Dr Meltem Weger
Postdoctoral Research Fellow
Institute for Molecular Bioscience
+61 7 334 62060

Researcher biography
Meltem Weger is Postdoctoral Research Fellow in the laboratory of A/Prof. Frederic Gachon at the Institute for Molecular Bioscience (IMB) at the University of Queensland. Meltem is interested in the understanding of the role of the stress axis and the circadian clock for (patho-) physiology and metabolism.
Journal Articles
Jouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119
Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2022). The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review. Cellular Physiology and Biochemistry, 56 (S2), 1-11. doi: 10.33594/000000489
Weger, Benjamin D., Gobet, Cédric, David, Fabrice P. A., Atger, Florian, Martin, Eva, Phillips, Nicholas E., Charpagne, Aline, Weger, Meltem, Naef, Felix and Gachon, Frédéric (2021). Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. Proceedings of the National Academy of Sciences, 118 (3) e2015803118, 1-12. doi: 10.1073/pnas.2015803118
Weger, Meltem, Alpern, Daniel, Cherix, Antoine, Ghosal, Sriparna, Grosse, Jocelyn, Russeil, Julie, Gruetter, Rolf, de Kloet, E Ronald, Deplancke, Bart and Sandi, Carmen (2020). Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Scientific Reports, 10 (1) 18308, 1-15. doi: 10.1038/s41598-020-75326-9
Weger, Meltem, Weger, Benjamin D, Schink, Andrea, Takamiya, Masanari, Stegmaier, Johannes, Gobet, Cédric, Parisi, Alice, Kobitski, Andrei Yu, Mertes, Jonas, Krone, Nils, Strähle, Uwe, Nienhaus, Gerd Ulrich, Mikut, Ralf, Gachon, Frédéric, Gut, Philipp and Dickmeis, Thomas (2020). MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife, 9 e57068, 1-35. doi: 10.7554/elife.57068
Papilloud, Aurélie, Weger, Meltem, Bacq, Alexandre, Zalachoras, Ioannis, Hollis, Fiona, Larrieu, Thomas, Battivelli, Dorian, Grosse, Jocelyn, Zanoletti, Olivia, Parnaudeau, Sébastien, Tronche, François and Sandi, Carmen (2020). The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents. Psychoneuroendocrinology, 112 104538, 104538. doi: 10.1016/j.psyneuen.2019.104538
Weger, Meltem, Weger, Benjamin D., Goerling, Benjamin, Poschet, Gernot, Yildiz, Melek, Hell, Ruediger, Luy, Burkhard, Akcay, Teoman, Guran, Tulay, Dickmeis, Thomas, Mueller, Ferenc and Krone, Nils (2018). Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine, 36, 376-389. doi: 10.1016/j.ebiom.2018.09.024
Weger, M., Diotel, N., Weger, B. D., Beil, T., Zaucker, A., Eachus, H. L., Oakes, J. A., do Rego, J. L., Storbeck, K. -H., Gut, P., Straehle, U., Rastegar, S., Mueller, F. and Krone, N. (2018). Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of Neuroendocrinology, 30 (4) e12586, e12586. doi: 10.1111/jne.12586
Weger, Meltem and Sandi, Carmen (2018). High anxiety trait: a vulnerable phenotype for stress-induced depression. Neuroscience and Biobehavioral Reviews, 87, 27-37. doi: 10.1016/j.neubiorev.2018.01.012
Weger, Meltem, Sevelinges, Yannick, Grosse, Jocelyn, de Suduiraut, Isabelle Guillot, Zanoletti, Olivia and Sandi, Carmen (2018). Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination. Physiology and Behavior, 186, 31-36. doi: 10.1016/j.physbeh.2018.01.008
Eachus, Helen, Zaucker, Andreas, Oakes, James A., Griffin, Aliesha, Weger, Meltem, Guran, Tulay, Taylor, Angela, Harris, Abigail, Greenfield, Andy, Quanson, Jonathan L., Storbeck, Karl-Heinz, Cunliffe, Vincent T., Muller, Ferenc and Krone, Nils (2017). Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158 (12), 4165-4173. doi: 10.1210/en.2017-00549
Weger, Meltem, Diotel, Nicolas, Dorsemans, Anne-Claire, Dickmeis, Thomas and Weger, Benjamin D. (2017). Stem cells and the circadian clock. Developmental Biology, 431 (2), 111-123. doi: 10.1016/j.ydbio.2017.09.012
Dorsemans, Anne-Claire, Soule, Stephanie, Weger, Meltem, Bourdon, Emmanuel, d'Hellencourt, Christian Lefebvre, Meilhac, Olivier and Diotel, Nicolas (2017). Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish. Journal of Comparative Neurology, 525 (3), 442-458. doi: 10.1002/cne.24065
Weger, Benjamin D., Weger, Meltem, Goerling, Benjamin, Schink, Andrea, Gobet, Cedric, Keime, Celine, Poschet, Gernot, Jost, Bernard, Krone, Nils, Hell, Ruediger, Gachon, Frederic, Luy, Burkhard and Dickmeis, Thomas (2016). Extensive regulation of diurnal transcription and metabolism by glucocorticoids. PLoS Genetics, 12 (12) e1006512, e1006512. doi: 10.1371/journal.pgen.1006512
Griffin, Aliesha, Parajes, Silvia, Weger, Meltem, Zaucker, Andreas, Taylor, Angela E., O'Neil, Donna M., Mueller, Ferenc and Krone, Nils (2016). Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish. Endocrinology, 157 (3), 1122-1134. doi: 10.1210/en.2015-1480
Tixier, Vanessa, Bataille, Laetitia, Etard, Christelle, Jagla, Teresa, Weger, Meltem, DaPonte, Jean Philippe, Straehle, Uwe, Dickmeis, Thomas and Jagla, Krzysztof (2013). Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 18982-18987. doi: 10.1073/pnas.1301262110
Dickmeis, Thomas, Weger, Benjamin D. and Weger, Meltem (2013). The circadian clock and glucocorticoids - Interactions across many time scales. Molecular and Cellular Endocrinology, 380 (1-2), 2-15. doi: 10.1016/j.mce.2013.05.012
Weger, Benjamin D., Weger, Meltem, Jung, Nicole, Lederer, Christin, Braese, Stefan and Dickmeis, Thomas (2013). A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. Journal of Visualized Experiments (79) e50439. doi: 10.3791/50439
Weger, Meltem, Weger, Benjamin D., Diotel, Nicolas, Rastegar, Sepand, Hirota, Tsuyoshi, Kay, Steve A., Straehle, Uwe and Dickmeis, Thomas (2013). Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology, 380 (2), 259-273. doi: 10.1016/j.ydbio.2013.04.035
Weger, Benjamin D., Weger, Meltem, Nusser, Michael, Brenner-Weiss, Gerald and Dickmeis, Thomas (2012). A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate. ACS Chemical Biology, 7 (7), 1178-1183. doi: 10.1021/cb3000474
Weger, Benjamin D., Sahinbas, Meltem, Otto, Georg W., Mracek, Philipp, Armant, Olivier, Dolle, Dirk, Lahiri, Kajori, Vallone, Daniela, Ettwiller, Laurence, Geisler, Robert, Foulkes, Nicholas S. and Dickmeis, Thomas (2011). The light responsive transcriptome of the zebrafish: function and regulation. PloS One, 6 (2) e17080, e17080. doi: 10.1371/journal.pone.0017080
Preprint
Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.