, Jasna and Gold, Vicki A. M. (2021). CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage. Nature Communications, 12 (1) 6316, 6316. doi: 10.1038/s41467-021-26610-3
Bettoni, Serena, Maziarz, Karolina, Stone, M. Rhia L., Blaskovich, Mark A. T., Potempa, Jan, Bazzo, Maria Luiza, Unemo, Magnus, Ram, Sanjay and Blom, Anna M. (2021). Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae. Frontiers in Immunology, 12 726801, 1-15. doi: 10.3389/fimmu.2021.726801
Kaspar, Felix, Stone, M. Rhia L., Neubauer, Peter and Kurreck, Anke (2021). Route efficiency assessment and review of the synthesis of β-nucleosides: Via N -glycosylation of nucleobases. Green Chemistry, 23 (1), 37-50. doi: 10.1039/d0gc02665d
Peschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107
Stone, M. Rhia L., Phetsang, Wanida, Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Visualization of bacterial resistance using fluorescent antibiotic probes. Journal of Visualized Experiments, 2020 (157) e60743. doi: 10.3791/60743
Stone, M. Rhia L., Łapińska, Urszula, Pagliara, Stefano, Masi, Muriel, Blanchfield, Joanne T., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance. RSC Chemical Biology, 1 (5), 395-404. doi: 10.1039/d0cb00118j
Peng, Hui, Chau, Viet Q., Phetsang, Wanida, Sebastian, Rebecca M., Stone, M. Rhia L., Datta, Shyamtanu, Renwick, Marian, Tamer, Yusuf T., Toprak, Erdal, Koh, Andrew Y., Blaskovich, Mark A.T. and Hulleman, John D. (2019). Non-antibiotic small-molecule regulation of DHFR-based destabilizing domains in vivo. Molecular Therapy - Methods and Clinical Development, 15, 27-39. doi: 10.1016/j.omtm.2019.08.002
Stone, M. Rhia L., Masi, Muriel, Phetsang, Wanida, Pagès, Jean-Marie, Cooper, Matthew A. and Blaskovich, Mark A. T. (2019). Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux. MedChemComm, 10 (6), 901-906. doi: 10.1039/c9md00124g
Stone, M Rhia L., Butler, Mark S., Phetsang, Wanida, Cooper, Matthew A. and Blaskovich, Mark A. T. (2018). Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance. Trends in Biotechnology, 36 (5), 523-536. doi: 10.1016/j.tibtech.2018.01.004
Moore, Peter W., Schuster, Julia K., Hewitt, Russell J., Stone, M. Rhia L., Teesdale-Spittle, Paul H. and Harvey, Joanne E. (2015). ChemInform abstract: divergent synthesis of 2-C-branched pyranosides and oxepines from 1,2-gem-dibromocyclopropyl carbohydrates. ChemInform, 46 (8), 1-1. doi: 10.1002/chin.201508276
Moore, Peter W., Schuster, Julia K., Hewitt, Russell J., Stone, M. Rhia L., Teesdale-Spittle, Paul H. and Harvey, Joanne E. (2014). Divergent synthesis of 2-C-branched pyranosides and oxepines from 1,2-gem-dibromocyclopropyl carbohydrates. Tetrahedron, 70 (39), 7032-7043. doi: 10.1016/j.tet.2014.06.069
Conference Paper
Blaskovich, Mark A., Phetsang, Wanida, Stone, M. Rhia L., Lapinska, Urszula, Pagliara, Stefano, Bhalla, Rajiv and Cooper, Matthew A. (2019). Antibiotic-derived molecular probes for bacterial imaging. SPIE BiOS 2019, San Francisco, California, 2-7 February 2019. Bellingham, WA United States: SPIE - International Society for Optical Engineering. doi: 10.1117/12.2507329
Thesis
Stone, Magali (2020). Tagged Antibiotics for Examination of Bacterial Resistance and Infection. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2020.937
Patent
Mark Blaskovich, Matt Cooper, Mark Butler, Rhia Stone and Wanida Phetsang (2018). Visualisation Constructs. WO/2018/102890.