Dr Amy Chan
Higher degree by research (PhD) student
Institute for Molecular Bioscience
+61 7 334 62356
After obtaining First Class Honours in 2014 in the Toth lab, Amy completed a year of voluntary research to explore her interests in the field of immunology. Working in collaboration with the Institute for Glycomics at Griffith University, she developed a novel prophylactic vaccine against streptococcus pyogenes. Amy joined the Inflammasome Lab in 2016 for her PhD studies under joint supervision from the Cooper group (The University of Queensland). Her current project attempts to unravel the mysteries of the little understood “non-canonical” inflammasome.
Book Chapter
Boucher, Dave, Chan, Amy, Ross, Connie and Schroder, Kate (2018). Quantifying caspase-1 activity in murine macrophages. Inflammation and cancer. (pp. 163-176) edited by Brendan J. Jenkins. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-7568-6_14
Journal Articles
Chan, Amy H., Burgener, Sabrina S., Vezyrgiannis, Kassandra, Wang, Xiaohui, Acklam, Jadie, Von Pein, Jessica B., Pizzuto, Malvina, Labzin, Larisa I., Boucher, Dave and Schroder, Kate (2023). Caspase-4 dimerisation and D289 auto-processing elicit an
interleukin-1β-converting enzyme. Life Science Alliance, 6 (10) e202301908, 1-11. doi: 10.26508/lsa.202301908
Chan, Amy H., Kok, Ethan Y. Y., Razali, Muhammad Asyraf M., Lawrie, Gwendolyn A. and Wang, Jack T.H. (2022). Student perceptions and engagement in video-based learning for microbiology education. International Journal of Innovation in Science and Mathematics Education, 30 (3), 2-18. doi: 10.30722/ijisme.30.03.001
Ross, Connie, Chan, Amy H., von Pein, Jessica B., Maddugoda, Madhavi P., Boucher, Dave and Schroder, Kate (2022). Inflammatory caspases: toward a unified model for caspase activation by inflammasomes. Annual Review of Immunology, 40 (1), 249-269. doi: 10.1146/annurev-immunol-101220-030653
Bonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316
Speir, Mary, Chan, Amy H, Simpson, Daniel S, Khan, Tashbib, Saunders, Tahnee L, Poon, Ivan KH and Atkin-Smith, Georgia K (2021). The Australasian Cell Death Society (ACDS): celebrating 50 years of Australasian cell death research. Immunology and Cell Biology, 100 (1), 9-14. doi: 10.1111/imcb.12510
Chan, Amy H. and Schroder, Kate (2019). Inflammasome signaling and regulation of interleukin-1 family cytokines. The Journal of Experimental Medicine, 217 (1) e20190314, jem.20190314. doi: 10.1084/jem.20190314
Ross, Connie, Chan, Amy H., Von Pein, Jessica, Boucher, Dave and Schroder, Kate (2018). Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome. Life Science Alliance, 1 (6) e201800237, e201800237. doi: 10.26508/lsa.201800237
Chan, Amy, Hussein, Waleed M., Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Mostafa, Ahmed, Eskandari, Sharareh, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016). Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorganic and Medicinal Chemistry, 24 (14), 3095-3101. doi: 10.1016/j.bmc.2016.03.063
Thesis
Chan, Amy H. (2020). Molecular mechanisms of non-canonical inflammasome activity. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/39055fb
Creative Works
Chan, Amy H. and Wang, Jack T. H. (2022). DNA sequencing - Expectation vs Reality?. Brisbane, Australia: Youtube.
Chan, Amy H. and Wang, Jack T. H. (2022). Colony PCR: save time in DNA Cloning. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). ELISA and Rapid Antigen Testing. Brisbane, Australia: YouTube.
Chan, Amy and Wang, Jack T. H. (2022). Protein Analysis: The Bradford Assay & Spectrophotometry. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). Fluorescence microscopy: separate signal from the noise. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). How to transform DNA. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). Polymerase Chain Reaction (PCR) & Gel Electrophoresis. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). Cell & Tissue Culture [Part 3]: Bacterial Culture & Cell Counting. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). Cell & Tissue Culture [Part 2]: Common Mistakes. Brisbane, Australia: YouTube.
Chan, Amy H. and Wang, Jack T. H. (2022). Cell & Tissue Culture [Part 1]: The Basics. Brisbane, Australia: YouTube.