Associate Professor Loic Yengo
Group Leader, Statistical Genomics
+61 7 334 62095
Journal Articles
Richard, Daniel, Muthuirulan, Pushpanathan, Young, Mariel, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Bartell, Eric, Hirschhorn, Joel and Capellini, Terence D. (2024). Functional genomics of human skeletal development and the patterning of height heritability. Cell. doi: 10.1016/j.cell.2024.10.040
Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Yengo, Loic, Zeng, Jian, Toivonen, Jarkko, Arvas, Mikko, Beaumont, Robin N., Freathy, Rachel M., Moen, Gunn-Helen, Warrington, Nicole M. and Evans, David M. (2024). DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits. Nature Communications, 15 (1) 9255, 1-14. doi: 10.1038/s41467-024-53495-9
Davies, Neil M., Hemani, Gibran, Neiderhiser, Jenae M., Martin, Hilary C., Mills, Melinda C., Visscher, Peter M., Yengo, Loïc, Young, Alexander Strudwick and Keller, Matthew C. (2024). The importance of family-based sampling for biobanks. Nature, 634 (8035), 795-803. doi: 10.1038/s41586-024-07721-5
Kemper, Kathryn E., Sidorenko, Julia, Wang, Huanwei, Hayes, Ben J., Wray, Naomi R., Yengo, Loic, Keller, Matthew C., Goddard, Michael and Visscher, Peter M. (2024). Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank. Nature Communications, 15 (1) 3776, 3776. doi: 10.1038/s41467-024-47802-7
Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Wang, Ying, Lin, Tian, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Snieder, Harold, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera Maya, Esteban A., Sanna, Serena, Swertz, Morris A., Vonk, Judith M., Wijmenga, Cisca, Yang, Jian, Wray, Naomi R., Goddard, Michael E., Visscher, Peter M., Zeng, Jian and LifeLines Cohort Study (2024). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. Nature Genetics, 56 (5), 1-11. doi: 10.1038/s41588-024-01704-y
Cabrera-Mendoza, Brenda, Wendt, Frank R., Pathak, Gita A., Yengo, Loic and Polimanti, Renato (2024). The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. Nature Human Behaviour, 8 (5), 976-987. doi: 10.1038/s41562-024-01828-5
Mbarek, Hamdi, Gordon, Scott D., Duffy, David L., Hubers, Nikki, Mortlock, Sally, Beck, Jeffrey J., Hottenga, Jouke-Jan, Pool, René, Dolan, Conor V., Actkins, Ky’Era V., Gerring, Zachary F., Van Dongen, Jenny, Ehli, Erik A., Iacono, William G., Mcgue, Matt, Chasman, Daniel I., Gallagher, C. Scott, Schilit, Samantha L. P., Morton, Cynthia C., Paré, Guillaume, Willemsen, Gonneke, Whiteman, David C., Olsen, Catherine M., Derom, Catherine, Vlietinck, Robert, Gudbjartsson, Daniel, Cannon-Albright, Lisa, Krapohl, Eva, Plomin, Robert ... Martin, Nicholas G. (2024). Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. Human Reproduction, 39 (1), 240-257. doi: 10.1093/humrep/dead247
Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor ... Frontini, Mattia (2024). SMIM1 absence is associated with reduced energy expenditure and excess weight. Med, 5 (9), 1083-1095.e6. doi: 10.1016/j.medj.2024.05.015
Wang, Xiaotong, Hivert, Valentin, Groot, Shiane, Wang, Ying, Yengo, Loic, McGrath, John J., Kemper, Kathryn E., Visscher, Peter M., Wray, Naomi R. and Revez, Joana A. (2023). Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D. PLoS Genetics, 19 (11) e1011033, e1011033. doi: 10.1371/journal.pgen.1011033
Hawkes, Gareth, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Beaumont, Robin N., Tyrrell, Jessica, Weedon, Michael N., Hirschhorn, Joel, Frayling, Timothy M. and Wood, Andrew R. (2023). Identification and analysis of individuals who deviate from their genetically-predicted phenotype. PLoS Genetics, 19 (9) e1010934. doi: 10.1371/journal.pgen.1010934
Campos, Adrian I., Namba, Shinichi, Lin, Shu-Chin, Nam, Kisung, Sidorenko, Julia, Wang, Huanwei, Kamatani, Yoichiro, The Biobank Japan Project, Wang, Ling-Hua, Lee, Seunggeun, Lin, Yen-Feng, Feng, Yen-Chen Anne, Okada, Yukinori, Visscher, Peter M. and Yengo, Loic (2023). Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores. Nature Genetics, 55 (10), 1769-1776. doi: 10.1038/s41588-023-01500-0
Niemi, Mari E. K., Karjalainen, Juha, Liao, Rachel G., Neale, Benjamin M., Daly, Mark, Ganna, Andrea, Pathak, Gita A., Andrews, Shea J., Kanai, Masahiro, Veerapen, Kumar, Fernandez-Cadenas, Israel, Schulte, Eva C., Striano, Pasquale, Marttila, Minttu, Minica, Camelia, Marouli, Eirini, Karim, Mohd Anisul, Wendt, Frank R., Savage, Jeanne, Sloofman, Laura, Butler-Laporte, Guillaume, Kim, Han-Na, Kanoni, Stavroula, Okada, Yukinori, Byun, Jinyoung, Han, Younghun, Uddin, Mohammed Jashim, Smith, George Davey, Willer, Cristen J. ... Donohue, Chloe (2023). Erratum to: Mapping the human genetic architecture of COVID-19 (Nature, (2021), 600, 7889, (472-477), 10.1038/s41586-021-03767-x). Nature, 621 (7977), E7-E26. doi: 10.1093/1476-4687
Li, Josephine H., Brenner, Laura N., Kaur, Varinderpal, Figueroa, Katherine, Schroeder, Philip, Huerta-Chagoya, Alicia, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Chan, Kei Hang Katie, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng ... Florez, Jose C. (2023). Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH. Diabetologia, 66 (7), 1260-1272. doi: 10.1007/s00125-023-05922-7
Baronas, John M., Bartell, Eric, Eliasen, Anders, Doench, John G., Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Kronenberg, Henry M., Hirschhorn, Joel N. and Renthal, Nora E. (2023). Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci. Cell Genomics, 3 (5) 100299, 100299. doi: 10.1016/j.xgen.2023.100299
Yengo, Loic (2023). Mate choice through a genomic lens. Nature Reviews Genetics, 24 (10), 664-664. doi: 10.1038/s41576-023-00605-w
Abdellaoui, Abdel, Yengo, Loic, Verweij, Karin J. H. and Visscher, Peter M. (2023). 15 years of GWAS discovery: realizing the promise. The American Journal of Human Genetics, 110 (2), 179-194. doi: 10.1016/j.ajhg.2022.12.011
Qiao, Zhen, Sidorenko, Julia, Revez, Joana A., Xue, Angli, Lu, Xueling, Pärna, Katri, Snieder, Harold, Visscher, Peter M., Wray, Naomi R., Yengo, Loic and Lifelines Cohort Study (2023). Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose. Nature Communications, 14 (1) 451, 1-11. doi: 10.1038/s41467-023-36013-1
Pang, Shichao, Yengo, Loic, Nelson, Christopher P., Bourier, Felix, Zeng, Lingyao, Li, Ling, Kessler, Thorsten, Erdmann, Jeanette, Mägi, Reedik, Läll, Kristi, Metspalu, Andres, Mueller-Myhsok, Bertram, Samani, Nilesh J., Visscher, Peter M. and Schunkert, Heribert (2023). Genetic and modifiable risk factors combine multiplicatively in common disease. Clinical Research in Cardiology, 112 (2), 247-257. doi: 10.1007/s00392-022-02081-4
Huang, Jie, Huffman, Jennifer E., Huang, Yunfeng, Do Valle, Ítalo, Assimes, Themistocles L., Raghavan, Sridharan, Voight, Benjamin F., Liu, Chang, Barabási, Albert-László, Huang, Rose D. L., Hui, Qin, Nguyen, Xuan-Mai T., Ho, Yuk-Lam, Djousse, Luc, Lynch, Julie A., Vujkovic, Marijana, Tcheandjieu, Catherine, Tang, Hua, Damrauer, Scott M., Reaven, Peter D., Miller, Donald, Phillips, Lawrence S., Ng, Maggie C. Y., Graff, Mariaelisa, Haiman, Christopher A., Loos, Ruth J. F., North, Kari E., Yengo, Loic, Smith, George Davey ... VA Million Veteran Program (2022). Genomics and phenomics of body mass index reveals a complex disease network. Nature Communications, 13 (1) 7973, 1-10. doi: 10.1038/s41467-022-35553-2
Border, Richard, O’Rourke, Sean, de Candia, Teresa, Goddard, Michael E., Visscher, Peter M., Yengo, Loic, Jones, Matt and Keller, Matthew C. (2022). Author Correction: Assortative mating biases marker-based heritability estimators (Nature Communications, (2022), 13, 1, (660), 10.1038/s41467-022-28294-9). Nature Communications, 13 (1) 1903, 1903. doi: 10.1038/s41467-022-29652-3
Yengo, Loic (2022). The Yearbook: 11 early-career researchers to watch. Nature Medicine, 28 (12), 2441-2443. doi: 10.1038/s41591-022-02133-2
Gomez, Lina, Díaz-Torres, Santiago, Colodro-Conde, Lucía, Garcia-Marin, Luis M., Yap, Chloe X., Byrne, Enda M., Yengo, Loic, Lind, Penelope A., Wray, Naomi R., Medland, Sarah E., Hickie, Ian B., Lupton, Michelle K., Rentería, Miguel E., Martin, Nicholas G. and Campos, Adrian I. (2022). Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study. European Archives of Psychiatry and Clinical Neuroscience, 273 (6), 1359-1368. doi: 10.1007/s00406-022-01527-0
Visscher, Peter M. and Yengo, Loic (2022). The effect of the scale of grant scoring on ranking accuracy. F1000Research, 11 1197, 1-18. doi: 10.12688/f1000research.125400.1
Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U., Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D., Graham, Sarah E., Mukamel, Ronen E., Spracklen, Cassandra N., Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H., Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E., Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling ... Understanding Society Scientific Group (2022). A saturated map of common genetic variants associated with human height. Nature, 610 (7933), 704-712. doi: 10.1038/s41586-022-05275-y
Yamamoto, Kenichi, Sonehara, Kyuto, Namba, Shinichi, Konuma, Takahiro, Masuko, Hironori, Miyawaki, Satoru, Kamatani, Yoichiro, Hizawa, Nobuyuki, Ozono, Keiichi, Yengo, Loic, Okada, Yukinori and The BioBank Japan Project (2022). Genetic footprints of assortative mating in the Japanese population. Nature Human Behaviour, 7 (1), 1-9. doi: 10.1038/s41562-022-01438-z
Mahajan, Anubha, Spracklen, Cassandra N., Zhang, Weihua, Ng, Maggie C. Y., Petty, Lauren E., Kitajima, Hidetoshi, Yu, Grace Z., Rüeger, Sina, Speidel, Leo, Kim, Young Jin, Horikoshi, Momoko, Mercader, Josep M., Taliun, Daniel, Moon, Sanghoon, Kwak, Soo-Heon, Robertson, Neil R., Rayner, Nigel W., Loh, Marie, Kim, Bong-Jo, Chiou, Joshua, Miguel-Escalada, Irene, della Briotta Parolo, Pietro, Lin, Kuang, Bragg, Fiona, Preuss, Michael H., Takeuchi, Fumihiko, Nano, Jana, Guo, Xiuqing, Lamri, Amel ... Morris, Andrew P. (2022). Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nature Genetics, 54 (5), 560-572. doi: 10.1038/s41588-022-01058-3
Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hyeokmoon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Hicks, Barry, Tian, Chao, Hinds, David A., Ahlskog, Rafael, Magnusson, Patrik K E, Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David J., Freese, Jeremy, Herd, Pamela, Watson, Chelsea, Jala, Jonathan, Conley, Dalton, Koellinger, Philipp D., Johannesson, Magnus, Laibson, David, Meyer, Michelle N. ... Social Science Genetic Association Consortium (2022). Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals. Nature Genetics, 54 (4), 437-449. doi: 10.1038/s41588-022-01016-z
Wainschtein, Pierrick, Jain, Deepti, Zheng, Zhili, Aslibekyan, Stella, Becker, Diane, Bi, Wenjian, Brody, Jennifer, Carlson, Jenna C., Correa, Adolfo, Du, Margaret Mengmeng, Fernandez-Rhodes, Lindsay, Ferrier, Kendra R., Graff, Misa, Guo, Xiuqing, He, Jiang, Heard-Costa, Nancy L., Highland, Heather M., Hirschhorn, Joel N., Howard-Claudio, Candace M., Isasi, Carmen R., Jackson, Rebecca, Jiang, Jicai, Joehanes, Roby, Justice, Anne E., Kalyani, Rita R., Kardia, Sharon, Lange, Ethan, LeBoff, Meryl, Lee, Seunggeun ... NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium (2022). Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nature Genetics, 54 (3), 263-273. doi: 10.1038/s41588-021-00997-7
Yengo, Loic and Colleran, Heidi (2022). Constrained human genes under scrutiny. Nature, 603 (7903), 799-801. doi: 10.1038/d41586-022-00693-4
Border, Richard, O’Rourke, Sean, de Candia, Teresa, Goddard, Michael E., Visscher, Peter M., Yengo, Loic, Jones, Matt and Keller, Matthew C. (2022). Assortative mating biases marker-based heritability estimators. Nature Communications, 13 (1) 660. doi: 10.1038/s41467-022-28294-9
Niemi, Mari E. K., Karjalainen, Juha, Daly, Mark, Ganna, Andrea, Mehtonen, Juha, Cordioli, Mattia, Kaunisto, Mari, Pigazzini, Sara, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Daly, Mark J., Liao, Rachel G., Kanai, Masahiro, Veerapen, Kumar, Minica, Camelia, Trankiem, Amy, Balaconis, Mary K., Nguyen, Huy, Solomonson, Matthew, Francioli, Laurent, Wang, Qingbo, Green, Robert C., Bryant, Sam, Finucane, Hilary, Martin, Alicia R., Zhou, Wei, Nkambule, Lindokuhle, Karczewski, Konrad J. ... COVID-19 Host Genetics Initiative (2021). Mapping the human genetic architecture of COVID-19. Nature, 600 (7889), 472-477+. doi: 10.1038/s41586-021-03767-x
Porcu, Eleonora, Gilardi, Federica, Darrous, Liza, Yengo, Loic, Bararpour, Nasim, Gasser, Marie, Marques-Vidal, Pedro, Froguel, Philippe, Waeber, Gerard, Thomas, Aurelien and Kutalik, Zoltán (2021). Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes. Scientific Reports, 11 (1) 6197, 6197. doi: 10.1038/s41598-021-85684-7
Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa ... Prokopenko, Inga (2021). Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9). Nature Communications, 12 (1) 995, 995. doi: 10.1038/s41467-021-21276-3
Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa ... Prokopenko, Inga (2021). Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications, 12 (1) 24, 24. doi: 10.1038/s41467-020-19366-9
Pathak, Gita A., Singh, Kritika, Miller-Fleming, Tyne W., Wendt, Frank R., Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K. and Mancuso, Nicholas (2021). Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. Nature Communications, 12 (1) 4569, 4569. doi: 10.1038/s41467-021-24824-z
Wang, Xiaotong, Lin, Tian, Yengo, Loic, Sidorenko, Julia, Wray, Naomi R. and Levinson, Douglas F. (2021). Polygenic burden could explain high rates of affective disorders in a community with restricted founder population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 186 (6), 367-375. doi: 10.1002/ajmg.b.32876
Visscher, Peter M., Yengo, Loic, Cox, Nancy J. and Wray, Naomi R. (2021). Discovery and implications of polygenicity of common diseases. Science, 373 (6562), 1468-1473. doi: 10.1126/science.abi8206
van Blokland, Irene V., Lanting, Pauline, Ori, Anil P.S., Vonk, Judith M., Warmerdam, Robert C.A., Herkert, Johanna C., Boulogne, Floranne, Claringbould, Annique, Lopera-Maya, Esteban A., Bartels, Meike, Hottenga, Jouke-Jan, Ganna, Andrea, Karjalainen, Juha, Hayward, Caroline, Fawns-Ritchie, Chloe, Campbell, Archie, Porteous, David, Cirulli, Elizabeth T., Barrett, Kelly M. Schiabor, Riffle, Stephen, Bolze, Alexandre, White, Simon, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Lim, Yan Wei, Lu, James T., Washington, Nicole L., de Geus, Eco J. C. ... Yengo, Loic (2021). Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility. PLoS One, 16 (8) e0255402, 1-18. doi: 10.1371/journal.pone.0255402
Yengo, Loic, Yang, Jian, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2021). Genomic partitioning of inbreeding depression in humans. American Journal of Human Genetics, 108 (8), 1488-1501. doi: 10.1016/j.ajhg.2021.06.005
Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian'an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Chan, Kei Hang Katie, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C. ... Barroso, Inês (2021). The trans-ancestral genomic architecture of glycemic traits. Nature genetics, 53 (6), 840-860. doi: 10.1038/s41588-021-00852-9
Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021). American Journal of Human Genetics, 108 (5), 962-962. doi: 10.1016/j.ajhg.2021.04.012
Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christian, Brandewinder, Marie, Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N, Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M and Vandewalle, Gilles (2021). Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137). Sleep, 44 (5) zsaa137. doi: 10.1093/sleep/zsab079
Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals. The American Journal of Human Genetics, 108 (5), 786-798. doi: 10.1016/j.ajhg.2021.02.014
Guo, Jing, Bakshi, Andrew, Wang, Ying, Jiang, Longda, Yengo, Loic, Goddard, Michael E., Visscher, Peter M. and Yang, Jian (2021). Quantifying genetic heterogeneity between continental populations for human height and body mass index. Scientific Reports, 11 (1) 5240, 1-9. doi: 10.1038/s41598-021-84739-z
Zeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3
Kemper, Kathryn E., Yengo, Loic, Zheng, Zhili, Abdellaoui, Abdel, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2021). Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals. Nature Communications, 12 (1) 1050, 1050. doi: 10.1038/s41467-021-21283-4
Baselmans, Bart M.L., Yengo, Loic, van Rheenen, Wouter and Wray, Naomi R. (2021). Risk in relatives, heritability, SNP-based heritability and genetic correlations in psychiatric disorders: a review. Biological Psychiatry, 89 (1), 11-19. doi: 10.1016/j.biopsych.2020.05.034
Vogelezang, Suzanne, Bradfield, Jonathan P., Ahluwalia, Tarunveer S., Curtin, John A., Lakka, Timo A., Grarup, Niels, Scholz, Markus, van der Most, Peter J., Monnereau, Claire, Stergiakouli, Evie, Heiskala, Anni, Horikoshi, Momoko, Fedko, Iryna O., Vilor-Tejedor, Natalia, Cousminer, Diana L., Standl, Marie, Wang, Carol A., Viikari, Jorma, Geller, Frank, Íñiguez, Carmen, Pitkänen, Niina, Chesi, Alessandra, Bacelis, Jonas, Yengo, Loic, Torrent, Maties, Ntalla, Ioanna, Helgeland, Øyvind, Selzam, Saskia, Vonk, Judith M. ... Felix, Janine F. (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genetics, 16 (10) e1008718, e1008718. doi: 10.1371/journal.pgen.1008718
Bonnefond, Amélie, Boissel, Mathilde, Bolze, Alexandre, Durand, Emmanuelle, Toussaint, Bénédicte, Vaillant, Emmanuel, Gaget, Stefan, Graeve, Franck De, Dechaume, Aurélie, Allegaert, Frédéric, Guilcher, David Le, Yengo, Loïc, Dhennin, Véronique, Borys, Jean-Michel, Lu, James T., Cirulli, Elizabeth T., Elhanan, Gai, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Franc, Sylvia, Charpentier, Guillaume, Vaxillaire, Martine, Canouil, Mickaël, Washington, Nicole L., Grzymski, Joseph J. and Froguel, Philippe (2020). Pathogenic variants in actionable MODY genes are associated with type 2 diabetes. Nature Metabolism, 2 (10), 1126-1134. doi: 10.1038/s42255-020-00294-3
Zhang, Qian, Sidorenko, Julia, Couvy-Duchesne, Baptiste, Marioni, Riccardo E., Wright, Margaret J., Goate, Alison M., Marcora, Edoardo, Huang, Kuan-lin, Porter, Tenielle, Laws, Simon M., Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Sachdev, Perminder S., Mather, Karen A., Armstrong, Nicola J., Thalamuthu, Anbupalam, Brodaty, Henry, Yengo, Loic, Yang, Jian, Wray, Naomi R., McRae, Allan F. and Visscher, Peter M. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11 (1) 4799, 1-11. doi: 10.1038/s41467-020-18534-1
Raymond, Biaty, Yengo, Loic, Costilla, Roy, Schrooten, Chris, Bouwman, Aniek C., Hayes, Ben J., Veerkamp, Roel F. and Visscher, Peter M. (2020). Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock. PLoS Genetics , 16 (9) e1008780, 1-20. doi: 10.1371/journal.pgen.1008780
Wang, Ying, Guo, Jing, Ni, Guiyan, Yang, Jian, Visscher, Peter M. and Yengo, Loic (2020). Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations. Nature Communications, 11 (1) 3865, 3865. doi: 10.1038/s41467-020-17719-y
Couvy‐Duchesne, Baptiste, Strike, Lachlan T., Zhang, Futao, Holtz, Yan, Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Colliot, Olivier, Wright, Margaret J., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2020). A unified framework for association and prediction from vertex‐wise grey‐matter structure. Human Brain Mapping, 41 (14) hbm.25109, 4062-4076. doi: 10.1002/hbm.25109
Yengo, Loic, Sidari, Morgan, Verweij, Karin J. H., Visscher, Peter M., Keller, Matthew C. and Zietsch, Brendan P. (2019). No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: A reappraisal of Domingue et al (2018). Behavior Genetics, 50 (1), 67-71. doi: 10.1007/s10519-019-09979-2
Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2019). Improved polygenic prediction by Bayesian multiple regression on summary statistics. Nature Communications, 10 (1) 5086, 1-10. doi: 10.1038/s41467-019-12653-0
Abdellaoui, Abdel, Hugh-Jones, David, Yengo, Loic, Kemper, Kathryn E., Nivard, Michel G., Veul, Laura, Holtz, Yan, Zietsch, Brendan P., Frayling, Timothy M., Wray, Naomi R., Yang, Jian, Verweij, Karin J. H. and Visscher, Peter M. (2019). Genetic correlates of social stratification in Great Britain. Nature Human Behaviour, 3 (12), 1332-1342. doi: 10.1038/s41562-019-0757-5
Yengo, Loic, Wray, Naomi R. and Visscher, Peter M. (2019). Extreme inbreeding in a European ancestry sample from the contemporary UK population. Nature Communications, 10 (1) 3719, 3719. doi: 10.1038/s41467-019-11724-6
Wray, Naomi R. and Yengo, Loic (2019). Assortative mating in autism spectrum disorder: toward an evidence base from DNA data, but not there yet. Biological Psychiatry, 86 (4), 250-252. doi: 10.1016/j.biopsych.2019.06.007
Liu, Ching-Ti, Merino, Jordi, Rybin, Denis, DiCorpo, Daniel, Benke, Kelly S., Bragg-Gresham, Jennifer L., Canouil, Mickaël, Corre, Tanguy, Grallert, Harald, Isaacs, Aaron, Kutalik, Zoltan, Lahti, Jari, Marullo, Letizia, Marzi, Carola, Rasmussen-Torvik, Laura J., Rocheleau, Ghislain, Rueedi, Rico, Scapoli, Chiara, Verweij, Niek, Vogelzangs, Nicole, Willems, Sara M., Yengo, Loïc, Bakker, Stephan J. L., Beilby, John, Hui, Jennie, Kajantie, Eero, Müller-Nurasyid, Martina, Rathmann, Wolfgang, Balkau, Beverley ... Bouatia-Naji, Nabila (2019). Genome-wide association study of change in fasting glucose over time in 13,807 non-diabetic European ancestry individuals. Scientific Reports, 9 (1) 9439. doi: 10.1038/s41598-019-45823-7
Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2019). Genome-wide association study of medication-use and associated disease in the UK Biobank. Nature Communications, 10 (1) 1891, 1891. doi: 10.1038/s41467-019-09572-5
Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valerie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tonu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh ... McCarthy, Mark (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51 (3), 452-+. doi: 10.1038/s41588-018-0334-2
Pulit, Sara L., Stoneman, Charli, Morris, Andrew P., Wood, Andrew R., Glastonbury, Craig A., Tyrrell, Jessica, Yengo, Loïc, Ferreira, Teresa, Marouli, Eirini, Ji, Yingjie, Yang, Jian, Jones, Samuel, Beaumont, Robin, Croteau-Chonka, Damien C., Winkler, Thomas W., Consortium, Giant, Hattersley, Andrew T., Loos, Ruth J F, Hirschhorn, Joel N., Visscher, Peter M., Frayling, Timothy M., Yaghootkar, Hanieh and Lindgren, Cecilia M. (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Human Molecular Genetics, 28 (1), 166-174. doi: 10.1093/hmg/ddy327
Yengo, Loic and Visscher, Peter M. (2018). Assortative mating on complex traits revisited: Double first cousins and the X-chromosome. Theoretical Population Biology, 124, 51-60. doi: 10.1016/j.tpb.2018.09.002
Yengo, Loic, Robinson, Matthew R., Keller, Matthew C., Kemper, Kathryn E., Yang, Yuanhao, Trzaskowski, Maciej, Gratten, Jacob, Turley, Patrick, Cesarini, David, Benjamin, Daniel J., Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2018). Imprint of assortative mating on the human genome. Nature Human Behaviour, 2 (12), 948-954. doi: 10.1038/s41562-018-0476-3
Yap, Chloe X., Sidorenko, Julia, Marioni, Riccardo E., Yengo, Loic, Wray, Naomi R. and Visscher, Peter M. (2018). Erratum: Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness (Nature communications (2018) 9 1 (2537)). Nature communications, 9 (1) 4953, 4953. doi: 10.1038/s41467-018-07400-w
Ligthart, Symen, Vaez, Ahmad, Võsa, Urmo, Stathopoulou, Maria G., de Vries, Paul S., Prins, Bram P., Van der Most, Peter J., Tanaka, Toshiko, Naderi, Elnaz, Rose, Lynda M., Wu, Ying, Karlsson, Robert, Barbalic, Maja, Lin, Honghuang, Pool, René, Zhu, Gu, Macé, Aurélien, Sidore, Carlo, Trompet, Stella, Mangino, Massimo, Sabater-Lleal, Maria, Kemp, John P., Abbasi, Ali, Kacprowski, Tim, Verweij, Niek, Smith, Albert V., Huang, Tao, Marzi, Carola, Feitosa, Mary F. ... Alizadeh, Behrooz Z. (2018). Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders. American Journal of Human Genetics, 103 (5), 691-706. doi: 10.1016/j.ajhg.2018.09.009
Yengo, Loic, Sidorenko, Julia, Kemper, Kathryn E., Zheng, Zhili, Wood, Andrew R., Weedon, Michael N., Frayling, Timothy M., Hirschhorn, Joel, Yang, Jian and Visscher, Peter M. (2018). Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Human Molecular Genetics, 27 (20), 3641-3649. doi: 10.1093/hmg/ddy271
Imatoh, Takuya, Yengo, Loic, Rocheleau, Ghislain, Kamimura, Seiichiro, Maeda, Shiro, Miyazaki, Motonobu and Froguel, Philippe (2018). ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers. Lipids, 53 (8), 797-807. doi: 10.1002/lipd.12087
Xue, Angli, Wu, Yang, Zhu, Zhihong, Zhang, Futao, Kemper, Kathryn E., Zheng, Zhili, Yengo, Loic, Lloyd-Jones, Luke R., Sidorenko, Julia, Wu, Yeda, eQTLGen Consortium, McRae, Allan F., Visscher, Peter M., Zeng, Jian and Yang, Jian (2018). Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications, 9 (1) 2941, 2941. doi: 10.1038/s41467-018-04951-w
Lee, James J., Wedow, Robbee, Okbay, Aysu, Kong, Edward, Maghzian, Omeed, Zacher, Meghan, Nguyen-Viet, Tuan Anh, Bowers, Peter, Sidorenko, Julia, Karlsson Linnér, Richard, Fontana, Mark Alan, Kundu, Tushar, Lee, Chanwook, Li, Hui, Li, Ruoxi, Royer, Rebecca, Timshel, Pascal N., Walters, Raymond K., Willoughby, Emily A., Yengo, Loïc, 23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium, Alver, Maris, Bao, Yanchun, Clark, David W., Day, Felix R., Furlotte, Nicholas A., Joshi, Peter K. ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112-1121. doi: 10.1038/s41588-018-0147-3
Abderrahmani, Amar, Yengo, Loïc, Caiazzo, Robert, Canouil, Mickaël, Cauchi, Stéphane, Raverdy, Violeta, Plaisance, Valérie, Pawlowski, Valérie, Lobbens, Stéphane, Maillet, Julie, Rolland, Laure, Boutry, Raphael, Queniat, Gurvan, Kwapich, Maxime, Tenenbaum, Mathie, Bricambert, Julien, Saussenthaler, Sophie, Anthony, Elodie, Jha, Pooja, Derop, Julien, Sand, Olivier, Rabearivelo, Iandry, Leloire, Audrey, Pigeyre, Marie, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine, Dayeh, Tasnim, Lassailly, Guillaume, Mathurin, Philippe ... Froguel, Philippe (2018). Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity-associated type 2 diabetes. Diabetes, 67 (7), 1310-1321. doi: 10.2337/db17-1539
Yap, Chloe X., Sirodenko, Julia, Marioni, Riccardo E., Yengo, Loic, Wray, Naomi R. and Visscher, Peter M. (2018). Misestimation of heritability and prediction accuracy of male-pattern baldness. Nature Communications, 9 (1) 2537, 2537. doi: 10.1038/s41467-018-04807-3
Qi, Ting, Wu, Yang, Zeng, Jian, Zhang, Futao, Xue, Angli, Jiang, Longda, Zhu, Zhihong, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, eQTLGen Consortium, Marioni, Riccardo E., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications, 9 (1) 2282, 2282. doi: 10.1038/s41467-018-04558-1
Rivas, Manuel A., Avila, Brandon E., Koskela, Jukka, Huang, Hailiang, Stevens, Christine, Pirinen, Matti, Haritunians, Talin, Neale, Benjamin M., Kurki, Mitja, Ganna, Andrea, Graham, Daniel, Glaser, Benjamin, Peter, Inga, Atzmon, Gil, Barzilai, Nir, Levine, Adam P., Schiff, Elena, Pontikos, Nikolas, Weisburd, Ben, Lek, Monkol, Karczewski, Konrad J., Bloom, Jonathan, Minikel, Eric V., Petersen, Britt-Sabina, Beaugerie, Laurent, Seksik, Philippe, Cosnes, Jacques, Schreiber, Stefan, Bokemeyer, Bernd ... T2D-GENES Consortium (2018). Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genetics, 14 (5) e1007329, 1-25. doi: 10.1371/journal.pgen.1007329
Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746-753. doi: 10.1038/s41588-018-0101-4
Mahajan, Anubha, Wessel, Jennifer, Willems, Sara M., Zhao, Wei, Robertson, Neil R., Chu, Audrey Y., Gan, Wei, Kitajima, Hidetoshi, Taliun, Daniel, Rayner, N. William, Guo, Xiuqing, Lu, Yingchang, Li, Man, Jensen, Richard A., Hu, Yao, Huo, Shaofeng, Lohman, Kurt K., Zhang, Weihua, Cook, James P., Prins, Bram Peter, Flannick, Jason, Grarup, Niels, Trubetskoy, Vassily Vladimirovich, Kravic, Jasmina, Kim, Young Jin, Rybin, Denis V., Yaghootkar, Hanieh, Müller-Nurasyid, Martina, Meidtner, Karina ... GIANT Consortium (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article. Nature Genetics, 50 (4), 559-571. doi: 10.1038/s41588-018-0084-1
Yengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2018). Reply to Kardos et al.: estimation of inbreeding depression from SNP data. Proceedings of the National Academy of Sciences, 115 (11), E2494-E2495. doi: 10.1073/pnas.1718598115
Flannick, Jason, Fuchsberger, Christian, Mahajan, Anubha, Teslovich, Tanya M., Agarwala, Vineeta, Gaulton, Kyle J., Caulkins, Lizz, Koesterer, Ryan, Ma, Clement, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R B, Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn ... McCarthy, Mark I. (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5 (1) 180002, 180002. doi: 10.1038/sdata.2018.2
Mahajan, Anubha, Taliun, Daniel, Thurner, Matthias, Robertson, Neil R., Torres, Jason M., Rayner, N. William, Payne, Anthony J., Steinthorsdottir, Valgerdur, Scott, Robert A., Grarup, Niels, Cook, James P., Schmidt, Ellen M., Wuttke, Matthias, Sarnowski, Chloé, Mägi, Reedik, Nano, Jana, Gieger, Christian, Trompet, Stella, Lecoeur, Cécile, Preuss, Michael H., Prins, Bram Peter, Guo, Xiuqing, Bielak, Lawrence F., Below, Jennifer E., Bowden, Donald W., Chambers, John Campbell, Kim, Young Jin, Ng, Maggie C. Y., Petty, Lauren E. ... McCarthy, Mark I. (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505-1513. doi: 10.1038/s41588-018-0241-6
Flannick, Jason, Fuchsberger, Christian, Mahajan, Anubha, Teslovich, Tanya M., Agarwala, Vineeta, Gaulton, Kyle J., Caulkins, Lizz, Koesterer, Ryan, Ma, Clement, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R.B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N. William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josée, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., Van De Bunt, Martijn ... McCarthy, Mark I. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4 (1) 170179, 170179. doi: 10.1038/sdata.2017.179
Scott, Robert A., Scott, Laura J., Mägi, Reedik, Marullo, Letizia, Gaulton, Kyle J., Kaakinen, Marika, Pervjakova, Natalia, Pers, Tune H., Johnson, Andrew D., Eicher, John D., Jackson, Anne U., Ferreira, Teresa, Lee, Yeji, Ma, Clement, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Van Zuydam, Natalie R., Mahajan, Anubha, Chen, Han, Almgren, Peter, Voight, Ben F., Grallert, Harald, Müller-Nurasyid, Martina, Ried, Janina S., Rayner, Nigel W., Robertson, Neil, Karssen, Lennart C., van Leeuwen, Elisabeth M. ... Prokopenko, Inga (2017). An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes, 66 (11), 2888-2902. doi: 10.2337/db16-1253
Wheeler, Eleanor, Leong, Aaron, Liu, Ching-Ti, Hivert, Marie-France, Strawbridge, Rona J., Podmore, Clara, Li, Man, Yao, Jie, Sim, Xueling, Hong, Jaeyoung, Chu, Audrey Y., Zhang, Weihua, Wang, Xu, Chen, Peng, Maruthur, Nisa M., Porneala, Bianca C., Sharp, Stephen J., Jia, Yucheng, Kabagambe, Edmond K., Chang, Li-Ching, Chen, Wei-Min, Elks, Cathy E., Evans, Daniel S., Fan, Qiao, Giulianini, Franco, Go, Min Jin, Hottenga, Jouke-Jan, Hu, Yao, Jackson, Anne U. ... Meigs, James B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: a transethnic genome-wide meta-analysis. PLoS Medicine, 14 (9) e1002383, e1002383. doi: 10.1371/journal.pmed.1002383
Yengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2017). Detection and quantification of inbreeding depression for complex traits from SNP data. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 114 (32), 8602-8607. doi: 10.1073/pnas.1621096114
Verbanck, Marie, Canouil, Mickael, Leloire, Audrey, Dhennin, Veronique, Coumoul, Xavier, Yengo, Loïc, Froguel, Philippe and Poulain-Godefroy, Odile (2017). Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS One, 12 (6) e0179583, e0179583. doi: 10.1371/journal.pone.0179583
Peddinti, Gopal, Cobb, Jeff, Yengo, Loic, Froguel, Philippe, Kravic, Jasmina, Balkau, Beverley, Tuomi, Tiinamaija, Aittokallio, Tero and Groop, Leif (2017). Early metabolic markers identify potential targets for the prevention of type 2 diabetes. Diabetologia, 60 (9), 1740-1750. doi: 10.1007/s00125-017-4325-0
Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J. ... Kilpeläinen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity ― a meta-analysis of 200,452 adults. PLoS Genetics, 13 (4) e1006528, e1006528. doi: 10.1371/journal.pgen.1006528
Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin, Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y., Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zolta'n, Xue, Luting, Mahajan, Anubha, Renström, Frida, Wu, Joseph, Qi, Qibin, Ahmad, Shafqat, Alfred, Tamuno, Amin, Najaf, Bielak, Lawrence F., Bonnefond, Amelie, Bragg, Jennifer ... Cupples, L. Adrienne (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (1) 14977, 14977. doi: 10.1038/ncomms14977
Bonnefond, Amélie, Yengo, Loïc, Dechaume, Aurélie, Canouil, Mickaël, Castelain, Maxime, Roger, Estelle, Allegaert, Frédéric, Caiazzo, Robert, Raverdy, Violeta, Pigeyre, Marie, Arredouani, Abdelilah, Borys, Jean-Michel, Levy-Marchal, Claire, Weill, Jacques, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Pattou, François, Brousseau, Thierry and Froguel, Philippe (2017). Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach. BMC Medicine, 15 (1) 37, 37. doi: 10.1186/s12916-017-0784-x
Schumann, Gunter, Liu, Chunyu, O'Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Lepe, Marcelo Segura, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hallfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Asa, Joshi, PeterK., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu ... Elliott, Paul (2016). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences, 113 (50), 14372-14377. doi: 10.1073/pnas.1611243113
Morandi, Anita, Bonnefond, Amelie, Lobbens, Stephane, Yengo, Loic, del Giudice, Emanuele Miraglia, Grandone, Anna, Levy-Marchal, Claire, Weill, Jacques, Maffeis, Claudio and Froguel, Philippe (2016). Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths. Journal of Clinical Endocrinology and Metabolism, 101 (11), 4244-4250. doi: 10.1210/jc.2016-2432
Barban, Nicola, Jansen, Rick, de Vlaming, Ronald, Vaez, Ahmad, Mandemakers, Jornt J., Tropf, Felix C., Shen, Xia, Wilson, James F., Chasman, Daniel I., Nolte, Illa M., Tragante, Vinicius, van der Laan, Sander W., Perry, John R. B., Kong, Augustine, Ahluwalia, Tarunveer S., Albrecht, Eva, Yerges-Armstrong, Laura, Atzmon, Gil, Auro, Kirsi, Ayers, Kristin, Bakshi, Andrew, Ben-Avraham, Danny, Berger, Klaus, Bergman, Aviv, Bertram, Lars, Bielak, Lawrence F., Bjornsdottir, Gyda, Bonder, Marc Jan, Broer, Linda ... Mills, Melinda C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 (12), 1462-1472. doi: 10.1038/ng.3698
Field, Yair, Boyle, Evan A., Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I. and Pritchard, Jonathan K. (2016). Detection of human adaptation during the past 2000 years. Science, 354 (6313), 1-10. doi: 10.1126/science.aag0776
Yengo, Loic, Arredouani, Abdelilah, Marre, Michel, Roussel, Ronan, Vaxillaire, Martine, Falchi, Mario, Haoudi, Abdelali, Tichet, Jean, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2016). Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Molecular Metabolism, 5 (10), 918-925. doi: 10.1016/j.molmet.2016.08.011
Ehret, G.B., Ferreira, T., Chasman, D.I., Jackson, A.U., Schmidt, E.M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L.A., Kanoni, S., Petersen, A.-K., Pihur, V., Strawbridge, R.J., Shungin, D., Hughes, M.F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., Kleber, M.E., Guo, X., Lyytikainen, L.-P., Fava, C., Eriksson, N., Nolte, I.M., Magnusson, P.K., Salfati, E.L., Rallidis, L.S. ... Munroe, P.B. (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10), 1171-1184. doi: 10.1038/ng.3667
Lazaridis, Iosif, Nadel, Dani, Rollefson, Gary, Merrett, Deborah C., Rohland, Nadin, Mallick, Swapan, Fernandes, Daniel, Novak, Mario, Gamarra, Beatriz, Sirak, Kendra, Connell, Sarah, Stewardson, Kristin, Harney, Eadaoin, Fu, Qiaomei, Gonzalez-Fortes, Gloria, Jones, Eppie R., Roodenberg, Songul Alpaslan, Lengyel, Gyorgy, Bocquentin, Fanny, Gasparian, Boris, Monge, Janet M., Gregg, Michael, Eshed, Vered, Mizrahi, Ahuva-Sivan, Meiklejohn, Christopher, Gerritsen, Fokke, Bejenaru, Luminita, Blueher, Matthias, Campbell, Archie ... Reich, David (2016). Genomic insights into the origin of farming in the ancient Near East. Nature, 536 (7617), 419-424. doi: 10.1038/nature19310
Yengo, Loic, Jacques, Julien, Biernacki, Christophe and Canouil, Mickael (2016). Variable clustering in high-dimensional linear regression: The R package clere. The R Journal, 8 (1), 92-106. doi: 10.32614/rj-2016-006
Fuchsberger, Christian, Flannick, Jason, Teslovich, Tanya M., Mahajan, Anubha, Agarwala, Vineeta, Gaulton, Kyle J., Ma, Clement, Fontanillas, Pierre, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R. B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N. William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn, Pearson, Richard D. ... McCarthy, Mark I. (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41-47. doi: 10.1038/nature18642
Favennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Helene, Leloire, Audrey, Guillemin, Gilles J., Yengo, Loic, Allorge, Delphine, Froguel, Philippe, Pattou, Francois and Poulain-Godefroy, Odile (2016). Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis. Plos One, 11 (6) e0158051, e0158051. doi: 10.1371/journal.pone.0158051
Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tõnu, Fall, Tove, Kilpeläinen, Tuomas O., Lu, Yingchang, Mägi, Reedik, Mihailov, Evelin, Pers, Tune H., Rüeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J.F. (2016). Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378). PLoS Genetics, 12 (6) e1006166. doi: 10.1371/JOURNAL.PGEN.1006166
Rabhi, Nabil, Denechaud, Pierre-Damien, Gromada, Xavier, Hannou, Sarah Anissa, Zhang, Hongbo, Rashid, Talha, Salas, Elisabet, Durand, Emmanuelle, Sand, Olivier, Bonnefond, Amelie, Yengo, Loic, Chavey, Carine, Bonner, Caroline, Kerr-Conte, Julie, Abderrahmani, Amar, Auwerx, Johan, Fajas, Lluis, Froguel, Philippe and Annicotte, Jean-Sebastien (2016). KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein response. Cell Reports, 15 (5), 1051-1061. doi: 10.1016/j.celrep.2016.03.079
Horikoshi, Momoko, Pasquali, Lorenzo, Wiltshire, Steven, Huyghe, Jeroen R., Mahajan, Anubha, Asimit, Jennifer L., Ferreira, Teresa, Locke, Adam E., Robertson, Neil R., Wang, Xu, Sim, Xueling, Fujita, Hayato, Hara, Kazuo, Young, Robin, Zhang, Weihua, Choi, Sungkyoung, Chen, Han, Kaur, Ismeet, Takeuchi, Fumihiko, Fontanillas, Pierre, Thuillier, Dorothee, Yengo, Loic, Below, Jennifer E., Tam, Claudia H. T., Wu, Ying, Abecasis, Goncalo, Altshuler, David, Bell, Graeme I., Blangero, John ... Morris, Andrew P. (2016). Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics, 25 (10) ddw048, 2070-2081. doi: 10.1093/hmg/ddw048
Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin ... Loos, Ruth J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7 (1) 10495, 10495-10495. doi: 10.1038/ncomms10495
Pattaro, Cristian, Teumer, Alexander, Gorski, Mathias, Chu, Audrey Y., Li, Man, Mijatovic, Vladan, Garnaas, Maija, Tin, Adrienne, Sorice, Rossella, Li, Yong, Taliun, Daniel, Olden, Matthias, Foster, Meredith, Yang, Qiong, Chen, Ming-Huei, Pers, Tune H., Johnson, Andrew D., Ko, Yi-An, Fuchsberger, Christian, Tayo, Bamidele, Nalls, Michael, Feitosa, Mary F., Isaacs, Aaron, Dehghan, Abbas, d'Adamo, Pio, Adeyemo, Adebowale, Dieffenbach, Aida Karina, Zonderman, Alan B., Nolte, Ilja M. ... Fox, Caroline S. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7 (1) 10023. doi: 10.1038/ncomms10023
Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna ... Jaddoe, Vincent W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 (2), 389-403. doi: 10.1093/hmg/ddv472
Gaulton, Kyle J., Ferreira, Teresa, Lee, Yeji, Raimondo, Anne, Maegi, Reedik, Reschen, Michael E., Mahajan, Anubha, Locke, Adam, Rayner, N. William, Robertson, Neil, Scott, Robert A., Prokopenko, Inga, Scott, Laura J., Green, Todd, Sparso, Thomas, Thuillier, Dorothee, Yengo, Loic, Grallert, Harald, Wahl, Simone, Franberg, Mattias, Strawbridge, Rona J., Kestler, Hans, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Karssen, Lennart C. ... Morris, Andrew P. (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47 (12), 1415-1425. doi: 10.1038/ng.3437
Favennec, Marie, Hennart, Benjamin, Caiazzo, Robert, Leloire, Audrey, Yengo, Loic, Verbanck, Marie, Arredouani, Abdelilah, Marre, Michel, Pigeyre, Marie, Bessede, Alban, Guillemin, Gilles J., Chinetti, Giulia, Staels, Bart, Pattou, Francois, Balkau, Beverley, Allorge, Delphine, Froguel, Philippe and Poulain-Godefroy, Odile (2015). The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity, 23 (10), 2066-2074. doi: 10.1002/oby.21199
Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tonu, Fall, Tove, Kilpelainen, Tuomas O., Lu, Yingchang, Magi, Reedik, Mihailov, Evelin, Pers, Tune H., Rueeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J. F. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PL o S Genetics, 11 (10) e1005378, 1-42. doi: 10.1371/journal.pgen.1005378
Chambers, John C., Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R., Rota, Federica, Scott, William R., Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C., Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, Francois, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole ... Kooner, Jaspal S. (2015). Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study. Lancet Diabetes and Endocrinology, 3 (7), 526-534. doi: 10.1016/S2213-8587(15)00127-8
Joshi, Peter K., Esko, Tonu, Mattsson, Hannele, Eklund, Niina, Gandin, Ilaria, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Smith, Albert V., Zhang, Weihua, Okada, Yukinori, Stancakova, Alena, Faul, Jessica D., Zhao, Wei, Bartz, Traci M., Concas, Maria Pina, Franceschini, Nora, Enroth, Stefan, Vitart, Veronique, Trompet, Stella, Guo, Xiuqing, Chasman, Daniel I., O'Connel, Jeffrey R., Corre, Tanguy, Nongmaithem, Suraj S., Chen, Yuning, Mangino, Massimo, Ruggiero, Daniela, Traglia, Michela ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459-462. doi: 10.1038/nature14618
Bonnefond, Amelie, Yengo, Loic, Le May, Cedric, Fumeron, Frederic, Marre, Michel, Balkau, Beverley, Charpentier, Guillaume, Franc, Sylvia, Froguel, Philippe and Cariou, Bertrand (2015). The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia, 58 (9), 2051-2055. doi: 10.1007/s00125-015-3659-8
Shungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Locke, Adam E, Magi, Reedik, Strawbridge, Rona J, Pers, Tune H, Fischer, Krista, Justice, Anne E, Workalemahu, Tsegaselassie, Wu, Joseph M.W, Buchkovich, Martin L, Heard-Costa, Nancy L, Roman, Tamara S, Drong, Alexander W, Song, Ci, Gustafsson, Stefan, Day, Felix R, Esko, Tonu, Fall, Tove, Kutalik, Zoltan, Luan, Jian'an, Randall, Joshua C, Scherag, Andre, Vedantam, Sailaja, Wood, Andrew R, Chen, Jin, Fehrmann, Rudolf ... Shah, Sonia (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187-196. doi: 10.1038/nature14132
Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K. ... Shah, Sonia (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197-206. doi: 10.1038/nature14177
Mejia-Bentez, Maria A., Bonnefond, Amelie, Yengo, Loic, Huyvaert, Marlene, Dechaume, Aurelie, Peralta-Romero, Jesus, Kluender-Kluender, Miguel, Garcia Mena, Jaime, Moustafa, Julia S. El-Sayed, Falchi, Mario, Cruz, Miguel and Froguel, Philippe (2015). Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia, 58 (2), 290-294. doi: 10.1007/s00125-014-3441-3
Wood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaja, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltan, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., Karjalainen, Juha, Lo, Ken Sin, Locke, Adam E., Magi, Reedik, Mihailov, Evelin, Porcu, Evelin, Randall, Joshua C., Scherag, Andre, Vinkhuyzen, Anne A. E., Westra, Harm-Jan ... Frayling, Timothy M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173-1186. doi: 10.1038/ng.3097
Vaxillaire, Martine, Yengo, Loic, Lobbens, Stephane, Rocheleau, Ghislain, Eury, Elodie, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2014). Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study. Diabetologia, 57 (8), 1601-1610. doi: 10.1007/s00125-014-3277-x
Dik, Vincent K., Bueno-de-Mesquita, H. B(as), Van Oijen, Martijn G. H., Siersema, Peter D., Uiterwaal, Cuno S. P. M., Van Gils, Carla H., Van Duijnhoven, Fraenzel J. B., Cauchi, Stephane, Yengo, Loic, Froguel, Philippe, Overvad, Kim, Bech, Bodil H., Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuehn, Tilman, Campa, Daniele, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Peppa, Eleni, Oikonomou, Eleni, Palli, Domenico, Grioni, Sara, Vineis, Paolo, Tumino, Rosaria, Panico, Salvatore ... Riboli, Elio (2014). Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study. International Journal of Cancer, 135 (2), 401-412. doi: 10.1002/ijc.28655
Rouskas, Konstantinos, Cauchi, Stephane, Raverdy, Violeta, Yengo, Loic, Froguel, Philippe and Pattou, Francois (2014). Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surgery for Obesity and Related Diseases, 10 (4), 679-683. doi: 10.1016/j.soard.2013.12.016
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Shah, Sonia and Yengo, Loic (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234-246. doi: 10.1038/ng.2897
Bonnet, Fabrice, Roussel, Ronan, Natali, Andrea, Cauchi, Stephane, Petrie, John, Laville, Martine, Yengo, Loic, Froguel, Philippe, Lange, Celine, Lantieri, Olivier, Marre, Michel, Balkau, Beverley and Ferrannini, Ele (2013). Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts. Diabetologia, 56 (11), 2414-2423. doi: 10.1007/s00125-013-3021-y
Robiou-du-Pont, Sebastien, Yengo, Loic, Vaillant, Emmanuel, Lobbens, Stephane, Durand, Emmanuelle, Horber, Fritz, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Froguel, Philippe and Meyre, David (2013). Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. Journal of Molecular Medicine, 91 (9), 1109-1115. doi: 10.1007/s00109-013-1027-z
Bonnefond, Amelie, Skrobek, Boris, Lobbens, Stephane, Eury, Elodie, Thuillier, Dorothee, Cauchi, Stephane, Lantieri, Olivier, Balkau, Beverley, Riboli, Elio, Marre, Michel, Charpentier, Guillaume, Yengo, Loic and Froguel, Philippe (2013). Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nature Genetics, 45 (9), 1040-1043. doi: 10.1038/ng.2700
den Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U. ... Loos, Ruth J. F. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621-634. doi: 10.1038/ng.2610
Bonnefond, A., Vaillant, E., Philippe, J., Skrobek, B., Lobbens, S., Yengo, L., Huyvaert, M., Cave, H., Busiah, K., Scharfmann, R., Polak, M., Abdul-Rasoul, M., Froguel, P. and Vaxillaire, M. (2013). Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family. Diabetes and Metabolism, 39 (3), 276-280. doi: 10.1016/j.diabet.2013.02.007
Bonnefond, A., Yengo, L., Philippe, J., Dechaume, A., Ezzidi, I., Vaillant, E., Gjesing, A. P., Andersson, E. A., Czernichow, S., Hercberg, S., Hadjadj, S., Charpentier, G., Lantieri, O., Balkau, B., Marre, M., Pedersen, O., Hansen, T., Froguel, P. and Vaxillaire, M. (2013). Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. Diabetologia, 56 (3), 492-496. doi: 10.1007/s00125-012-2794-8
Koettgen, Anna, Albrecht, Eva, Teumer, Alexander, Vitart, Veronique, Krumsiek, Jan, Hundertmark, Claudia, Pistis, Giorgio, Ruggiero, Daniela, O'Seaghdha, Conall M., Haller, Toomas, Yang, Qiong, Tanaka, Toshiko, Johnson, Andrew D., Kutalik, Zoltan, Smith, Albert V., Shi, Julia, Struchalin, Maksim, Middelberg, Rita P. S., Brown, Morris J., Gaffo, Angelo L., Pirastu, Nicola, Li, Guo, Hayward, Caroline, Zemunik, Tatijana, Huffman, Jennifer, Yengo, Loic, Zhao, Jing Hua, Demirkan, Ayse, Feitosa, Mary F. ... Gieger, Christian (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45 (2), 145-154. doi: 10.1038/ng.2500
Mejia-Benitez, Aurora, Kluender-Kluender, Miguel, Yengo, Loic, Meyre, David, Aradillas, Celia, Cruz, Esperanza, Perez-Luque, Elva, Manuel Malacara, Juan, Eugenia Garay, Maria, Peralta-Romero, Jesus, Flores-Huerta, Samuel, Garcia-Mena, Jaime, Froguel, Philippe, Cruz, Miguel and Bonnefond, Amelie (2013). Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. Bmc Medical Genetics, 14 (1) 21. doi: 10.1186/1471-2350-14-21
Albrechtsen, A., Grarup, N., Li, Y., Sparso, T., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancakova, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M. ... Pedersen, O. (2013). Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia, 56 (2), 298-310. doi: 10.1007/s00125-012-2756-1
Bottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Zeller, Tanja, Liquet, Benoit, Newcombe, Paul, Yengo, Loic, Wild, Philipp S., Schillert, Arne, Ziegler, Andreas, Nielsen, Sune F., Butterworth, Adam S., Ho, Weang Kee, Castagne, Raphaele, Munzel, Thomas, Tregouet, David, Falchi, Mario, Cambien, Francois, Nordestgaard, Borge G., Fumeron, Frederic, Tybjaerg-Hansen, Anne, Froguel, Philippe, Danesh, John, Petretto, Enrico, Blankenberg, Stefan, Tiret, Laurence and Richardson, Sylvia (2013). GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm. PLoS Genetics, 9 (8) e1003657, e1003657. doi: 10.1371/journal.pgen.1003657
Robiou-du-Pont, S., Bonnefond, A., Yengo, L., Vaillant, E., Lobbens, S., Durand, E., Weill, J., Lantieri, O., Balkau, B., Charpentier, G., Marre, M., Froguel, P. and Meyre, D. (2013). Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. International Journal of Obesity, 37 (7), 980-985. doi: 10.1038/ijo.2012.175
Cauchi, S., Ezzidi, I., El Achhab, Y., Mtiraoui, N., Chaieb, L., Salah, D., Nejjari, C., Labrune, Y., Yengo, L., Beury, D., Vaxillaire, M., Mahjoub, T., Chikri, M. and Froguel, P. (2012). European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes and Metabolism, 38 (4), 316-323. doi: 10.1016/j.diabet.2012.02.003
Morris, Andrew P., Voight, Benjamin F., Teslovich, Tanya M., Ferreira, Teresa, Segre, Ayellet V., Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Khan, Hassan, Grallert, Harald, Mahajan, Anubha, Prokopenko, Inga, Kang, Hyun Min, Dina, Christian, Esko, Tonu, Fraser, Ross M., Kanoni, Stavroula, Kumar, Ashish, Lagou, Vasiliki, Langenberg, Claudia, Luan, Jian'an, Lindgren, Cecilia M., Mueller-Nurasyid, Martina, Pechlivanis, Sonali, Rayner, N. William, Scott, Laura J., Wiltshire, Steven, Yengo, Loic, Kinnunen, Leena, Rossin, Elizabeth J. ... Shah, Sonia (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44 (9), 981-990. doi: 10.1038/ng.2383
Okada, Y., Sim, X., Go, M. J., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y. Y., Kim, Y. J., Lee, J. Y., Han, B. g., Kang, D., Chen, C. h., Tsai, F. j., Chang, L. c., Fann, S. j., Mei, H., Rao, D. c., Hixson, J. e., Chen, S. ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904-909. doi: 10.1038/ng.2352
Perry, John R. B., Voight, Benjamin F., Yengo, Loic, Amin, Najaf, Dupuis, Josee, Ganser, Martha, Grallert, Harald, Navarro, Pau, Li, Man, Qi, Lu, Steinthorsdottir, Valgerdur, Scott, Robert A., Almgren, Peter, Arking, Dan E., Aulchenko, Yurii, Balkau, Beverley, Benediktsson, Rafn, Bergman, Richard N., Boerwinkle, Eric, Bonnycastle, Lori, Burtt, Noel P., Campbell, Harry, Charpentier, Guillaume, Collins, Francis S., Gieger, Christian, Green, Todd, Hadjadj, Samy, Hattersley, Andrew T., Herder, Christian ... Cauchi, Stephane (2012). Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. Plos Genetics, 8 (5) e1002741, e1002741. doi: 10.1371/journal.pgen.1002741
Ichimura, Atsuhiko, Hirasawa, Akira, Poulain-Godefroy, Odile, Bonnefond, Amelie, Hara, Takafumi, Yengo, Loic, Kimura, Ikuo, Leloire, Audrey, Liu, Ning, Iida, Keiko, Choquet, Helene, Besnard, Philippe, Lecoeur, Cecile, Vivequin, Sidonie, Ayukawa, Kumiko, Takeuchi, Masato, Ozawa, Kentaro, Tauber, Maithe, Maffeis, Claudio, Morandi, Anita, Buzzetti, Raffaella, Elliott, Paul, Pouta, Anneli, Jarvelin, Marjo-Riitta, Koerner, Antje, Kiess, Wieland, Pigeyre, Marie, Caiazzo, Roberto, Van Hul, Wim ... Froguel, Philippe (2012). Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature, 483 (7389), 350-354. doi: 10.1038/nature10798
Bonnefond, A., Poulain-Godefroy, O., Ichimura, A., Hirasawa, A., Yengo, L., Leloire, A., Choquet, H., Meyre, D., Pattou, F., Wolowczuk, I., Tsujimoto, G. and Froguel, P. (2012). O53 - Alteration of the omega-3 unsaturated fatty acid receptor GPR120 leads to obesity in humans and mice O53 L'altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l'Homme et la Souris. Diabetes and Metabolism, 38. doi: 10.1016/S1262-3636(12)71031-5
Marquez, Marcel, Huyvaert, Marlene, Perry, John R. B., Pearson, Richard D., Falchi, Mario, Morris, Andrew P., Vivequin, Sidonie, Lobbens, Stephane, Yengo, Loic, Gaget, Stefan, Pattou, Francois, Poulain-Godefroy, Odile, Charpentier, Guillaume, Carlsson, Lena M. S., Jacobson, Peter, Sjostrom, Lars, Lantieri, Olivier, Heude, Barbara, Walley, Andrew, Balkau, Beverley, Marre, Michel, Froguel, Philippe and Cauchi, Stephane (2012). Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes, 61 (2), 524-530. doi: 10.2337/db11-0728
Creemers, John W. M., Choquet, Helene, Stijnen, Pieter, Vatin, Vincent, Pigeyre, Marie, Beckers, Sigri, Meulemans, Sandra, Than, Manuel E., Yengo, Loic, Tauber, Maithe, Balkan, Beverley, Elliott, Paul, Jarvelin, Marjo-Riitta, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Pattou, Francois, Froguel, Philippe and Meyre, David (2012). Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes, 61 (2), 383-390. doi: 10.2337/db11-0305
Bonnefond, Amelie, Clement, Nathalie, Fawcett, Katherine, Yengo, Loic, Vaillant, Emmanuel, Guillaume, Jean-Luc, Dechaume, Aurelie, Payne, Felicity, Roussel, Ronan, Czernichow, Sebastien, Hercberg, Serge, Hadjadj, Samy, Balkau, Beverley, Marre, Michel, Lantieri, Olivier, Langenberg, Claudia, Bouatia-Naji, Nabila, Charpentier, Guillaume, Vaxillaire, Martine, Rocheleau, Ghislain, Wareham, Nicholas J., Sladek, Robert, McCarthy, Mark I., Dina, Christian, Barroso, Ines, Jockers, Ralf and Froguel, Philippe (2012). Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nature Genetics, 44 (3), 297-301. doi: 10.1038/ng.1053
Scott, Robert A., Lagou, Vasiliki, Welch, Ryan P., Wheeler, Eleanor, Montasser, May E., Luan, Jian’an, Mägi, Reedik, Strawbridge, Rona J., Rehnberg, Emil, Gustafsson, Stefan, Kanoni, Stavroula, Rasmussen-Torvik, Laura J., Yengo, Loïc, Lecoeur, Cecile, Shungin, Dmitry, Sanna, Serena, Sidore, Carlo, Johnson, Paul C. D., Jukema, J. Wouter, Johnson, Toby, Mahajan, Anubha, Verweij, Niek, Thorleifsson, Gudmar, Hottenga, Jouke-Jan, Shah, Sonia, Smith, Albert V., Sennblad, Bengt, Gieger, Christian, Salo, Perttu ... Barroso, Inês (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991-1005. doi: 10.1038/ng.2385
Bonnefond, Amelie, Lomberk, Gwen, Buttar, Navtej, Busiah, Kanetee, Vaillant, Emmanuel, Lobbens, Stephane, Yengo, Loic, Dechaume, Aurelie, Mignot, Brigitte, Simon, Albane, Scharfmann, Raphael, Neve, Bernadette, Tanyolac, Sinan, Hodoglugil, Ugur, Pattou, Francois, Cave, Helene, Iovanna, Juan, Stein, Roland, Polak, Michel, Vaxillaire, Martine, Froguel, Philippe and Urrutia, Raul (2011). Disruption of a novel Krüppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. Journal of Biological Chemistry, 286 (32), 28414-28424. doi: 10.1074/jbc.M110.215822
Conference Papers
Zeng, Jian, Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja, Snieder, Harold, Yang, Jian, Wray, Naomi, Goddard, Michael and Visscher, Peter (2023). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. World Congress of Psychiatric Genetics (WCPG), Montreal, ON, Canada, 10 - 14 October 2023. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2023.08.063
Yengo, L. and on behalf of GIANT Consortium (the height working group) (2022). Discoveries and lessons from a genome-wide association study of human height in >5 million individuals. 12th World Congress on Genetics Applied to Livestock Production (WCGALP), Rotterdam, Netherlands, 3-8 July 2022. Wageningen, Netherlands: Wageningen Academic Publishers. doi: 10.3920/978-90-8686-940-4_3
Mendoza, Brenda Cabrera, Wendt, Frank, Pathak, Gita, Yengo, Loic and Polimanti, Renato (2022). The Impact of Socioeconomic Status in the Polygenic Risk of Psychiatric Traits and Disorders: Evidence of Assortative Mating and Participation Bias in UK Biobank. 77th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), New Orleans La, Apr 28-30, 2022. NEW YORK: ELSEVIER SCIENCE INC.
Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hermon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Tian, Chao, Ahlskog, Rafael, Magnusson, Patrik K. E., Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David, Freese, Jeremy, Herd, Pamela, Watson, Chelsea, Jala, Jonathan, Conley, Dalton C., Koellinger, Philipp D., Johannesson, Magnus, Laibson, David I., Meyer, Michelle N., Lee, James J., Kong, Augustine ... Young, Alexander I. (2021). Polygenic prediction within and between families from a 3-million-person GWAS of educational attainment. Behavior Genetics Association 51st Annual Meeting, Online, 2021. New York, NY United States: Springer. doi: 10.1007/s10519-021-10087-3
Gratten, Jacob, Yang, Yuanhao, Trzaskowski, Maciej, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, Zhang, Futao, Zhu, Zhihong, Mcrae, Allan, Yang, Jian, Wray, Naomi and Visscher, Peter (2019). Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothers. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2018.08.167
Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Whitfield, John B., Streit, Fabian, Gordon, Scott, Kemper, Kathryn E., Yengo, Loic, Zheng, Zhili, Trzaskowski, Maciej, de Zeeuw, Eveline L., Nivard, Michel G., Das, Marjolijn, Neale, Rachel E., MacGregor, Stuart, Olsen, Catherine M., Whiteman, David C., Boomsma, Dorret I., Yang, Jian, Rietschel, Marcella, McGrath, John J., Medland, Sarah E. and Martin, Nicholas G. (2018). Association between population density and genetic risk for schizophrenia. Chicago, IL, United States: American Medical Association. doi: 10.1001/jamapsychiatry.2018.1581
Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, 20-23 June 2018. New York, NY United States: Springer New York.
Yengo, Loïc, Brochot, Céline and Péry, Alexandre (2010). Combined global sensitivity analysis and population PBPK modeling for assessing consistency of TCDD toxicokinetics data in mice. doi: 10.1016/j.sbspro.2010.05.220