Dr Caroline Holley
Higher degree by research (PhD) student & Postdoctoral Research Fellow
Institute for Molecular Bioscience
+61 7 334 62351
Caroline joined the Inflammasome Lab in 2014 for a postgraduate Honours project supervised by Dr Kate Schroder. Her project involved using a flow cytometry-based assay to screen a panel of pattern recognition receptors for the ability to trigger oligomerisation of the inflammasome adaptor ASC. Caroline's research earned her a First Class Honours. In 2015, Caroline returned to the Inflammasome Lab as a research assistant. In January 2017, Caroline begins her PhD in inflammation.
Journal Articles
Lawrence, Grace M.E.P., Holley, Caroline L. and Schroder, Kate (2022). Parkinson's disease: connecting mitochondria to inflammasomes. Trends in Immunology, 43 (11), 877-885. doi: 10.1016/j.it.2022.09.010
Lawrence, Grace M.E.P., Holley, Caroline L. and Schroder, Kate (2022). Come on mtDNA, light my fire. Immunity, 55 (8), 1331-1333. doi: 10.1016/j.immuni.2022.07.011
Milner, Mark T., Lawrence, Grace M. E. P., Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S. and Schroder, Kate (2022). Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols, 3 (2) 101295, 1-16. doi: 10.1016/j.xpro.2022.101295
Holley, Caroline L. and Schroder, Kate (2020). The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdown. Clinical & Translational Immunology, 9 (2) e01109, e01109. doi: 10.1002/cti2.1109
Holley, Caroline L., Coll, Rebecca C. and Schroder, Kate (2018). NLRC3 restrains responses to a T. Immunity, 49 (6), 989-991. doi: 10.1016/j.immuni.2018.12.003
Coll, Rebecca C., Holley, Caroline L. and Schroder, Kate (2018). Correction: Mitochondrial DNA synthesis fuels NLRP3 inflammasome. Cell Research, 28 (12), 1202-1202. doi: 10.1038/s41422-018-0112-9
Coll, Rebecca C., Holley, Caroline L. and Schroder, Kate (2018). Mitochondrial DNA synthesis fuels NLRP3 inflammasome. Cell Research, 28 (11), 1046-1047. doi: 10.1038/s41422-018-0093-8
Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027
Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222
Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270
Masters, Seth L., Lagou, Vasiliki, Jéru, Isabelle, Baker, Paul J., Van Eyck, Lien, Parry, David A., Lawless, Dylan, De Nardo, Dominic, Garcia-Perez, Josselyn E., Dagley, Laura F., Holley, Caroline L., Dooley, James, Moghaddas, Fiona, Pasciuto, Emanuela, Jeandel, Pierre-Yves, Sciot, Raf, Lyras, Dena, Webb, Andrew I., Nicholson, Sandra E., De Somer, Lien, van Nieuwenhove, Erika, Ruuth-Praz, Julia, Copin, Bruno, Cochet, Emmanuelle, Medlej-Hashim, Myrna, Megarbane, Andre, Schroder, Kate, Savic, Sinisa, Goris, An ... Liston, Adrian (2016). Familial auto inflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activation. Science Translational Medicine, 8 (332) 332ra45, 1-9. doi: 10.1126/scitranslmed.aaf1471
Thesis
Holley, Caroline (2021). The cell biology of pyroptosis. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/08e7958