Dr Jianying Han
Research Fellow
Institute for Molecular Bioscience
+61 7 344 36293
Researcher biography
Jianying Han (PhD) is an Early Career Research Fellow and Natural Product Chemist at the Institute for Molecular Bioscience, specialising in the discovery of structurally novel and biologically active small molecules from unique microbial resources. His research focuses on unlocking the chemical diversity of underexplored microorganisms, particularly rare Actinobacteria and other environmentally derived microbes. Dr Han integrates microbial cultivation strategies, genome-guided discovery, and advanced chemical analysis to activate silent biosynthetic pathways and reveal new classes of natural products. His work employs innovative approaches including high-throughput cultivation matrices, co-cultivation, precursor-directed biosynthesis, and microbial biotransformation to expand the chemical space accessible from microbial metabolites. Through these strategies, He aims to identify new bioactive compounds with potential applications in agriculture, biotechnology, and pharmaceutical discovery, while contributing to the development of Australia's microbial resources and bioeconomy.
Book Chapters
Ren, Biao, Huang, Pei, Zhang, Jingyu, He, Wenni, Han, Jianying, Liu, Xueting and Zhang, Lixin (2015). Main applications of antibiotics. Antibiotics : current innovations and future trends. (pp. 19-47) edited by Sergio Sánchez and Arnold L. Demain. Norfolk, United Kingdom: Caister Academic Press.
Han, Jianying, Zhang, Jingyu, He, Wenni, Huang, Pei, Oyeleye, Ayokunmi, Liu, Xueting and Zhang, Lixin (2015). Bioassay-guided identification of bioactive molecules from traditional Chinese medicines. Chemical biology: methods and protocols. (pp. 187-196) edited by Hempel, JE, Williams, CH and Hong, CC. New York, United States: Humana Press. doi: 10.1007/978-1-4939-2269-7_15
Zhang, Jingyu, Han, Jianying, Oyeleye, Ayokunmi, Liu, Miaomiao, Liu, Xueting and Zhang, Lixin (2015). Extraction methods of natural products from traditional Chinese medicines. Chemical biology: methods and protocols. (pp. 177-185) edited by Jonathan E. Hempel, Charles H. Williams and Charles C. Hong. New York, United States: Humana Press. doi: 10.1007/978-1-4939-2269-7_14
Journal Articles
Jin, Shengbin, Bruhn, David F., Burkman, Erica J., Childs, Cynthia T., Han, Jianying, Khalil, Zeinab G., Moreno, Yovany, Salim, Angela A., Samarasekera, Kaumadi, Tangerina, Marcelo M. P. and Capon, Robert J. (2026). Goondoxazoles A–C: anthelmintic spiroketal polyketide alkaloids and other benzoxazoles from Australian pasture soil-derived Streptomyces spp.. Antibiotics, 15 (3), 302. doi: 10.3390/antibiotics15030302
Han, Jianying, Bernhardt, Paul V., Bruhn, David F., Burkman, Erica, Roberts, Dana C., Moreno, Yovany, Salim, Angela A., Wu, Taizong and Capon, Robert J. (2026). Goondicones I–K and Cratermycins A–D: Cultivation Profiling Enabled the Search for New Anthelmintics from an Australian Pasture Soil-Derived Actinomadura sp. Journal of Agricultural and Food Chemistry, 74 (11), 9403-9413. doi: 10.1021/acs.jafc.5c17192
Han, Jianying, Bruhn, David F., Burkman, Erica, Roberts, Dana C., Gong, Kaikai, Moreno, Yovany, Salim, Angela A., Sritharan, Thulasi and Capon, Robert J. (2026). Goondastatins and Goondazines: Triamide-Hydroxamate and Piperazine Anthelmintics from Australian Pasture Soil-Derived Actinomadura and Streptomyces spp. Journal of Natural Products, 89 (3), 1071-1080. doi: 10.1021/acs.jnatprod.6c00120
Yin, Qiang, Han, Jianying, Yang, Guixiang, Song, Zhijun, Zou, Keke, Lv, Kangjie, Lin, Zexu, Ma, Lei, Liu, Miaomiao, Feng, Yunjiang, Quinn, Ronald J., Hsiang, Tom, Zhang, Lixin, Liu, Xueting, Zhu, Guoliang and Zhang, Jingyu (2025). New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus Bipolaris sorokiniana 11134. Natural Products and Bioprospecting, 15 (1) 29, 1-13. doi: 10.1007/s13659-025-00508-9
Han, Jianying, Van Voorhis, Wesley C., Quinn, Ronald J. and Liu, Miaomiao (2025). Discovery of lithospermate B as a potential ligand for the malarial E2 ubiquitin-conjugating enzyme via multiplexed native mass spectrometry. Chemosensors, 13 (5) 166, 1-13. doi: 10.3390/chemosensors13050166
Han, Jianying, Liu, Xueting, Zhang, Lixin, Quinn, Ronald J. and Liu, Miaomiao (2025). Nuclear magnetic resonance fingerprinting and principal component analysis strategies lead to anti-tuberculosis natural product discovery from actinomycetes. Antibiotics, 14 (1) 108, 1-26. doi: 10.3390/antibiotics14010108
Han, Jianying, Bruhn, David F., Childs, Cynthia T., Moreno, Yovany, Salim, Angela A., Wu, Taizong and Capon, Robert J. (2024). Goondicones A–H: Spiro-isoindolinone heartworm anthelmintics from an Australian pasture-soil-derived Streptomyces sp.. Antibiotics, 13 (12) 1222, 1222. doi: 10.3390/antibiotics13121222
Han, Jianying, Bruhn, David F., Roberts, Dana C., Burkman, Erica, Moreno, Yovany, Salim, Angela A. and Capon, Robert J. (2024). Goondomycins A–H: Carbocyclic ansa-Polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis. Journal of Natural Products, 87 (12), 2810-2821. doi: 10.1021/acs.jnatprod.4c00987
Han, Jianying, Bruhn, David F, Roberts, Dana C., Burkman, Erica J., Moreno, Yovany, Bernhardt, Paul V., Salim, Angela A. and Capon, Robert J. (2024). Goondolinones A and B: Terpenyl-quinolin-4(1H)-ones from an Australian volcanic crater soil-derived Actinomadura sp., with selective activity against Dirofilaria immitis (Heartworm). Journal of Natural Products, 87 (12), 2855-2862. doi: 10.1021/acs.jnatprod.4c01146
Han, Jianying, Liu, Xueting, Zhang, Lixin, Van Voorhis, Wesley C., Quinn, Ronald J. and Liu, Miaomiao (2024). Rapid discovery of antimicrobial and antimalarial agents from natural product fragments. Separations, 11 (7) 194, 194. doi: 10.3390/separations11070194
Han, Jianying, Bernhardt, Paul V. and Capon, Robert J. (2024). Goondansamycins A–H: Benzenoid Ansamycins from an Australian volcanic crater soil-derived Actinomadura sp. S4S-00069B08. Journal of Natural Products, 87 (5), 1471-1478. doi: 10.1021/acs.jnatprod.4c00336
Han, Jianying, Liu, Xueting, Zhang, Lixin, Quinn, Ronald J. and Feng, Yunjiang (2022). Anti-mycobacterial natural products and mechanisms of action. Natural Product Reports, 39 (1), 77-89. doi: 10.1039/d1np00011j
Jiang, Lan, Zhu, Guoliang, Han, Jianying, Hou, Chengjian, Zhang, Xue, Wang, Zhixin, Yuan, Weize, Lv, Kangjie, Cong, Zhanren, Wang, Xinye, Chen, Xiangyin, Karthik, Loganathan, Yang, Huanting, Wang, Xuyuan, Tan, Gaoyi, Liu, Guang, Zhao, Liya, Xia, Xuekui, Liu, Xiangyang, Gao, Shushan, Ma, Lei, Liu, Mei, Ren, Biao, Dai, Huanqin, Quinn, Ronald J., Hsiang, Tom, Zhang, Jingyu, Zhang, Lixin and Liu, Xueting (2021). Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi. Applied Microbiology and Biotechnology, 105 (13), 5407-5417. doi: 10.1007/s00253-021-11192-3
Han, Jianying, Jiang, Lan, Zhang, Lixin, Quinn, Ronald J., Liu, Xueting and Feng, Yunjiang (2021). Peculiarities of meroterpenoids and their bioproduction. Applied Microbiology and Biotechnology, 105 (10), 3987-4003. doi: 10.1007/s00253-021-11312-z
Liu, Miaomiao, Han, Jianying, Feng, Yunjiang, Guymer, Gordon, Forster, Paul and Quinn, Ronald J. (2021). Antimicrobial benzyltetrahydroisoquinoline-derived alkaloids from the leaves of Doryphora aromatica. Journal of Natural Products, 84 (3), 676-682. doi: 10.1021/acs.jnatprod.0c01093
Nguyen, Duy Thanh, Iqbal, Jamila, Han, Jianying, Pierens, Gregory K., Wood, Stephen A., Mellick, George D. and Feng, Yunjiang (2020). Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line. Bioorganic and Medicinal Chemistry, 28 (21) 115732, 1-9. doi: 10.1016/j.bmc.2020.115732
Han, Jianying, Liu, Miaomiao, Jenkins, Ian D., Liu, Xueting, Zhang, Lixin, Quinn, Ronald J. and Feng, Yunjiang (2020). Genome-inspired chemical exploration of marine fungus aspergillus fumigatus MF071. Marine Drugs, 18 (7) md18070353, 352. doi: 10.3390/md18070352
Elnaas, Ali R., Grice, Darren, Han, Jianying, Feng, Yunjiang, Capua, Angela Di, Mak, Tin, Laureanti, Joseph A., Buchko, Garry W., Myler, Peter J., Cook, Gregory, Quinn, Ronald J. and Liu, Miaomiao (2020). Discovery of a natural product that binds to the mycobacterium tuberculosis protein Rv1466 using native mass spectrometry. Molecules, 25 (10) 2384, 2384. doi: 10.3390/molecules25102384
Han, Jianying, Zhang, Jingyu, Song, Zhijun, Zhu, Guoliang, Liu, Miaomiao, Dai, Huanqin, Hsiang, Tom, Liu, Xueting, Zhang, Lixin, Quinn, Ronald J and Feng, Yunjiang (2020). Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Applied Microbiology and Biotechnology, 104 (9), 3835-3846. doi: 10.1007/s00253-020-10522-1
Zhang, Jingyu, Wang, Zhenzhen, Song, Zhijun, Karthik, Loganathan, Hou, Chengjian, Zhu, Guoliang, Jiang, Lan, Han, Jianying, Ma, Rong, Li, Li, Zhang, Lixin, Liu, Xueting and Hsiang, Tom (2019). Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049. Synthetic and Systems Biotechnology, 4 (4), 173-179. doi: 10.1016/j.synbio.2019.09.001
Han, Jianying, Zhang, Jingyu, Song, Zhijun, Liu, Miaomiao, Hu, Jiansen, Hou, Chengjian, Zhu, Guoliang, Jiang, Lan, Xia, Xuekui, Quinn, Ronald J., Feng, Yunjiang, Zhang, Lixin, Hsiang, Tom and Liu, Xueting (2019). Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Applied Microbiology and Biotechnology, 103 (13), 5167-5181. doi: 10.1007/s00253-019-09821-z
Liu, Miaomiao, Grkovic, Tanja, Liu, Xueting, Han, Jianying, Zhang, Lixin and Quinn, Ronald J. (2017). A systems approach using OSMAC, Log P and NMR fingerprinting: an approach to novelty. Synthetic and Systems Biotechnology, 2 (4), 276-286. doi: 10.1016/j.synbio.2017.10.001
He, Wenni, Liu, Miaomiao, Li, Xiaolin, Zhang, Xiaoping, Abdel-Mageed, Wael M., Li, Li, Wang, Wenzhao, Zhang, Jingyu, Han, Jianying, Dai, Huanqin, Quinn, Ronald J., Liu, Hung-wen, Luo, Houwei, Zhang, Lixin and Liu, Xueting (2016). Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity. Applied Microbiology and Biotechnology, 100 (19), 8349-8357. doi: 10.1007/s00253-016-7488-6
Huang, Pei, Xie, Feng, Ren, Biao, Wang, Qian, Wang, Jian, Wang, Qi, Abdel-Mageed, Wael M., Liu, Miaomiao, Han, Jianying, Oyeleye, Ayokunmi, Shen, Jinzhao, Song, Fuhang, Dai, Huanqin, Liu, Xueting and Zhang, Lixin (2016). Anti-MRSA and anti-TB metabolites from marine-derived Verrucosispora sp MS100047. Applied Microbiology and Biotechnology, 100 (17), 7437-7447. doi: 10.1007/s00253-016-7406-y
He, Wenni, Liu, Miaomiao, Huang, Pei, Abdel-Mageed, Wael M., Han, Jianying, Watrous, Jeramie D., Nguyen, Don D., Wang, Wenzhao, Song, Fuhang, Dai, Huanqin, Zhang, Jingyu, Quinn, Ronald J., Grkovi, Tanja, Luo, Houwei, Zhang, Lixin and Liu, Xueting (2016). Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation. Synthetic and Systems Biotechnology, 1 (3), 187-194. doi: 10.1016/j.synbio.2016.05.002
Romero, C. A., Grkovic, T., Han, J., Zhang, L., French, J. R. J., Kurtboke, D. I. and Quinn, R. J. (2015). NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species. RSC Advances, 5 (126), 104524-104534. doi: 10.1039/c5ra17553d
Conference Papers
Han, Jianying (2025). Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis. 32nd International Symposium on the Chemistry of Natural Products and 12th International Congress on Biodiversity (ISCNP32 & ICOB12), Sydney, NSW, Australia, 24 - 28 August 2025.
Han, Jianying (2024). Goondomycins and goondolinones: carbocyclic ansa-polyketides and terpenyl-quinolin-4(1H)-ones with selective activity against Dirofilaria immitis (heartworm). 3rd Aus-NZ Natural Products Chemistry & Biology Symposium / RACI NSW Natural Products Symposium, Sydney, NSW Australia, 11-12 November 2024.
Han, Jianying, Bruhn, David F., Roberts, Dana C., Burkman, Erica, Moreno, Yovany and Capon, Robert J. (2024). Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis (heartworm). IMB Centre for Chemistry and Drug Discovery Symposium, St Lucia, QLD Australia, 7 November 2024.
Han, Jianying (2024). Genome- and MS-inspired microbial natural product discovery. Binzhou Medical University 2024 "Brain Pub" Graduate Academic Research Forum, Online, 23 March 2024.
Han, Jianying, Jin, Shengbin, Sritharan, Thulasi, Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2023). The search for anthelmintics from Australian soil microbes based on integrated bioassay, MATRIX and GNPS molecular networking approach. IMB Centre for Chemistry and Drug Discovery Symposium, Brisbane, QLD Australia, 2 November 2023.
Han, Jianying (2022). Genome-inspired chemical investigation of phytopathogenic fungus Bipolaris sorokiniana strain 11134. IMB Seminar Series: Chemistry and Structural Biology, Brisbane, QLD, Australia, 25 August 2022.
Han, Jianying (2020). Exploring the potential of endophytes and fungi as sources of antimicrobial compounds.. 5th Queensland Annual Chemistry Symposium, Brisbane, QLD, Australia, 27 November 2020.
Han, Jianying (2019). Exploring the potential of endophytes and fungi as sources of antibacterial compounds. 6th GRIDD SIMM Annual Symposium, Brisbane, QLD, Australia, 11 October 2019.
Han, Jianying, Liu, Xueting, Zhang, Lixin, Quinn, Ronald and Feng, Yunjiang (2019). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. Gordon Research Conference, Castelldefels, Spain, 6-12 July 2019.
Han, Jianying (2019). Exploring the potential of endophytes and fungi as sources of antibacterial compounds.. 4th Queensland Annual Chemistry Symposium, Brisbane, QLD, Australia, 29 November 2019.
Han, Jianying, Quinn, Ronald and Feng, Yunjiang (2019). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. Brisbane Life Science ECR Symposium (BLiSS), Brisbane, QLD, Australia, 7 June 2019.
Han, Jianying, Quinn, Ronald and Feng, Yunjiang (2018). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. Griffith Cross-Institute Infectious Diseases Symposium, Brisbane, QLD, Australia, 16 November 2028.
Han, Jianying (2018). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. 3rd Queensland Annual Chemistry Symposium, Brisbane, QLD, Australia, 23 November 2018.
Han, Jianying (2018). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. 5th SIMM GRIDD symposium, Suzhou, China, 30-31 August 2028.
Seminar Papers
Han, Jianying (2025). Anthelmintic discovery from Australian microbes: a bioassay–GNPS–MATRIX approach. Institute for Molecular Bioscience, The University of Queensland, Brisbane.
Han, Jianying (2025). Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis. IMB Research Day. Institute for Molecular Bioscience, The University of Queensland, Brisbane.