Professor Michael O'Sullivan
Honorary Professor
Institute for Molecular Bioscience
Researcher biography
Overview
Professor Michael O'Sullivan is a neuroscientist, neurologist and group leader at the Institute for Molecular Bioscience (IMB). His main research interest is the neurobiology of brain injury, with an emphasis on mechanisms of resilience and recovery of the brain after injury. His previous work has developed understanding in two broad areas:
- The cognitive neuroscience of memory and cognitive control – and how distributed and dynamic networks in the brain support these functions, which are often affected by injury.
- How injury alters network structure and function leading to symptoms in day-to-day life - and intrinsic mechanisms of neural adaptation that modulate the effect of injury
At the Institute for Molecular Bioscience, O'Sullivan is building a research program on cellular and molecular events that influence adaptation and recovery, including the role of innate immunity and glial cells. This program includes novel approaches to neuroprotection and the role of astrocytes as key regulators of glutamate and neuroinflammation. A major theme is identification of therapeutic targets, and evaluation of disease progression or treatment response in vivo, using advanced human imaging with MRI, PET and novel radiotracers. In addition to his Institute work, O'Sullivan leads clinical and biomarker projects in stroke and traumatic brain injury and is a member of the NHMRC Centre for Research Excellence in vascular mechanisms of cognitive impairment.
The group is at the forefront in the application of advanced techniques to investigate brain structure and function in vivo, including diffusion MRI and tractography, the use of functional MRI and EEG to examine to examine dynamic network interactions, and PET to examine neurochemistry.
Supervision
Professor O'Sullivan supervises PhD projects across multiple research areas, including clinical science, cognitive neuroscience, animal models and computational neuroscience (such as machine learning and deep learning algorithms for diagnosis and prediction of prognosis). Expressions of interest from potential PhD and honours students are welcome.
Book Chapter
Werring, David J. and O’Sullivan, Mike (2011). Cerebral microbleeds and cognitive impairment. Cerebral Microbleeds: Pathophysiology to Clinical Practice. (pp. 152-158) Cambridge University Press. doi: 10.1017/CBO9780511974892.020
Journal Articles
Oestreich, Lena K. L., Lo, Jessica W., Di Biase, Maria A., Sachdev, Perminder S., Mok, Alice H., Wright, Paul, Crawford, John D., Lam, Ben, Traykov, Latchezar, Köhler, Sebastian, Staals, Julie E. A., van Oostenbrugge, Robert, Chen, Christopher, Desmond, David W., Yu, Kyung‐Ho, Lee, Minwoo, Klimkowicz‐Mrowiec, Aleksandra, Bordet, Régis, O'Sullivan, Michael J. and Zalesky, Andrew (2024). Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets. Psychiatry and Clinical Neurosciences, 78 (4), 229-236. doi: 10.1111/pcn.13633
Harding, Ian H, Ryan, Joanne, Heritier, Stephane, Spark, Simone, Flanagan, Zachary, McIntyre, Richard, Anderson, Craig S, Naismith, Sharon L, Chong, Trevor T-J, O'Sullivan, Michael, Egan, Gary, Law, Meng and Zoungas, Sophia (2023). STAREE-Mind Imaging Study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals. BMJ Neurology Open, 5 (2) ARTN e000541, e000541. doi: 10.1136/bmjno-2023-000541
Li, Xuqian, Rangelov, Dragan, Mattingley, Jason B., Oestreich, Lena, Lévy-Bencheton, Delphine and O'Sullivan, Michael J. (2023). White matter microstructure is associated with the precision of visual working memory. NeuroImage, 272 120069, 1-11. doi: 10.1016/j.neuroimage.2023.120069
O’Sullivan, Michael J., Li, Xuqian, Galligan, Dana and Pendlebury, Sarah T. (2022). Cognitive recovery after stroke: memory. Stroke, 54 (1), 44-54. doi: 10.1161/strokeaha.122.041497
Oestreich, Lena K L, Wright, Paul and O’Sullivan, Michael J (2022). Hyperconnectivity and altered interactions of a nucleus accumbens network in post-stroke depression. Brain Communications, 4 (6) fcac281, 1-13. doi: 10.1093/braincomms/fcac281
Betrouni, Nacim, Jiang, Jiyang, Duering, Marco, Georgakis, Marios K., Oestreich, Lena, Sachdev, Perminder S., O’Sullivan, Michael, Wright, Paul, Lo, Jessica W., Bordet, Régis and on behalf of the Stroke and Cognition (STROKOG) Collaboration (2022). Texture features of magnetic resonance images predict poststroke cognitive impairment: validation in a multicenter study. Stroke, 53 (11), 101161STROKEAHA122039732-3454. doi: 10.1161/strokeaha.122.039732
O’Sullivan, Michael J., Oestreich, Lena K. L., Wright, Paul and Clarkson, Andrew N. (2022). Cholinergic and hippocampal systems facilitate cross-domain cognitive recovery after stroke. Brain, 145 (5), 1698-1710. doi: 10.1093/brain/awac070
Li, Xuqian, O'Sullivan, Michael J and Mattingley, Jason B. (2022). Delay activity during visual working memory: a meta-analysis of 30 fMRI experiments. NeuroImage, 255 119204, 119204. doi: 10.1016/j.neuroimage.2022.119204
Oestreich, Lena KL. and O’Sullivan, Michael J. (2022). Transdiagnostic in vivo magnetic resonance imaging markers of neuroinflammation. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7 (7), 638-658. doi: 10.1016/j.bpsc.2022.01.003
De Lucia, Chiara, Murphy, Tytus, Maruszak, Aleksandra, Wright, Paul, Powell, Timothy R., Hartopp, Naomi, De Jong, Simone, O'Sullivan, Michael J., Breen, Gerome, Price, Jack, Lovestone, Simon and Thuret, Sandrine (2021). Serum from older adults increases apoptosis and molecular aging markers in human hippocampal progenitor cells. Aging and Disease, 12 (8), 2151-2172. doi: 10.14336/AD.2021.0409
Major, Brendan, Symons, Georgia F., Sinclair, Ben, O'Brien, William T., Costello, Daniel, Wright, David K., Clough, Meaghan, Mutimer, Steven, Sun, Mujun, Yamakawa, Glenn R., Brady, Rhys D., O'Sullivan, Michael J., Mychasiuk, Richelle, McDonald, Stuart J., O'Brien, Terence J., Law, Meng, Kolbe, Scott and Shultz, Sandy R. (2021). White and gray matter abnormalities in Australian footballers with a history of sports-related concussion: An MRI study. Cerebral Cortex, 31 (12), 5331-5338. doi: 10.1093/cercor/bhab161
Wright, Paul, Veronese, Mattia, Mazibuko, Ndabezinhle, Turkheimer, Federico E., Rabiner, Eugenii A., Ballard, Clive G., Williams, Steven C. R., Hari Narayanan, Avinash Kumar, Osrah, Bahiya, Williams, Ricky, Marques, Tiago R., Howes, Oliver D., Roncaroli, Federico and O'Sullivan, Michael J. (2020). Patterns of mitochondrial TSPO binding in cerebral small vessel disease: an in vivo PET study with neuropathological comparison. Frontiers in Neurology, 11 541377, 541377. doi: 10.3389/fneur.2020.541377
Mazibuko, Ndaba, Tuura, Ruth O'Gorman, Sztriha, Laszlo, O'Daly, Owen, Barker, Gareth J., Williams, Steven C. R., O'Sullivan, Michael and Kalra, Lalit (2020). Subacute Changes in N-Acetylaspartate (NAA) Following Ischemic Stroke: A Serial MR Spectroscopy Pilot Study. Diagnostics, 10 (7) 482, 482. doi: 10.3390/diagnostics10070482
Tay, Jonathan, Lisiecka-Ford, Danuta M., Hollocks, Matthew J., Tuladhar, Anil M., Barrick, Thomas R., Forster, Anne, O’Sullivan, Michael J., Husain, Masud, de Leeuw, Frank-Erik, Morris, Robin G. and Markus, Hugh S. (2020). Network neuroscience of apathy in cerebrovascular disease. Progress in Neurobiology, 188 101785, 101785. doi: 10.1016/j.pneurobio.2020.101785
McFall, Aisling, Hietamies, Tuuli M, Bernard, Ashton, Aimable, Margaux, Allan, Stuart M, Bath, Philip M, Brezzo, Gaia, Carare, Roxana O, Carswell, Hilary V, Clarkson, Andrew N, Currie, Gillian, Farr, Tracy D, Fowler, Jill H, Good, Mark, Hainsworth, Atticus H, Hall, Catherine, Horsburgh, Karen, Kalaria, Rajesh, Kehoe, Patrick, Lawrence, Catherine, Macleod, Malcolm, McColl, Barry W, McNeilly, Alison, Miller, Alyson A, Miners, Scott, Mok, Vincent, O’Sullivan, Michael, Platt, Bettina, Sena, Emily S ... Quinn, Terence J (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40 (7), 1402-1414. doi: 10.1177/0271678X20910552
Oestreich, Lena K. L., Wright, Paul and O'Sullivan, Michael J. (2020). Microstructural changes in the reward system are associated with post-stroke depression. NeuroImage: Clinical, 28 102360, 102360. doi: 10.1016/j.nicl.2020.102360
McDonald, Matthew W., Black, Sandra E., Copland, David A., Corbett, Dale, Dijkhuizen, Rick M., Farr, Tracy D., Jeffers, Matthew S., Kaaria, Rajesh N., Karayanidis, Frini, Leff, Alexander P., Nithianantharajah, Jess, Pendlebury, Sarah, Quinn, Terence J., Clarkson, Andrew N. and O'Sullivan, Michael J. (2019). Cognition in stroke rehabilitation and recovery research: consensus-based core recommendations from the second stroke recovery and rehabilitation roundtable. Neurorehabilitation and Neural Repair, 33 (11), 943-950. doi: 10.1177/1545968319886444
McDonald, Matthew W., Black, Sandra E., Copland, David A., Corbett, Dale, Dijkhuizen, Rick M., Farr, Tracy D., Jeffers, Matthew S., Kalaria, Rajesh N., Karayanidis, Frini, Leff, Alexander P., Nithianantharajah, Jess, Pendlebury, Sarah, Quinn, Terence J., Clarkson, Andrew N. and O’Sullivan, Michael J. (2019). Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14 (8), 1747493019873600-782. doi: 10.1177/1747493019873600
O'Sullivan, Michael, Brownsett, Sonia and Copland, David (2019). Language and language disorders: neuroscience to clinical practice. Practical Neurology, 19 (5), practneurol-2018. doi: 10.1136/practneurol-2018-001961
Bernhardt, Julie, Borschmann, Karen N., Kwakkel, Gert, Burridge, Jane H., Eng, Janice J., Walker, Marion F., Bird, Marie-Louise, Cramer, Steven C., Hayward, Kathryn S., O’Sullivan, Michael J., Clarkson, Andrew N. and Corbett, Dale (2019). Setting the scene for the Second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14 (5), 450-456. doi: 10.1177/1747493019851287
Hartopp, Naomi, Wright, Paul, Ray, Nicola J., Evans, Tavia E., Metzler-Baddeley, Claudia, Aggleton, John P. and O’Sullivan, Michael J. (2019). A key role for subiculum-fornix connectivity in recollection in older age. Frontiers in Systems Neuroscience, 12 70, 70. doi: 10.3389/fnsys.2018.00070
Evans, Tavia E., Adams, Hieab H. H., Licher, Silvan, Wolters, Frank J., van der Lugt, Aad, Ikram, M. Kamran, O'Sullivan, Michael J., Vernooij, Meike W. and Ikram, M. Arfan (2018). Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia. NeuroImage, 178, 129-135. doi: 10.1016/j.neuroimage.2018.05.041
Horsburgh, Karen, Wardlaw, Joanna M., van Agtmael, Tom, Allan, Stuart M., Ashford, Mike L.J., Bath, Philip M., Brown, Rosalind, Berwick, Jason, Cader, M. Zameel, Carare, Roxana O., Davis, John B., Duncombe, Jessica, Farr, Tracy D., Fowler, Jill H., Goense, Jozien, Granata, Alessandra, Hall, Catherine N., Hainsworth, Atticus H., Harvey, Adam, Hawkes, Cheryl A., Joutel, Anne, Kalaria, Rajesh N., Kehoe, Patrick G., Lawrence, Catherine B., Lockhart, Andy, Love, Seth, Macleod, Malcolm R., Macrae, I. Mhairi, Markus, Hugh S. ... Work, Lorraine M. (2018). Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132 (8), 851-868. doi: 10.1042/CS20171620
Gan, C. L., O'Sullivan, M. J., Metzler-Baddeley, C. and Halpin, S. (2017). Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment. Clinical Radiology, 72 (11), 915-922. doi: 10.1016/j.crad.2017.04.021
Berlot, Rok and O'Sullivan, Michael J. (2017). What can the topology of white matter structural networks tell us about mild cognitive impairment?. Future Neurology, 12 (1), 35-50. doi: 10.2217/fnl-2016-0022
Berlot, Rok, Metzler-Baddeley, Claudia, Ikram, M. Arfan, Jones, Derek K. and O'Sullivan, Michael J. (2016). Global efficiency of structural networks mediates cognitive control in mild cognitive impairment. Frontiers in Aging Neuroscience, 8 (DEC) 292. doi: 10.3389/fnagi.2016.00292
Evans, Tavia E., O’Sullivan, Michael J. , de Groot, Marius, Niessen, Wiro J., Hofman, Albert, Krestin, Gabriel P. , van der Lugt, Aad, Portegies, Marileen L. P. , Koudstaal, Peter J., Bos, Daniel, Vernooij, Meike W. and Ikram, M. Arfan (2016). White matter microstructure improves stroke prediction in the general population. Stroke, 47 (11), 2756-2762. doi: 10.1161/STROKEAHA.116.014651
O'Sullivan, Michael J. and Vann, Seralynne D. (2016). Amyloid imaging and Alzheimer's disease: the unsolved cases. Brain, 139 (9), 2342-2344. doi: 10.1093/brain/aww166
Greenan, Caroline, Murphy, Lynn, Yu, Ly-Mee, Kehoe, Patrick G., Coulthard, Elizabeth, Bath, Philip, Stewart, Robert, Jones, Rob, Corbett, Anne, Thomas, Alan, Connelly, Peter, Arrojo, Frank, Canning, Rachel, Wallach, Sylvia, Henderson, Catherine, McGuinness, Bernadette, O'Sullivan, Mike, Holmes, Clive, Knapp, Martin, Ballard, Clive and Passmore, Peter (2016). A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol. Trials, 17 (324) 324. doi: 10.1186/s13063-016-1449-3
Reijmer, Yael D., Fotiadis, Panagiotis, Piantoni, Giovanni, Boulouis, Gregoire, Kelly, Kathleen E., Gurol, Mahmut E., Leemans, Alexander, O'Sullivan, Michael J., Greenberg, Steven M. and Viswanathan, Anand (2016). Small vessel disease and cognitive impairment: the relevance of central network connections. Human Brain Mapping, 37 (7), 2446-2454. doi: 10.1002/hbm.23186
Cooper, Sarah Anne and O'Sullivan, Michael (2016). Here, there and everywhere: higher visual function and the dorsal visual stream. Practical Neurology, 16 (3), 176-183. doi: 10.1136/practneurol-2015-001168
Christiansen, Kat, Aggleton, John P., Parker, Greg D., O'Sullivan, Michael J., Vann, Seralynne D. and Metzler-Baddeley, Claudia (2016). The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: an MRI tractography study. NeuroImage, 130, 35-47. doi: 10.1016/j.neuroimage.2015.12.055
Rees, D. Aled, Udiawar, Maneesh, Berlot, Rok, Jones, Derek K. and O'Sullivan, Michael J. (2016). White matter microstructure and cognitive function in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 101 (1), 314-323. doi: 10.1210/jc.2015-2318
Reijmer, Y. D., Schultz, A. P., Leemans, A., O'Sullivan, M. J., Gurol, M. E., Sperling, R., Greenberg, S. M., Viswanathan, A. and Hedden, T. (2015). Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities. NeuroImage, 117, 222-229. doi: 10.1016/j.neuroimage.2015.05.054
Ray, Nicola J., Metzler-Baddeley, Claudia, Khondoker, Mizanur R., Grothe, Michel J., Teipel, Stefan, Wright, Paul, Heinsen, Helmut, Jones, Derek K., Aggleton, John P. and O'Sullivan, Michael J. (2015). Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience, 35 (2), 739-747. doi: 10.1523/JNEUROSCI.3617-14.2015
Berlot, Rok, Metzler-Baddeley, Claudia, Jones, Derek K. and O'Sullivan, Michael J. (2014). CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment. NeuroImage, 92, 27-35. doi: 10.1016/j.neuroimage.2014.01.031
Ballard, Clive and O'Sullivan, Michael J. (2013). Alzheimer disease and stroke: cognitive and neuroimaging predictors of AD and stroke. Nature Reviews Neurology, 9 (11), 605-606. doi: 10.1038/nrneurol.2013.215
Metzler-Baddeley, Claudia, Baddeley, Roland J., Jones, Derek K., Aggleton, John P. and O'Sullivan, Michael J. (2013). Individual differences in fornix microstructure and Body Mass Index. PloS One, 8 (3) e59849, e59849. doi: 10.1371/journal.pone.0059849
Metzler-Baddeley, Claudia, Jones, Derek K., Steventon, Jessica, Westacott, Laura, Aggleton, John P. and O'Sullivan, Michael J. (2012). Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience, 32 (49), 17612-17619. doi: 10.1523/JNEUROSCI.3299-12.2012
Metzler-Baddeley, Claudia, Hunt, Sarah, Jones, Derek K., Leemans, Alexander, Aggleton, John P. and O'Sullivan, Michael J. (2012). Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology, 79 (23), 2233-2240. doi: 10.1212/WNL.0b013e31827689e8
Metzler-Baddeley, Claudia, O'Sullivan, Michael J., Bells, Sonya, Pasternak, Ofer and Jones, Derek K. (2012). How and how not to correct for CSF-contamination in diffusion MRI. NeuroImage, 59 (2), 1394-1403. doi: 10.1016/j.neuroimage.2011.08.043
Epelbaum, S., Benisty, S., Reyes, S., O'Sullivan, M., Jouvent, E., Duering, M., Herve, D., Opherk, C., Hernandez, K., Kurtz, A., Viswanathan, A., Bousser, M. G., Dichgans, M. and Chabriat, H. (2011). Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. Neurobiology of Aging, 32 (12), 2172-2182. doi: 10.1016/j.neurobiolaging.2009.12.018
Metzler-Baddeley, Claudia, Jones, Derek K., Belaroussi, Boubakeur, Aggleton, John P. and O'Sullivan, Michael J. (2011). Frontotemporal connections in episodic memory and aging: a diffusion MRI tractography study. Journal of Neuroscience, 31 (37), 13236-13245. doi: 10.1523/JNEUROSCI.2317-11.2011
O'Sullivan, Michael J., Neal, James W., Walters, R. Jon, Smith, Eric E. and Hughes, Thomas A. T. (2011). South Wales joint neuroscience meeting, Bridgend, 29 April 2010: A 66-year-old man who suddenly couldn't drive. Practical Neurology, 11 (3), 153-159. doi: 10.1136/practneurol-2011-000020
Viswanathan, Anand, Godin, Ophelia, Jouvent, Eric, O'Sullivan, Michael, Gschwendtner, Andreas, Peters, Nils, Duering, Marco, Guichard, Jean-Pierre, Holtmannspoetter, Markus, Dufouil, Carole, Pachai, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2010). Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL. Neurobiology of Aging, 31 (9), 1629-1636. doi: 10.1016/j.neurobiolaging.2008.09.001
O’Sullivan, Mike (2009). Patterns of atrophy on MRI and the boundary between ageing and Alzheimer’s disease. Reviews in Clinical Gerontology, 19 (4), 295-307. doi: 10.1017/S0959259809990426
O'Sullivan, Mike, Ngo, Elmar, Viswanathan, Anand, Jouvent, Eric, Gschwendtner, Andreas, Saemann, Philipp G., Duering, Marco, Pachai, Chahin, Bousser, Marie-Germaine, Chabriat, Hugues and Dichgans, Martin (2009). Hippocampal volume is an independent predictor of cognitive performance in CADASIL. Neurobiology of Aging, 30 (6), 890-897. doi: 10.1016/j.neurobiolaging.2007.09.002
Reyes, S., Viswanathan, A., Godin, O., Dufouil, C., Benisty, S., Hernandez, K., Kurtz, A., Jouvent, E., O'Sullivan, M., Czernecki, V., Bousser, M. G., Dichgans, M. and Chabriat, H. (2009). Apathy: A major symptom in Cadasil. Neurology, 72 (10), 905-910. doi: 10.1212/01.wnl.0000344166.03470.f8
O'Sullivan, Mike, Jouvent, Eric, Saernann, Philipp G., Mangin, Jean-Francois, Viswanathan, Anand, Gschwendtner, Andreas, Bracoud, Luc, Pachai, Chahin, Chabriat, Hugues and Dichgans, Martin (2008). Measurement of brain atrophy in subcortical vascular disease: A comparison of different approaches and the impact of ischaemic lesions. Neuroimage, 43 (2), 312-320. doi: 10.1016/j.neuroimage.2008.07.049
Jouvent, Eric, Mangin, Jean-François, Porcher, Raphael, Viswanathan, Anand, O'Sullivan, Mike, Guichard, Jean-Pierre, Dichgans, Martin, Bousser, Marie-Germaine and Chabriat, Hugues (2008). Cortical changes in cerebral small vessel diseases: A 3D MRI study of cortical morphology in CADASIL. Brain, 131 (8), 2201-2208. doi: 10.1093/brain/awn129
Benisty, Sarah, Hernandez, Karen, Viswanathan, Anand, Reyes, Sonia, Kurtz, Annie, O'Sullivan, Michael, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2008). Diagnostic criteria of vascular dementia in CADASIL. Stroke, 39 (3), 838-844. doi: 10.1161/STROKEAHA.107.490672
O'Sullivan, Mike (2008). Leukoaraiosis. Practical Neurology, 8 (1), 26-38. doi: 10.1136/jnnp.2007.139428
O'Sullivan, Mike (2008). Prestroke cognitive function and cerebrovascular disease: If they interact, it may not be through symptomatic stroke. Stroke, 39 (1), 3-4. doi: 10.1161/STROKEAHA.107.496679
Viswanathan, A., Gschwendtner, A., Guichard, J. P., Buffon, F., Cumurciuc, R., O'Sullivan, M., Holtmannspötter, M., Pachai, C., Bousser, M. G., Dichgans, M. and Chabriat, H. (2007). Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL. Neurology, 69 (2), 172-179. doi: 10.1212/01.wnl.0000265221.05610.70
Jouvent, Eric, Viswanathan, Anand, Mangin, Jean-François, O'Sullivan, Mike, Guichard, Jean-Pierre, Gschwendtner, Andreas, Cumurciuc, Rodica, Buffon, Frédérique, Peters, Nils, Pachaï, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2007). Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL. Stroke, 38 (6), 1786-1790. doi: 10.1161/STROKEAHA.106.478263
Nitkunan, Arani, McIntyre, Dominick J.O., Barrick, Thomas R., O'Sullivan, Michael, Shen, Yuji, Clark, Chris A., Howe, Franklyn A. and Markus, Hugh S. (2006). Correlations between MRS and DTI in cerebral small vessel disease. NMR in Biomedicine, 19 (5), 610-616. doi: 10.1002/nbm.1052
Jones, Derek K., Catani, Marco, Pierpaoli, Carlo, Reeves, Suzanne J. C., Shergill, Sukhwinder S., O'Sullivan, Michael, Golesworthy, Pasha, McGuire, Phillip, Horsfield, Mark A., Simmons, Andrew, Williams, Steven C. R. and Howard, Robert J. (2006). Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Human Brain Mapping, 27 (3), 230-238. doi: 10.1002/hbm.20179
Charlton, R. A., Barrick, T. R., McIntyre, D. J., Shen, Y., O'Sullivan, M., Howe, F. A., Clark, C. A., Morris, R. G. and Markus, H. S. (2006). White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology, 66 (2), 217-222. doi: 10.1212/01.wnl.0000194256.15247.83
O'Sullivan, Mike, Morris, R. G. and Markus, H. S. (2005). Brief cognitive assessment for patients with cerebral small vessel disease. Journal of Neurology, Neurosurgery and Psychiatry, 76 (8), 1140-1145. doi: 10.1136/jnnp.2004.045963
O'Sullivan, M., Barrick, T. R., Morris, R. G., Clark, C. A. and Markus, H. S. (2005). Damage within a network of white matter regions underlies executive dysfunction in CADASIL. Neurology, 65 (10), 1584-1590. doi: 10.1212/01.wnl.0000184480.07394.fb
Jones, Derek K., Catani, Marco, Pierpaoli, Carlo, Reeves, Suzanne J., Shergill, Sukhwinder S., O'Sullivan, Michael, Maguire, Philip, Horsfield, Mark A., Simmons, Andrew, Williams, Steven C. R. and Howard, Robert J. (2005). A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis. American Journal of Geriatric Psychiatry, 13 (12), 1092-1099. doi: 10.1097/00019442-200512000-00009
O'Sullivan, Michael, Singhal, Sumeet, Charlton, Rebecca and Markus, Hugh S. (2004). Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia. Neurology, 62 (5), 702-707. doi: 10.1212/01.WNL.0000113760.72706.D2
O'Sullivan, M., Morris, R. G., Huckstep, B., Jones, D. K., Williams, S. C.R. and Markus, H. S. (2004). Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. Journal of Neurology, Neurosurgery and Psychiatry, 75 (3), 441-447. doi: 10.1136/jnnp.2003.014910
Hassan, A., Gormley, K., O'Sullivan, M., Knight, J., Sham, P., Vallance, P., Bamford, J. and Markus, Hugh (2004). Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease. Stroke, 35 (3), 654-659. doi: 10.1161/01.STR.0000117238.75736.53
Hassan, Ahamad, Hunt, Beverley J., O'Sullivan, Michael, Bell, Rachel, D'Souza, Reuben, Jeffery, Steve, Bamford, John M. and Markus, Hugh S. (2004). Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain, 127 (1), 212-219. doi: 10.1093/brain/awh023
O'Sullivan, Michael, Rich, Philip M., Barrick, Thomas R., Clark, Christopher A. and Markus, Hugh S. (2003). Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. American Journal of Neuroradiology, 24 (7), 1348-1354.
Hassan, Ahamad, Hunt, Beverley J., O'Sullivan, Michael, Parmar, Kiran, Bamford, John M., Briley, Dennis, Brown, Martin M., Thomas, Dafydd J. and Markus, Hugh S. (2003). Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain, 126 (2), 424-432. doi: 10.1093/brain/awg040
O'Sullivan, M., Lythgoe, D. J., Pereira, A. C., Summers, P. E., Jarosz, J. M., Williams, S. C.R. and Markus, H. S. (2002). Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology, 59 (3), 321-326. doi: 10.1212/WNL.59.3.321
O'Sullivan, M., Summers, P. E., Jones, D. K., Jarosz, J. M., Williams, S. C.R. and Markus, H. S. (2001). Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study. Neurology, 57 (12), 2307-2310. doi: 10.1212/WNL.57.12.2307
O'Sullivan, Mike, Jones, D. K., Summers, P. E., Morris, R. G., Williams, S. C.R. and Markus, H. S. (2001). Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology, 57 (4), 632-638. doi: 10.1212/WNL.57.4.632
O'Sullivan, Michael, Jarosz, J. M., Martin, R. J., Deasy, N., Powell, J. F. and Markus, H. S. (2001). MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology, 56 (5), 628-634. doi: 10.1212/WNL.56.5.628
Markus, H. S., Lythgoe, D. J., Ostegaard, L., O'Sullivan, M. and Williams, S. C.R. (2000). Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. Journal of Neurology Neurosurgery and Psychiatry, 69 (1), 48-53. doi: 10.1136/jnnp.69.1.48
Conference Papers
Oestreich, L. K. L., Wright, P. and O'Sullivan, M. J. (2021). Aberrant brain dynamics and structure associated with post-stroke depression. Stroke Society of Australasia Annual Scientific Meeting, Perth, WA Australia, 13–15 October 2021. London, United Kingdom: SAGE Publications.
Veronese, M., Wright, P., Mazibuko, N., Turkheimer, F. E., Rabiner, E. E., Ballard, C. G., Williams, S. C. R., Williams, R., Roncaroli, F. and O'Sullivan, M. J. (2019). Investigating neuroinflammation in small vessel disease with [11C]PBR28 PET imaging and post-mortem tissue validation. 29th International Symposium on Cerebral Blood Flow, Metabolism and Function / 14th International Conference on Quantification of Brain Function with PET (BRAIN and BRAIN Pet), Yokohama Japan, 4-7 July, 2019. London, United Kingdom: Sage Publications. doi: 10.1177/0271678X19850985
Bernhardt, Julie, Borschmann, Karen, Kwakkel, Gert, Burridge, Jane, Eng, Janice, Walker, Marion, Bird, Marie-Louise, Cramer, Steven, Hayward, Kathryn, O'Sullivan, Michael, Clarkson, Andrew and Corbett, Dale (2019). Consensus building at the Second International Stroke Recovery and Rehabilitation Roundtable. SSA 2019 Conference, Canberra, Australia, 10 – 13 September 2019. London, United Kingdom: Sage Publications. doi: 10.1177/1747493019862960
Oestreich, Lena, Wright, Paul, Williams, Steven and O'Sullivan, Michael (2019). Towards the development of neuroimaging biomarkers for post-stroke depression. SSA 2019 Conference, Canberra, Australia, 10 – 13 September 2019. London, United Kingdom: Sage Publications. doi: 10.1177/1747493019862960
Wright, P. and O'Sullivan, M. J. (2018). Predictors of episodic memory recovery one year after stroke. World Stroke Congress 2018, London, United Kingdom: Sage Publications.
Evans, T., O'Sullivan, M., Niessen, W., Ikram, M. A. and Vernooij, M. (2018). Lacunar infarct burden within white matter tracts and cognitive function. World Stroke Congress 2018, London, United Kingdom: Sage Publications.
O'Sullivan, Michael (2010). Imaging small vessel disease: Lesion topography, networks, and cognitive deficits investigated with MRI. 27th Princeton Conference 2010, Boston Ma, Apr 22-24, 2010. doi: 10.1161/STROKEAHA.110.595314