Dr Yang Wu

Wu, Yang, Qi, Ting, Wray, Naomi R., Visscher, Peter M., Zeng, Jian and Yang, Jian (2023). Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes. Cell Genomics, 3 (8) 100344, 100344. doi: 10.1016/j.xgen.2023.100344

Yang, Yuanhao, Zhou, Yuan, Nyholt, Dale R., Yap, Chloe X., Tannenberg, Rudolph K., Wang, Ying, Wu, Yang, Zhu, Zhihong, Taylor, Bruce V. and Gratten, Jacob (2023). The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders. Cell Genomics, 3 (2) 100249, 100249. doi: 10.1016/j.xgen.2022.100249

Qi, Ting, Wu, Yang, Fang, Hailing, Zhang, Futao, Liu, Shouye, Zeng, Jian and Yang, Jian (2022). Genetic control of RNA splicing and its distinct role in complex trait variation. Nature Genetics, 54 (9), 1355-1363. doi: 10.1038/s41588-022-01154-4

Niemi, Mari E. K., Karjalainen, Juha, Daly, Mark, Ganna, Andrea, Mehtonen, Juha, Cordioli, Mattia, Kaunisto, Mari, Pigazzini, Sara, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Daly, Mark J., Liao, Rachel G., Kanai, Masahiro, Veerapen, Kumar, Minica, Camelia, Trankiem, Amy, Balaconis, Mary K., Nguyen, Huy, Solomonson, Matthew, Francioli, Laurent, Wang, Qingbo, Green, Robert C., Bryant, Sam, Finucane, Hilary, Martin, Alicia R., Zhou, Wei, Nkambule, Lindokuhle, Karczewski, Konrad J. ... COVID-19 Host Genetics Initiative (2021). Mapping the human genetic architecture of COVID-19. Nature, 600 (7889), 472-477+. doi: 10.1038/s41586-021-03767-x

Chen, Wenhan, Wu, Yang, Zheng, Zhili, Qi, Ting, Visscher, Peter M., Zhu, Zhihong and Yang, Jian (2021). Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors. Nature Communications, 12 (1) 7117, 7117. doi: 10.1038/s41467-021-27438-7

Pairo-Castineira, Erola, Clohisey, Sara, Klaric, Lucija, Bretherick, Andrew D., Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Parkinson, Nick, Fourman, Max Head, Russell, Clark D., Furniss, James, Richmond, Anne, Gountouna, Elvina, Wrobel, Nicola, Harrison, David, Wang, Bo, Wu, Yang, Meynert, Alison, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Moutsianas, Loukas, Yang, Zhijian, Zhai, Ranran, Zheng, Chenqing, Grimes, Graeme, Beale, Rupert, Millar, Jonathan, Shih, Barbara ... Baillie, J. Kenneth (2021). Genetic mechanisms of critical illness in COVID-19. Nature, 591 (7848), 92-98. doi: 10.1038/s41586-020-03065-y

Sun, Xiwei, Xue, Angli, Qi, Ting, Chen, Dan, Shi, Dandan, Wu, Yang, Zheng, Zhili, Zeng, Jian and Yang, Jian (2021). Tumor mutational burden is polygenic and genetically associated with complex traits and diseases. Cancer Research, 81 (5) canres.3459.2020, 12230-1239. doi: 10.1158/0008-5472.can-20-3459

Zeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3

Folkersen, Lasse, Gustafsson, Stefan, Wang, Qin, Hansen, Daniel Hvidberg, Hedman, Åsa K., Schork, Andrew, Page, Karen, Zhernakova, Daria V., Wu, Yang, Peters, James, Eriksson, Niclas, Bergen, Sarah E., Boutin, Thibaud S., Bretherick, Andrew D., Enroth, Stefan, Kalnapenkis, Anette, Gådin, Jesper R., Suur, Bianca E., Chen, Yan, Matic, Ljubica, Gale, Jeremy D., Lee, Julie, Zhang, Weidong, Quazi, Amira, Ala-Korpela, Mika, Choi, Seung Hoan, Claringbould, Annique, Danesh, John, Davey Smith, George ... Mälarstig, Anders (2020). Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. Nature Metabolism, 2 (10), 1135-1148. doi: 10.1038/s42255-020-00287-2

Wu, Yang, Qi, Ting, Wang, Huanwei, Zhang, Futao, Zheng, Zhili, Phillips-Cremins, Jennifer E., Deary, Ian J., McRae, Allan F., Wray, Naomi R., Zeng, Jian and Yang, Jian (2020). Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data. Nature Communications, 11 (1) 2061, 1-12. doi: 10.1038/s41467-020-15587-0

Pouget, Jennie G., Han, Buhm, Wu, Yang, Mignot, Emmanuel, Ollila, Hanna M., Barker, Jonathan, Spain, Sarah, Dand, Nick, Trembath, Richard, Martin, Javier, Mayes, Maureen D., Bossini-Castillo, Lara, López-Isac, Elena, Jin, Ying, Santorico, Stephanie A., Spritz, Richard A., Hakonarson, Hakon, Polychronakos, Constantin, Raychaudhuri, Soumya and Knight, Jo (2019). Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk. Human Molecular Genetics, 28 (20), 3498-3513. doi: 10.1093/hmg/ddz145

Wang, Huanwei, Zhang, Futao, Zeng, Jian, Wu, Yang, Kemper, Kathryn E., Xue, Angli, Zhang, Min, Powell, Joseph E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2019). Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. Science Advances, 5 (8) eaaw3538, 1-12. doi: 10.1126/sciadv.aaw3538

Kassam, Irfahan, Wu, Yang, Yang, Jian, Visscher, Peter M. and McRae, Allan F. (2019). Tissue-specific sex-differences in human gene expression. Human Molecular Genetics, 28 (17), 2976-2986. doi: 10.1093/hmg/ddz090

Mortlock, Sally, Restuadi, Restuadi, Levien, Rupert, Girling, Jane E., Holdsworth-Carson, Sarah J., Healey, Martin, Zhu, Zhihong, Qi, Ting, Wu, Yang, Lukowski, Samuel W., Rogers, Peter A. W., Yang, Jian, McRae, Allan F., Fung, Jenny N. and Montgomery, Grant W. (2019). Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clinical Epigenetics, 11 (1) 49, 49. doi: 10.1186/s13148-019-0648-7

Foo, Jerome C., Streit, Fabian, Frank, Josef, Witt, Stephanie H., Treutlein, Jens, Baune, Bernhard T., Moebus, Susanne, Joeckel, Karl-Heinz, Forstner, Andreas J., Noethen, Markus M., Rietschel, Marcella, Sartorius, Alexander, Kranaster, Laura, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1), 35-45. doi: 10.1002/ajmg.b.32700

Yap, Chloe X., Sidorenko, Julia, Wu, Yang, Kemper, Kathryn E., Yang, Jian, Wray, Naomi R., Robinson, Matthew R. and Visscher, Peter M. (2018). Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Nature Communications, 9 (1) 5407, 5407. doi: 10.1038/s41467-018-07862-y

Xue, Angli, Wu, Yang, Zhu, Zhihong, Zhang, Futao, Kemper, Kathryn E., Zheng, Zhili, Yengo, Loic, Lloyd-Jones, Luke R., Sidorenko, Julia, Wu, Yeda, eQTLGen Consortium, McRae, Allan F., Visscher, Peter M., Zeng, Jian and Yang, Jian (2018). Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications, 9 (1) 2941, 2941. doi: 10.1038/s41467-018-04951-w

Qi, Ting, Wu, Yang, Zeng, Jian, Zhang, Futao, Xue, Angli, Jiang, Longda, Zhu, Zhihong, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, eQTLGen Consortium, Marioni, Riccardo E., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications, 9 (1) 2282, 2282. doi: 10.1038/s41467-018-04558-1

Guo, Jing, Wu, Yang, Zhu, Zhihong, Zheng, Zhili, Trzaskowski, Maciej, Zeng, Jian, Robinson, Matthew R., Visscher, Peter M. and Yang, Jian (2018). Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications, 9 (1) 1865, 1865. doi: 10.1038/s41467-018-04191-y

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746-753. doi: 10.1038/s41588-018-0101-4

Wu, Yang, Zeng, Jian, Zhang, Futao, Zhu, Zhihong, Qi, Ting, Zheng, Zhili, Lloyd-Jones, Luke R., Marioni, Riccardo E., Martin, Nicholas G., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nature Communications, 9 (918) 918, 918. doi: 10.1038/s41467-018-03371-0

Zhu, Zhihong, Zheng, Zhili, Zhang, Futao, Wu, Yang, Trzaskowski, Maciej, Maier, Robert, Robinson, Matthew R., McGrath, John J, Visscher, Peter M, Wray, Naomi R and Yang, Jian (2018). Causal associations between risk factors and common diseases inferred from GWAS summary data. Nature Communications, 9 (1) 224, 224. doi: 10.1038/s41467-017-02317-2

Wu, Yang, Zheng, Zhili, Visscher, Peter M. and Yang, Jian (2017). Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data. Genome Biology, 18 (1) 86, 86. doi: 10.1186/s13059-017-1216-0

Zhang, Wengang, Xu, Lingyang, Gao, Huijiang, Wu, Yang, Gao, Xue, Zhang, Lupei, Zhu, Bo, Song, Yuxin, Bao, Jinshan, Li, Junya and Chen, Yan (2016). Detection of candidate genes for growth and carcass traits using genome-wide association strategy in Chinese Simmental beef cattle. Animal Production Science, 58 (2), 224-233. doi: 10.1071/AN16165

Xia, Jiangwei, Qi, Xin, Wu, Yang, Zhu, Bo, Xu, Lingyang, Zhang, Lupei, Gao, Xue, Chen, Yan, Li, Junya and Gao, Huijiang (2016). Genome-wide association study identifies loci and candidate genes for meat quality traits in Simmental beef cattle. Mammalian Genome, 27 (5-6), 246-255. doi: 10.1007/s00335-016-9635-x

Zhu, Bo, Zhu, Miao, Jiang, Jicai, Niu, Hong, Wang, Yanhui, Wu, Yang, Xu, Lingyang, Chen, Yan, Zhang, Lupei, Gao, Xue, Gao, Huijiang, Liu, Jianfeng and Li, Junya (2016). The impact of variable degrees of freedom and scale parameters in Bayesian methods for genomic prediction in Chinese Simmental beef cattle. PL o S One, 11 (5) e0154118, e0154118. doi: 10.1371/journal.pone.0154118

Fan, Huizhong, Wu, Yang, Zhou, Xiaojing, Xia, Jiangwei, Zhang, Wengang, Song, Yuxin, Liu, Fei, Chen, Yan, Zhang, Lupei, Gao, Xue, Gao, Huijiang and Li, Junya (2015). Pathway-based genome-wide association studies for two meat production traits in Simmental cattle. Scientific Reports, 5 (1) 18389. doi: 10.1038/srep18389

Wu, Yang, Fan, Huizhong, Jing, Shengyun, Xia, Jiangwei, Chen, Yan, Zhang, Lupei, Gao, Xue, Li, Junya, Gao, Huijiang and Ren, Hongyan (2015). A genome-wide scan for copy number variations using high-density single nucleotide polymorphism array in Simmental cattle. Animal Genetics, 46 (3), 289-298. doi: 10.1111/age.12288

Gao, H., Wu, Y., Zhang, T., Wu, Y., Jiang, L., Zhan, J., Li, J. and Yang, R. (2015). Correction: Multiple-trait genome-wide association study based on principal component analysis for residual covariance matrix (vol 113, pg 526, 2014). Heredity, 114 (4), 428-428. doi: 10.1038/hdy.2015.11

Jiang, Dan, Wang, Hongwei, Li, Jiahan, Wu, Yang, Fang, Ming and Yang, Runqing (2014). Cox regression model for dissecting genetic architecture of survival time. Genomics, 104 (6), 472-476. doi: 10.1016/j.ygeno.2014.10.002

Gao, H., Zhang, T., Wu, Y., Wu, Y., Jiang, L., Zhan, J., Li, J. and Yang, R. (2014). Multiple-trait genome-wide association study based on principal component analysis for residual covariance matrix. Heredity, 113 (6), 526-532. doi: 10.1038/hdy.2014.57

Wu, Yang, Fan, Huizhong, Wang, Yanhui, Zhang, Lupei, Gao, Xue, Chen, Yan, Li, Junya, Ren, HongYan and Gao, Huijiang (2014). Genome-Wide Association Studies Using Haplotypes and Individual SNPs in Simmental Cattle. PLoS ONE, 9 (10) e109330, e109330. doi: 10.1371/journal.pone.0109330

Xing, Jun, Gao, Huijiang, Wu, Yang, Wu, Yani, Li, Hongwang and Yang, Runqing (2014). Generalized Linear Model for Mapping Discrete Trait Loci Implemented with LASSO Algorithm. PL o S One, 9 (9) e106985, e106985. doi: 10.1371/journal.pone.0106985

Fan, Huizhong, Wu, Yang, Qi, Xin, Zhang, Jingjing, Li, Juan, Gao, Xue, Zhang, Lupei, Li, Junya and Gao, HuiJiang (2014). Genome-wide detection of selective signatures in Simmental cattle. Journal of Applied Genetics, 55 (3), 343-351. doi: 10.1007/s13353-014-0200-6

Gao, Huijiang, Wu, Yang, Li, Jiahan, Li, Hongwang, Li, Junya and Yang, Runqing (2014). Forward LASSO analysis for high-order interactions in genome-wide association study. Briefings in Bioinformatics, 15 (4) bbt037, 552-561. doi: 10.1093/bib/bbt037

Zhu, M., Zhu, B., Wang, Y. H., Wu, Y., Xu, L., Guo, L. P., Yuan, Z. R., Zhang, L. P., Gao, X., Gao, H. J., Xu, S. Z. and Li, J. Y. (2013). Linkage disequilibrium estimation of Chinese beef Simmental cattle using high-density SNP panels. Asian-Australasian Journal of Animal Sciences, 26 (6), 772-779. doi: 10.5713/ajas.2012.12721

Zeng, Jian, Wu, Yang, Zheng, Zhili, Thibaut, Loic, Goddard, Michael, Wray, Naomi and Visscher, Peter (2024). Genome-wide Fine-mapping Improves Identification Of Causal Variants. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.037

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, 20-23 June 2018. New York, NY United States: Springer New York.

Kassam, Irfahan, Wu, Yang, Visscher, Peter M. and McRae, Allan F. (2017). Tissue-specific sexual dimorphism in autosomal gene expression. Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Cambridge, England, 9-11 September 2017. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/gepi.22062

Wu, Yang (2019). The genetic regulatory mechanisms underpinning complex trait variation in humans. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2019.739

Dr Yang Wu

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